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Journal Articles

A predictive model for therapy failure in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitor therapy

Clinical Trials & Observations
Xiaoshuai Zhang, Bingcheng Liu, Jian Huang, Yanli Zhang, Na Xu, Robert Peter Gale, Weiming Li, Xiaoli Liu, Huanling Zhu, Ling Pan, Yunfan Yang, Hai Lin, Xin Du, Rong Liang, Chunyan Chen, Xiaodong Wang, Guohui Li, Zhuogang Liu, Yanqing Zhang, Zhenfang Liu, Jianda Hu, Chunshui Liu, Fei Li, Wei Yang, Li Meng, Yanqiu Han, Li’e Lin, Zhenyu Zhao, Chuanqing Tu, Caifeng Zheng, Yanliang Bai, Zeping Zhou, Suning Chen, Huiying Qiu, Lijie Yang, Xiuli Sun, Hui Sun, Li Zhou, Zelin Liu, Danyu Wang, Jianxin Guo, Liping Pang, Qingshu Zeng, Xiaohui Suo, Weihua Zhang, Yuanjun Zheng, Xiaojun Huang, Qian Jiang
Journal: Blood
Blood (2024) 144 (18): 1951–1961.
https://doi.org/10.1182/blood.2024024761
Published: 2024
Includes: Supplemental data
Journal Articles

Flumatinib Versus Nilotinib for Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia

Suning Chen, Yanli Zhang, Na Xu, Hui Sun, Li Weiming, Yunfan Yang, Zunmin Zhu, Minghui Duan, Sixuan Qian, Yu Zhu, Jianmin Luo, Xiaodong Wang, Wei Yang, Weiying Gu, Fei Li, Bingcheng Liu, Yunxiao Xu, Zhenfang Liu, Chunling Wang, Yirong Jiang, Li Meng, Qin Wen, Yanli Xu, Xingli Zou, Wei Wang, Yan Xue, Hao Xu, Kehong Bi, Fuling Zhou, Liangming Ma, Rong Fu, Guifang Ouyang, Kaiyang Ding, Depei Wu
Journal: Blood
Blood (2023) 142 (Supplement 1): 1797.
https://doi.org/10.1182/blood-2023-179073
Published: 2023
Journal Articles

Evaluating Effectiveness and Safety of Flumatinib for Chronic Phase Chronic Myeloid Leukemia in (CML-CP) without Optimal Response (Warning, Failure) to Imatinib or/and Dasatinib

Li Weiming, Yanli Zhang, Zhiwei Wu, Qin Wen, Qing Leng, Shuting Wu, Xiaodong Wang, Shiming Chen, Guolin Yuan, Sixuan Qian, Suning Chen, Daozi Jiang, Lianjun Diao, Zhenfang Xi, Hui Wu, Hui Sun, Lijie Yang, Hongjuan Wang, Xuefang Zhang, Yanli Xu, Xielan Zhao, Na Xu, Li Meng, Zunmin Zhu, Youfang Zhao, Meifang Su, Zhuangzhi Yang, Chuancai Liu, Danlei Han, Yu Hu
Journal: Blood
Blood (2023) 142 (Supplement 1): 3171.
https://doi.org/10.1182/blood-2023-179142
Published: 2023
Journal Articles

A Novel Post-Transplant Regimen for Selectively Promoting Unrelated Cord Blood Engraftment in Haploidentical-Cord Transplantation in Childhood Leukemia: A Single-Arm, Dual-Center Trial

Yongsheng Ruan, Xiaodong Wang, Yuelin He, Xuan Liu, Qiujun Liu, Yuhua Xiao, Chunfu Li, Sixi Liu, Xiaoqin Feng
Journal: Blood
Blood (2023) 142 (Supplement 1): 3532.
https://doi.org/10.1182/blood-2023-186896
Published: 2023
Journal Articles

Bmf-500: An Orally Bioavailable Covalent Inhibitor of FLT3 with High Selectivity and Potent Antileukemic Activity in FLT3-Mutated AML

Brian Law, Tripta Rughwani, Tenley C. Archer, Lekha Kumar, Daniel Lu, Priyanka Somanath, Yan Ma, Xiaodong Wang, David Sperandio, Steve Morris, Thorsten Kirschberg, Mini Balakrishnan, Thomas Butler
Journal: Blood
Blood (2022) 140 (Supplement 1): 6191–6192.
https://doi.org/10.1182/blood-2022-170445
Published: 2022
Journal Articles

Subjects with Chronic Myeloid Leukemia Identified As Intermediate- or High-Risk Subjects Using the Imatinib Therapy Failure (IMTF) Model Benefit from Initial Therapy with a Second-Generation Tyrosine Kinase Inhibitor

Xiaoshuai Zhang, Bingcheng Liu, Jian Huang, Gongli Zhang, Xiaoli Liu, Na Xu, Weiming Li, Xin Du, Jianyu Weng, Hai Lin, Rong Liang, Chunyan Chen, Huanling Zhu, Ling Pan, Yun-fan Yang, Xiaodong WANG, Guohui Li, Zhuogang Liu, Zhenfang Liu, Jianda Hu, Chunshui Liu, Li Fei, Wei Yang, Li Meng, Robert Peter Gale, Xiao Jun Huang, Qian Jiang
Journal: Blood
Blood (2022) 140 (Supplement 1): 3891–3894.
https://doi.org/10.1182/blood-2022-168812
Published: 2022
Journal Articles

Is the 2 nd Generation Tyrosine Kinase-Inhibitor a Better Initial Therapy Than Imatinib in Persons with Chronic Myeloid Leukemia Presenting in Accelerated Phase: A Multicenter Retrospective Study

Sen Yang, Xiaoshuai Zhang, Yanli Zhang, Xin Du, Jianyu Weng, Huanling Zhu, Ling Pan, Yun-fan Yang, Li Meng, Zhenfang Liu, Xiaoli Liu, Na Xu, Chunyan Chen, Xiaodong WANG, Rong Liang, Jian Huang, Guohui Li, Chunshui Liu, Hai Lin, Jianda Hu, Li Fei, Bingcheng Liu, Weiming Li, Zhuogang Liu, Wei Yang, Xiao Jun Huang, Qian Jiang
Journal: Blood
Blood (2022) 140 (Supplement 1): 815–817.
https://doi.org/10.1182/blood-2022-166855
Published: 2022
Journal Articles

Validation and Use of Predictive Scoring Systems for Molecular Responses in 5,203 Persons with Chronic Myeloid Leukemia

Xiaoshuai Zhang, Bingcheng Liu, Jian Huang, Gongli Zhang, Xiaoli Liu, Na Xu, Weiming Li, Xin Du, Jianyu Weng, Hai Lin, Rong Liang, Chunyan Chen, Huanling Zhu, Ling Pan, Yunfan Yang, Xiaodong WANG, Guohui Li, Zhuogang Liu, Zhenfang Liu, Jianda Hu, Chunshui Liu, Li Fei, Wei Yang, Li Meng, Robert Peter Gale, Xiao Jun Huang, Qian Jiang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9620–9623.
https://doi.org/10.1182/blood-2022-166431
Published: 2022
Journal Articles

A Predictive Scoring System for Therapy Failure in Persons with Chronic Myeloid Leukemia Receiving Initial a Second-Generation Tyrosine Kinase Inhibitor Therapy

Xiaoshuai Zhang, Bingcheng Liu, Jian Huang, Gongli Zhang, Xiaoli Liu, Na Xu, Weiming Li, Xin Du, Jianyu Weng, Hai Lin, Rong Liang, Chunyan Chen, Huanling Zhu, Ling Pan, Yun-fan Yang, Xiaodong WANG, Guohui Li, Zhuogang Liu, Zhenfang Liu, Jianda Hu, Chunshui Liu, Li Fei, Wei Yang, Li Meng, Robert Peter Gale, Xiao Jun Huang, Qian Jiang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9637–9639.
https://doi.org/10.1182/blood-2022-168703
Published: 2022
Journal Articles

Post Transplantation Fludarabine and Cyclophosphamide Selected and Promoted Low Dose of Unrelated UCB Implanation in Combined Transplantation of Haploid and UCB Stem Cells in Childhood Leukemia: 40 Cases Report in Double Center

Yuhua Xiao, Sixi Liu, Chunfu Li, Wing Hang Leung, Xiaoqin Feng, Yuelin He, Xiaodong Wang, Xiaoling Wang, Li Yu, Libai Chen, Jianyun Wen, Xuan Liu, Yongsheng Ruan, Xiaoting Liu, Yuqiong Ren
Journal: Blood
Blood (2021) 138 (Supplement 1): 2875.
https://doi.org/10.1182/blood-2021-150888
Published: 2021
Journal Articles

Therapeutic Targeting of Mertk and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia

Ryan J Summers, Juhi Jain, Eleana Vasileiadi, Brittany Smith, Madison Stout, James Kelvin, Xiaodong Wang, Stephen V Frye, H. Shelton Earp, Jeffrey W. Tyner, Erik Dreaden, Deborah DeRyckere, Douglas K Graham
Journal: Blood
Blood (2021) 138 (Supplement 1): 1184.
https://doi.org/10.1182/blood-2021-151726
Published: 2021
Journal Articles

Dasatinib Promotes the Maturation of Healthy Donors and Chronic Myelogenous Leukemia Patients Derived Dendritic Cells

Wangjun Cao, Lin He, Hong Zheng, MDPhD, Xiaobing Huang, Xi Yang, Xiaodong WANG, MD, Jingying Dai, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 53–54.
https://doi.org/10.1182/blood-2020-138462
Published: 2020
Journal Articles

The Increase on Th1 and CD8+T Levels While a Decrease on Treg Level after Dasatinib Treatment Indicate a Better Therapeutic Response to Dasatinib and Deeper Clinical Remission in Chronic Myelogenous Leukemia Patients

Jingying Dai, PhD, Hong Zheng, MD PhD, Xiaobing Huang, Xi Yang, Xiaodong WANG, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5376.
https://doi.org/10.1182/blood-2019-128413
Published: 2019
Journal Articles

Complementary Transplantation Improved Results of Both Peripheral Blood Stem Cells and Unrelated Cord Blood Transplants in Thalassemia: A Multi-Center Study from China

Chunfu Li, MD, Sixi Liu, MD PhD, Yuelin He, MD, Xiaodong Wang, MD, Jianyun Liao, MD, Shan Li, MD, Xiaolin Zheng, MD, Xuedong Wu, MD PhD, Changgang Li, MD, Xiaoqin Feng, Feiqiu Wen, MD PhD, Huaying Liu, MD, Xiaohui Zhou, MD, Zhiyong Peng, MD, Lan He, MD, Chaoke Bu, MD, Leung Wing, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4617.
https://doi.org/10.1182/blood-2019-129697
Published: 2019
Journal Articles

Mertk Inhibition Promotes Anti-Leukemia Immunity By Reversing T Cell Suppression Via the PD-1 Axis

Alisa Lee-Sherick, MD, Kristen Jacobsen, PhD, Curtis J. Henry, PhD, Rebecca Parker, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4019.
https://doi.org/10.1182/blood-2018-99-119818
Published: 2018
Journal Articles

Long Term Results for Childhood Acute Lymphoblastic Leukemia: An Institutional Review

Huirong Mai, Ximin Fang, Xiuli Yuan, Xiaodong Wang, Sixi Liu, MD, Ying Wang, Changgang Li, MD, Chi Kong Li, MD, Feiqiu Wen
Journal: Blood
Blood (2018) 132 (Supplement 1): 5161.
https://doi.org/10.1182/blood-2018-99-119080
Published: 2018
Journal Articles

Dasatinib Significantly Enhances the Level of Th1 Cells While Decreases the Level of Treg Cells in Chronic Myeloid Leukemia Patients, and Th1 Can be a Potential Marker for Evaluating the Therapeutic Efficacy and Prognosis

Jingying Dai, PhD, Xi Yang, Xiaobing Huang, Hong Zheng, MD PhD, Xiaodong Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4272.
https://doi.org/10.1182/blood-2018-99-113032
Published: 2018
Journal Articles

Epigenetic Therapy Targets Th1/Th17 Polarization to Reversing Immune Evasion and Treating Leukemia Relapse Post Allogeneic Stem Cell Transplantation in Non-APL AML Patients

Xi Yang, Hong Zheng, MD PhD, Jingying Dai, PhD, Chenglong Li, MDand PhD, Rong Zhang, MD PhD, Xiaodong WANG, MD, Chunsen Wang, MD, Xiaobing Huang
Journal: Blood
Blood (2018) 132 (Supplement 1): 3424.
https://doi.org/10.1182/blood-2018-99-111671
Published: 2018
Journal Articles

This Is a Title in Chidamide, a Novel HDAC Inhibitor, Is Effective for Treating Leukemia Relapse Post Allogeneic Stem Cell Transplantation and Results in Th1 Polarization in AML Patients with AML1-ETO

Xi Yang, Xiaobing Huang, MDand PhD, Hong Zheng, MDPhD, Chenglong Li, MDand PhD, Jingying Dai, PhD, Rong Zhang, MDand PhD, Xiaodong Wang, PhD, Chunsen Wang, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3278.
https://doi.org/10.1182/blood.V130.Suppl_1.3278.3278
Published: 2017
Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Myeloid Leukemia

Katherine A Minson, MD, Madeline G Huey, BA, Annie Qiu, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3823.
https://doi.org/10.1182/blood.V130.Suppl_1.3823.3823
Published: 2017