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Journal Articles

Clofarabine in Combination with High-Dose Cytarabine and Liposomal Daunorubicin in Pediatric AML: Results of a Phase 1B Combination Study By the ITCC Consortium

Christian M. Zwaan, MD PhD, Michael Dworzak, MD PhD, Thomas Klingebiel, MD, Claudia Rössig, MD, Guy Leverger, MD, Jan Stary, Evelina S. de Bont, MDPhD, Satianand Ramnarain, MSc, Yves Bertrand, MD, Benoit Brethon, MD, Brigitte Strahm, MD, Gertjan J. Kaspers, MD PhD, Dirk Reinhardt, MD PhD

Blood (2014) 124 (21): 989.

https://doi.org/10.1182/blood.V124.21.989.989

Published: 2014

Journal Articles

Glucocorticoid-Induced Proliferation and Differentiation of Untreated Pediatric AML Cells

Eric Haarman, MD, PhD, Jacqueline Cloos, PhD, Christian M. Zwaan, MD, PhD, Valerie de Haas, MD, PhD, Dirk Reinhardt, MD, PhD, Ursula Creutzig, MD, PhD, Gertjan J. Kaspers, MD, PhD

Blood (2011) 118 (21): 4873.

https://doi.org/10.1182/blood.V118.21.4873.4873

Published: 2011

Journal Articles

Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression

Denise Niewerth, MSc, Niels Franke, MD, Gerrit Jansen, PhD, Johan van Meerloo, MSc, Yehuda Assaraf, Prof, Christopher J Kirk, Elena T Chan, Sonja Zweegman, MD, PhD, Gertjan J. Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2011) 118 (21): 1513.

https://doi.org/10.1182/blood.V118.21.1513.1513

Published: 2011

Journal Articles

Gemtuzumab Ozogamicin In Refractory Childhood Acute Myeloid Leukemia.

Dirk Reinhardt, MD, PhD, Christian M. Zwaan, MD, PhD, Annette Sander, Christine Neuhoff, Gertjan J. Kaspers, MD, PhD, Ursula Creutzig, MD

Blood (2010) 116 (21): 1075.

https://doi.org/10.1182/blood.V116.21.1075.1075

Published: 2010

Journal Articles

Clinical and Prognostic Significance of Eosinophilia and Inv(16)/t(16;16) In Pediatric Acute Myelomonocytic Leukemia (AML-M4).

Ingrid E.M. Bank, BsC, Válerie de Haas, MD, PhD, H. Berna Beverloo, PhD, Christian M. Zwaan, MD, PhD, Gertjan J. Kaspers, MD, PhD

Blood (2010) 116 (21): 1664.

https://doi.org/10.1182/blood.V116.21.1664.1664

Published: 2010

Journal Articles

High IGSF4 expression In Pediatric Acute Monoblastic Leukemia with t(9;11)

Eva A Coenen, MD, Jenny Kuipers, Brian V Balgobind, Jan Stary, Andre Baruchel, Valerie de Haas, Evelina S. De Bont, MD, PhD, Dirk Reinhardt, MD, PhD, Gertjan J. Kaspers, MD, PhD, Jacqueline Cloos, Astrid Danen-van Oorschot, Monique L. Den Boer, Rolf Marschalek, Claus Meyer, Rob Pieters, MD, PhD, Christian M. Zwaan, MD, PhD, Marry van den Heuvel-Eibrink

Blood (2010) 116 (21): 3614.

https://doi.org/10.1182/blood.V116.21.3614.3614

Published: 2010

Journal Articles

Relapsed AML Patients with Mutational Shifts Harbor An Oligoclonal Primitive Cell Compartment at Presentation; Evidence for Clonal Selection towards Relapse

Costa Bachas, Gerrit Jan Schuurhuis, PhD, Zinia J. Kwidama, Angèle Kelder, Alexander N. Snel, Gertjan J. Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2010) 116 (21): 751.

https://doi.org/10.1182/blood.V116.21.751.751

Published: 2010

Journal Articles

Clinical Impact of Additional Cytogenetic Aberrations and Complex Karyotype In Pediatric 11q23/ MLL -Rearranged AML: Results from an International Retrospective Study

Blood (2010) 116 (21): 762.

https://doi.org/10.1182/blood.V116.21.762.762

Published: 2010

Journal Articles

Prognostic Significance of Early Treatment Response in Pediatric Relapsed Acute Myeloid Leukemia: Results from the International Study Relapsed AML 2001/01.

Gertjan J. Kaspers, M. Zimmermann, D. Reinhardt, R. Tamminga, B. Gibson, H. Armendariz, M. Dworzak, S. Ha, L. Hovi, A. Maschan, N. Philippe, B. Razzouk, C. Rizzari, P. Smisek, O. Smith, B. Stark, A. Will, U. Creutzig

Blood (2007) 110 (11): 1843.

https://doi.org/10.1182/blood.V110.11.1843.1843

Published: 2007

Journal Articles

Differences in Cyto- and Molecular Genetic Abnormalities between Children <2 Years and Older Children with Acute Myeloid Leukemia.

Brian V. Balgobind, Iris H. Hollink, Dirk Reinhardt, Jutta Bradtke, Andrea Teigler-Schlegel, Anne R. von Bergh, Jacqueline Cloos, Gertjan J. Kaspers, Elisabeth van Wering, Z. Zemanova, Jan Stary, Jean-Michel Cayuela, Andre Baruchel, Marry M. van den Heuvel-Eibrink, Christian M. Zwaan

Blood (2007) 110 (11): 1830.

https://doi.org/10.1182/blood.V110.11.1830.1830

Published: 2007

Journal Articles

Nucleophosmin Gene Mutations Identify a Favorable Risk Group in Childhood Acute Myeloid Leukemia with a Normal Karyotype.

Iris H. Hollink, Christian M. Zwaan, Marry M. van den Heuvel-Eibrink, Martin Zimmerman, Susan Arentsen-Peters, Rob Pieters, Jacqueline Cloos, Gertjan J. Kaspers, Siebold S. De Graaf, Ursula Creutzig, Dirk Reinhardt, Christian Thiede

Blood (2007) 110 (11): 366.

https://doi.org/10.1182/blood.V110.11.366.366

Published: 2007

Journal Articles

Methylation of the PTPNS1 Promoter Region in Pediatric Acute Promyelocytic Leukemia.

Isabelle Hubeek, PhD, Jacqueline Cloos, PhD, Ellen M. van Beek, MSc, Richard Broekhuizen, Arjan A. Van de Loosdrecht, MD PhD, Michel Zwaan, MD PhD, Brian Balgobind, MD, Timo K. van den Berg, PhD, Gertjan J. Kaspers, MD PhD

Blood (2007) 110 (11): 4315.

https://doi.org/10.1182/blood.V110.11.4315.4315

Published: 2007

Journal Articles

Ex Vivo Activity of Bortezomib and Dexamethasone Combinations Against Childhood Acute Leukemia Cells.

Niels E. Franke, MD, Ina van Zantwijk, Gertjan J. Kaspers, MD,PhD, Josefien Vink, MSc, Dirk Reinhardt, MD,PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD

Blood (2007) 110 (11): 4205.

https://doi.org/10.1182/blood.V110.11.4205.4205

Published: 2007

Journal Articles

Potential for Cure by Chemotherapy Only, without Allogeneic Stem Cell Transplantation, in Pediatric Relapsed Acute Myeloid Leukemia?.

Gertjan J. Kaspers, MD, PhD, Bianca F. Goemans, MD, PhD, Carin Korbijn, Rienk Y. Tamminga, MD, PhD, Karel Hählen, MD, PhD

Blood (2007) 110 (11): 2865.

https://doi.org/10.1182/blood.V110.11.2865.2865

Published: 2007

Journal Articles

Molecular Mechanisms of Bortezomib Resistance in Acute Lymphoblastic Leukemia Cells in Comparison with Multiple Myeloma Cells.

Niels E. Franke, MD, Ruud Oerlemans, MSc, Sonja Zweegman, MD, PhD, Ina van Zantwijk, Gertjan J. Kaspers, MD, PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD

Blood (2007) 110 (11): 3469.

https://doi.org/10.1182/blood.V110.11.3469.3469

Published: 2007

Journal Articles

Individualized Tumor Response (ITR) Profiling for Drug Selection in Tailored Therapy: Meta-Analysis of 1929 Cases of Leukemia and Lymphoma.

Andrew G. Bosanquet, PhD, MRCPath, Gertjan J. Kaspers, MD, PhD, Rolf Larsson, MD, Robert A. Nagourney, MD, PhD, Peter Nygren, MD, PhD, Rob Pieters, MD, PhD, Peter Staib, MD, Ulf Tidefelt, MD, PhD, C. Michel Zwaan, MD, PhD, Larry M. Weisenthal, MD, PhD

Blood (2007) 110 (11): 3471.

https://doi.org/10.1182/blood.V110.11.3471.3471

Published: 2007

Journal Articles

Favorable Interactions between Aplidin (Plitidepsin) and Conventional Anticancer Agents in Leukemic Cell Lines and Acute Leukemia Patient Samples.

Gertjan J. Kaspers, R. Broekhuizen, B. Goemans, E. Vladimirskaya, J. Jimeno

Blood (2005) 106 (11): 4442.

https://doi.org/10.1182/blood.V106.11.4442.4442

Published: 2005

Journal Articles

Relapsed Acute Myeloid Leukemia in Children and Adolescents: Interim Results of the International Randomised Phase III Study “Relapsed AML 2001/01”.

Gertjan J. Kaspers, M. Zimmermann, G. Fleischhack, R. Tamminga, B. Gibson, H. Armendariz, M. Dworzak, S. Ha, L. Hovi, A. Maschan, N. Philippe, B. Razzouk, C. Rizzari, P. Smisek, O. Smith, B. Stark, U. Creutzig

Blood (2005) 106 (11): 897.

https://doi.org/10.1182/blood.V106.11.897.897

Published: 2005

Journal Articles

Methotrexate in Relapsed Childhood Acute Myeloid Leukemia: A Single Agent Therapeutic Window Study.

Gertjan J. Kaspers, Dirk Reinhardt, Gudrun Fleischhack, Hortensia Armendariz, Batia Stark, Christian M. Zwaan, Martin Zimmermann, Ursula Creutzig

Blood (2004) 104 (11): 4509.

https://doi.org/10.1182/blood.V104.11.4509.4509

Published: 2004

NARROW

Clofarabine in Combination with High-Dose Cytarabine and Liposomal Daunorubicin in Pediatric AML: Results of a Phase 1B Combination Study By the ITCC Consortium

Glucocorticoid-Induced Proliferation and Differentiation of Untreated Pediatric AML Cells

Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression

Gemtuzumab Ozogamicin In Refractory Childhood Acute Myeloid Leukemia.

Clinical and Prognostic Significance of Eosinophilia and Inv(16)/t(16;16) In Pediatric Acute Myelomonocytic Leukemia (AML-M4).

High IGSF4 expression In Pediatric Acute Monoblastic Leukemia with t(9;11)

Relapsed AML Patients with Mutational Shifts Harbor An Oligoclonal Primitive Cell Compartment at Presentation; Evidence for Clonal Selection towards Relapse

Clinical Impact of Additional Cytogenetic Aberrations and Complex Karyotype In Pediatric 11q23/ MLL -Rearranged AML: Results from an International Retrospective Study

Prognostic Significance of Early Treatment Response in Pediatric Relapsed Acute Myeloid Leukemia: Results from the International Study Relapsed AML 2001/01.

Differences in Cyto- and Molecular Genetic Abnormalities between Children <2 Years and Older Children with Acute Myeloid Leukemia.

Nucleophosmin Gene Mutations Identify a Favorable Risk Group in Childhood Acute Myeloid Leukemia with a Normal Karyotype.

Methylation of the PTPNS1 Promoter Region in Pediatric Acute Promyelocytic Leukemia.

Ex Vivo Activity of Bortezomib and Dexamethasone Combinations Against Childhood Acute Leukemia Cells.

Potential for Cure by Chemotherapy Only, without Allogeneic Stem Cell Transplantation, in Pediatric Relapsed Acute Myeloid Leukemia?.

Molecular Mechanisms of Bortezomib Resistance in Acute Lymphoblastic Leukemia Cells in Comparison with Multiple Myeloma Cells.

Individualized Tumor Response (ITR) Profiling for Drug Selection in Tailored Therapy: Meta-Analysis of 1929 Cases of Leukemia and Lymphoma.

Relapsed Acute Myeloid Leukemia in Children and Adolescents: Interim Report of the International Randomised Phase III Study Relapsed AML 2001/01.

Favorable Interactions between Aplidin (Plitidepsin) and Conventional Anticancer Agents in Leukemic Cell Lines and Acute Leukemia Patient Samples.

Relapsed Acute Myeloid Leukemia in Children and Adolescents: Interim Results of the International Randomised Phase III Study “Relapsed AML 2001/01”.

Methotrexate in Relapsed Childhood Acute Myeloid Leukemia: A Single Agent Therapeutic Window Study.

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American Society of Hematology

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American Society of Hematology

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