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Journal Articles

NF1 Tumor Suppressor Gene Inactivation in Juvenile Myelomonocytic Leukemia: New Genetic Evidence and Consequences for Diagnostic Work-up

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-136294

Published: 2020

Journal Articles

DNA Methylation As a Biomarker of Outcome in JMML: An International Effort Towards Clinical Implementation

Julia Meyer, PhD, Maximillian Schönung, Christian Flotho, MD PhD, Adam B. Olshen, PhD, Mark Hartmann, PhD, Christoph Plass, PhD, Yusuke Okuno, MD PhD, Yoshiyuki Takahashi, MD PhD, Norihiro Murakami, MD PhD, Manabu Wakamatsu, MD, Mignon L. Loh, MD, Charlotte M. Niemeyer, MD, Hideki Muramatsu, MD PhD, Daniel B. Lipka, MD, Elliot Stieglitz, MD

Blood (2019) 134 (Supplement_1): 1693.

https://doi.org/10.1182/blood-2019-131279

Published: 2019

Journal Articles

High-Throughput RNA Sequencing Analysis Reveals Distinct Molecular Signature in NRAS and PTPN11 JMML Patients

Pier Paolo Leoncini, PhD, Alessandro Domenico Silvestris, PhD, Patrizia Vitullo, PhD, Marco Zecca, MD, Christian Flotho, MD PhD, Charlotte M. Niemeyer, MD, Angela Gallo, PhD, Alice Bertaina, MD PhD, Franco Locatelli, MD PhD, Pietro Merli, MD

Blood (2019) 134 (Supplement_1): 4229.

https://doi.org/10.1182/blood-2019-129965

Published: 2019

Journal Articles

Long Non-Coding RNAs As Novel Therapeutic Targets in Juvenile Myelomonocytic Leukemia: Proof of Concept Study

Mattias Hofmans, MD, Barbara Depreter, PhD PharmD, Tim Lammens, PhD, Helene Cave, PharmD, PhD, Christian Flotho, MD PhD, Henrik Hasle, Valerie de Haas, MD PhD, Charlotte M. Niemeyer, MD, Jan Stary, Prof., MD PhD, Pieter Van Vlierberghe, PhD, Jan Philippé, MD PhD, Barbara De Moerloose, MD PhD

Blood (2019) 134 (Supplement_1): 1701.

https://doi.org/10.1182/blood-2019-123715

Published: 2019

Journal Articles

Aberrant DNA Methylation Characterizes a Subtype of Juvenile Myelomonocytic Leukemia (JMML) with Poor Outcome.

Christiane Batz, MS, Inga Sandrock, BS, Peter Nöllke, MPH, Brigitte Strahm, MD, Henrik Hasle, MD, Marco Zecca, MD, Jan Starý, MD, Eva Bergsträsser, MD, Barbara De Moerloose, MD, Monika Trebo, MD, PhD, Marry M. van den Heuvel, MD, PhD, Dorota Wojcik, MD, Franco Locatelli, MD, Charlotte M Niemeyer, MD, Christian Flotho, MD

Blood (2009) 114 (22): 828.

https://doi.org/10.1182/blood.V114.22.828.828

Published: 2009

Journal Articles

Germline Mutations in CBL Cause a Predisposition to Juvenile Myelomonocytic Leukemia.

Blood (2009) 114 (22): 310.

https://doi.org/10.1182/blood.V114.22.310.310

Published: 2009

Journal Articles

Increased C-Jun and Reduced GATA2 Expression Promotes Aberrant Monocytic Differentiation and Expansion Induced by Activating PTPN11 Mutants

Zhenyun Yang, Takako Kondo, Ph.D., Cara s Voorhorst, MS, Sarah C Nabinger, Leila Ndong, Fuqin Yin, Edward m Chan, M.D., Oliver Wurstlin, Christian Kratz, Charlotte Marie Niemeyer, MD, Christian Flotho, MD, Eri Hashino, Rebecca Chan, MD, PhD

Blood (2008) 112 (11): 3720.

https://doi.org/10.1182/blood.V112.11.3720.3720

Published: 2008

Journal Articles

Development of an Allele-Specific Minimal Residual Disease Assay for Patients with Juvenile Myelomonocytic Leukemia-Moving beyond Clinical Assessment.

Sophie Archambeault, Ayami Yoshimi, MD, Christian Kratz, MD, Miriam Reising, Alexandra Fischer, Peter Noellke, PhD, Franco Locatelli, MD, Petr Sedlacek, MD, Christian Flotho, MD, Marco Zecca, MD, Peter Dean Emanuel, MD, Robert Castleberry, MD, Charlotte Marie Niemeyer, MD, Peter Bader, MD, Mignon Loh, MD

Blood (2006) 108 (11): 2681.

https://doi.org/10.1182/blood.V108.11.2681.2681

Published: 2006

Journal Articles

Genome-Wide Single Nucleotide Polymorphism Analysis in Juvenile Myelomonocytic Leukemia Uncovers Long-Range Uniparental Disomy Surrounding the NF1 Locus in Cases Associated with Type 1 Neurofibromatosis but Not in Cases with Mutant RAS or PTPN11 .

Christian Flotho, MD, Doris Steinemann, PhD, Gudrun Göhring, MD, Charles Mullighan, MD, Geoffrey Neale, PhD, Brigitte Schlegelberger, MD, James Downing, MD, Charlotte Marie Niemeyer, MD

Blood (2006) 108 (11): 1453.

https://doi.org/10.1182/blood.V108.11.1453.1453

Published: 2006

Journal Articles

Effects of the DNA Methylase Inhibitor Zebularine on Global Gene Expression in AML1-ETO -Positive Acute Myeloid Leukemia.

Christian Flotho, MD, Guangchun Song, MS, James R. Downing, MD

Blood (2005) 106 (11): 2998.

https://doi.org/10.1182/blood.V106.11.2998.2998

Published: 2005

Journal Articles

Genome-Wide Expression Profiling and Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia.

Christian Flotho, MD, Elaine Coustan-Smith, MS, Guangchun Song, MS, Cheng Cheng, PhD, Deiqing Pei, MS, Ching-Hon Pui, MD, James R. Downing, MD, Dario Campana, MD, PhD

Blood (2005) 106 (11): 87.

https://doi.org/10.1182/blood.V106.11.87.87

Published: 2005

Journal Articles

The Combined Expression of AML1-ETO and Oncogenic RAS Is Insufficient To Induce Acute Myeloid Leukemia (AML).

Christian Flotho, MD, Weili Sun, MD, PHD, Sheila Shurtleff, PHD, Shouli Yang, PHD, James R. Downing, MD

Blood (2004) 104 (11): 2557.

https://doi.org/10.1182/blood.V104.11.2557.2557

Published: 2004

Journal Articles

Identification of Aberrantly Regulated Genes through Comparison of Genome-Wide Expression Profiles and Karyotype in Hyperdiploid >50 Chromosomes Pediatric Acute Lymphoblastic Leukemia.

Christian Flotho, MD, Susana C. Raimondi, PHD, James R. Downing, MD

Blood (2004) 104 (11): 420.

https://doi.org/10.1182/blood.V104.11.420.420

Published: 2004

NARROW

NF1 Tumor Suppressor Gene Inactivation in Juvenile Myelomonocytic Leukemia: New Genetic Evidence and Consequences for Diagnostic Work-up

DNA Methylation As a Biomarker of Outcome in JMML: An International Effort Towards Clinical Implementation

High-Throughput RNA Sequencing Analysis Reveals Distinct Molecular Signature in NRAS and PTPN11 JMML Patients

Long Non-Coding RNAs As Novel Therapeutic Targets in Juvenile Myelomonocytic Leukemia: Proof of Concept Study

Aberrant DNA Methylation Characterizes a Subtype of Juvenile Myelomonocytic Leukemia (JMML) with Poor Outcome.

Germline Mutations in CBL Cause a Predisposition to Juvenile Myelomonocytic Leukemia.

Increased C-Jun and Reduced GATA2 Expression Promotes Aberrant Monocytic Differentiation and Expansion Induced by Activating PTPN11 Mutants

Development of an Allele-Specific Minimal Residual Disease Assay for Patients with Juvenile Myelomonocytic Leukemia-Moving beyond Clinical Assessment.

Genome-Wide Single Nucleotide Polymorphism Analysis in Juvenile Myelomonocytic Leukemia Uncovers Long-Range Uniparental Disomy Surrounding the NF1 Locus in Cases Associated with Type 1 Neurofibromatosis but Not in Cases with Mutant RAS or PTPN11 .

Effects of the DNA Methylase Inhibitor Zebularine on Global Gene Expression in AML1-ETO -Positive Acute Myeloid Leukemia.

Genome-Wide Expression Profiling and Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia.

The Combined Expression of AML1-ETO and Oncogenic RAS Is Insufficient To Induce Acute Myeloid Leukemia (AML).

Identification of Aberrantly Regulated Genes through Comparison of Genome-Wide Expression Profiles and Karyotype in Hyperdiploid >50 Chromosomes Pediatric Acute Lymphoblastic Leukemia.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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