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Journal Articles

PU.1-Dependent Enhancer Decommissioning Drives Transformation of Tet2 deficient Hematopoietic Stem and Progenitor Cells

Maria M. Aivalioti, MS., Tushar D Bhagat, PhD, Aditi Paranjpe, MS., Boris Bartholdy, PhD, Kith Pradhan, PhD, Mario Pujato, PhD, Amit Verma, MBBS, Britta Will, PhD

Blood (2020) 136 (Supplement 1): 40.

https://doi.org/10.1182/blood-2020-142070

Published: 2020

Journal Articles

Chaperone-Mediated Autophagy Ensures Hematopoietic Stem Cell Maintenance

Shuxian Dong, PhD, Britta Will, PhD, Ana Maria Cuervo, MD PhD

Blood (2019) 134 (Supplement_1): 272.

https://doi.org/10.1182/blood-2019-132230

Published: 2019

Journal Articles

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Blood (2019) 134 (Supplement_1): 4224.

https://doi.org/10.1182/blood-2019-124458

Published: 2019

Journal Articles

Azacytidine Inhibits Megakaryopoiesis Via the Induction of Immunogenic RNA Species and Activation of Type-I Interferon Signaling

Ujunwa Cynthia Okoye-Okafor, MS,PhD, Komal Kumar Javarappa, PhD, Dimitrios Tsallos, BSc(Hons),MSc, Joseph J Saad, MSc, BSc, Lumie Benard, Victor Thiruthuvanathan, M.S, Sally Cole, Madhuri Tatiparthy, M.S., Stephen Ruiz, B.Sc, Stefanie DeFronzo, Celine Pallaud, PhD, Pedro Marques Ramos, PhD, Amit Verma, MBBS, Aditi Shastri, MD, Caroline A Heckman, PhD, Britta Will, PhD

Blood (2019) 134 (Supplement_1): 1280.

https://doi.org/10.1182/blood-2019-131461

Published: 2019

Journal Articles

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

Srinivas Aluri, Kimo Bachiashvili, MD, Anjali Budhathoki, MD, Tushar D Bhagat, PhD, Gaurav S Choudhary, PhD, Shanisha Gordon, Nandini Ramachandra, Kith Pradhan, PhD, Shahina Maqbool, Aditi Shastri, MD, Jung Im Huh, Sunjin Hwang, Kim Seong-Jin, PhD, Hui Zhang, Britta Will, PhD, Amittha Wickrema, PhD, Ulrich G. Steidl, MD PhD, Amit Verma, MBBS

Blood (2019) 134 (Supplement_1): 2990.

https://doi.org/10.1182/blood-2019-127561

Published: 2019

Journal Articles

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

Blood (2019) 134 (Supplement_1): 3720.

https://doi.org/10.1182/blood-2019-129276

Published: 2019

Journal Articles

Therapeutic Targeting of the Ubiquitin Conjugating Enzyme UBE2N in Myeloid Malignancies

Blood (2018) 132 (Supplement 1): 4050.

https://doi.org/10.1182/blood-2018-99-115359

Published: 2018

Journal Articles

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Blood (2017) 130 (Supplement 1): 858.

https://doi.org/10.1182/blood.V130.Suppl_1.858.858

Published: 2017

Journal Articles

Dual Inhibition of Mdmx and Mdm2 Using an Alpha-Helical P53 Stapled Peptide (ALRN-6924) As a Novel Therapeutic Strategy in Acute Myeloid Leukemia

Luis A. Carvajal, PhD, Daniela Ben-Neriah, B.S, Adrien Senecal, PhD, Lumie Bernard, M.S, Swathi-Rao Narayanagari, M.S, Charles Kenworthy, B.S, Victor Thiruthuvanathan, M.S, Vincent Guerlavais, PhD, D. Allen Annis, PhD, Boris Bartholdy, PhD, Britta Will, PhD, Jesus Anampa, MD, Ioannis Mantzaris, MD, Manuel A. Aivado, MD PhD, Robert H Singer, PhD, Robert Coleman, PhD, Amit Verma, MD, Ulrich G. Steidl, MDPhD

Blood (2017) 130 (Supplement 1): 795.

https://doi.org/10.1182/blood.V130.Suppl_1.795.795

Published: 2017

Journal Articles

AML-Associated Somatic Mutations Can be Detected in Stem and Progenitor Populations in Patients with Antecedent Multiple Myeloma Years before Onset of Therapy-Related Transformation

Ashwin Sridharan, Carolina D. Schinke, MD, George Georgiev, Mariana Da Silva Ferreira, Kith Pradhan, PhD, Yu Xia, PhD, Maya Panjikaran, MS, Gregory Sims, Chirag Bhagat, Armin Graber, Christoph Heuck, MD, Daisy Alapat, MD, Niels Weinhold, PhD, Sarah K Johnson, PhD, Bart Barlogie, MD PhD, Gareth J. Morgan, MD PhD, Ulrich G. Steidl, MDPhD, Britta Will, PhD, Amit Verma, MD

Blood (2017) 130 (Supplement 1): 2706.

https://doi.org/10.1182/blood.V130.Suppl_1.2706.2706

Published: 2017

Journal Articles

Pre-Clinical Modeling of Concomitant Therapy with Azacytidine and Eltrombopag in MDS/AML

Sally Cole, Lumie Benard, Luis A. Carvajal, PhD, Amit Verma, MD, Ulrich G. Steidl, MDPhD, Pedro Marques Ramos, PhD, Celine Pallaud, PhD, Britta Will, PhD

Blood (2017) 130 (Supplement 1): 2950.

https://doi.org/10.1182/blood.V130.Suppl_1.2950.2950

Published: 2017

Journal Articles

LSD1 Inhibition Exerts Its Anti-Leukemic Effect By Recommissioning PU.1- and C/Ebpα-Dependent Enhancers in AML

Monica Cusan, MD, Sheng Cai, MD PhD, Helai P Mohammad, PhD, Andrei V. Krivtsov, PhD, Alan Chramiec, Evangelia Loizou, Daniel G. Tenen, MD, Min Ye, PhD, Britta Will, PhD, Ulrich G. Steidl, MDPhD, Ryan G. Kruger, PhD, Richard Koche, PhD, Scott Armstrong, MD PhD

Blood (2017) 130 (Supplement 1): 242.

https://doi.org/10.1182/blood.V130.Suppl_1.242.242

Published: 2017

Journal Articles

Targeting MDS and AML Stem Cells with AZD-9150 Mediated Inhibition of STAT3

Blood (2016) 128 (22): 4314.

https://doi.org/10.1182/blood.V128.22.4314.4314

Published: 2016

Journal Articles

Examination of Phosphoprotein Targets in Timed Samples from Patients with RAS -Mutated AML during Concurrent Treatment with Alpelisib and Binimetinib on the Phase Ib Clinical Trial CMEK162X2109

Kira Gritsman, MD PhD, Robert P. Hasserjian, MD, Taneisha Sinclair, David M. Weinstock, MD, Britta Will, PhD, Ulrich Steidl, MD PhD, Karen K. Ballen, MD, Amir T. Fathi, MD, Amit Verma, MD, Dejan Juric, MD, Philip C. Amrein, MD

Blood (2016) 128 (22): 2749.

https://doi.org/10.1182/blood.V128.22.2749.2749

Published: 2016

Journal Articles

HIV Is Associated with a High Rate of Unexplained Multilineage Cytopenias and Portends a Poor Prognosis in Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Justin Kaner, MD, Santiago Thibaud, MD, Ashwin Sridharan, MD, Amer Assal, MD, Rahul Polineni, MD, Barry Zingman, MD, Anjali Sharma, MD, Harold Kunal Elias, MD, Louis Weiss, MD MPH, Murali Janakiram, MD, Ira Braunschweig, MD, Swati Goel, MD, Ulrich Steidl, MDPhD, Kith Pradhan, PhD, Aditi Shastri, MD, Britta Will, PhD, Ioannis Mantzaris, MD, Mark Chaitowitz, MD, Amit Verma, MD

Blood (2016) 128 (22): 4345.

https://doi.org/10.1182/blood.V128.22.4345.4345

Published: 2016

Journal Articles

Minimal Reduction of PU.1 Is Sufficient to Induce a Preleukemic State and Promote Development of Acute Myeloid Leukemia

Britta Will, PhD, Thomas O. Vogler, Swathi-rao Narayanagari, Boris Bartholdy, Tihomira I. Todorova, MSc, Jiahao Chen, Yiting Yu, Jillian Mayer, Mariana da Silva Ferreira, Laura Barreyro, PhD, Luis Carvajal, Michael Roth, MD, Johanna van Oers, Sonja Schaetzlein, Christine McMahon, MD, Winifried Edelmann, Amit Verma, MD, Ulrich Steidl, MDPhD

Blood (2015) 126 (23): 305.

https://doi.org/10.1182/blood.V126.23.305.305

Published: 2015

Journal Articles

Interleukin-1 Drives Precocious Myeloid Differentiation of Hematopoietic Stem Cells at the Expense of Self-Renewal

Eric Martin Pietras, PhD, Cristina Mirantes-Barbeito, PhD, Sarah Fong, Dirk Loffler, PhD, Larisa Vladimirovna Kovtonyuk, Ranjani Lakshminarashimhan, Chih Peng Chin, Jose-Marc Techner, Britta Will, PhD, Claus Nerlov, PhD, Ulrich Steidl, MD PhD, Markus Manz, MD, Timm Schroeder, PhD, Emmanuelle Passegue, PhD

Blood (2015) 126 (23): 778.

https://doi.org/10.1182/blood.V126.23.778.778

Published: 2015

Journal Articles

New Allosteric Inhibitors of Mutant IDH1 in Acute Myeloid Leukemia

Blood (2015) 126 (23): 787.

https://doi.org/10.1182/blood.V126.23.787.787

Published: 2015

Journal Articles

Targeting of MDS and AML Stem Cells Via Inhibition of STAT3 By Pyrimethamine

Aditi Shastri, MD, Carolina Schinke, MD, Asya Varshavsky Yanovsky, MD PhD, Tushar D. Bhagat, PhD, Orsolya Giricz, Laura Barreyro, M.Sc., Jacqueline Boultwood, PhD, Andrea Pellagati, Yiting Yu, PhD, Jennifer R. Brown, MD PhD, David A. Frank, MD PhD, Bhaskar Das, PhD, Suman Kambhampati, MD, Britta Will, PhD, Ulrich Steidl, MDPhD, Amit Verma, MD

Blood (2014) 124 (21): 3602.

https://doi.org/10.1182/blood.V124.21.3602.3602

Published: 2014

Journal Articles

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

Tushar D Bhagat, PhD, Matthias Bartenstein, MD, Yiting Yu, PhD, A. Mario Q. Marcondes, MD PhD, Britta Will, PhD, Orsolya Giricz, PhD, Davendra P. Sohal, MD MPH, Ioannis Mantzaris, MD, Amittha Wickrema, PhD, Christine Mcmahon, MD, Yeung Cecilia, MD, John Greally, MB, PhD, Siddhartha Mukherjee, MD PhD, Ulrich Steidl, MD PhD, H. Joachim Deeg, MD, Amit Verma, MD

Blood (2014) 124 (21): 4379.

https://doi.org/10.1182/blood.V124.21.4379.4379

Published: 2014

NARROW

PU.1-Dependent Enhancer Decommissioning Drives Transformation of Tet2 deficient Hematopoietic Stem and Progenitor Cells

Chaperone-Mediated Autophagy Ensures Hematopoietic Stem Cell Maintenance

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Azacytidine Inhibits Megakaryopoiesis Via the Induction of Immunogenic RNA Species and Activation of Type-I Interferon Signaling

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

Therapeutic Targeting of the Ubiquitin Conjugating Enzyme UBE2N in Myeloid Malignancies

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Dual Inhibition of Mdmx and Mdm2 Using an Alpha-Helical P53 Stapled Peptide (ALRN-6924) As a Novel Therapeutic Strategy in Acute Myeloid Leukemia

AML-Associated Somatic Mutations Can be Detected in Stem and Progenitor Populations in Patients with Antecedent Multiple Myeloma Years before Onset of Therapy-Related Transformation

Pre-Clinical Modeling of Concomitant Therapy with Azacytidine and Eltrombopag in MDS/AML

LSD1 Inhibition Exerts Its Anti-Leukemic Effect By Recommissioning PU.1- and C/Ebpα-Dependent Enhancers in AML

Targeting MDS and AML Stem Cells with AZD-9150 Mediated Inhibition of STAT3

Examination of Phosphoprotein Targets in Timed Samples from Patients with RAS -Mutated AML during Concurrent Treatment with Alpelisib and Binimetinib on the Phase Ib Clinical Trial CMEK162X2109

HIV Is Associated with a High Rate of Unexplained Multilineage Cytopenias and Portends a Poor Prognosis in Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Minimal Reduction of PU.1 Is Sufficient to Induce a Preleukemic State and Promote Development of Acute Myeloid Leukemia

Interleukin-1 Drives Precocious Myeloid Differentiation of Hematopoietic Stem Cells at the Expense of Self-Renewal

New Allosteric Inhibitors of Mutant IDH1 in Acute Myeloid Leukemia

Targeting of MDS and AML Stem Cells Via Inhibition of STAT3 By Pyrimethamine

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

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American Society of Hematology

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ASH Publications

American Society of Hematology

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