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Journal Articles

Ropeginterferon Alfa-2b for Pre-Fibrotic Primary Myelofibrosis and DIPSS Low/Intermediate-1 Risk Myelofibrosis: Durable Responses and Evidence of Disease Modification

Harinder Gill, Lester Au, Garret Man Kit Leung, Dorothy Tsai, Rita Yim, Lynn Chin, Vivian Li, Paul Lee, Albert Chun Fung Sin, Hsin An Hou, Chih-Cheng Chen, Yok Lam Kwong
Journal: Blood
Blood (2023) 142 (Supplement 1): 4562.
https://doi.org/10.1182/blood-2023-180922
Published: 2023
Journal Articles

Developing CD70-Targeted CAR-T Cells for the Treatment of Hematological and Solid Malignancies

Yuan Lu, Hui Huang, Cheng Chen, Hui Wang, Huilin Wu, Xiaoqin Liu, Wei Zhao, Chunyan Gao, Siyuan Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 12695.
https://doi.org/10.1182/blood-2022-160106
Published: 2022
Journal Articles

Efficacy and Safety of Ropeginterferon Alfa-2b for Pre-Fibrotic Primary Myelofibrosis and DIPSS Low/Intermediate-1 Risk Myelofibrosis

Harinder Gill, Lester Au, Rita Yim, Lynn Chin, Vivian Li, Paul Lee, Garret MK Leung, Carmen Lee, Tony Kwun Yat Wu, Cheong Ngai, Ryan Ho, Albert Chun Fung Sin, Hsin-An Hou, Chih-Cheng Chen, Yok-Lam Kwong
Journal: Blood
Blood (2022) 140 (Supplement 1): 1522.
https://doi.org/10.1182/blood-2022-169613
Published: 2022
Journal Articles

Leonurine Promotes the Maturation of Healthy Donors and Multiple Myeloma Patients Derived-Dendritic Cells

Cheng Chen, Lin He, Xi Wang, Zichen Ye, Rong Xiao, Hong Zheng, Shu Chen, Hui Li, Xi Yang, Xuemei Wang, Yu Wang, Xuemei Ye, Xiaobing Huang, Jingying Dai
Journal: Blood
Blood (2022) 140 (Supplement 1): 12439.
https://doi.org/10.1182/blood-2022-157665
Published: 2022
Journal Articles

Treatment of Ropeginterferon Alpha-2b Achieves Hematologic Remission and Molecular Response in Patients with Hydroxyurea- and/or Anagrelide-Resistant/Intolerant Myeloproliferative Neoplasms

Chih-Cheng Chen, Ming-Chung Kuo, Yi-Jiun Su, Cih-En Huang, Chia-Chen Hsu, Yu-Ying Wu, Ying-Ju Chen, Lee-Yung Shih
Journal: Blood
Blood (2021) 138 (Supplement 1): 4631.
https://doi.org/10.1182/blood-2021-147746
Published: 2021
Journal Articles

Changes in the Incidence and Overall Survival of Patients with Myeloproliferative Neoplasms between 2002 and 2016 in the United States

Srdan Verstovsek, MD PhD, Jingbo Yu, MD PhD, Robyn M. Scherber, MD, Shivani Pandya, MS, Christopher Dieyi, MPH, Chien-Cheng Chen, MS, Shreekant Parasuraman, BPharm, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-141090
Published: 2020
Journal Articles

Developing a Novel Anti-Bcma CAR-T for Relapsed or Refractory Multiple Myeloma

Xin Yao, PhD, Shigui Zhu, PhD, Jiaqi Huang, PhD, Xiaoyan Qu, MD PhD, Judy Zhu, MD, Yutian Wei, MS, Liping Lan, MS, Xiaoteng LV, MS, Junfeng Wu, PhD, Rirfei Wang, MS, Dingzhu Yang, Chengxiao Zheng, MD, DiJun Zhao, MS, Lei Fan, MD PhD, Fei Huang, Hua Lu, MD PhD, Chaocan Zhang, MS, Cheng Chen, PhD, Yanfeng Li, MS, Jiaqiang Ren, MD PhD, Li Zhang, MD, Michael Humphries, MD, Jianyong Li, MD, Yihong Yao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 50.
https://doi.org/10.1182/blood-2019-125372
Published: 2019
Journal Articles

Antileukemic Activity of 8-Chloro-Adenosine (8-Cl-Ado) Is Mediated By Mir-155 Degradation and ErbB3 Binding Protein (Ebp1)-Dependent p53 Activation: A Novel Therapeutic Approach for FLT3-ITD Acute Myeloid Leukemia (AML)

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Bijender Kumar, PhD, Corey James Morales, BA, BS, Chao Liu, PhD, Lisa S Chen, PhD, Tea Pemovska, PhD, Ryan Thompson, BS, Ling Li, PhD, Dinh Hoa Hoang, BS, Bin Zhang, PhD, Lucy Ghoda, PhD, Claudia Kowolik, PhD, Mika Kontro, MD, Krister Wennerberg, PhD, Calum Leitch, PhD, Xiaochun Yu, MD PhD, Ching-Cheng Chen, PhD, David Horne, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, Steven T Rosen
Journal: Blood
Blood (2018) 132 (Supplement 1): 3938.
https://doi.org/10.1182/blood-2018-99-119880
Published: 2018
Journal Articles

64 cu-DOTA-Anti-CD33 PET-CT Imaging for Acute Myeloid Leukemia and Image-Guided Treatment

Srideshikan Sargur Madabushi, PhD, Darren Zuro, Jamison Brooks, B.S, Bijender Kumar, PhD, Liliana E Parra, Marvin Orellana, B.S, Indu Nair, PhD, Junie Chea, Kofi Poku, PharmD, Ching-Cheng Chen, PhD, James Sanchez, PhD, John E. Shively, Daniel A. Vallera, PhD, Jeffrey Wong, MD, Anthony S. Stein, MD, David Colcher, PhD, Paul Yazaki, PhD, Susanta Hui, PhD, DABR.
Journal: Blood
Blood (2018) 132 (Supplement 1): 2747.
https://doi.org/10.1182/blood-2018-99-117878
Published: 2018
Journal Articles

MMP9 Inhibition Rescues the Erythroid Defect in RPS14-Deficient Del(5q) MDS Models

Minyoung Youn, PhD, Haigen Huang, PhD, Cheng Chen, Sharon Kam, BS, Mark C Wilkes, Hee-Don Chae, PhD, Anupama Narla, MD, Shuo Lin, PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 756.
https://doi.org/10.1182/blood-2018-99-117508
Published: 2018
Journal Articles

Leukemia Cells Remodel Adipocyte Niches and Their Progenitor Functions to Generate Leukemia Favoring Niche

Bijender Kumar, PhD, Marvin Orellana, B.S, Jamison Brooks, B.S, Srideshikan Sargur Madabushi, PhD, Liliana E Parra, Darren Zuro, Qiong Wang, Ching-Cheng Chen, PhD, Susanta Hui, PhD, DABR.
Journal: Blood
Blood (2018) 132 (Supplement 1): 1294.
https://doi.org/10.1182/blood-2018-99-115689
Published: 2018
Journal Articles

Single-Cell RNA Sequencing Discloses Distinct Transcriptomic Profiling in Essential Thrombocythemia

Chia-Chen Hsu, PhD, Cih-En Huang, MD, Ying-Ju Chen, Yuying Wu, MD, Hsing-Yi Tsou, Chian-Pei Li, Wei-Hsuan Chuang, Yi-Hua Lai, Yi-Hsuan Lin, Chih-Cheng Chen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3061.
https://doi.org/10.1182/blood-2018-99-113990
Published: 2018
Journal Articles

Comparison of Molecular Responses between e14a2 and e13a2 BCR-ABL1 Transcripts in Patients with Chronic Myeloid Leukemia in Chronic Phase Treated with Front-Line Second Generation Tyrosine Kinase Inhibitors: Taiwan CML Study

Yi-Jiun Su, MD, Ming-Chung Kuo, MD, Chieh-Lin Teng, MD, Tsai-Yun Chen, MD, Ming-Chun Ma, MD, Pei-Ching Hsiao, MD, Ming-Chung Wang, MD, Tung-Huei Lin, MS, Wen-Li Hwang, MD, Chih-Cheng Chen, MD, Youngsen Yang, MD, Sung-Nan Pei, MD, Yen-Min Huang, MD, Sin-Syue Li, MD, Ming-Yang Lee, MD, Hung-I Cheng, MD, Lee-Yung Shih, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1603.
https://doi.org/10.1182/blood.V130.Suppl_1.1603.1603
Published: 2017
Journal Articles

8-Chloro-Adenosine Inhibits Molecular Poor-Risk Acute Myeloid Leukemia (AML) and Leukemic Stem Cells (LSC) Growth and Synergizes with the BCL-2 Inhibitor Venetoclax (ABT-199)

Ralf Buettner, PhD, Ching-Cheng Chen, PhD, Bijender Kumar, PhD, Corey Morales, BA, BS, Lisa S Chen, PhD, Krister Wennerberg, PhD, Ryan Thompson, MS, Tea Pemovska, MSc, Ling Li, PhD, Bin Zhang, PhD, Claudia Kowolik, PhD, Mika Kontro, MD, Calum Leitch, MD, David Horne, PhD, Joycelynne Palmer, PhD, Varsha Gandhi, PhD, Guido Marcucci, MD, Vinod Pullarkat, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2016) 128 (22): 2758.
https://doi.org/10.1182/blood.V128.22.2758.2758
Published: 2016
Journal Articles

Aberrant Let7a/HMGA2 Signaling Axis with Unique Clinical Phenotype in JAK2 -Mutated Myeloproliferative Neoplasms

Chia-Chen Hsu, PhD, Chih-Cheng Chen, MD PhD, Jyh-Pyng Gau, MD PhD, Cih-En Huang, MD, Jie-Yu You, MD PhD, Jrhau Lung, PhD, YI-Yang Chen, Hsing-Ying Ho, MS, Chian-Pei Li, MS, Chang-Hsien Lu, MD, Kuan-Der Lee, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5492.
https://doi.org/10.1182/blood.V128.22.5492.5492
Published: 2016
Journal Articles

CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice

Qi Cai, Robin Jeannet, Wei-Kai Hua, Guerry J. Cook, Bin Zhang, Jing Qi, Hongjun Liu, Ling Li, Ching-Cheng Chen, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2016) 128 (11): 1503–1515.
https://doi.org/10.1182/blood-2016-01-693119
Published: 2016
Includes: Supplemental data
Journal Articles

Dicer Ablations in Bone Marrow Niche Impair Hematopoietic Progenitor/Stem Cells and Induce Myelodysplasia in Young Mice but Are Dispensable for Adult Hematopoiesis

Bijender Kumar, PhD, Mayra Garcia, PhD, Guido Marcucci, MD, Ching-Cheng Chen, PhD
Journal: Blood
Blood (2015) 126 (23): 1196.
https://doi.org/10.1182/blood.V126.23.1196.1196
Published: 2015
Journal Articles

Knockdown (KD) of Mir-126 Expression Enhances Tyrosine Kinase Inhibitor (TKI)-Mediated Targeting of Chronic Myelogenous Leukemia (CML) Stem Cells

Bin Zhang, PhD, Ling Li, PhD, Ching-Cheng Chen, PhD, Anthony S. Stein, MD, Haris Ali, MD, David S. Snyder, MD, Allen Lin, Adrienne Dorrance, PhD, Piotr Swiderski, PhD, Ravi Bhatia, MD, Danilo Perrotti, MD PhD, Stephen J. Forman, MD, Ya-Huei Kuo, PhD, Marcin Kortylewski, PhD, Guido Marcucci, MD
Journal: Blood
Blood (2015) 126 (23): 51.
https://doi.org/10.1182/blood.V126.23.51.51
Published: 2015
Journal Articles

Proteomics Profiling of Leukemia Derived Exosomes: A Potential Role in Leukemic Transformation

Bijender Kumar, PhD, Lei Zhang, PhD, Yunan Miao, Gerald Wuenschell, Allen Lin, Vinod Pullarkat, MD, Guido Marcucci, MD, Robert Hickey, PhD, Ching-Cheng Chen, PhD
Journal: Blood
Blood (2015) 126 (23): 3857.
https://doi.org/10.1182/blood.V126.23.3857.3857
Published: 2015
Journal Articles

8-Chloro-Adenosine Inhibits Molecular Poor-Risk Acute Myeloid Leukemia (AML) and Leukemic Stem Cells (LSC) Growth Via Novel RNA- and ATP-Directed Mechanisms: A Novel Therapeutic Approach for AML

Ralf Buettner, PhD, Ching-Cheng Chen, PhD, Bijender Kumar, PhD, Lisa S Chen, PhD, Krister Wennerberg, PhD, Ryan Thompson, MS, Tea Pemovska, MSc, Ling Li, PhD, Varsha Gandhi, PhD, Guido Marcucci, MD, Vinod Pullarkat, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2015) 126 (23): 792.
https://doi.org/10.1182/blood.V126.23.792.792
Published: 2015