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Journal Articles

Bioavailable Dual-Protein Degraders of CK1α and Transcriptional Kinase CDK9 As Potential Therapeutics for Hematological Malignancies

Leah Fung, PhD, Aparajita Hoskote Chourasia, PhD, Eduardo Torres, MSc, Imelda Lam, BSc, Paul Erdman, MSc, David Hecht, PhD, Robert Sullivan, PhD, Brooke McElwee, BSc, Normand Richard, MSc, Avanthika Venkatachalam, MSc, Irit Snir-Alkalay, PhD, Kyle WH Chan, PhD, Frank Mercurio, PhD, Yinon Ben-Neriah, MD PhD, David I Stirling, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4643.
https://doi.org/10.1182/blood-2019-131834
Published: 2019
Journal Articles

Targeting AML: The Development of Two Functionally and Mechanistically Distinct Classes of Cereblon-Mediated Protein Homeostatic Modulators

Aparajita Hoskote Chourasia, PhD, Leah Fung, PhD, Brooke McElwee, BSc, Normand Richard, MSc, Imelda Lam, BSc, Eduardo Torres, MSc, Paul Erdman, MSc, Robert Sullivan, PhD, David Hecht, PhD, Kyle WH Chan, PhD, Frank Mercurio, PhD, David I Stirling, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3361.
https://doi.org/10.1182/blood-2019-131872
Published: 2019
Journal Articles

Protein Homeostatic Modulators, a Novel Class of Cereblon-Targeting Small Molecules As Potential Clinical Candidates in Multiple Myeloma

Jianxuan Zou, PhD, Richard J. Jones, PhD, Janet E. Mertz, PhD, Hua Wang, PhD, Isere Kuiatse, PhD, Bob Sullivan, PhD, Leah Fung, PhD, Normand Richard, PhD, Paul Erdman, PhD, Eduardo Torres, PhD, Aparajita Hoskote Chourasia, PhD, Kyle WH Chan, PhD, Frank Mercurio, PhD, David I Stirling, PhD, Robert Z. Orlowski, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4418.
https://doi.org/10.1182/blood.V130.Suppl_1.4418.4418
Published: 2017
Journal Articles

Targeting the Transcriptional Addiction of Leukemia Stem Cells By a New Class of Protein Kinase Inhibitors

Yinon Ben-Neriah, MD PhD, Avanthika Venkatachalam, MSc, Avner Fink, PhD, Eric Hung, MSc, Joseph Vacca, PhD, Frank Mercurio, PhD, Moshe Oren, PhD, Eli Pikarsky, MDPhD, Irit Snir-Alkalay, PhD, Waleed Minzel, MSc
Journal: Blood
Blood (2017) 130 (Supplement 1): 812.
https://doi.org/10.1182/blood.V130.Suppl_1.812.812
Published: 2017
Journal Articles

GSK-3 Spatial Regulation Has an Essential Role in Lenalidomide Activity and Represents a Biomarker of Clinical Response in CLL

Suzanne Trudel, MD, Sam Scanga, PhD, Fabrizio G Mastronardi, PhD, Ellen Nong Wei, MSc, Frank Mercurio, PhD, Antonia Lopez-Girona, PhD, Svetlana Gaidarova, MS, David R. Webb, PhD, Christine Chen, MD, Keith Stewart, MBA, MB, CHB, Armen S Manoukian, PhD
Journal: Blood
Blood (2012) 120 (21): 1793.
https://doi.org/10.1182/blood.V120.21.1793.1793
Published: 2012
Journal Articles

Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases

Yibing Xu, Jianwu Li, Gregory D. Ferguson, Frank Mercurio, Gody Khambatta, Lisa Morrison, Antonia Lopez-Girona, Laura G. Corral, David R. Webb, Brydon L. Bennett, Weilin Xie
Journal: Blood
Blood (2009) 114 (2): 338–345.
https://doi.org/10.1182/blood-2009-02-200543
Published: 2009
Journal Articles

Identification of Novel Activities of Immunomodulatory Drugs: Cytoskeleton Reorganization through Modulation of Rho GTPases

Yibing Xu, PhD, JianWu Li, M.D., Greg Ferguson, Ph.D., Frank Mercurio, Ph.D., Gody Khambatta, Lisa Morrison, Ph.D., Antonia Lopez-Girona, Laura G Corral, Sr., David Webb, Ph.D., Brydon L. Bennett, Ph.D., Weilin Xie, Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2565.
https://doi.org/10.1182/blood.V112.11.2565.2565
Published: 2008
Journal Articles

Targeting the p27 E3 ligase SCF Skp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

Qing Chen, Weilin Xie, Deborah J. Kuhn, Peter M. Voorhees, Antonia Lopez-Girona, Derek Mendy, Laura G. Corral, Veronique Plantevin Krenitsky, Weiming Xu, Laure Moutouh-de Parseval, David R. Webb, Frank Mercurio, Keiichi I. Nakayama, Keiko Nakayama, Robert Z. Orlowski
Journal: Blood
Blood (2008) 111 (9): 4690–4699.
https://doi.org/10.1182/blood-2007-09-112904
Published: 2008
Includes: Supplemental data
Journal Articles

Targeting the p27 Kip1 E3 Ubiquitin Ligase for the Treatment of Multiple Myeloma and Other Hematological Malignancies.

Qing Chen, PhD, Weilin Xie, PhD, Deborah J. Kuhn, PhD, Peter M. Voorhees, MD, Derek Mendy, MD, Antonia Lopez-Girona, PhD, Veronique Plantevin, PhD, Weiming Xu, PhD, Laura De Parseval, PhD, Laura G. Corral, PhD, Emilia Glezer, PhD, Kyle Chan, PhD, Frank Mercurio, PhD, Robert Z. Orlowski, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 372.
https://doi.org/10.1182/blood.V108.11.372.372
Published: 2006