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Journal Articles

IL-9 secreted by leukemia stem cells induces Th1-skewed CD4 + T cells, which promote their expansion

Ramin Radpour, Cedric Simillion, Bofei Wang, Hussein A. Abbas, Carsten Riether, Adrian F. Ochsenbein

Blood (2024) 144 (8): 888–903.

https://doi.org/10.1182/blood.2024024000

Published: 2024

Includes: Supplemental data

Journal Articles

Monoclonal Antibodies Targeting LIGHT Block Ltbr Signalling and Eliminate Acute Myeloid Leukemia Stem Cells

Sabine Hoepner, Tim Delahaye, Carsten Riether, Adrian Ochsenbein

Blood (2023) 142 (Supplement 1): 5956.

https://doi.org/10.1182/blood-2023-180914

Published: 2023

Journal Articles

CD70/CD27 Signaling Promotes Expansion of Clonal Plasma Cells in Multiple Myeloma and Is a Promising Therapeutic Target in Advanced Disease

Stefan Forster, Chantal Bachmann, Maxime Boy, Ramin Radpour, Christian M Schuerch, Frido Brühl, Carsten Riether, Adrian Ochsenbein

Blood (2023) 142 (Supplement 1): 1936.

https://doi.org/10.1182/blood-2023-188431

Published: 2023

Journal Articles

Generation Natural Killer Cell-Mimic Nanoparticles for Active Targeting of Acute Myeloid Leukemia

Hojjat Alizadeh Zeinabad, Wen Jie Yeoh, Philippe Krebs, Carsten Riether, Mihai Lomora, Yara Banz, Eva Szegezdi

Blood (2022) 140 (Supplement 1): 10682–10683.

https://doi.org/10.1182/blood-2022-166893

Published: 2022

Journal Articles

Wnt and Notch Pathways Regulate Stemness of Myeloid Leukemia Cells Via IL33/ST2 Signaling

Pascal Naef, Ramin Radpour, Carla Jaeger-Ruckstuhl, Nils Bodmer, Gabriela M Baerlocher, Hartmut Döhner, Konstanze Döhner, Carsten Riether, Adrian Ochsenbein

Blood (2022) 140 (Supplement 1): 2986–2987.

https://doi.org/10.1182/blood-2022-164810

Published: 2022

Journal Articles

MP0533: A Multispecific Darpin CD3 Engager Targeting CD33, CD123, and CD70 for the Treatment of AML and MDS Designed to Selectively Target Leukemic Stem Cells

Blood (2022) 140 (Supplement 1): 2251–2252.

https://doi.org/10.1182/blood-2022-163075

Published: 2022

Journal Articles

Avidity-Engineered CD3 Engaging DARPin ® Targeting Three Tumor Associated Antigens Induce Strong and Specific T Cell Dependent Killing of AML Cells with Potential for Improved Safety

Blood (2021) 138 (Supplement 1): 1164.

https://doi.org/10.1182/blood-2021-152790

Published: 2021

Journal Articles

ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions

Nina Germic, Aref Hosseini, Darko Stojkov, Kevin Oberson, Meike Claus, Charaf Benarafa, Sara Calzavarini, Anne Angelillo-Scherrer, Isabelle C. Arnold, Anne Müller, Carsten Riether, Shida Yousefi, Hans-Uwe Simon

Blood (2021) 137 (21): 2958–2969.

https://doi.org/10.1182/blood.2020010208

Published: 2021

Includes: Supplemental data

Journal Articles

Splenic CD24 low Red Pulp Macrophages Provide an Alternate Niche for Chronic Myeloid Leukemia Stem Cells

Michael A Amrein, MD PhD, Elias D Bührer, MD PhD, Stefan Forster, MD, Stephan Isringhausen, Christian M Schürch, MD PhD, Salil S. Bhate, MMath, Mohamad Al Sayed, PhD, Cesar Nombela Arrieta, PhD, Ramin Radpour, PhD, Carsten Riether, PhD, Adrian F Ochsenbein, MD

Blood (2019) 134 (Supplement_1): 1634.

https://doi.org/10.1182/blood-2019-126593

Published: 2019

Journal Articles

Targeting CD70 with Cusatuzumab Eliminates Acute Myeloid Leukemia Stem Cells in Humans

Blood (2019) 134 (Supplement_1): 234.

https://doi.org/10.1182/blood-2019-129916

Published: 2019

Journal Articles

CD93-Signaling Regulates Self-Renewal and Proliferation of Chronic Myeloid Leukemia Stem Cells in Mice and Humans and Might be a Promising Target for Treatment

Carsten Riether, PhD, Ramin Radpour, PhD, Chantal L. Bachmann, MSc, Christian M Schürch, MD PhD, Miroslav Arambasic, PhD, Gabriela M Baerlocher, MD, Adrian F Ochsenbein, MD

Blood (2019) 134 (Supplement_1): 187.

https://doi.org/10.1182/blood-2019-127864

Published: 2019

Journal Articles

The Combination of the BCL-2 Antagonist Venetoclax with the CD70-Targeting Antibody Cusatuzumab Synergistically Eliminates Primary Human Leukemia Stem Cells

Carsten Riether, PhD, Tanja Chiorazzo, PhD, Amy J. Johnson, PhD, Christina Diane Drenberg, PhD, Khaja Waheeduddin Syed, BPharm, MS, Mahan Moshir, MSc, Anna Hultberg, PhD, Nicolas Leupin, Hans De Haard, Adrian F Ochsenbein, MD

Blood (2019) 134 (Supplement_1): 3918.

https://doi.org/10.1182/blood-2019-127464

Published: 2019

Journal Articles

Argx-110 Targeting CD70, in Combination with Azacitidine, Shows Favorable Safety Profile and Promising Anti-Leukemia Activity in Newly Diagnosed AML Patients in an Ongoing Phase 1/2 Clinical Trial

Adrian F Ochsenbein, MD, Carsten Riether, PhD, Ulrike Bacher, Rouven Müller, MD, Sabine Höpner, PhD, Yara Banz, Magdalena Hinterbrandner, Msc, Mario Bargetzi, MD, Markus G. Manz, MD, Luc Van Rompaey, PhD, Mahan Moshir, MSc, Tim Delahaye, MSc, Domenica Gandini, MD PhD, Ellen Erzeel, Anna Hultberg, PhD, Samson Fung, MD, Hans De Haard, PhD, Nicolas Leupin, MD, Thomas Pabst, MD PhD

Blood (2018) 132 (Supplement 1): 2680.

https://doi.org/10.1182/blood-2018-99-118302

Published: 2018

Journal Articles

The Traf2 and Nck-Interacting Kinase Is a Conserved Regulator of Self-Renewal in Hematopoietic and Leukemia Stem Cells

Michael A Amrein, MD, Elias D Bührer, MD, Carla Ruckstuhl, PhD, Sabine Höpner, PhD, Carsten Riether, PhD, Adrian F Ochsenbein, MD

Blood (2017) 130 (Supplement 1): 1137.

https://doi.org/10.1182/blood.V130.Suppl_1.1137.1137

Published: 2017

Journal Articles

Blocking CD70/CD27 Signaling in Combination with Hypomethylating Agents Eradicates Human CD34 + AML Stem and Progenitor Cells in Vitro and In Vivo

Magdalena Hinterbrandner, Msc, Nils Maria Kallen, Ursina Lüthi, Thomas Pabst, MD, Luc Van Rompaey, PhD, Nicolas Leupin, MD, Hans De Haard, PhD, Adrian F Ochsenbein, MD, Carsten Riether, PhD

Blood (2017) 130 (Supplement 1): 2652.

https://doi.org/10.1182/blood.V130.Suppl_1.2652.2652

Published: 2017

Journal Articles

Splenic Red Pulp Macrophages Provide a Secondary Stem Cell Niche for Chronic Myeloid Leukemia Stem Cells

Elias D Bührer, MD, Michael A Amrein, MD, Stephan Isringhausen, Cesar Nombela-Arrieta, Carsten Riether, PhD, Adrian F Ochsenbein, MD

Blood (2017) 130 (Supplement 1): 2861.

https://doi.org/10.1182/blood.V130.Suppl_1.2861.2861

Published: 2017

Journal Articles

CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies

Mohamad F. Al Sayed, Carla A. Ruckstuhl, Tamara Hilmenyuk, Christina Claus, Jean-Pierre Bourquin, Beat C. Bornhauser, Ramin Radpour, Carsten Riether, Adrian F. Ochsenbein

Blood (2017) 130 (3): 297–309.

https://doi.org/10.1182/blood-2016-12-756585

Published: 2017

Includes: Supplemental data

Journal Articles

CD70/CD27 Signaling Mediates Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors By Compensatory Activation of the Wnt Pathway

Carsten Riether, PhD, Christian M. Schürch, MD PhD, Ramin Radpour, PhD, Magdalena Hinterbrandner, Anne-Laure Huguenin, Adrian F. Ochsenbein, Prof. MD

Blood (2014) 124 (21): 400.

https://doi.org/10.1182/blood.V124.21.400.400

Published: 2014

NARROW

IL-9 secreted by leukemia stem cells induces Th1-skewed CD4 + T cells, which promote their expansion

Monoclonal Antibodies Targeting LIGHT Block Ltbr Signalling and Eliminate Acute Myeloid Leukemia Stem Cells

CD70/CD27 Signaling Promotes Expansion of Clonal Plasma Cells in Multiple Myeloma and Is a Promising Therapeutic Target in Advanced Disease

Generation Natural Killer Cell-Mimic Nanoparticles for Active Targeting of Acute Myeloid Leukemia

Wnt and Notch Pathways Regulate Stemness of Myeloid Leukemia Cells Via IL33/ST2 Signaling

MP0533: A Multispecific Darpin CD3 Engager Targeting CD33, CD123, and CD70 for the Treatment of AML and MDS Designed to Selectively Target Leukemic Stem Cells

Avidity-Engineered CD3 Engaging DARPin ® Targeting Three Tumor Associated Antigens Induce Strong and Specific T Cell Dependent Killing of AML Cells with Potential for Improved Safety

ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions

Splenic CD24 low Red Pulp Macrophages Provide an Alternate Niche for Chronic Myeloid Leukemia Stem Cells

Targeting CD70 with Cusatuzumab Eliminates Acute Myeloid Leukemia Stem Cells in Humans

CD93-Signaling Regulates Self-Renewal and Proliferation of Chronic Myeloid Leukemia Stem Cells in Mice and Humans and Might be a Promising Target for Treatment

The Combination of the BCL-2 Antagonist Venetoclax with the CD70-Targeting Antibody Cusatuzumab Synergistically Eliminates Primary Human Leukemia Stem Cells

Argx-110 Targeting CD70, in Combination with Azacitidine, Shows Favorable Safety Profile and Promising Anti-Leukemia Activity in Newly Diagnosed AML Patients in an Ongoing Phase 1/2 Clinical Trial

The Traf2 and Nck-Interacting Kinase Is a Conserved Regulator of Self-Renewal in Hematopoietic and Leukemia Stem Cells

Blocking CD70/CD27 Signaling in Combination with Hypomethylating Agents Eradicates Human CD34 + AML Stem and Progenitor Cells in Vitro and In Vivo

Splenic Red Pulp Macrophages Provide a Secondary Stem Cell Niche for Chronic Myeloid Leukemia Stem Cells

CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies

CD70/CD27 Signaling Mediates Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors By Compensatory Activation of the Wnt Pathway

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American Society of Hematology

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American Society of Hematology

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