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Journal Articles

DNA Methylation As a Biomarker of Outcome in JMML: An International Effort Towards Clinical Implementation

Julia Meyer, PhD, Maximillian Schönung, Christian Flotho, MD PhD, Adam B. Olshen, PhD, Mark Hartmann, PhD, Christoph Plass, PhD, Yusuke Okuno, MD PhD, Yoshiyuki Takahashi, MD PhD, Norihiro Murakami, MD PhD, Manabu Wakamatsu, MD, Mignon L. Loh, MD, Charlotte M. Niemeyer, MD, Hideki Muramatsu, MD PhD, Daniel B. Lipka, MD, Elliot Stieglitz, MD

Blood (2019) 134 (Supplement_1): 1693.

https://doi.org/10.1182/blood-2019-131279

Published: 2019

Journal Articles

Deconvolution of Hematopoietic Commitment Decisions By Genome-Wide Analysis of Progressive DNA Methylation Changes

Blood (2019) 134 (Supplement_1): 1179.

https://doi.org/10.1182/blood-2019-124429

Published: 2019

Journal Articles

Malignant NK Cells from EBV(+) Human Extranodal NK/T Cell Lymphoma Exhibit Features of a Distinct NK Cell Developmental Subset Found in Mucosal Associated Lymphoid Tissue

Anjali Mishra, PhD, Bethany L Mundy-Bosse, PhD, Karen A Young, Christoph Weigel, PhD, Emily Smith, Ahmed Elshafa, Youssef Youssef, Kathleen McConnell, Christoph Plass, PhD, Jonathan E Brammer, MD, Robert A Baiocchi, MD PhD, Michael A. Caligiuri, MD, Pierluigi Porcu, MD, Aharon G. Freud, MD PhD, Christopher C. Oakes, PhD

Blood (2017) 130 (Supplement 1): 1451.

https://doi.org/10.1182/blood.V130.Suppl_1.1451.1451

Published: 2017

Journal Articles

Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia

Blood (2015) 126 (23): 2436.

https://doi.org/10.1182/blood.V126.23.2436.2436

Published: 2015

Journal Articles

IL-10 Production By CLL Cells Is Enhanced in the Anergic IGHV Mutated Subset and Associates with Reduced DNA Methylation of the IL-10 Locus

Samantha Drennan, PhD, Annalisa D'Avola, MSc, Yifang Gao, PhD, Eleni Chrysostomou, MSc, Andrew J Steele, PhD, Thorsten Zenz, MD, Christoph Plass, PhD, Peter W Johnson, MD, Anthony P Williams, PhD FRCPath, Graham Packham, PhD, Freda K Stevenson, DPhil, Christopher C. Oakes, PhD, Francesco Forconi, MD DM, PhD FRCPath

Blood (2015) 126 (23): 2917.

https://doi.org/10.1182/blood.V126.23.2917.2917

Published: 2015

Journal Articles

NFATc1 Is Transcriptionally Activated in Chronic Lymphocytic Leukemia (CLL) By Promotor DNA-Hypomethylation Which Correlates with in-Vitro Vulnerability to Calcineurin Inhibitors

Christine Wolf, Katharina Filarsky, Angela Garding, PhD, Rainer Claus, MD, Christopher C Oakes, PhD, Irina Idler, PhD, Christoph Plass, PhD, Peter Lichter, PhD, Hartmut Doehner, MD, Stephan Stilgenbauer, MD, Daniel Mertens, PhD

Blood (2014) 124 (21): 1941.

https://doi.org/10.1182/blood.V124.21.1941.1941

Published: 2014

Journal Articles

Heterogeneity and Evolution Of DNA Methylation In Chronic Lymphocytic Leukemia

Christopher C Oakes, Ph.D, Rainer Claus, MD, Lei Gu, Yassen Assenov, Jennifer Hüllein, Manuela Zucknick, David Brocks, Olga Bogatyrova, Christopher R. Schmidt, Laura Rassenti, PhD, Thomas J. Kipps, MD, PhD, Daniel Mertens, PhD, Peter Lichter, PhD, Hartmut Döhner, MD, Stephan Stilgenbauer, MD, John C. Byrd, MD, Thorsten Zenz, MD, Christoph Plass, PhD

Blood (2013) 122 (21): 1626.

https://doi.org/10.1182/blood.V122.21.1626.1626

Published: 2013

Journal Articles

Epo-Induced Erythroid Maturation Is Dependent On Plcγ1 Signalling

Tina M Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, Inga Griehl, cand. med., Lars Bullinger, MD, PhD, Konstanze Doehner, MD, Christoph Plass, PhD, Daniel B Lipka, MD, Florian H Heidel, MD, Thomas Fischer, M.D. Ph.D.

Blood (2013) 122 (21): 1182.

https://doi.org/10.1182/blood.V122.21.1182.1182

Published: 2013

Journal Articles

Differential DNA Methylation Predicts Response To Combined Treatment Regimens With a DNA Methyltransferase Inhibitor In Acute Myeloid Leukemia (AML)

Maximilian Schmutz, Manuela Zucknick, PhD, Richard F. Schlenk, MD, Konstanze Döhner, MD, Hartmut Döhner, MD, Christoph Plass, PhD, Lars Bullinger, MD, PhD, Rainer Claus, MD

Blood (2013) 122 (21): 2539.

https://doi.org/10.1182/blood.V122.21.2539.2539

Published: 2013

Journal Articles

AML1-ETO Collaborates with the TALE Homeobox Genes MEIS1 and MEIS2 in Inducing AML.

Naidu M Vegi, PhD, Josef Klappacher, MSc, Franz Oswald, PhD, Rainer Claus, MD, Medhanie M Mulaw, PhD, Verena Thiel, Msc, Vijay P.S Rawat, PhD, Leticia Quintanilla Fend, MD, Christoph Plass, PhD, Konstanze Döhner, MD, Hartmut Döhner, MD, Wolfgang Hiddemann, MD, Michaela Feuring Buske, MD, Christian Buske, MD

Blood (2012) 120 (21): 2387.

https://doi.org/10.1182/blood.V120.21.2387.2387

Published: 2012

Journal Articles

The Hsp90 Inhibitor 17-DMAG Increases SOCS3 and Regulates Cytokine Production, Migration and Cell Death in Chronic Lymphocytic Leukemia

Erin K Hertlein, PhD, Timothy L. Chen, Rainer Claus, MD, Christoph Plass, PhD, Amy Lehman, David Jarjoura, PhD, Kami Maddocks, MD, Jeffrey A. Jones, MD, MPH, David M. Lucas, PhD, Amy J. Johnson, PhD, John C. Byrd, MD

Blood (2012) 120 (21): 1362.

https://doi.org/10.1182/blood.V120.21.1362.1362

Published: 2012

Journal Articles

Aberrant Epigenetic Suppression of the Ptprot Gene Encoding a Protein Tyrosine Phosphatase Targeting KIT in Acute Myeloid Leukemia

Tasneem Motiwala, PhD, Satavisha Roy, Shujun Liu, Ph.D, Sebastian Schwind, MD, Rainer Claus, MD, Xiaokui Mo, PhD, Ramiro Garzon, MD, Hartmut Dohner, MD, Konstanze Dohner, MD, PhD, David Jarjoura, PhD, Christoph Plass, PhD, Guido Marcucci, MD, Samson T. Jacob, PhD

Blood (2012) 120 (21): 1322.

https://doi.org/10.1182/blood.V120.21.1322.1322

Published: 2012

Journal Articles

TOSO Deficiency Exerts Impact On BAFF-R Expression, Thereby Causing Impaired B Cell Development in Vivo

Alexandra Schulz, PhD, Yoon Jung Park, Ph.D., Rainer Claus, MD, Hamid Kashkar, PhD, Jens Seeger, PhD, Julia Claasen, Christian P. Pallasch, MD, Christoph Plass, PhD, Michael Hallek, MD, Clemens Wendtner, Lukas P. Frenzel, MD

Blood (2012) 120 (21): 3898.

https://doi.org/10.1182/blood.V120.21.3898.3898

Published: 2012

Journal Articles

The Relative Significance of ZAP -70 Promoter Methylation As a Prognostic Factor in Previously Untreated Chronic Lymphocytic Leukemia: Validation of Results Using a Second Large CLL Research Consortium (CRC) Patient Data Set

Rainer Claus, MD, Amy S. Ruppert, MAS, David M. Lucas, PhD, Manuela Zucknick, PhD, Laura Z. Rassenti, Ph.D., Andrew Greaves, Donna S. Neuberg, ScD, William G. Wierda, MD, Ph.D., Michael J. Keating, MD, Jennifer R. Brown, MD, PhD, John G Gribben, Kanti R. Rai, M.D., Michael R. Grever, MD, Neil E. Kay, MD, Thomas J. Kipps, MD, PhD, Christoph Plass, PhD, John C. Byrd, MD

Blood (2012) 120 (21): 3865.

https://doi.org/10.1182/blood.V120.21.3865.3865

Published: 2012

Journal Articles

Sustained NF-Kappa B Activity In Chronic Lymphocytic Leukemia Is Independent of Genetic and Epigenetic Modifications of the Tumor Suppressor Genes CYLD and A20

Lukas P. Frenzel, MD, Janine Schwamb, MD, Rainer Claus, MD, Julia Claasen, Reinhild Brinker, Christian P. Pallasch, MD, Christoph Plass, PhD, Clemens-Martin Wendtner, MD

Blood (2010) 116 (21): 3597.

https://doi.org/10.1182/blood.V116.21.3597.3597

Published: 2010

Journal Articles

Microenvironment Influences Expression of TOSO – a Novel NF-Kappa B Target Gene In Chronic Lymphocytic Leukemia

Lukas P. Frenzel, MD, Alexandra Schulz, Christian P. Pallasch, MD, Rainer Claus, MD, Sabine Ponader, PhD, Jan A. Burger, MD, PhD, Michael Hallek, MD, Christoph Plass, PhD, Clemens-Martin Wendtner, MD

Blood (2010) 116 (21): 695.

https://doi.org/10.1182/blood.V116.21.695.695

Published: 2010

Journal Articles

Deregulation of miRNAs by Epigenetic Silencing Disrupts Suppression of the Oncogene PLAG1 in Chronic Lymphocytic Leukemia.

Christian P Pallasch, MD, Michaela Patz, PhD, Yoon Jung Park, PhD, Susanne Hagist, MD, Daniela Eggle, PhD, Rainer Claus, MD, Svenja Debey-Pascher, PhD, Alexandra Schulz, Lukas P Frenzel, MD, Julia Claasen, Nadine Kutsch, Günter Krause, PhD, Christine Mayr, MD, Andreas Rosenwald, MD, Christoph Plass, PhD, Joachim L Schultze, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD

Blood (2009) 114 (22): 3463.

https://doi.org/10.1182/blood.V114.22.3463.3463

Published: 2009

Journal Articles

Dual Epigenetic Control of CCAAT/Enhancer Binding Protein α (C/EBPα) Expression in Acute Myeloid Leukemia.

Bjoern Hackanson, MD, Kristi L. Bennett, Romulo M. Brena, PhD, Jinmai Jiang, PhD, Katie Maharry, Susan P. Whitman, PhD, Thomas D. Schmittgen, PhD, Michael Luebbert, MD, PhD, Guido Marcucci, MD, Clara D. Bloomfield, MD, Christoph Plass, PhD

Blood (2007) 110 (11): 2116.

https://doi.org/10.1182/blood.V110.11.2116.2116

Published: 2007

Journal Articles

The Tumor Suppressor Gene SLC5A8 Is Selectively Silenced in MLL Partial Tandem Duplication-Positive Acute Myeloid Leukemia with Normal Cytogenetics.

Susan P. Whitman, PhD, Jing Wen, Gina Muto, Bjoern Hackanson, MD, Li Yu, MD, Chunhui Liu, Joseph L. Sanfilippo, Guido Marcucci, MD, Laura J. Rush, DVM, PhD, Christoph Plass, PhD, Michael A. Caligiuri, MD

Blood (2006) 108 (11): 9.

https://doi.org/10.1182/blood.V108.11.9.9

Published: 2006

Journal Articles

In Vitro and In Vivo Evidence That TSC-22 Is a Putative Tumor Suppressor Gene in Primary Murine and Human Leukemia.

Jianhua Yu, PhD, Li Yu, PhD, Bjoern Hackanson, MD, Min Wei, BS, Zachary Boyd, BS, Akihiko Yokohama, PhD, Chunhui Liu, BS, Rossana Trotta, PhD, Hsiaoyin C. Mao, MS, Brian Becknell, PhD, Michael S. Jaung, Shujun Liu, PhD, John C. Byrd, MD, Guido Marcucci, MD, Christoph Plass, PhD, Michael A. Caligiuri, MD

Blood (2006) 108 (11): 2211.

https://doi.org/10.1182/blood.V108.11.2211.2211

Published: 2006

NARROW

DNA Methylation As a Biomarker of Outcome in JMML: An International Effort Towards Clinical Implementation

Deconvolution of Hematopoietic Commitment Decisions By Genome-Wide Analysis of Progressive DNA Methylation Changes

Malignant NK Cells from EBV(+) Human Extranodal NK/T Cell Lymphoma Exhibit Features of a Distinct NK Cell Developmental Subset Found in Mucosal Associated Lymphoid Tissue

Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia

IL-10 Production By CLL Cells Is Enhanced in the Anergic IGHV Mutated Subset and Associates with Reduced DNA Methylation of the IL-10 Locus

NFATc1 Is Transcriptionally Activated in Chronic Lymphocytic Leukemia (CLL) By Promotor DNA-Hypomethylation Which Correlates with in-Vitro Vulnerability to Calcineurin Inhibitors

Heterogeneity and Evolution Of DNA Methylation In Chronic Lymphocytic Leukemia

Epo-Induced Erythroid Maturation Is Dependent On Plcγ1 Signalling

Differential DNA Methylation Predicts Response To Combined Treatment Regimens With a DNA Methyltransferase Inhibitor In Acute Myeloid Leukemia (AML)

AML1-ETO Collaborates with the TALE Homeobox Genes MEIS1 and MEIS2 in Inducing AML.

The Hsp90 Inhibitor 17-DMAG Increases SOCS3 and Regulates Cytokine Production, Migration and Cell Death in Chronic Lymphocytic Leukemia

Aberrant Epigenetic Suppression of the Ptprot Gene Encoding a Protein Tyrosine Phosphatase Targeting KIT in Acute Myeloid Leukemia

TOSO Deficiency Exerts Impact On BAFF-R Expression, Thereby Causing Impaired B Cell Development in Vivo

The Relative Significance of ZAP -70 Promoter Methylation As a Prognostic Factor in Previously Untreated Chronic Lymphocytic Leukemia: Validation of Results Using a Second Large CLL Research Consortium (CRC) Patient Data Set

Sustained NF-Kappa B Activity In Chronic Lymphocytic Leukemia Is Independent of Genetic and Epigenetic Modifications of the Tumor Suppressor Genes CYLD and A20

Microenvironment Influences Expression of TOSO – a Novel NF-Kappa B Target Gene In Chronic Lymphocytic Leukemia

Deregulation of miRNAs by Epigenetic Silencing Disrupts Suppression of the Oncogene PLAG1 in Chronic Lymphocytic Leukemia.

Dual Epigenetic Control of CCAAT/Enhancer Binding Protein α (C/EBPα) Expression in Acute Myeloid Leukemia.

The Tumor Suppressor Gene SLC5A8 Is Selectively Silenced in MLL Partial Tandem Duplication-Positive Acute Myeloid Leukemia with Normal Cytogenetics.

In Vitro and In Vivo Evidence That TSC-22 Is a Putative Tumor Suppressor Gene in Primary Murine and Human Leukemia.

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American Society of Hematology

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American Society of Hematology

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