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Journal Articles

 2 -Antiplasmin Gene Deficiency in Mice Is Associated With Enhanced Fibrinolytic Potential Without Overt Bleeding

H.R. Lijnen, K. Okada, O. Matsuo, D. Collen, M. Dewerchin

Blood (1999) 93 (7): 2274–2281.

https://doi.org/10.1182/blood.V93.7.2274

Published: 1999

Journal Articles

Stromelysin-1 (MMP-3)–Independent Gelatinase Expression and Activation in Mice

H.R. Lijnen, J. Silence, B. Van Hoef, D. Collen

Blood (1998) 91 (6): 2045–2053.

https://doi.org/10.1182/blood.V91.6.2045

Published: 1998

Journal Articles

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen

HR Lijnen, P Carmeliet, A Bouche, L Moons, VA Ploplis, EF Plow, D Collen

Blood (1996) 88 (3): 870–876.

https://doi.org/10.1182/blood.V88.3.870.870

Published: 1996

Journal Articles

Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?

D Collen, HR Lijnen

Blood (1994) 84 (3): 680–686.

https://doi.org/10.1182/blood.V84.3.680.680

Published: 1994

Journal Articles

Accelerated thrombin generation during anticoagulation in patients with unstable angina pectoris [letter]

HD Garabedian, HK Gold, JB Newell, D Collen, JN Hagstrom, EG Bovill

Blood (1994) 83 (4): 1155.

https://doi.org/10.1182/blood.V83.4.1155a.1155a

Published: 1994

Journal Articles

Regulation by alpha 2-antiplasmin and fibrin of the activation of plasminogen with recombinant staphylokinase in plasma

K Silence, D Collen, HR Lijnen

Blood (1993) 82 (4): 1175–1183.

https://doi.org/10.1182/blood.V82.4.1175.1175

Published: 1993

Journal Articles

Pharmacokinetic and thrombolytic properties of chimeric plasminogen activators consisting of a single-chain Fv fragment of a fibrin- specific antibody fused to single-chain urokinase

P Holvoet, Y Laroche, JM Stassen, HR Lijnen, B Van Hoef, F De Cock, A Van Houtven, Y Gansemans, G Matthyssens, D Collen

Blood (1993) 81 (3): 696–703.

https://doi.org/10.1182/blood.V81.3.696.696

Published: 1993

Journal Articles

Antithrombotic properties of L-cysteine, N-(mercaptoacetyl)-D-Tyr-Arg- Gly-Asp-sulfoxide (G4120) in a hamster platelet-rich femoral vein thrombosis model

Y Imura, JM Stassen, S Bunting, F Stockmans, D Collen

Blood (1992) 80 (5): 1247–1253.

https://doi.org/10.1182/blood.V80.5.1247.1247

Published: 1992

Journal Articles

Thrombolytic and pharmacokinetic properties of an immunoconjugate of single-chain urokinase-type plasminogen activator (u-PA) and a bispecific monoclonal antibody against fibrin and against u-PA in baboons

Y Imura, JM Stassen, T Kurokawa, S Iwasa, HR Lijnen, D Collen

Blood (1992) 79 (9): 2322–2329.

https://doi.org/10.1182/blood.V79.9.2322.2322

Published: 1992

Journal Articles

Biochemical and biologic properties of rt-PA del (K296-G302), a recombinant human tissue-type plasminogen activator deletion mutant resistant to plasminogen activator inhibitor-1

XK Li, HR Lijnen, L Nelles, B Van Hoef, JM Stassen, D Collen

Blood (1992) 79 (2): 417–429.

https://doi.org/10.1182/blood.V79.2.417.417

Published: 1992

Journal Articles

Basic and clinical aspects of fibrinolysis and thrombolysis

D Collen, HR Lijnen

Blood (1991) 78 (12): 3114–3124.

https://doi.org/10.1182/blood.V78.12.3114.3114

Published: 1991

Journal Articles

Effect of chemical conjugation of recombinant single-chain urokinase- type plasminogen activator with monoclonal antiplatelet antibodies on platelet aggregation and on plasma clot lysis in vitro and in vivo

M Dewerchin, HR Lijnen, JM Stassen, F De Cock, T Quertermous, MH Ginsberg, EF Plow, D Collen

Blood (1991) 78 (4): 1005–1018.

https://doi.org/10.1182/blood.V78.4.1005.1005

Published: 1991

Journal Articles

Comparative thrombolytic properties of bolus injections and continuous infusions of a chimeric (t-PA/u-PA) plasminogen activator in a hamster pulmonary embolism model

HR Lu, HR Lijnen, JM Stassen, D Collen

Blood (1991) 78 (1): 125–131.

https://doi.org/10.1182/blood.V78.1.125.125

Published: 1991

Journal Articles

Requirement of heparin for arterial and venous thrombolysis with recombinant tissue-type plasminogen activator

HJ Rapold, HR Lu, ZM Wu, H Nijs, D Collen

Blood (1991) 77 (5): 1020–1024.

https://doi.org/10.1182/blood.V77.5.1020.1020

Published: 1991

Journal Articles

Comparison of intravenous bolus injection or continuous infusion of recombinant single chain urokinase-type plasminogen activator (saruplase) for thrombolysis. A canine model of combined coronary arterial and femoral venous thrombosis

HJ Rapold, ZM Wu, T Stassen, F Van de Werf, D Collen

Blood (1990) 76 (8): 1558–1563.

https://doi.org/10.1182/blood.V76.8.1558.1558

Published: 1990

Journal Articles

A monoclonal antibody specific for two-chain urokinase-type plasminogen activator. Application to the study of the mechanism of clot lysis with single-chain urokinase-type plasminogen activator in plasma

PJ Declerck, HR Lijnen, M Verstreken, H Moreau, D Collen

Blood (1990) 75 (9): 1794–1800.

https://doi.org/10.1182/blood.V75.9.1794.1794

Published: 1990

Journal Articles

The mechanism of plasminogen activation and fibrin dissolution by single chain urokinase-type plasminogen activator in a plasma milieu in vitro

HR Lijnen, B Van Hoef, F De Cock, D Collen

Blood (1989) 73 (7): 1864–1872.

https://doi.org/10.1182/blood.V73.7.1864.1864

Published: 1989

Journal Articles

Thrombolytic properties of human tissue-type plasminogen activator, single-chain urokinase-type plasminogen activator, and synergistic combinations in venous thrombosis models in dogs and rabbits

DJ Spriggs, JM Stassen, Y Hashimoto, D Collen

Blood (1989) 73 (5): 1207–1212.

https://doi.org/10.1182/blood.V73.5.1207.1207

Published: 1989

Journal Articles

Plasminogen receptors, urokinase receptors, and their modulation on human endothelial cells

LA Miles, EG Levin, J Plescia, D Collen, EF Plow

Blood (1988) 72 (2): 628–635.

https://doi.org/10.1182/blood.V72.2.628.628

Published: 1988

Journal Articles

Pharmacokinetics and thrombolytic properties of deletion mutants of human tissue-type plasminogen activator in rabbits

D Collen, JM Stassen, G Larsen

Blood (1988) 71 (1): 216–219.

https://doi.org/10.1182/blood.V71.1.216.216

Published: 1988

NARROW

 2 -Antiplasmin Gene Deficiency in Mice Is Associated With Enhanced Fibrinolytic Potential Without Overt Bleeding

Stromelysin-1 (MMP-3)–Independent Gelatinase Expression and Activation in Mice

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen

Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?

Accelerated thrombin generation during anticoagulation in patients with unstable angina pectoris [letter]

Regulation by alpha 2-antiplasmin and fibrin of the activation of plasminogen with recombinant staphylokinase in plasma

Pharmacokinetic and thrombolytic properties of chimeric plasminogen activators consisting of a single-chain Fv fragment of a fibrin- specific antibody fused to single-chain urokinase

Antithrombotic properties of L-cysteine, N-(mercaptoacetyl)-D-Tyr-Arg- Gly-Asp-sulfoxide (G4120) in a hamster platelet-rich femoral vein thrombosis model

Thrombolytic and pharmacokinetic properties of an immunoconjugate of single-chain urokinase-type plasminogen activator (u-PA) and a bispecific monoclonal antibody against fibrin and against u-PA in baboons

Biochemical and biologic properties of rt-PA del (K296-G302), a recombinant human tissue-type plasminogen activator deletion mutant resistant to plasminogen activator inhibitor-1

Basic and clinical aspects of fibrinolysis and thrombolysis

Effect of chemical conjugation of recombinant single-chain urokinase- type plasminogen activator with monoclonal antiplatelet antibodies on platelet aggregation and on plasma clot lysis in vitro and in vivo

Comparative thrombolytic properties of bolus injections and continuous infusions of a chimeric (t-PA/u-PA) plasminogen activator in a hamster pulmonary embolism model

Requirement of heparin for arterial and venous thrombolysis with recombinant tissue-type plasminogen activator

Comparison of intravenous bolus injection or continuous infusion of recombinant single chain urokinase-type plasminogen activator (saruplase) for thrombolysis. A canine model of combined coronary arterial and femoral venous thrombosis

A monoclonal antibody specific for two-chain urokinase-type plasminogen activator. Application to the study of the mechanism of clot lysis with single-chain urokinase-type plasminogen activator in plasma

The mechanism of plasminogen activation and fibrin dissolution by single chain urokinase-type plasminogen activator in a plasma milieu in vitro

Thrombolytic properties of human tissue-type plasminogen activator, single-chain urokinase-type plasminogen activator, and synergistic combinations in venous thrombosis models in dogs and rabbits

Plasminogen receptors, urokinase receptors, and their modulation on human endothelial cells

Pharmacokinetics and thrombolytic properties of deletion mutants of human tissue-type plasminogen activator in rabbits

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