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Journal Articles

Multiple Myeloma-Specific Targeted Therapy: Use of the Tumor Specific Immunoglobulin Gene Sequence to Activate Drugs Only within Tumor Cells.

Zhi-Wei Li, PhD, Dror Shalitin, PhD, Jennifer Finefield, Crystal Leung, Mengyin Hu, Jing Shen, Mingjie Li, Cathy S Wang, Jeffrey A Steinberg, Eric Sanchez, Haiming Chen, MD, PhD, Robert M Williams, PhD, Benjamin Bonavida, PhD, James R. Berenson, MD

Blood (2009) 114 (22): 1851.

https://doi.org/10.1182/blood.V114.22.1851.1851

Published: 2009

Journal Articles

Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis

Haiming Chen, Richard A. Campbell, Yunchao Chang, Mingjie Li, Cathy S. Wang, Jennifer Li, Eric Sanchez, Michael Share, Jeffrey Steinberg, Ariana Berenson, Dror Shalitin, Zhaohui Zeng, Dorina Gui, Pablo Perez-Pinera, Ronald J. Berenson, Jonathan Said, Benjamin Bonavida, Thomas F. Deuel, James R. Berenson

Blood (2009) 113 (9): 1992–2002.

https://doi.org/10.1182/blood-2008-02-133751

Published: 2009

Journal Articles

A Novel Targeted Therapeutic Approach to Multiple Myeloma Using Tumor Specific Anti-Sense RNA Sequences

Zhi-Wei Li, PhD, Dror Shalitin, PhD, Jing Shen, Michael Share, Mingjie Li, Cathy S Wang, Eric Sanchez, Jeffrey A Steinberg, Haiming Chen, MD, PhD, Benjamin Bonavida, PhD, James R. Berenson, MD

Blood (2008) 112 (11): 2727.

https://doi.org/10.1182/blood.V112.11.2727.2727

Published: 2008

Journal Articles

Blockage of TRAF6 Signaling Inhibits Osteoclast Formation and Tumor Cell through Blocking the NF-kB and JNK Pathways in Multiple Myeloma.

Haiming Chen, MD, PhD, Mingjie Li, Jennifer Li, Richard A. Campbell, Cathy S. Wang, Eric Sanchez, Jeffrey Steinberg, Michael Share, Dror Shalitin, PhD, James Wang, Shi-Jason Xie, Benjamin Bonavida, PhD, James R. Berenson, MD

Blood (2007) 110 (11): 2511.

https://doi.org/10.1182/blood.V110.11.2511.2511

Published: 2007

Journal Articles

Wnt/β-Catenin Signaling Is Essential for the Transdifferentiation of Monocytes into Endothelial Cells by mCSF and Pleiotrophin.

Haiming Chen, MD, PhD, Mingjie Li, Richard Campbell, Cathy S. Wang, Jennifer Li, Eric Sanchez, Jeffrey Steinberg, Michael Share, Dror Shalitin, PhD, James Wang, Shi-Jason Xie, Yunchao Chang, PhD, Benjamin Bonavida, PhD, Thomas F. Deuel, MD, James R. Berenson, MD

Blood (2007) 110 (11): 1512.

https://doi.org/10.1182/blood.V110.11.1512.1512

Published: 2007

Journal Articles

Zoledronic Acid Suppresses Vasculogenesis: A New Effect of Bisphosphonates.

Haiming Chen, MD, PhD, Cathy S. Wang, Jennifer Li, Richard A. Campbell, Mingjie Li, Eric Sanchez, Jeffrey Steinberg, Michael Share, Dror Shalitin, PhD, James Wang, Shi-Jason Xie, Yunchao Chang, MD, Benjamin Bonavida, PhD, Thomas F. Deuel, MD, James R. Berenson, MD

Blood (2007) 110 (11): 3913.

https://doi.org/10.1182/blood.V110.11.3913.3913

Published: 2007

Journal Articles

The Novel Potent Pan-Deacetylase (DAC) Inhibitor, Panobinostat (LBH589), Markedly Enhances the Anti-Myeloma Effects of Chemotherapy In Vitro and In Vivo .

Richard A. Campbell, BS, Eric Sanchez, BA, Jeffrey Steinberg, BS, Michael Share, BA, Joseph Wang, Mingjie Li, Haiming Chen, MD, PhD, Dror Shalitin, PhD, Shen Pang, PhD, Jonathan Said, MD, James R. Berenson, MD

Blood (2007) 110 (11): 2520.

https://doi.org/10.1182/blood.V110.11.2520.2520

Published: 2007

Journal Articles

The Combination of the mTOR Inhibitor Rapamycin and Protein Kinase C Inhibitors Produces Marked Synergistic Anti-Myeloma Effects.

Dror Shalitin, PhD, Michael Share, BA, Richard A. Campbell, BS, Jeffrey Steinberg, BS, Eric Sanchez, BA, Joseph Wang, Richard Leuchter, Mingjie Li, Cathy S. Wang, BS, Haiming Chen, MD, PhD, James R. Berenson, MD

Blood (2007) 110 (11): 4800.

https://doi.org/10.1182/blood.V110.11.4800.4800

Published: 2007

Journal Articles

The mTOR Inhibitor RAD001 (Everolimus) Inhibits Myeloma Tumor Growth In Vivo and Enhances the Anti-MM Effects of Bortezomib and Arsenic Trioxide.

Richard A. Campbell, BS, Eric Sanchez, BA, Jeffrey Steinberg, BS, Michael Share, BA, Joseph Wang, Mingjie Li, Richard Leuchter, Haiming Chen, MD, PhD, Dror Shalitin, PhD, Shen Pang, PhD, Jonathan Said, MD, James R. Berenson, MD

Blood (2007) 110 (11): 4801.

https://doi.org/10.1182/blood.V110.11.4801.4801

Published: 2007

Journal Articles

An Anti-VEGF Antibody, in Combination with Bortezomib, Markedly Inhibits Tumor Growth in SCID-hu Models of Human Multiple Myeloma.

Blood (2007) 110 (11): 4802.

https://doi.org/10.1182/blood.V110.11.4802.4802

Published: 2007

Journal Articles

Unique Pattern of Raf-1 Kinase Inhibitory Protein (RKIP) Expression in Multiple Myeloma (MM) Compared to Other Tumor Types: Overexpression of RKIP and a Phosphorylated RKIP Is Common in MM Tumor Cells.

Stavroula Baritaki, Sara Huerta-Yepez, Kam Yeung, Manuel Penichet, Haiming Chen, Dror Shalitin, James Berenson, Benjamin Bonavida

Blood (2007) 110 (11): 4852.

https://doi.org/10.1182/blood.V110.11.4852.4852

Published: 2007

Journal Articles

Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth

Haiming Chen, Melinda S. Gordon, Richard A. Campbell, Mingjie Li, Cathy S. Wang, Hee Jin Lee, Eric Sanchez, Steven J. Manyak, Dorina Gui, Dror Shalitin, Jonathan Said, Yunchao Chang, Thomas F. Deuel, Stavroula Baritaki, Benjamin Bonavida, James R. Berenson

Blood (2007) 110 (1): 287–295.

https://doi.org/10.1182/blood-2006-08-042374

Published: 2007

Journal Articles

Arsenic Trioxide Affects Early Stage Angiogenesis through Inhibition of CD14 Monocyte Transdifferentiation into Endothelial Cells Induced by Pleiotrophin and mCSF.

Haiming Chen, MD, PhD, Mingjie Li, Richard A. Campbell, Melinda S. Gordon, PhD, Dror Shalitin, PhD, Cathy S. Wang, Ariana M. Berenson, Jennifer Li, Hetty Wong, James Wang, Benjamin Bonavida, PhD, James R. Berenson, MD

Blood (2006) 108 (11): 1267.

https://doi.org/10.1182/blood.V108.11.1267.1267

Published: 2006

Journal Articles

Pleiotrophin Is Highly Produced by Myeloma and Breast Cancer and Transdifferentiates Human Monocytes into Endothelial Cells That Are Incorporated into Tumoral Blood Vessels.

Haiming Chen, MD, PhD, Richard A. Campbell, Mingjie Li, Melinda S. Gordon, PhD, Dror Shalitin, PhD, Cathy S. Wang, Ariana M. Berenson, Jennifer Li, Hetty Wong, Benjamin Bonavida, PhD, James R. Berenson, MD

Blood (2006) 108 (11): 1269.

https://doi.org/10.1182/blood.V108.11.1269.1269

Published: 2006

Journal Articles

PK11195, a Ligand of the Peripheral Benzodiazepine Receptor, Inhibits Myeloma Cell Growth In Vitro and Chemosensitizes Myeloma Cells In Vivo in SCID-hu Models of Human Multiple Myeloma.

Richard A. Campbell, Eric Sanchez, Haiming Chen, MD, PhD, Lauren Turker, Olivia Trac, Mingjie Li, Dror Shalitin, PhD, Melinda S. Gordon, PhD, Shen Pang, PhD, Benjamin Bonavida, PhD, Jonathan Said, MD, Ronald J. Berenson, MD, James R. Berenson, MD

Blood (2006) 108 (11): 3459.

https://doi.org/10.1182/blood.V108.11.3459.3459

Published: 2006

Journal Articles

ZIO-101, a Novel Organic Arsenic, Inhibits Human Myeloma Cell Growth in a SCID-hu Model.

Richard A. Campbell, Eric Sanchez, Haiming Chen, MD, PhD, Lauren Turker, Mingjie Li, Olivia Trac, Dror Shalitin, Melinda S. Gordon, PhD, Shen Pang, PhD, Benjamin Bonavida, PhD, Jonathan Said, MD, Barbara Wallner, PhD, Robert P. Gale, MD, PhD, James R. Berenson, MD

Blood (2006) 108 (11): 3462.

https://doi.org/10.1182/blood.V108.11.3462.3462

Published: 2006

Journal Articles

Blocking TRAF6 Function Domain by TRAF6 Dominant Negative (TRAF6dn) for Inhibition of Multiple Myeloma Cell Proliferative and Increase of Apoptosis through Regulation of NF-κB and JNK Pathways.

Haiming Chen, MD, PhD, Mingjie Li, Richard A. Campbell, Melinda S. Gordon, PhD, Dror Shalitin, Cathy S. Wang, Ariana M. Berenson, Jennifer Li, Charles B. Drucker, Benjamin Bonavida, PhD, James R. Berenson, MD

Blood (2006) 108 (11): 3434.

https://doi.org/10.1182/blood.V108.11.3434.3434

Published: 2006

Journal Articles

Effects of a Novel Histone Deacetylase Inhibitor, PXD101, When Used as Monotherapy or in Combination with Bortezomib on Tumor Growth in Mouse Models of Human Multiple Myeloma.

Blood (2006) 108 (11): 3483.

https://doi.org/10.1182/blood.V108.11.3483.3483

Published: 2006

Journal Articles

Anti-VEGF Antibody Treatment Markedly Inhibits Tumor Growth in SCID-hu Models of Human Multiple Myeloma.

Blood (2006) 108 (11): 846.

https://doi.org/10.1182/blood.V108.11.846.846

Published: 2006

NARROW

Multiple Myeloma-Specific Targeted Therapy: Use of the Tumor Specific Immunoglobulin Gene Sequence to Activate Drugs Only within Tumor Cells.

Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis

A Novel Targeted Therapeutic Approach to Multiple Myeloma Using Tumor Specific Anti-Sense RNA Sequences

Blockage of TRAF6 Signaling Inhibits Osteoclast Formation and Tumor Cell through Blocking the NF-kB and JNK Pathways in Multiple Myeloma.

Wnt/β-Catenin Signaling Is Essential for the Transdifferentiation of Monocytes into Endothelial Cells by mCSF and Pleiotrophin.

Zoledronic Acid Suppresses Vasculogenesis: A New Effect of Bisphosphonates.

The Novel Potent Pan-Deacetylase (DAC) Inhibitor, Panobinostat (LBH589), Markedly Enhances the Anti-Myeloma Effects of Chemotherapy In Vitro and In Vivo .

The Combination of the mTOR Inhibitor Rapamycin and Protein Kinase C Inhibitors Produces Marked Synergistic Anti-Myeloma Effects.

The mTOR Inhibitor RAD001 (Everolimus) Inhibits Myeloma Tumor Growth In Vivo and Enhances the Anti-MM Effects of Bortezomib and Arsenic Trioxide.

An Anti-VEGF Antibody, in Combination with Bortezomib, Markedly Inhibits Tumor Growth in SCID-hu Models of Human Multiple Myeloma.

Unique Pattern of Raf-1 Kinase Inhibitory Protein (RKIP) Expression in Multiple Myeloma (MM) Compared to Other Tumor Types: Overexpression of RKIP and a Phosphorylated RKIP Is Common in MM Tumor Cells.

Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth

Arsenic Trioxide Affects Early Stage Angiogenesis through Inhibition of CD14 Monocyte Transdifferentiation into Endothelial Cells Induced by Pleiotrophin and mCSF.

Pleiotrophin Is Highly Produced by Myeloma and Breast Cancer and Transdifferentiates Human Monocytes into Endothelial Cells That Are Incorporated into Tumoral Blood Vessels.

PK11195, a Ligand of the Peripheral Benzodiazepine Receptor, Inhibits Myeloma Cell Growth In Vitro and Chemosensitizes Myeloma Cells In Vivo in SCID-hu Models of Human Multiple Myeloma.

ZIO-101, a Novel Organic Arsenic, Inhibits Human Myeloma Cell Growth in a SCID-hu Model.

Blocking TRAF6 Function Domain by TRAF6 Dominant Negative (TRAF6dn) for Inhibition of Multiple Myeloma Cell Proliferative and Increase of Apoptosis through Regulation of NF-κB and JNK Pathways.

Effects of a Novel Histone Deacetylase Inhibitor, PXD101, When Used as Monotherapy or in Combination with Bortezomib on Tumor Growth in Mouse Models of Human Multiple Myeloma.

Anti-VEGF Antibody Treatment Markedly Inhibits Tumor Growth in SCID-hu Models of Human Multiple Myeloma.

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American Society of Hematology

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American Society of Hematology

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