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Debbie Roeleveld
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Journal Articles

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Laurens T Van Der Meer, PhD, Samantha YA Terry, PhD, Dorette van Ingen Schenau, MSc, Kiki Andree, MSc, Gerben M Franssen, BSc, Debbie Roeleveld, MSc, Bart Metselaar, PhD, Thomas Reinheckel, PhD, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 3768.
https://doi.org/10.1182/blood.V126.23.3768.3768
Published: 2015
Journal Articles

A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics

Clinical Trials & Observations
Laurens T. van der Meer, Esmé Waanders, Marloes Levers, Hanka Venselaar, Debbie Roeleveld, Joachim Boos, Claudia Lanvers, Roger J. Brüggemann, Roland P. Kuiper, Peter M. Hoogerbrugge, Frank N. van Leeuwen, D. Maroeska te Loo
Journal: Blood
Blood (2014) 124 (19): 3027–3029.
https://doi.org/10.1182/blood-2014-06-582627
Published: 2014
Includes: Supplemental data
Journal Articles

A Germline Mutation in Cathepsin B in a Child with ALL Points towards a Key Role for This Enzyme in L-Asparaginase Pharmacokinetics.

Laurens T. van der Meer, PhD, Esmé Waanders, PhD, Marloes Levers, BSc, Hanka Venselaar, MSc, Debbie Roeleveld, BSc, Joachim Boos, MD, PhD, Claudia Lanvers-Kaminsky, PhD, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD, D. Maroeska W.M. te Loo, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2458.
https://doi.org/10.1182/blood.V120.21.2458.2458
Published: 2012