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Journal Articles

Prognostic Discrimination of Children and Adolescents with Chronic Myeloid Leukemia Based on the EUTOS Long Term Survival (ELTS) Score

Frédéric Millot, MD, Joelle Guilhot, PhD, Meinolf Suttorp, MD PhD, Adalet Meral Güneş, MD, Petr Sedlacek, MD, Evelina S De Bont, MD PhD, Chi Kong Li, MBBS, MD, Krzysztof Kalwak, MD, Birgitte Lausen, Srdjana Culic, MD, Barbara De Moerloose, MD, Andrea Biondi, MD, Andre Baruchel, MD PhD

Blood (2016) 128 (22): 626.

https://doi.org/10.1182/blood.V128.22.626.626

Published: 2016

Journal Articles

Clofarabine in Combination with High-Dose Cytarabine and Liposomal Daunorubicin in Pediatric AML: Results of a Phase 1B Combination Study By the ITCC Consortium

Christian M. Zwaan, MD PhD, Michael Dworzak, MD PhD, Thomas Klingebiel, MD, Claudia Rössig, MD, Guy Leverger, MD, Jan Stary, Evelina S. de Bont, MDPhD, Satianand Ramnarain, MSc, Yves Bertrand, MD, Benoit Brethon, MD, Brigitte Strahm, MD, Gertjan J. Kaspers, MD PhD, Dirk Reinhardt, MD PhD

Blood (2014) 124 (21): 989.

https://doi.org/10.1182/blood.V124.21.989.989

Published: 2014

Journal Articles

Results of a Feasibility and Phase II Study on Bortezomib (BTZ) in Pediatric Multiply Relapsed or Refractory Acute Lymphoblastic Leukemia: Complete Hematological Responses with a Modestly Intensive Regimen Including BTZ

Gertjan Kaspers, MD PhD, Denise Niewerth, MSc, Satianand Ramnarain, MSc, Andishe Attarbaschi, MD, André Baruchel, MD, Evelina S De Bont, MDPhD, Franca Fagioli, MD, Barbara De Moerloose, MD PhD, Karsten Nysom, MD, Giuseppe Palumbo, MD, Dirk Reinhardt, MD PhD, Pierre-Simon Rohrlich, MDPhD, Pauline Simon, MD, Arend von Stackelberg, MD, C. Michel Zwaan, MD PhD

Blood (2014) 124 (21): 2290.

https://doi.org/10.1182/blood.V124.21.2290.2290

Published: 2014

Journal Articles

Anthracycline Type during Induction Associated with Outcome in Pediatric t(8;21) and Inv(16) AML

Henrik Hasle, Jonas Abrahamsson, MD PhD, Evelina S De Bont, MDPhD, Valerie de Haas, Barbara De Moerloose, Erik Forestier, MD PhD, Shau Yin Ha, Jesper Heldrup, Kirsi Jahnukainen, Ólafur G Jónsson, MD, Birgitte Lausen, MD, Josefine Palle, MD PhD, Ardine Reedijk, MSc, Kadri Saks, MD, Bernward Zeller

Blood (2014) 124 (21): 11.

https://doi.org/10.1182/blood.V124.21.11.11

Published: 2014

Journal Articles

B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Specific Copy Number Alterations Are Unique For Progressive Pediatric Chronic Myeloid Leukemia (CML): A Large Cohort Study

Naomi E van der Sligte, Manuela Krumbholz, PhD, Agata Pastorczak, MD, Blanca Scheijen, PhD, Josephine T. Tauer, Christina Nowasz, Edwin Sonneveld, PhD, Truuske H. de Bock, PhD, Tiny G. Meeuwsen - de Boer, BSc, Simon V. van Reijmersdal, BSc, Roland P. Kuiper, PhD, Jutta Bradtke, PhD, Markus Metzler, MD, Meinolf Suttorp, Evelina S. De Bont, Frank N. van Leeuwen, PhD

Blood (2013) 122 (21): 2715.

https://doi.org/10.1182/blood.V122.21.2715.2715

Published: 2013

Journal Articles

Safety and Pharmacokinetics Of Clofarabine In Combination With High-Dose Cytarabine and Liposomal Daunorubicin In Pediatric AML: Results Of a Phase 1 Combination Study By The ITCC Consortium

Christian M. Zwaan, Michael Dworzak, Thomas Klingebiel, MD, Claudia Rossig, MD, Guy Leverger, MD, Jan Stary, Evelina S. De Bont, MD, PhD, Satianand Ramnarain, MSc, Yves Bertrand, MD, Essam A Ghazaly, MD, Dirk Reinhardt

Blood (2013) 122 (21): 2693.

https://doi.org/10.1182/blood.V122.21.2693.2693

Published: 2013

Journal Articles

Insights in Dynamic Kinome Reprogramming As a Consequence of MEK Inhibition in MLL-Rearranged AML.

Kim R Kampen, Arja ter Elst, PhD, Sander H Diks, PhD, Frank JG Scherpen, Valerie De Haas, Maikel P Peppelenbosch, Evelina S. De Bont, MD, PhD

Blood (2012) 120 (21): 2338.

https://doi.org/10.1182/blood.V120.21.2338.2338

Published: 2012

Journal Articles

Frequency and Prognostic Relevance of Gene Mutations in Pediatric AML Patients At First Relapse.

Costa Bachas, MSc, Gerrit Jan Schuurhuis, PhD, Dirk Reinhardt, MD, Ursula Creutzig, MD, PhD, Zinia J. Kwidama, BSc, C. Michel Zwaan, MD, PhD, Marry M. van den Heuvel-Eibrink, Evelina S De Bont, MD, PhD, Sara Elitzur, MD, Carmelo Rizzari, MD, PhD, Valérie de Haas, MD, PhD, Martin Zimmermann, Jacqueline Cloos, PhD, Gertjan J.L. Kaspers, MD, PhD

Blood (2012) 120 (21): 2480.

https://doi.org/10.1182/blood.V120.21.2480.2480

Published: 2012

Journal Articles

Harnessing Gene Expression Profiles for the Identification of Drug Resistance Genes in Pediatric AML

Costa Bachas, MSc, Gerrit Jan Schuurhuis, PhD, C. Michel Zwaan, MD, PhD, Marry M. van den Heuvel-Eibrink, Monique L. Den Boer, PhD, Zinia J. Kwidama, BSc, Evelina S. De Bont, MD, PhD, Dirk Reinhardt, MD, Ursula Creutzig, MD, PhD, Valérie de Haas, MD, PhD, Yehuda Assaraf, PhD, Gertjan J.L. Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2012) 120 (21): 283.

https://doi.org/10.1182/blood.V120.21.283.283

Published: 2012

Journal Articles

Activation of the EfnB1/EphB1 Forward Signaling Promotes Cell Cycle Arrest in Acute Myeloid Leukemia Cells

Kim R Kampen, Arja ter Elst, PhD, Evelina S. De Bont, MD, PhD

Blood (2012) 120 (21): 4719.

https://doi.org/10.1182/blood.V120.21.4719.4719

Published: 2012

Journal Articles

The International Registry for Chronic Myeloid Leukemia (CML) in Children and Adolescents (I-CML-Ped-Study): Objectives and Preliminary Results

Frédéric Millot, Meinolf Suttorp, MD, Joelle Guilhot, Ph.D., Pietr Sedlacek, Evelina S De Bont, Chi Kong Li, MBBS, MD, Krzysztof Kalwak, Birgitte Lausen, Culic Srdjana, Marie-Françoise Dresse, Andrea Biondi, MD, André Baruchel

Blood (2012) 120 (21): 3741.

https://doi.org/10.1182/blood.V120.21.3741.3741

Published: 2012

Journal Articles

EphrinB1 Activation As a Potential New Treatment Option in AML

Arja ter Elst, PhD, Kim R Kampen, Sander H Diks, PhD, Steven M. Kornblau, MD, Guillermo Garcia-Manero, Evelina S. De Bont, MD, PhD

Blood (2011) 118 (21): 5235.

https://doi.org/10.1182/blood.V118.21.5235.5235

Published: 2011

Journal Articles

Cyclic-AMP Responsive Element Binding Protein 1 (CREB) As a New Potential Druggable Target in Pediatric Acute Lymphoblastic Leukemia

Naomi E van der Sligte, Arja ter Elst, PhD, Kim R Kampen, Frank JG Scherpen, Hendrik Mulder, Sander H Diks, PhD, Frank N. van Leeuwen, PhD, Evelina S. De Bont, MD, PhD

Blood (2011) 118 (21): 1368.

https://doi.org/10.1182/blood.V118.21.1368.1368

Published: 2011

Journal Articles

Patterns of Bone Marrow Micro Vessel Morphology in AML and High Risk MDS Predict Treatment Outcome Following Intensive Chemotherapy and Bevacizumab

Alida C. Weidenaar, Arja ter Elst, PhD, Cees AGM van Montfort, PhD, Tiny G.J. Meeuwsen-de Boer, Stefano Rosati, MD, Mario Bargetzi, MD, Carlos Graux, MD, PhD, Alois Gratwohl, MD, PhD, Bob Lowenberg, MD, PhD, Gert Ossenkoppele, MD, PhD, Evelina S. De Bont, MD, PhD

Blood (2011) 118 (21): 1555.

https://doi.org/10.1182/blood.V118.21.1555.1555

Published: 2011

Journal Articles

Gene Expression Profiling In Leukemic Stem Cell-Enriched AML CD34 + Cell Fraction Identifies Target Genes That Predict Prognosis In Normal Karyotype AML

Carolien M Woolthuis, Hendrik JM de Jonge, Annet Z Vos, Andre B Mulder, MD, Eva van den Berg, P.M. Kluin, MD, PhD, Karen van der Weide, Evelina S. De Bont, MD, PhD, Geert A Huls, MD, PhD, Edo Vellenga, MD, PhD, Jan J. Schuringa, PhD

Blood (2010) 116 (21): 952.

https://doi.org/10.1182/blood.V116.21.952.952

Published: 2010

Journal Articles

Targeting Multiple Active Kinase Pathways In 11q23 Translocated Pediatric Acute Myeloid Leukemia Using a VEGFR2 Antibody Together with a MEK Inhibitor.

Arja ter Elst, Kim R Kampen, Sander H Diks, Frank JG Scherpen, Válerie de Haas, MD, PhD, Maikel P Peppelenbosch, Evelina S. De Bont, MD, PhD

Blood (2010) 116 (21): 3626.

https://doi.org/10.1182/blood.V116.21.3626.3626

Published: 2010

Journal Articles

High IGSF4 expression In Pediatric Acute Monoblastic Leukemia with t(9;11)

Eva A Coenen, MD, Jenny Kuipers, Brian V Balgobind, Jan Stary, Andre Baruchel, Valerie de Haas, Evelina S. De Bont, MD, PhD, Dirk Reinhardt, MD, PhD, Gertjan J. Kaspers, MD, PhD, Jacqueline Cloos, Astrid Danen-van Oorschot, Monique L. Den Boer, Rolf Marschalek, Claus Meyer, Rob Pieters, MD, PhD, Christian M. Zwaan, MD, PhD, Marry van den Heuvel-Eibrink

Blood (2010) 116 (21): 3614.

https://doi.org/10.1182/blood.V116.21.3614.3614

Published: 2010

Journal Articles

Epidermal Growth Factor Receptor Expression and Activity In Acute Myeloid Leukemia

Arja ter Elst, Steven M. Kornblau, MD, Frank jg Scherpen, Yi Hua Qiu, MD, Nianxiang Zhang, Kevin R Coombes, Evelina S. De Bont, MD, PhD

Blood (2010) 116 (21): 3144.

https://doi.org/10.1182/blood.V116.21.3144.3144

Published: 2010

Journal Articles

Kinome Profiling in Acute Myeloid Leukemia as a New Approach for Target Discovery.

Arja ter Elst, Maikel P Peppelenbosch, Sander H Diks, Rob Ruijtenbeek, Piet J Boender, Rik de Wijn, Frank J.G. Scherpen, Willem A Kamps, Evelina S De Bont

Blood (2008) 112 (11): 1201.

https://doi.org/10.1182/blood.V112.11.1201.1201

Published: 2008

Journal Articles

The Role of VEGFA in Malignant Progression in AML

Alida C Weidenaar, Arja ter Elst, Henk-Marijn de Jonge, Tiny Meeuwsen-de Boer, Willem A Kamps, Evelina S De Bont

Blood (2008) 112 (11): 203.

https://doi.org/10.1182/blood.V112.11.203.203

Published: 2008

NARROW

Prognostic Discrimination of Children and Adolescents with Chronic Myeloid Leukemia Based on the EUTOS Long Term Survival (ELTS) Score

Clofarabine in Combination with High-Dose Cytarabine and Liposomal Daunorubicin in Pediatric AML: Results of a Phase 1B Combination Study By the ITCC Consortium

Results of a Feasibility and Phase II Study on Bortezomib (BTZ) in Pediatric Multiply Relapsed or Refractory Acute Lymphoblastic Leukemia: Complete Hematological Responses with a Modestly Intensive Regimen Including BTZ

Anthracycline Type during Induction Associated with Outcome in Pediatric t(8;21) and Inv(16) AML

B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Specific Copy Number Alterations Are Unique For Progressive Pediatric Chronic Myeloid Leukemia (CML): A Large Cohort Study

Safety and Pharmacokinetics Of Clofarabine In Combination With High-Dose Cytarabine and Liposomal Daunorubicin In Pediatric AML: Results Of a Phase 1 Combination Study By The ITCC Consortium

Insights in Dynamic Kinome Reprogramming As a Consequence of MEK Inhibition in MLL-Rearranged AML.

Frequency and Prognostic Relevance of Gene Mutations in Pediatric AML Patients At First Relapse.

Harnessing Gene Expression Profiles for the Identification of Drug Resistance Genes in Pediatric AML

Activation of the EfnB1/EphB1 Forward Signaling Promotes Cell Cycle Arrest in Acute Myeloid Leukemia Cells

The International Registry for Chronic Myeloid Leukemia (CML) in Children and Adolescents (I-CML-Ped-Study): Objectives and Preliminary Results

EphrinB1 Activation As a Potential New Treatment Option in AML

Cyclic-AMP Responsive Element Binding Protein 1 (CREB) As a New Potential Druggable Target in Pediatric Acute Lymphoblastic Leukemia

Patterns of Bone Marrow Micro Vessel Morphology in AML and High Risk MDS Predict Treatment Outcome Following Intensive Chemotherapy and Bevacizumab

Gene Expression Profiling In Leukemic Stem Cell-Enriched AML CD34 + Cell Fraction Identifies Target Genes That Predict Prognosis In Normal Karyotype AML

Targeting Multiple Active Kinase Pathways In 11q23 Translocated Pediatric Acute Myeloid Leukemia Using a VEGFR2 Antibody Together with a MEK Inhibitor.

High IGSF4 expression In Pediatric Acute Monoblastic Leukemia with t(9;11)

Epidermal Growth Factor Receptor Expression and Activity In Acute Myeloid Leukemia

Kinome Profiling in Acute Myeloid Leukemia as a New Approach for Target Discovery.

The Role of VEGFA in Malignant Progression in AML

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American Society of Hematology

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