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Journal Articles

Single-Cell Multi-Omics in Human Clonal Hematopoiesis Reveals That DNMT3A R882 Mutations Perturb Early Progenitor States through Selective Hypomethylation

Anna S Nam, MD, Neville Dusaj, MS, Franco Izzo, PhD, Rekha Murali, MS, Tarek H Mouhieddine, MD, Robert M Myers, Jesus Sotelo, Salima Benbarche, PhD, Federico Gaiti, PhD, Sabrin Tahri, MD MSc, Omar Abdel-Wahab, MD, Irene M. Ghobrial, MD, Ronan Chaligne, PhD, Dan A. Landau, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-142574

Published: 2020

Journal Articles

Single-Cell Multi-Omics Reveals Distinct Paths to Survival of Admixed BTK C481 Mutant Vs. Wild-Type Cells in Clinically Progressing Chronic Lymphocytic Leukemia

Blood (2020) 136 (Supplement 1): 40–42.

https://doi.org/10.1182/blood-2020-138374

Published: 2020

Journal Articles

Robust Discovery of Candidate DNA Methylation Cancer Drivers

Heng Pan, PhD, Loïc Renaud, MD MSc, Ronan Chaligne, PhD, Johannes Bloehdorn, MD, Eugen Tausch, MD, Daniel Mertens, PhD, Anna-Maria Fink, MD, Kirsten Fischer, MD, Chao Zhang, PhD, Doron Betel, PhD, Andreas Gnirke, Marcin Imielinski, Jerome Moreaux, PhD, Michael Hallek, Alexander Meissner, PhD, Stephan Stilgenbauer, MD, Catherine J. Wu, MD, Olivier Elemento, PhD, Dan A. Landau, MD PhD

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-136830

Published: 2020

Journal Articles

Multiplatform Profiling Characterizes Functional Networks in Genomically Stable and Instable Chronic Lymphocytic Leukemia

Blood (2020) 136 (Supplement 1): 12–13.

https://doi.org/10.1182/blood-2020-141552

Published: 2020

Journal Articles

High Throughput Droplet Single-Cell Genotyping of Transcriptomes (GoT) Reveals the Cell Identity Dependency of the Transcriptional Output of Somatic Mutations

Anna S Nam, MD, Kyu-Tae Kim, PhD, Ronan Chaligne, PhD, Franco Izzo, PhD, Chelston Ang, MS, Nathaniel Omans, MS, Alessandro Pastore, Justin Taylor, MD, Alicia Alonso, Wayne Tam, MD PhD, Ronald Hoffman, MD, Joseph Scandura, MDPhD, Raul Rabadan, PhD, Omar I Abdel-Wahab, MD, Peter Smibert, PhD, Dan A. Landau, MD PhD

Blood (2018) 132 (Supplement 1): 541.

https://doi.org/10.1182/blood-2018-99-119236

Published: 2018

Journal Articles

Epigenetic Heterogeneity in Non-Hodgkin Lymphoma

Dan A. Landau, MD PhD

Blood (2018) 132 (Supplement 1): SCI-35.

https://doi.org/10.1182/blood-2018-99-109500

Published: 2018

Journal Articles

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells

Josephine Wesely, PhD MSc, BSc, Andriana G. Kotini, PhD, Maria Georgomanoli, PhD, Hanzhi Luo, PhD, Han Yuan, Franco Izzo, PhD, Dan A. Landau, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD, Eirini P. Papapetrou, MD PhD

Blood (2018) 132 (Supplement 1): 772.

https://doi.org/10.1182/blood-2018-99-111506

Published: 2018

Journal Articles

m 6 A Maintains Hematopoietic Stem and Progenitor Cell Identity

Yuanming Cheng, PhD, Hanzhi Luo, PhD, Franco Izzo, PhD, Brian F Pickering, PhD, Ly P Vu, PhD, Alexandra Schurer, BS, Saroj Gourkanti, BA, Samie R. Jaffrey, MD PhD, Dan A. Landau, MD PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 327.

https://doi.org/10.1182/blood-2018-99-117191

Published: 2018

Journal Articles

Multimodal Single-Cell Profiling Defines the Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution

Ronan Chaligne, PhD, Federico Gaiti, PhD, Franco Izzo, PhD, Steven Kothen-Hill, MS, Hongcang Gu, Kevin Huang, BS, Davide Risso, PhD, Rafael Schulman, BS, Ryan M Brand, Stanley C Lee, PhD, Asaf Poran, Kye-Tae Kim, PhD, Alessandro Pastore, Alicia Alonso, Andreas Gnirke, Catherine J. Wu, MD, Omar I Abdel-Wahab, MD, Alexander Meissner, PhD, Dan A. Landau, MD PhD

Blood (2018) 132 (Supplement 1): 1312.

https://doi.org/10.1182/blood-2018-99-115596

Published: 2018

Journal Articles

Single-Cell Methylome and Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation

Franco Izzo, PhD, Asaf Poran, Stanley Chun-Wei Lee, PhD, Ronan Chaligne, PhD, Federico Gaiti, PhD, Steven Kothen-Hill, MS, Rafael Schulman, BS, Michelle Ki, Kenigsberg Ephraim, PhD, Omar Abdel-Wahab, MD, Dan A. Landau, MD PhD

Blood (2017) 130 (Supplement 1): 559.

https://doi.org/10.1182/blood.V130.Suppl_1.559.559

Published: 2017

Journal Articles

Single Cell Bisulfite Sequencing Defines Epigenetic Diversification in Chronic Lymphocytic Leukemia

Dan A. Landau, MD PhD, Kendell Clement, Hongcang Gu, Evan Biederstedt, MA, Divy Kangeyan, Steven Hill, Lili Wang, MD PhD, Martin Aryee, PhD, Andreas Gnirke, Alex Meissner, Catherine J Wu, MD

Blood (2016) 128 (22): 1047.

https://doi.org/10.1182/blood.V128.22.1047.1047

Published: 2016

Journal Articles

The Landscape of Dynamic Genetic Changes in Ibrutinib-Treated CLL

Dan A. Landau, MD PhD, Clare Sun, MD, Daniel Rosebrock, Mariela Campbell, Sarah E. M. Herman, PhD, Julia Hoellenriegel, MS, Mohammed Farooqui, Wandi Zhang, MD, Donna S. Neuberg, ScD, Dimitri Livitz, Ignaty Leshchiner, Gad Getz, PhD, Jan Burger, MD PhD, Adrian Wiestner, MD PhD, Catherine J Wu, MD

Blood (2016) 128 (22): 188.

https://doi.org/10.1182/blood.V128.22.188.188

Published: 2016

Journal Articles

Dynamic Alterations in Gene Expression in Ibrutinib Treated CLL Reveal Profound Impact on Multiple Signaling Pathways

Sarah E. M. Herman, PhD, Delong Liu, PhD, Dan A. Landau, MD PhD, Clare Sun, MD, Mohammed Farooqui, Catherine J Wu, MD, Adrian Wiestner, MDPhD

Blood (2016) 128 (22): 189.

https://doi.org/10.1182/blood.V128.22.189.189

Published: 2016

Journal Articles

Quantitative Clonal Dynamics Define Mechanisms of CLL Evolution in Response to Combination Chemotherapy

Blood (2015) 126 (23): 362.

https://doi.org/10.1182/blood.V126.23.362.362

Published: 2015

Journal Articles

Novel Putative Driver Gene Mutations in Chronic Lymphocytic Leukemia (CLL): Results from a Combined Analysis of Whole-Exome Sequencing of 262 Primary CLL Samples

Dan A. Landau, MD PhD, Chip Stewart, PhD, Johannes G. Reiter, Michael Lawrence, PhD, Carrie Sougnez, Jennifer R. Brown, Armando Lopez-Guillermo, MD, Stacey Gabriel, PhD, Eric Lander, PhD, Donna S. Neuberg, ScD, Carlos López-Otín, Elias Campo, Gad Getz, PhD, Catherine J. Wu, MD

Blood (2014) 124 (21): 1952.

https://doi.org/10.1182/blood.V124.21.1952.1952

Published: 2014

Journal Articles

Subclonal Driver Mutations Predict Shorter Progression Free Survival in Chronic Lymphocytic Leukemia Following First-Line Chemo(immuno)Therapy: Results from the CLL8 Trial

Blood (2014) 124 (21): 1938.

https://doi.org/10.1182/blood.V124.21.1938.1938

Published: 2014

Journal Articles

Whole Genome Sequencing of Indolent CLL Reveals Novel Structural Rearrangements

Siddha Kasar, Grace Tiao, Reina Improgo, PhD, Adam Kiezun, PhD, Carrie Sougnez, Samira Bahl, PhD, Stacey M. Fernandes, Alexander R. Vartanov, Kevin Hoang, Stacey Gabriel, PhD, Dan A. Landau, MD PhD, Catherine J Wu, MD, Eric Lander, PhD, Haesook T. Kim, PhD, Gad Getz, PhD, Jennifer R. Brown, MD PhD

Blood (2014) 124 (21): 1939.

https://doi.org/10.1182/blood.V124.21.1939.1939

Published: 2014

Journal Articles

Integrated Single-Cell Detection of Genotype and Phenotype in SF3B1-Mutated Chronic Lymphocytic Leukemia Cells

Lili Wang, MD PhD, Dylan Kotliar, BA, Jean Fan, Shuqiang Li, PhD, Jonna Grimsby, Dan A. Landau, MD PhD, Jennifer R. Brown, MD PhD, Niall Lennon, Donna Neuberg, ScD, Kenneth J Livak, Catherine J. Wu, MD

Blood (2014) 124 (21): 1943.

https://doi.org/10.1182/blood.V124.21.1943.1943

Published: 2014

NARROW

Single-Cell Multi-Omics in Human Clonal Hematopoiesis Reveals That DNMT3A R882 Mutations Perturb Early Progenitor States through Selective Hypomethylation

Single-Cell Multi-Omics Reveals Distinct Paths to Survival of Admixed BTK C481 Mutant Vs. Wild-Type Cells in Clinically Progressing Chronic Lymphocytic Leukemia

Robust Discovery of Candidate DNA Methylation Cancer Drivers

Multiplatform Profiling Characterizes Functional Networks in Genomically Stable and Instable Chronic Lymphocytic Leukemia

High Throughput Droplet Single-Cell Genotyping of Transcriptomes (GoT) Reveals the Cell Identity Dependency of the Transcriptional Output of Somatic Mutations

Epigenetic Heterogeneity in Non-Hodgkin Lymphoma

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells

m 6 A Maintains Hematopoietic Stem and Progenitor Cell Identity

Multimodal Single-Cell Profiling Defines the Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution

Single-Cell Methylome and Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation

Single Cell Bisulfite Sequencing Defines Epigenetic Diversification in Chronic Lymphocytic Leukemia

The Landscape of Dynamic Genetic Changes in Ibrutinib-Treated CLL

Dynamic Alterations in Gene Expression in Ibrutinib Treated CLL Reveal Profound Impact on Multiple Signaling Pathways

Quantitative Clonal Dynamics Define Mechanisms of CLL Evolution in Response to Combination Chemotherapy

Novel Putative Driver Gene Mutations in Chronic Lymphocytic Leukemia (CLL): Results from a Combined Analysis of Whole-Exome Sequencing of 262 Primary CLL Samples

Subclonal Driver Mutations Predict Shorter Progression Free Survival in Chronic Lymphocytic Leukemia Following First-Line Chemo(immuno)Therapy: Results from the CLL8 Trial

Whole Genome Sequencing of Indolent CLL Reveals Novel Structural Rearrangements

Integrated Single-Cell Detection of Genotype and Phenotype in SF3B1-Mutated Chronic Lymphocytic Leukemia Cells

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American Society of Hematology

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American Society of Hematology

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