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Manuela Zucknick
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Journal Articles

Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia

Clinical Trials & Observations
Rainer Claus, David M. Lucas, Amy S. Ruppert, Katie E. Williams, Daniel Weng, Kara Patterson, Manuela Zucknick, Christopher C. Oakes, Laura Z. Rassenti, Andrew W. Greaves, Susan Geyer, William G. Wierda, Jennifer R. Brown, John G. Gribben, Jacqueline C. Barrientos, Kanti R. Rai, Neil E. Kay, Thomas J. Kipps, Peter Shields, Weiqiang Zhao, Michael R. Grever, Christoph Plass, John C. Byrd
Journal: Blood
Blood (2014) 124 (1): 42–48.
https://doi.org/10.1182/blood-2014-02-555722
Published: 2014
Includes: Supplemental data
Journal Articles

Heterogeneity and Evolution Of DNA Methylation In Chronic Lymphocytic Leukemia

Christopher C Oakes, Ph.D, Rainer Claus, MD, Lei Gu, Yassen Assenov, Jennifer Hüllein, Manuela Zucknick, David Brocks, Olga Bogatyrova, Christopher R. Schmidt, Laura Rassenti, PhD, Thomas J. Kipps, MD, PhD, Daniel Mertens, PhD, Peter Lichter, PhD, Hartmut Döhner, MD, Stephan Stilgenbauer, MD, John C. Byrd, MD, Thorsten Zenz, MD, Christoph Plass, PhD
Journal: Blood
Blood (2013) 122 (21): 1626.
https://doi.org/10.1182/blood.V122.21.1626.1626
Published: 2013
Journal Articles

Differential DNA Methylation Predicts Response To Combined Treatment Regimens With a DNA Methyltransferase Inhibitor In Acute Myeloid Leukemia (AML)

Maximilian Schmutz, Manuela Zucknick, PhD, Richard F. Schlenk, MD, Konstanze Döhner, MD, Hartmut Döhner, MD, Christoph Plass, PhD, Lars Bullinger, MD, PhD, Rainer Claus, MD
Journal: Blood
Blood (2013) 122 (21): 2539.
https://doi.org/10.1182/blood.V122.21.2539.2539
Published: 2013
Journal Articles

The Relative Significance of ZAP -70 Promoter Methylation As a Prognostic Factor in Previously Untreated Chronic Lymphocytic Leukemia: Validation of Results Using a Second Large CLL Research Consortium (CRC) Patient Data Set

Rainer Claus, MD, Amy S. Ruppert, MAS, David M. Lucas, PhD, Manuela Zucknick, PhD, Laura Z. Rassenti, Ph.D., Andrew Greaves, Donna S. Neuberg, ScD, William G. Wierda, MD, Ph.D., Michael J. Keating, MD, Jennifer R. Brown, MD, PhD, John G Gribben, Kanti R. Rai, M.D., Michael R. Grever, MD, Neil E. Kay, MD, Thomas J. Kipps, MD, PhD, Christoph Plass, PhD, John C. Byrd, MD
Journal: Blood
Blood (2012) 120 (21): 3865.
https://doi.org/10.1182/blood.V120.21.3865.3865
Published: 2012
Journal Articles

Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies

Clinical Trials & Observations
Sabine Kayser, Manuela Zucknick, Konstanze Döhner, Jürgen Krauter, Claus-Henning Köhne, Heinz A. Horst, Gerhard Held, Marie von Lilienfeld-Toal, Sibylla Wilhelm, Mathias Rummel, Ulrich Germing, Katharina Götze, David Nachbaur, Brigitte Schlegelberger, Gudrun Göhring, Daniela Späth, Carina Morlok, Veronica Teleanu, Arnold Ganser, Hartmut Döhner, Richard F. Schlenk, for the German-Austrian AML Study Group
Journal: Blood
Blood (2012) 119 (2): 551–558.
https://doi.org/10.1182/blood-2011-07-367508
Published: 2012
Includes: Supplemental data
Journal Articles

Decitabine (DAC) Treatment Induces Very Early In Vivo DNA Methylation and Transcriptome Changes in Primary AML Peripheral Blood Blasts

Rainer Claus, Dietmar Pfeifer, PhD, Maika Almstedt, Björn Hackanson, Manuela Zucknick, PhD, Christoph Plass, Michael Lübbert
Journal: Blood
Blood (2011) 118 (21): 1360.
https://doi.org/10.1182/blood.V118.21.1360.1360
Published: 2011
Journal Articles

Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome

Christiane Olk-Batz, Anna R. Poetsch, Peter Nöllke, Rainer Claus, Manuela Zucknick, Inga Sandrock, Tania Witte, Brigitte Strahm, Henrik Hasle, Marco Zecca, Jan Starý, Eva Bergstraesser, Barbara De Moerloose, Monika Trebo, Marry M. van den Heuvel-Eibrink, Dorota Wojcik, Franco Locatelli, Christoph Plass, Charlotte M. Niemeyer, Christian Flotho, the European Working Group of Myelodysplastic Syndromes in Childhood (EWOG-MDS)
Journal: Blood
Blood (2011) 117 (18): 4871–4880.
https://doi.org/10.1182/blood-2010-08-298968
Published: 2011
Includes: Supplemental data
Journal Articles

The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML

Clinical Trials & Observations
Sabine Kayser, Konstanze Döhner, Jürgen Krauter, Claus-Henning Köhne, Heinz A. Horst, Gerhard Held, Marie von Lilienfeld-Toal, Sibylla Wilhelm, Andrea Kündgen, Katharina Götze, Mathias Rummel, David Nachbaur, Brigitte Schlegelberger, Gudrun Göhring, Daniela Späth, Carina Morlok, Manuela Zucknick, Arnold Ganser, Hartmut Döhner, Richard F. Schlenk, for the German-Austrian AMLSG
Journal: Blood
Blood (2011) 117 (7): 2137–2145.
https://doi.org/10.1182/blood-2010-08-301713
Published: 2011
Includes: Supplemental data
Journal Articles

Comprehensive Protein Expression Analysis of Chronic Lymphocytic Leukemia Uncovers a Correlation of CDK4, P27 and P53 with Hierarchical Risk and Suggests a Dichotomy of Apoptosis and Proliferation.

Dirk Winkler, MD, Christof Schneider, MD, Daniela Nitsch, MD, Kerstin Schulze, Thorsten Zenz, MD, Julia Mohr, Andreas Buehler, MD, Annett Habermann, Manuela Zucknick, Axel Benner, Hartmut Döhner, MD, Stephan Stilgenbauer, MD, Daniel Mertens
Journal: Blood
Blood (2009) 114 (22): 1255.
https://doi.org/10.1182/blood.V114.22.1255.1255
Published: 2009
Journal Articles

Type and Number of Secondary Molecular Lesions Improve Outcome Prediction in Acute Myeloid Leukemia (AML) with inv(16) or t(16;16): A Study of the German-Austrian AML Study Group (AMLSG).

Peter Paschka, M.D., Juan Du, M.D., Richard F. Schlenk, M.D., Verena I. Gaidzik, M.D., Lars Bullinger, M.D., Andrea Corbacioglu, Ph.D., Manuela Zucknick, Ph.D., Axel Benner, M.Sc., Frank Stegelmann, M.D., Daniela Späth, Sabine Kayser, M.D., Brigitte Schlegelberger, M.D., Jürgen Krauter, M.D., Arnold Ganser, M.D., Hartmut Döhner, M.D., Konstanze Döhner, M.D.
Journal: Blood
Blood (2009) 114 (22): 824.
https://doi.org/10.1182/blood.V114.22.824.824
Published: 2009
Journal Articles

Mutations in the Fms-Related Tyrosine Kinase 3 (FLT3) Gene Independently Predict Poor Outcome in Acute Myeloid Leukemia (AML) with t(8;21): A Study of the German-Austrian AML Study Group (AMLSG).

Peter Paschka, M.D., Juan Du, M.D., Richard F. Schlenk, M.D., Lars Bullinger, M.D., Verena I. Gaidzik, M.D., Andrea Corbacioglu, Ph.D., Axel Benner, M.Sc., Manuela Zucknick, Ph.D., Frank Stegelmann, M.D., Daniela Späth, Sabine Kayser, M.D., Brigitte Schlegelberger, MD, Juergen Krauter, M.D., Arnold Ganser, M.D., Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2009) 114 (22): 825.
https://doi.org/10.1182/blood.V114.22.825.825
Published: 2009
Journal Articles

Analysis of the ETS Family Member Genes ERG, ETS2, ETS1 and FLI1 in Acute Myeloid Leukemia (AML) Patients with Normal Cytogenetics: Expression Levels and Impact On Clinical Outcome. A Study of the AMLSG.

Verena I. Gaidzik, M.D., Cailian Wang, M.D., Richard F. Schlenk, M.D., Lars Bullinger, M.D., Peter Paschka, M.D., Frank G. Rücker, M.D., Andrea Corbacioglu, Ph.D., Karina Eiwen, Jürgen Krauter, M.D., Brigitte Schlegelberger, MD, Arnold Ganser, M.D., Manuela Zucknick, Ph.D., Axel Benner, M.Sc., Hartmut Döhner, M.D., Konstanze Döhner, M.D.
Journal: Blood
Blood (2009) 114 (22): 1600.
https://doi.org/10.1182/blood.V114.22.1600.1600
Published: 2009