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Charles Karan
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Journal Articles

Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies

Clinical Trials & Observations
Changchun Deng, Mark R. Lipstein, Luigi Scotto, Xavier O. Jirau Serrano, Michael A. Mangone, Shirong Li, Jeremie Vendome, Yun Hao, Xiaoming Xu, Shi-Xian Deng, Ronald B. Realubit, Nicholas P. Tatonetti, Charles Karan, Suzanne Lentzsch, David A. Fruman, Barry Honig, Donald W. Landry, Owen A. O’Connor
Journal: Blood
Blood (2017) 129 (1): 88–99.
https://doi.org/10.1182/blood-2016-08-731240
Published: 2017
Includes: Supplemental data
Journal Articles

Disruption of the mTOR-eIF4F Axis By Selectively Targeting PI3Kdelta and Proteasome Potently Inhibits Cap Dependent Translation of c-Myc in Aggressive Lymphomas

Changchun Deng, MD PhD, Mark Lipstein, Luigi Scotto, PhD, Yun Hao, Nicholas P. Tatonetti, PhD, Michael Mangone, PhD, Shirong Li, PhD, Suzanne Lentzsch, Ronald B. Realubit, PhD, Charles Karan, Jr., PhD, Owen A. O'Connor, MD PhD
Journal: Blood
Blood (2015) 126 (23): 593.
https://doi.org/10.1182/blood.V126.23.593.593
Published: 2015
Journal Articles

Combination Of Selective HDAC Inhibitors That Target Specific HDAC Isoforms Synergistically Inhibits T Cell Lymphoma

Changchun Deng, MD, PhD, Richard Rodriguez, B.S., Christine McIntosh, Edward Holson, PH.D., Charles Karan, PH.D., Mark Lipstein, B.S., Owen A. O'Connor, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 5142.
https://doi.org/10.1182/blood.V122.21.5142.5142
Published: 2013
Journal Articles

Application of high-throughput screening to identify a novel αIIb-specific small- molecule inhibitor of αIIbβ3-mediated platelet interaction with fibrinogen

Robert Blue, Marta Murcia, Charles Karan, Markéta Jiroušková, Barry S. Coller
Journal: Blood
Blood (2008) 111 (3): 1248–1256.
https://doi.org/10.1182/blood-2007-08-105544
Published: 2008
Includes: Multimedia, Supplemental data
Journal Articles

Application of High Throughput Screening To Identify Novel Small Molecule Inhibitors of αIIbβ3-Mediated Platelet Adhesion to Fibrinogen.

Robert Blue, Markéta Jiroušková, Charles Karan, Barry S. Coller
Journal: Blood
Blood (2006) 108 (11): 144.
https://doi.org/10.1182/blood.V108.11.144.144
Published: 2006