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Journal Articles

Self-Supporting Human Acute Myeloid Leukemia (AML) Bone Marrow Organoids Established from Patient-Derived Xenografts Mimic the Human AML Microenvironment, with Distinct Cytokine Kinetics Correlating with Dynamic Cell Proliferation and Metabolic Shifts

Alejandro De Janon, Aashis Thapa, Fang Zhou, Ahmet Coskun, Athanasios Mantalaris, Douglas K. Graham, Deborah DeRyckere, Nicki Panoskaltsis

Blood (2023) 142 (Supplement 1): 1337.

https://doi.org/10.1182/blood-2023-189230

Published: 2023

Journal Articles

A Dynamic Personalized Human 3D Organoid for the Study of the Tumor Microenvironment and Metabolism in Acute Myeloid Leukemia Using Patient-Derived Xenografts

Alejandro De Janon, Madison Stout, Diana Fridlyand, Zhou Fang, Ahmet F. Coskun, Douglas K Graham, Athanasios Mantalaris, Deborah DeRyckere, Nicki Panoskaltsis

Blood (2022) 140 (Supplement 1): 1203–1204.

https://doi.org/10.1182/blood-2022-170225

Published: 2022

Journal Articles

A Single Cell Atlas and Interactive Web-Resource of Pediatric Cancers and Healthy Bone Marrow

Hope L Mumme, Swati S Bhasin, Mariam Nawaz, Beena E Thomas, Chenbin Huang, Deborah DeRyckere, Sharon M. Castellino, Daniel S. Wechsler, Sunil S. Raikar, Christopher C. Porter, Douglas K Graham, Manoj Bhasin

Blood (2022) 140 (Supplement 1): 2278–2279.

https://doi.org/10.1182/blood-2022-169153

Published: 2022

Journal Articles

Analysis of Single Cell Transcriptomics in Paired Pediatric T-ALL Samples Collected at Diagnosis and Following End of Induction Therapy Reveals an MRD-Associated Stem Cell Signature

Swati S Bhasin, Beena E Thomas, Ryan J Summers, Debasree Sarkar, Hope L Mumme, Mohammed Emam Mansour, William Pilcher, Sunita I. Park, Sharon M. Castellino, Deborah DeRyckere, Manoj Bhasin, Douglas K Graham

Blood (2021) 138 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2021-153841

Published: 2021

Journal Articles

Single Cell RNA Sequencing Driven Characterization of Rare B/Myeloid and T/Myeloid Mixed Phenotype Acute Leukemia

Hope L Mumme, Swati S Bhasin, Beena E Thomas, Deborah DeRyckere, Sharon M. Castellino, Douglas K Graham, Sunil S. Raikar, Manoj Bhasin

Blood (2021) 138 (Supplement 1): 3455.

https://doi.org/10.1182/blood-2021-153776

Published: 2021

Journal Articles

Pediatric Single Cell Cancer Atlas: An Integrative Web-Based Resource for Single Cell Transcriptome Data from Pediatric Leukemias

Hope L Mumme, Swati S Bhasin, Beena E Thomas, Bhakti Dwivedi, Deborah DeRyckere, Sharon M. Castellino, Daniel S. Wechsler, Sunil S. Raikar, Christopher C. Porter, Douglas K Graham, Manoj Bhasin

Blood (2021) 138 (Supplement 1): 3488.

https://doi.org/10.1182/blood-2021-154282

Published: 2021

Journal Articles

Therapeutic Targeting of Mertk and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia

Ryan J Summers, Juhi Jain, Eleana Vasileiadi, Brittany Smith, Madison Stout, James Kelvin, Xiaodong Wang, Stephen V Frye, H. Shelton Earp, Jeffrey W. Tyner, Erik Dreaden, Deborah DeRyckere, Douglas K Graham

Blood (2021) 138 (Supplement 1): 1184.

https://doi.org/10.1182/blood-2021-151726

Published: 2021

Journal Articles

Characterization of T-ALL-Specific Heterogenous Blast Populations Using High Resolution Single Cell Profiling

Swati S Bhasin, PhD, Ryan J Summers, MD, Beena E Thomas, Debasree Sarkar, PhD, Bhakti Dwivedi, PhD, Sunita I Park, MD, Deborah DeRyckere, BS,PhD, Sharon M. Castellino, MD MSc, Manoj Bhasin, PhD, Douglas K Graham, MD PhD

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-143017

Published: 2020

Journal Articles

Single Cell Transcriptomics Revealed AML and Non-AML Cell Clusters Relevant to Relapse and Remission in Pediatric AML

Beena E Thomas, Pruthvi Perumalla, MS, Swati S Bhasin, PhD, Debasree Sarkar, PhD, Bhakti Dwivedi, PhD, Sunita I Park, MD, Deborah DeRyckere, BS,PhD, Curtis J. Henry, PhD, Sunil S. Raikar, MD, Christopher C. Porter, MD, Melinda Pauly, MD, Ryan J Summers, MD, Sharon M. Castellino, MD MSc, Daniel S. Wechsler, MD PhD, Douglas K Graham, MD PhD, Manoj Bhasin, PhD

Blood (2020) 136 (Supplement 1): 24–25.

https://doi.org/10.1182/blood-2020-142513

Published: 2020

Journal Articles

Mertk Inhibition Promotes Anti-Leukemia Immunity By Reversing T Cell Suppression Via the PD-1 Axis

Alisa Lee-Sherick, MD, Kristen Jacobsen, PhD, Curtis J. Henry, PhD, Rebecca Parker, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD

Blood (2018) 132 (Supplement 1): 4019.

https://doi.org/10.1182/blood-2018-99-119818

Published: 2018

Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Myeloid Leukemia

Katherine A Minson, MD, Madeline G Huey, BA, Annie Qiu, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD

Blood (2017) 130 (Supplement 1): 3823.

https://doi.org/10.1182/blood.V130.Suppl_1.3823.3823

Published: 2017

Journal Articles

Mertk Is a Therapeutic Target in Early T-Precursor Acute Lymphoblastic Leukemia

Ryan J Summers, MD, Katherine A Minson, MD, Stephen V Frye, PhD, Xiaodong Wang, PhD, H. Shelton Earp, III, MD, Deborah DeRyckere, PhD, Douglas K. Graham, MD PhD

Blood (2017) 130 (Supplement 1): 2536.

https://doi.org/10.1182/blood.V130.Suppl_1.2536.2536

Published: 2017

Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Leukemia

Katherine A Minson, MD, Madeline G Huey, BS, Amanda A Hill, Irene Perez, Xiaodong Wang, PhD, Stephen Frye, PhD, H. Shelton Earp, III, MD, Deborah DeRyckere, PhD, Douglas K. Graham, MD PhD

Blood (2016) 128 (22): 2819.

https://doi.org/10.1182/blood.V128.22.2819.2819

Published: 2016

Journal Articles

MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia

Katherine A Minson, MD, Catherine C Smith, MD, Alisa B. Lee-Sherick, MD, Deborah DeRyckere, PhD, Elisabeth Lasater, PhD, Amanda A. Hill, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Neil P. Shah, MD PhD, Douglas K. Graham, MD PhD

Blood (2014) 124 (21): 3757.

https://doi.org/10.1182/blood.V124.21.3757.3757

Published: 2014

Journal Articles

UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia

Deborah DeRyckere, PhD, Alisa B. Lee-Sherick, MD, Amanda A. Hill, Lauren Page, BS, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Douglas K. Graham, MD PhD

Blood (2014) 124 (21): 998.

https://doi.org/10.1182/blood.V124.21.998.998

Published: 2014

Journal Articles

Mer Receptor Tyrosine Kinase Is a Novel Therapeutic Target In Multiple Myeloma

Sandra Christoph, Silke Maag, Deborah DeRyckere, Douglas K. Graham, MD, PhD, Stephen V Frye, H. Shelton Earp, III, Jing Liu, Chao Yang, Weihe Zhang, Xiaodong Wang, Ahmet H. Elmaagacli, Dietrich Beelen, MD

Blood (2013) 122 (21): 1957.

https://doi.org/10.1182/blood.V122.21.1957.1957

Published: 2013

Journal Articles

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Mediate Synergistic Inhibition Of Platelet Aggregation In Combination With ADP/P2Y Antagonists

Gilbert Acevedo, BS, Brian R. Branchford, MD, Luke Law, BS, Christine Brzezinski, Susan Sather, Gary Brodsky, PhD, Deborah DeRyckere, Ph.D., Weihe Zhang, H. Shelton Earp, III, Stephen V Frye, Douglas K. Graham, MD, PhD, Jorge Di Paola, MD

Blood (2013) 122 (21): 3507.

https://doi.org/10.1182/blood.V122.21.3507.3507

Published: 2013

Journal Articles

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Inhibit Platelet Aggregation In Vitro and Protect Mice From Arterial and Venous Thrombosis In Vivo

Gilbert Acevedo, BS, Brian R. Branchford, MD, Christine Brzezinski, Susan Sather, Gary Brodsky, PhD, Deborah DeRyckere, Ph.D., Weihe Zhang, Jing Liu, H. Shelton Earp, III, Xiaodong Wang, Stephen V Frye, Douglas K. Graham, MD, PhD, Jorge Di Paola, MD

Blood (2013) 122 (21): 2296.

https://doi.org/10.1182/blood.V122.21.2296.2296

Published: 2013

Journal Articles

UNC1666, a Dual Mer and Flt-3 Tyrosine Kinase Small Molecule Inhibitor In Acute Myeloid Leukemia

Alisa B. Lee-Sherick, MD, Kelly Menachof, Amanda A Hill, Sean Rinella, MPH, Jing Liu, Deborah DeRyckere, Xiaodong Wang, Stephen V Frye, H. Shelton Earp, III, Douglas K. Graham, MD, PhD

Blood (2013) 122 (21): 3849.

https://doi.org/10.1182/blood.V122.21.3849.3849

Published: 2013

Journal Articles

Development Of a Novel Small Molecule Inhibitor Of The Mer Tyrosine Kinase For Treatment Of Acute Lymphoblastic Leukemia

Deborah DeRyckere, Xiaodong Wang, Amanda A Hill, Weihe Zhang, Michael A Stashko, Susan Sather, Christopher E Cummings, William P Janzen, Stephen V Frye, H. Shelton Earp, III, Douglas K. Graham, MD, PhD

Blood (2013) 122 (21): 2666.

https://doi.org/10.1182/blood.V122.21.2666.2666

Published: 2013

NARROW

Self-Supporting Human Acute Myeloid Leukemia (AML) Bone Marrow Organoids Established from Patient-Derived Xenografts Mimic the Human AML Microenvironment, with Distinct Cytokine Kinetics Correlating with Dynamic Cell Proliferation and Metabolic Shifts

A Dynamic Personalized Human 3D Organoid for the Study of the Tumor Microenvironment and Metabolism in Acute Myeloid Leukemia Using Patient-Derived Xenografts

A Single Cell Atlas and Interactive Web-Resource of Pediatric Cancers and Healthy Bone Marrow

Analysis of Single Cell Transcriptomics in Paired Pediatric T-ALL Samples Collected at Diagnosis and Following End of Induction Therapy Reveals an MRD-Associated Stem Cell Signature

Single Cell RNA Sequencing Driven Characterization of Rare B/Myeloid and T/Myeloid Mixed Phenotype Acute Leukemia

Pediatric Single Cell Cancer Atlas: An Integrative Web-Based Resource for Single Cell Transcriptome Data from Pediatric Leukemias

Therapeutic Targeting of Mertk and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia

Characterization of T-ALL-Specific Heterogenous Blast Populations Using High Resolution Single Cell Profiling

Single Cell Transcriptomics Revealed AML and Non-AML Cell Clusters Relevant to Relapse and Remission in Pediatric AML

Mertk Inhibition Promotes Anti-Leukemia Immunity By Reversing T Cell Suppression Via the PD-1 Axis

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Myeloid Leukemia

Mertk Is a Therapeutic Target in Early T-Precursor Acute Lymphoblastic Leukemia

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Leukemia

MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia

UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia

Mer Receptor Tyrosine Kinase Is a Novel Therapeutic Target In Multiple Myeloma

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Mediate Synergistic Inhibition Of Platelet Aggregation In Combination With ADP/P2Y Antagonists

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Inhibit Platelet Aggregation In Vitro and Protect Mice From Arterial and Venous Thrombosis In Vivo

UNC1666, a Dual Mer and Flt-3 Tyrosine Kinase Small Molecule Inhibitor In Acute Myeloid Leukemia

Development Of a Novel Small Molecule Inhibitor Of The Mer Tyrosine Kinase For Treatment Of Acute Lymphoblastic Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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