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Journal Articles

IL-6 Mediates a Switch in Free Fatty Acid Metabolism from the Liver to the Bone Marrow to Support HSC Expansion during Infection

Katherine Hampton, Jayna Mistry, Rebecca S Maynard, Dominic Fowler-Shorten, Charlotte Hellmich, Naiara Beraza, Kristian Bowles, Stuart Rushworth

Blood (2023) 142 (Supplement 1): 1332.

https://doi.org/10.1182/blood-2023-178618

Published: 2023

Journal Articles

Sphingomyelinase Regulates the Release of Protumoral Mitochondria Containing-Vesicles from AML Cells

Matthew Markham, David Riley, Rebecca S Maynard, Katherine Hampton, Ravindu De Silva, Charlotte Hellmich, Kristian Bowles, Stuart Rushworth

Blood (2023) 142 (Supplement 1): 4337.

https://doi.org/10.1182/blood-2023-186059

Published: 2023

Journal Articles

The Aging Bone Marrow Niche Disrupts Glutamine Metabolism By Upregulating HSC Derived Glutamine Synthetase

Charlotte Hellmich, Edyta E Wojtowicz, Dominic Fowler-Shorten, Rebecca S Maynard, Katherine Hampton, Iain Macaulay, Kristian Bowles, Stuart Rushworth

Blood (2023) 142 (Supplement 1): 1304.

https://doi.org/10.1182/blood-2023-180194

Published: 2023

Journal Articles

Sting Activation in Bone Marrow Macrophages Targets AML Blasts for Phagocytosis in an ICAM-1 Dependent Mechanism

Ravindu De Silva, Matthew Markham, Rebecca S Maynard, Katherine Hampton, Charlotte Hellmich, Dominic Fowler-Shorten, Kristian Bowles, Stuart Rushworth

Blood (2023) 142 (Supplement 1): 1597.

https://doi.org/10.1182/blood-2023-185880

Published: 2023

Journal Articles

Acute Myeloid Leukemia Driven IL-3 Dependent Upregulation of BCL-2 in Non-Malignant Hematopoietic Progenitor Cells Increases Venetoclax Induced Cytopenias

Dominic Fowler-Shorten, Rebecca S Maynard, Katherine Hampton, Martha Ehikioya, Edyta E Wojtowicz, Kristian Bowles, Stuart Rushworth, Charlotte Hellmich

Blood (2023) 142 (Supplement 1): 293.

https://doi.org/10.1182/blood-2023-173835

Published: 2023

Journal Articles

AML Inhibits Lipid Uptake By the Liver through an HGF/c-MET Dependent Mechanism Which Results in an Increased Supply of Free Fatty Acid to the Tumor

Rebecca S Maynard, Charlotte Hellmich, Katherine Hampton, Dominic Fowler-Shorten, Matthew Markham, Annalisa Altera, Thomas Flint, Ravindu De Silva, Naiara Beraza, Kristian Bowles, Stuart Rushworth

Blood (2023) 142 (Supplement 1): 6031.

https://doi.org/10.1182/blood-2023-178574

Published: 2023

Journal Articles

Multiple Myeloma Induced IL-6 Reprograms Lipid Metabolism through a CD36 Dependent Mechanism

Martha Ehikioya, Annalisa Altera, Katherine Hampton, Rebecca S Maynard, Dominic Fowler-Shorten, Charlotte Hellmich, Kristian Bowles, Matthew Markham, Ravindu De Silva, Stuart Rushworth

Blood (2023) 142 (Supplement 1): 6566.

https://doi.org/10.1182/blood-2023-177900

Published: 2023

Journal Articles

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Aisha Jibril, Charlotte Hellmich, Edyta E. Wojtowicz, Katherine Hampton, Rebecca Maynard, Ravindu De Silva, Dominic J. Fowler-Shorten, Jayna J. Mistry, Jamie A. Moore, Kristian M. Bowles, Stuart A. Rushworth

Blood (2023) 141 (25): 3065–3077.

https://doi.org/10.1182/blood.2022018711

Published: 2023

Includes: Supplemental data

Journal Articles

Sting Agonists Activate Bone Marrow Macrophages and Synergise with Anti-CD47 Blockade Improving Survival in Animal Models of Acute Myeloid Leukemia

Rebecca S Maynard, Charlotte Hellmich, Katherine Hampton, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 9096.

https://doi.org/10.1182/blood-2022-157935

Published: 2022

Journal Articles

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

Charlotte Hellmich, Edyta Wojtowicz, Rebecca S Maynard, Katherine Hampton, Jayna J Mistry, Jamie A Moore, Aisha Jibril, Charlotte L Utting, Iain Macauley, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 8580–8581.

https://doi.org/10.1182/blood-2022-158264

Published: 2022

Journal Articles

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Rebecca S Maynard, Katherine Hampton, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 856.

https://doi.org/10.1182/blood-2022-158523

Published: 2022

Journal Articles

LC3-Associated Phagocytosis Is Impaired in Bone Marrow Macrophages during Ageing Leading to Defective Processing of Apoptotic Cells and Suppression of Sting Activation

Katherine Hampton, Charlotte Hellmich, Rebecca S Maynard, Jamie A Moore, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth

Blood (2022) 140 (Supplement 1): 5759.

https://doi.org/10.1182/blood-2022-169240

Published: 2022

Journal Articles

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

Jamie A Moore, Jayna J Mistry, Charlotte Hellmich, Rebecca H Horton, Edyta Wojtowicz, Aisha Jibril, Tom Wileman, Matthew Jefferson, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth

Blood (2021) 138 (Supplement 1): 3441.

https://doi.org/10.1182/blood-2021-152778

Published: 2021

Journal Articles

Multiple Myeloma Derived Mitochondrial Damps Induce Inflammation in the Bone Marrow Adipose Tissue Which Promotes Tumour Development

Aisha Jibril, Charlotte Hellmich, Jamie A Moore, Jayna J Mistry, Stuart A Rushworth, Kristian M Bowles, Victoria Willimott

Blood (2021) 138 (Supplement 1): 2654.

https://doi.org/10.1182/blood-2021-149191

Published: 2021

Journal Articles

BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress

Charlotte Hellmich, Jayna J Mistry, Aisha Jibril, Jamie A Moore, Benjamin B Johnson, James G W Smith, Edyta Wojtowicz, Naiara Beraza, Kristian M Bowles, Stuart A Rushworth

Blood (2021) 138 (Supplement 1): 1097.

https://doi.org/10.1182/blood-2021-148405

Published: 2021

Journal Articles

Investigating the Dual Targeting of BCL-2 and CD38 in Models of Acute Myeloid Leukemia

Jayna J Mistry, BSc, Charlotte Hellmich, Amelia Lambert, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Angela Collins, MBBS, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 10.

https://doi.org/10.1182/blood-2020-139527

Published: 2020

Journal Articles

Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, Aisha Jibril, BSc, Iain Macauley, PhD BSc, Mar Moreno-Gonzalez, Federica Di Palma, PhD, Naiara Beraza, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-139454

Published: 2020

Journal Articles

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Charlotte Hellmich, MBBChir, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Aisha Jibril, BSc, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-140311

Published: 2020

Journal Articles

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Aisha Jibril, BSc, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Victoria Willimott, MB BS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-139811

Published: 2020

Journal Articles

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

Yu Sun, BSc, MSc, PhD, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Anna Haestier, Cesar A. Gomez, MD PhD FRCPath, Christopher J Morris, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 689.

https://doi.org/10.1182/blood-2019-128268

Published: 2019

NARROW

IL-6 Mediates a Switch in Free Fatty Acid Metabolism from the Liver to the Bone Marrow to Support HSC Expansion during Infection

Sphingomyelinase Regulates the Release of Protumoral Mitochondria Containing-Vesicles from AML Cells

The Aging Bone Marrow Niche Disrupts Glutamine Metabolism By Upregulating HSC Derived Glutamine Synthetase

Sting Activation in Bone Marrow Macrophages Targets AML Blasts for Phagocytosis in an ICAM-1 Dependent Mechanism

Acute Myeloid Leukemia Driven IL-3 Dependent Upregulation of BCL-2 in Non-Malignant Hematopoietic Progenitor Cells Increases Venetoclax Induced Cytopenias

AML Inhibits Lipid Uptake By the Liver through an HGF/c-MET Dependent Mechanism Which Results in an Increased Supply of Free Fatty Acid to the Tumor

Multiple Myeloma Induced IL-6 Reprograms Lipid Metabolism through a CD36 Dependent Mechanism

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

Sting Agonists Activate Bone Marrow Macrophages and Synergise with Anti-CD47 Blockade Improving Survival in Animal Models of Acute Myeloid Leukemia

Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals

Malignant Plasma Cell Derived Mitochondrial Damps Activate Macrophages Via Sting Signalling to Promote Myeloma Development

LC3-Associated Phagocytosis Is Impaired in Bone Marrow Macrophages during Ageing Leading to Defective Processing of Apoptotic Cells and Suppression of Sting Activation

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

Multiple Myeloma Derived Mitochondrial Damps Induce Inflammation in the Bone Marrow Adipose Tissue Which Promotes Tumour Development

BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress

Investigating the Dual Targeting of BCL-2 and CD38 in Models of Acute Myeloid Leukemia

Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection

Myeloma Derived Mitochondrial Damage Associated Molecular Patterns Promote Pro-Tumoral Expansion By Inducing a Pro-Inflammatory Signature in the Bone Marrow Microenvironment

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

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American Society of Hematology

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ASH Publications

American Society of Hematology

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