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Journal Articles

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Xavier Calvo, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD

Blood (2019) 134 (Supplement_1): 3027.

https://doi.org/10.1182/blood-2019-122038

Published: 2019

Journal Articles

Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Xavier Calvo, MD PhD, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD

Blood (2019) 134 (Supplement_1): 3029.

https://doi.org/10.1182/blood-2019-122061

Published: 2019

Journal Articles

CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By Bruton's Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrutinib

Shih-Shih Chen, PhD, Constantine S. Tam, MBBS (Hons), MD, Alan G. Ramsay, BSc,MSc,PhD, Priyadarshini Ravichandran, Natalia C. Couto-Francisco, Michael Ibrahim, Gerardo Ferrer, PhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, He Zhou, Jacqueline C Barrientos, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2019) 134 (Supplement_1): 477.

https://doi.org/10.1182/blood-2019-127255

Published: 2019

Journal Articles

Chronic Lymphocytic Leukemia B Cells Display IgM and IgD Isotype-Restricted Features That Affect Association with Co-Receptors, BCR Signaling, and Leukemic B-Cell Growth In Vivo

Andrea Nicola Mazzarello, PhD, Marcus Dühren-von Minden, PhD, Eva Gentner, BSc, MSc, PhD, Palash Chandra Maity, PhD, Gerardo Ferrer, PhD, Tatyana Tarasenko, Stefano Vergani, PhD, Jacqueline C Barrientos, MD MS, Kanti R Rai, MD, Peter McGuire, Hassan Jumaa, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 3124.

https://doi.org/10.1182/blood-2018-99-119989

Published: 2018

Journal Articles

Extended Survival in CLL Patients Who Discontinued Idelalisib Because of Colitis Correlates with Higher Th17 Levels in Blood and Colon Tissue

Rukhsana Aslam, MD, Jacqueline C Barrientos, MD MS, Gerardo Ferrer, PhD, Pui Yan Chiu, Kanti R Rai, MD, Nicholas Chiorazzi, MD, Barbara Sherry, PhD

Blood (2018) 132 (Supplement 1): 1848.

https://doi.org/10.1182/blood-2018-99-116910

Published: 2018

Journal Articles

Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia

Gerardo Ferrer, PhD, Byeongho Jung, BS, Aslam Rukhsana, MD, Pui Yan Chiu, Andrea Nicola Mazzarello, PhD, Florenca Palacios, PhD, Shih-Shih Chen, PhD, Xiao J. Yan, MDPhD, Jacqueline C. Barrientos, MD MS, Jan A. Burger, MD PhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 239.

https://doi.org/10.1182/blood-2018-99-114799

Published: 2018

Journal Articles

Dual Inhibition of PI3K-δ and PI3K-γ By Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Patient-Derived Xenograft Model

Shih-Shih Chen, PhD, Jeffery Lorne Kutok, MD PhD, Gerardo Ferrer, PhD, Priyadarshini Ravichandran, Michael Ibrahim, Yasmine Kieso, MSCR, Jacqueline C Barrientos, MD MS, David T. Weaver, PhD, Jonathan A Pachter, PhD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 4420.

https://doi.org/10.1182/blood-2018-99-109853

Published: 2018

Journal Articles

Activated CLL B Cells Variably Modulate microRNA-155 Levels in Naïve CD4 + T Cells, and the Direction and Magnitude of microRNA-155 Change Correlates with Th17 Levels and Clinical Course

Byeongho Jung, BS, Gerardo Ferrer, PhD, Pui Yan Chiu, Rukhsana Aslam, MD, Florencia Palacios, PhD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 4402.

https://doi.org/10.1182/blood-2018-99-116505

Published: 2018

Journal Articles

Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Movement

Florencia Palacios, PhD, Xiao-Jie Yan, MD PhD, Gerardo Ferrer, PhD, Jacqueline C Barrientos, MD MS, Jonathan E. Kolitz, MD, Steven L. Allen, Rai Kanti R., MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1837.

https://doi.org/10.1182/blood-2018-99-115060

Published: 2018

Journal Articles

IGHV-D-J Repertoire Analysis Obtained By High-Throughput Sequencing of CD5+ B-Cells in CLL Patients: Prognostic Markers and Disease Development Implications

Davide Bagnara, PhD, Stefano Vergani, PhD, Andrea Nicola Mazzarello, PhD, Gerardo Ferrer, PhD, Franco Fais, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 54.

https://doi.org/10.1182/blood.V130.Suppl_1.54.54

Published: 2017

Journal Articles

Ibrutinib Disrupts IL-4R - IL-4 Axis By Inhibiting IL-4R Signaling and Reversing Th2/Th1 Polarization through Diminished CLECL1 in CLL B Cells

Shih-Shih Chen, PhD, Priyadarshini Ravichandran, Gerardo Ferrer, PhD, Andrea Nicola Mazzarello, PhD, Florencia Palacios, PhD, Michael Ibrahim, Yasmine Kieso, Jacqueline C. Barrientos, MD, Edward Clark, PhD, Barbara Sherry, PhD, Jan A. Burger, MD PhD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 387.

https://doi.org/10.1182/blood.V130.Suppl_1.387.387

Published: 2017

Journal Articles

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

Gerardo Ferrer, PhD, Brendan Franca, BS, Pui Yan Chiu, Stefano Vergani, PhD, Andrea Nicola Mazzarello, PhD, Florenca Palacios, PhD, Shihshih Chen, PhD, Davide Bagnara, PhD, Sophia Yancopoulos, Yun Liu, MS, Aliki Xochelli, MD, Xiao J. Yan, MDPhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Jacqueline C. Barrientos, MD, Kostas Stamatopoulos, Kanti Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4294.

https://doi.org/10.1182/blood.V130.Suppl_1.4294.4294

Published: 2017

Journal Articles

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

Andrea Nicola Mazzarello, PhD, Marcus Dühren-von Minden, PhD, Palash Chandra Maity, PhD, Gentner Eva, PhD, Stefano Vergani, PhD, Gerardo Ferrer, PhD, Davide Bagnara, PhD, Shih-Shih Chen, PhD, Sophia Yancopoulos, Xiao J. Yan, MDPhD, Jacqueline C. Barrientos, MD, Kanti Rai, MD, Hassan Jumaa, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 1716.

https://doi.org/10.1182/blood.V130.Suppl_1.1716.1716

Published: 2017

Journal Articles

In CLL, Myeloid-Derived Suppressor Cells and Their Monocytic and Granulocytic Varieties Differ in T-Cell Subset Association and Polarization Induction

Gerardo Ferrer, PhD, Brendan Franca, Pui Yan Chiu, MSc, Stefano Vergani, MS, Andrea Nicola Mazzarello, PhD, Florencia Palacios, PhD, Davide Bagnara, PhD, Shih-Shih Chen, PhD, Sophia Yancopoulos, PhD, Yun Liu, MS, Aliki Xochelli, MD PhD, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kostas Stamatopoulos, MD PhD, Kanti R. Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 4350.

https://doi.org/10.1182/blood.V128.22.4350.4350

Published: 2016

Journal Articles

CLL Stereotyped IGHV-D-J Rearrangements Can Be Detected Throughout Normal B-Cell Developmental Stages in Aged People When Using Ultra-Deep, Next Generation Sequencing Techniques

Stefano Vergani, MS, Davide Bagnara, PhD, Andrea Nicola Mazzarello, PhD, Gerardo Ferrer, PhD, Sophia Yancopoulos, PhD, Kostas Stamatopoulos, MD PhD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 2028.

https://doi.org/10.1182/blood.V128.22.2028.2028

Published: 2016

Journal Articles

Comparative Density Analyses of B Cell Receptor-Complex Components (Membrane IgM, Membrane IgD, and Stimulatory/Inhibitory Co-Receptors) on Intraclonal Subpopulations of CLL B Cells, before and during Ibrutinib Therapy

Andrea Nicola Mazzarello, PhD, Stefano Vergani, MS, Gerardo Ferrer, PhD, Yun Liu, MS, Shih-Shih Chen, PhD, Sophia Yancopoulos, PhD, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 4356.

https://doi.org/10.1182/blood.V128.22.4356.4356

Published: 2016

Journal Articles

Chronic Lymphocytic Leukemia Patients and Eµ- TCL1 Mice Share a Phenotype of Functional Granulocyte-like and Dysfunctional Monocyte-like Myeloid Derived Suppressor Cells

Gerardo Ferrer, PhD, Xiao-Jie Yan, MD PhD, Brendan Franca, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L Allen, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2015) 126 (23): 614.

https://doi.org/10.1182/blood.V126.23.614.614

Published: 2015

Journal Articles

Chronic Lymphocytic Leukemia Patients Exhibit Expanded Functional Granulocyte-like Myeloid Derived Suppressor Cells

Gerardo Ferrer, PhD, Rita Simone, PhD, Sonia Marsilio, PhD, Stefano Vergani, Andrea Nicola Mazzarello, PhD, Shih-Shih Chen, PhD, Xiao Jie Yan, PhD, Barbara Sherry, PhD, Jaqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 3279.

https://doi.org/10.1182/blood.V124.21.3279.3279

Published: 2014

Journal Articles

A 40-Microrna Signature Characterizes JAK2 V617F-Negative Essential Thrombocythemia: Role Of Mir-221 and Mir-203 In The Regulation Of The JAK-STAT Pathway

Alfons Navarro, PhD, Silvia Pairet, Aina Pons, Gerardo Ferrer, PhD, Raquel Longarón, Alberto Alvarez-Larrán, Luz Martínez-Avilés, Concepcion Fernández-Rodríguez, Mariano Monzó, MD, PhD, Carlos Besses, MD, PhD, Beatriz Bellosillo

Blood (2013) 122 (21): 2846.

https://doi.org/10.1182/blood.V122.21.2846.2846

Published: 2013

Journal Articles

Lenalidomide Promotes The Expansion Of CD8 T Cells With An Effector Memory Phenotype In a Murine Xenograft Model Of Chronic Lymphocytic Leukemia

Rita Simone, PhD, Sonia Marsilio, PhD, Piers E.M. Patten, MD, PhD, Gerardo Ferrer, PhD, Shih-Shih Chen, Ph.D., Xiao J. Yan, MD, PhD, Stefano Vergani, Msc, Andrea Nicola Mazzarello, PhD, Jacqueline C. Barrientos, MD, Steven L. Allen, M.D., Jonathan E. Kolitz, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2013) 122 (21): 119.

https://doi.org/10.1182/blood.V122.21.119.119

Published: 2013

NARROW

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?

CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By Bruton's Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrutinib

Chronic Lymphocytic Leukemia B Cells Display IgM and IgD Isotype-Restricted Features That Affect Association with Co-Receptors, BCR Signaling, and Leukemic B-Cell Growth In Vivo

Extended Survival in CLL Patients Who Discontinued Idelalisib Because of Colitis Correlates with Higher Th17 Levels in Blood and Colon Tissue

Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia

Dual Inhibition of PI3K-δ and PI3K-γ By Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Patient-Derived Xenograft Model

Activated CLL B Cells Variably Modulate microRNA-155 Levels in Naïve CD4 + T Cells, and the Direction and Magnitude of microRNA-155 Change Correlates with Th17 Levels and Clinical Course

Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Movement

IGHV-D-J Repertoire Analysis Obtained By High-Throughput Sequencing of CD5+ B-Cells in CLL Patients: Prognostic Markers and Disease Development Implications

Ibrutinib Disrupts IL-4R - IL-4 Axis By Inhibiting IL-4R Signaling and Reversing Th2/Th1 Polarization through Diminished CLECL1 in CLL B Cells

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

In CLL, Myeloid-Derived Suppressor Cells and Their Monocytic and Granulocytic Varieties Differ in T-Cell Subset Association and Polarization Induction

CLL Stereotyped IGHV-D-J Rearrangements Can Be Detected Throughout Normal B-Cell Developmental Stages in Aged People When Using Ultra-Deep, Next Generation Sequencing Techniques

Comparative Density Analyses of B Cell Receptor-Complex Components (Membrane IgM, Membrane IgD, and Stimulatory/Inhibitory Co-Receptors) on Intraclonal Subpopulations of CLL B Cells, before and during Ibrutinib Therapy

Chronic Lymphocytic Leukemia Patients and Eµ- TCL1 Mice Share a Phenotype of Functional Granulocyte-like and Dysfunctional Monocyte-like Myeloid Derived Suppressor Cells

Chronic Lymphocytic Leukemia Patients Exhibit Expanded Functional Granulocyte-like Myeloid Derived Suppressor Cells

A 40-Microrna Signature Characterizes JAK2 V617F-Negative Essential Thrombocythemia: Role Of Mir-221 and Mir-203 In The Regulation Of The JAK-STAT Pathway

Lenalidomide Promotes The Expansion Of CD8 T Cells With An Effector Memory Phenotype In a Murine Xenograft Model Of Chronic Lymphocytic Leukemia

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American Society of Hematology

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American Society of Hematology

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