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Journal Articles

Haemogenic Gastruloids Recapitulate Developmental Haematopoiesis and Provide an Ontogeny-Relevant Context to Dissect the Origins of Infant Leukemia

Denise Ragusa, Chun-Wai Suen, Gabriel Torregrosa, Liza Dijkhuis, Connor Byrne, Tina Balayo, Andrea Tavosanis, Jozef Durko, Kristen Place, Ana Filipa Domingues, Kamil Kranc, Jordi Garcia-Ojalvo, Alfonso Martinez Arias, Cristina Pina
Journal: Blood
Blood (2022) 140 (Supplement 1): 1684–1685.
https://doi.org/10.1182/blood-2022-169733
Published: 2022
Journal Articles

Transcriptional Heterogeneity Governs Cell Fate Diversification during Pre-Leukemia to Leukemia Progression

Shikha Gupta, MS, Ana Filipa Domingues, Oliwia Cyran, George Giotopoulos, PhD, Sudhakaran Prabakaran, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, Oliver M. Dovey, PhD, George S. Vassiliou, MD PhD FRCPath, MRCP, Cristina Pina, MDDPhil
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-136504
Published: 2020
Journal Articles

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Konstantinos Tzelepis, Etienne De Braekeleer, PhD MSc, Eliza Yankova, PhD, Justyna Rak, PhD, Demetrios Aspris, MSc, Ana Filipa Domingues, PhD, Richard Fosbeary, Alan Hendrick, PhD, Dan Leggate, PhD, Yaara Ofir-Rosenfeld, PhD, Alexandra Sapetschnig, PhD, Cristina Pina, MDDPhil, Mark Albertella, PhD, Wesley Blackaby, PhD, Oliver Rausch, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Tony Kouzarides, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 403.
https://doi.org/10.1182/blood-2019-127962
Published: 2019
Journal Articles

S-Adenosyl Methionine Synthesis Impacts Maintenance of Acute Myeloid Leukemia Cells with Regulation of Transcriptional Elongation

Alice V Taylor, BSc PGCE, Rita Romano Adao, MPharm, Cecilia Castro, PhD, Ana Filipa Domingues, MSc, Jules L Griffin, PhD, Antonio Curti, Cristina Pina, MD DPhil
Journal: Blood
Blood (2018) 132 (Supplement 1): 2605.
https://doi.org/10.1182/blood-2018-99-115004
Published: 2018
Journal Articles

SRPK1 Is a Therapeutic Vulnerability in Acute Myeloid Leukemia through Its Effects on Alternative Isoforms of Epigenetic Regulators Including BRD4

Konstantinos Tzelepis, PhD, Etienne De Braekeleer, PhD, Isaia Barbieri, PhD, Vijay Baskar, PhD, Demetrios Aspris, MSc, Francisco Hermida Prado, PhD, Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Hannes Postingl, PhD, David Bates, PhD, Andrew Bannister, PhD, Brian J.P Huntly, Cristina Pina, MDDPhil, Allan Bradley, PhD, Kosuke Yusa, PhD, Tony Kouzarides, PhD, George S. Vassiliou, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 781.
https://doi.org/10.1182/blood.V130.Suppl_1.781.781
Published: 2017
Journal Articles

Histone Acetyl-Transferase Kat2a Regulates Transcriptional Heterogeneity and Impacts Self-Renewal of Acute Myeloid Leukemia Cells in a Disease-Specific Manner

Ana Filipa Domingues, MSc, Rashmi Kulkarni, PhD, George Giotopoulos, PhD, Brian J.P Huntly, Sudhakaran Prabakaran, PhD, Cristina Pina, MDDPhil
Journal: Blood
Blood (2017) 130 (Supplement 1): 2486.
https://doi.org/10.1182/blood.V130.Suppl_1.2486.2486
Published: 2017
Journal Articles

Network Analysis Of Single Cells Identifies DDIT3 As a Nucleator Of Erythroid Signatures In Early Erythro-Myelopoiesis

Cristina Pina, MD DPhil, Jose Teles, PhD, Cristina Fugazza, PhD, Yanping Guo, DPhil, Gillian May, Ph.D., Carsten Peterson, PhD, Prof., Tariq Enver, Ph.D., Prof.
Journal: Blood
Blood (2013) 122 (21): 44.
https://doi.org/10.1182/blood.V122.21.44.44
Published: 2013
Journal Articles

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle

Alex J. Tipping, Cristina Pina, Anders Castor, Dengli Hong, Neil P. Rodrigues, Lorenza Lazzari, Gillian E. May, Sten Eirik W. Jacobsen, Tariq Enver
Journal: Blood
Blood (2009) 113 (12): 2661–2672.
https://doi.org/10.1182/blood-2008-06-161117
Published: 2009
Includes: Supplemental data
Journal Articles

Enforced Expression of GATA-2 Confers Quiescence on Human Hematopoietic Stem and Progenitor Cells In Vitro and In Vivo .

Alex J. Tipping, Cristina Pina, Anders Castor, Ann Atzberger, Dengli Hong, Lorenza Lazzari, Gillian May, Sten Eirik Jacobsen, Tariq Enver
Journal: Blood
Blood (2006) 108 (11): 83.
https://doi.org/10.1182/blood.V108.11.83.83
Published: 2006
Journal Articles

Transcriptional Programming in Quiescent Human Hematopoietic Stem Cells - Implications for Regulation of Lineage Commitment Decisions.

Cristina Pina, MD, Tariq Enver, PhD
Journal: Blood
Blood (2005) 106 (11): 1723.
https://doi.org/10.1182/blood.V106.11.1723.1723
Published: 2005