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Journal Articles

Lck Is a Crucial Anergy Regulator in CLL

Alexander Fuchs, Melanie Märklin, PhD, Jonas Heitmann, Felicia Truckenmüller, Sebastian Jonas Saur, MD, Manuela Ganser, Stefanie Bugl, Ursula Kohlhofer, Leticia Quintanilla-Martinez, MD, Hans-Georg Kopp, MD, Lothar Kanz, Anjana Rao, PhD, Stefan Wirths, MD, Martin R. Mueller, MD PhD

Blood (2017) 130 (Supplement 1): 3003.

https://doi.org/10.1182/blood.V130.Suppl_1.3003.3003

Published: 2017

Journal Articles

Platelet Programmed Cell Death Ligand 1 (pPDL-1) Is a Prognostic Marker in Advanced Lung Cancer

Clemens Hinterleitner, MD, Jasmin Strähle, Stefan Wirths, MD, Stefanie Bugl, Elke Malenke, Martin R. Mueller, MD PhD, Lothar Kanz, Hans-Georg Kopp, MD

Blood (2017) 130 (Supplement 1): 3610.

https://doi.org/10.1182/blood.V130.Suppl_1.3610.3610

Published: 2017

Journal Articles

Unique Alterations in the Immunopeptidome of Colorectal Cancer Reflect Specific Transformations in Cancer-Associated Signaling Pathways and Reveal Tumor-Specific HLA-Ligand Modulations

Sebastian P. Haen, MD, Daniel J. Kowalewski, Joerg Bernhardt, Linus Backert, Daniel Backes, Florian Dengler, Stefan Beckert, Ingmar Koenigsrainer, Hans-Georg Kopp, MD, Oliver Kohlbacher, Alfred Koenigsrainer, MD, Lothar Kanz, MD, Hans-Georg Rammensee, PhD, Stefan Stevanovic, PhD, Markus W. Loeffler, MD

Blood (2016) 128 (22): 862.

https://doi.org/10.1182/blood.V128.22.862.862

Published: 2016

Journal Articles

Knock-Down of the NFAT2 Long and Intermediate Isoforms Leads to CLL Acceleration

Jonas S Heitmann, MD, Melanie Märklin, PhD, Posdorowkin Anastasia, B.Sc, Alexander R Fuchs, M.Sc., Felicia M Truckenmüller, Hans-Georg Kopp, MD, Lothar Kanz, MD, Anjana Rao, PhD, Stefan Wirths, MD, Martin R Mueller, MD PhD

Blood (2016) 128 (22): 4371.

https://doi.org/10.1182/blood.V128.22.4371.4371

Published: 2016

Journal Articles

Interplay Between the Immune System and Colorectal Carcinoma - Towards Tumor-Specific Peptide-Based Vaccination for Any HLA-Type

Sebastian P. Haen, MD, Daniel Johannes Kowalewski, Stefan Stevanovic, PhD, Linus Backert, Florian Dengler, Daniel Backes, Stefan Beckert, Wagner Silvia, Ingmar Koenigsrainer, Hans-Georg Kopp, MD, Oliver Kohlbacher, Alfred Koenigsrainer, MD, Lothar Kanz, MD, Hans-Georg Rammensee, PhD, Markus W. Loeffler, MD

Blood (2015) 126 (23): 1027.

https://doi.org/10.1182/blood.V126.23.1027.1027

Published: 2015

Journal Articles

Defects in Primary Hemostasis and Acquired Von Willebrand Disease As Cause of Bleeding in Patients with Multiple Myeloma

Clemens Hinterleitner, MD, Klaus Peter Kreisselmeier, MD, Ann Christin Pecher, MD, Katja C. Weisel, Lothar Kanz, MD, Hans Georg Kopp, MD, Karl G. Jaschonek, MD

Blood (2015) 126 (23): 3540.

https://doi.org/10.1182/blood.V126.23.3540.3540

Published: 2015

Journal Articles

C-Cbl Regulates c-Mpl Receptor Trafficking and Its Internalization

Sebastian Jonas Saur, MD, Melanie Märklin, PhD, Manuela Ganser, Kyle Hoehn, James E David, PhD, Oliver Borst, MD, Lothar Kanz, MD, Hans-Georg Kopp, MD, Martin R Mueller, MD PhD

Blood (2015) 126 (23): 2388.

https://doi.org/10.1182/blood.V126.23.2388.2388

Published: 2015

Journal Articles

Genetic Loss of NFAT2 Leads to CLL Transformation

Melanie Märklin, PhD, Jonas Heitmann, Felicia Truckenmüller, Lothar Kanz, MD, Sebastian Jonas Saur, MD, Manuela Ganser, Bugl Stefanie, PhD, Hans-Georg Kopp, MD, Michael Haap, MD, Anjana Rao, PhD, Stefan Wirths, MD, Martin R Mueller, MD PhD

Blood (2015) 126 (23): 364.

https://doi.org/10.1182/blood.V126.23.364.364

Published: 2015

Journal Articles

Platelet-Derived Proteases ADAM10 and ADAM17 Impair NK Cell Immunosurveillance of Metastasizing Tumor Cells By Diminishing NKG2D Ligand Surface Expression

Stefanie Raab, MSc, Korbinian Nepomuk Kropp, Alexander Steinle, PhD, Gerd Klein, PhD, Lothar Kanz, MD, Hans-Georg Kopp, MD, Helmut R Salih, MD

Blood (2014) 124 (21): 4164.

https://doi.org/10.1182/blood.V124.21.4164.4164

Published: 2014

Journal Articles

NFAT2 Regulates Anergy Induction in CLL through Lck

Melanie Märklin, M. Sc., Jonas S. Heitmann, B. Sc., Alexandra Poljak, B. Sc., Stefanie Bugl, PhD, Hans-Georg Kopp, MD, Michael Haap, MD, Lothar Kanz, MD, Anjana Rao, PhD, Stefan Wirths, MD, Martin R. Müller, MD PhD

Blood (2014) 124 (21): 720.

https://doi.org/10.1182/blood.V124.21.720.720

Published: 2014

Journal Articles

C-CBL Is a Critical Negative Regulator of Megakaryopoesis

Sebastian J. Saur, MD, Melanie Märklin, M. Sc., Alexandra Poljak, B. Sc., Manuela Ganser, B. Sc., David E. James, PhD, Kyle Hoehn, PhD, Lothar Kanz, MD, Hans-Georg Kopp, MD, Martin R. Müller, MD PhD

Blood (2014) 124 (21): 1581.

https://doi.org/10.1182/blood.V124.21.1581.1581

Published: 2014

Journal Articles

Bone Marrow Derived Mesenchymal Cells Secrete Granulopoietic Cytokines upon Danger Signaling

Stefan Wirths, MD, Stefanie Bugl, PhD, Markus P. Radsak, MD, Melanie Märklin, PhD, Martin R. Müller, MD PhD, Lothar Kanz, MD, Hans-Georg Kopp, MD

Blood (2014) 124 (21): 4115.

https://doi.org/10.1182/blood.V124.21.4115.4115

Published: 2014

Journal Articles

Platelets Impair NK Cell Immunosurveillance Of Metastasizing Tumor Cells By Altering Surface Expression and Shedding Of Ligands For The Activating Immunoreceptor NKG2D

Stefanie Raab, Korbinian Nepomuk Kropp, Alexander Steinle, PhD, Lothar Kanz, MD, Hans-Georg Kopp, MD, Helmut R. Salih, MD

Blood (2013) 122 (21): 3488.

https://doi.org/10.1182/blood.V122.21.3488.3488

Published: 2013

Journal Articles

Transcriptional Mistargeting Of NFAT2 In CLL

Melanie Märklin, M. Sc., Jonas S. Heitmann, B. Sc., David Worbs, B. Sc., Alexandra Poljak, B. Sc., Claude Evouna, MD, Hans-Georg Kopp, MD, Lothar Kanz, MD, Anjana Rao, PhD, Stefan Wirths, MD, Martin R Müller, MD, PhD

Blood (2013) 122 (21): 4122.

https://doi.org/10.1182/blood.V122.21.4122.4122

Published: 2013

Journal Articles

NFAT2 Is a Critical Regulator Of Anergy Induction In CLL

Blood (2013) 122 (21): 869.

https://doi.org/10.1182/blood.V122.21.869.869

Published: 2013

Journal Articles

Overexpression and Aberrant Nuclear Translocation of NFAT2 in CLL

Jonas S. Heitmann, B. Sc., Melanie Märklin, M. Sc., Alexandra Poljak, B. Sc., Bettina S, Hackl, B. Sc., Juliane Sarah Stickel, MD, Lothar Kanz, MD, Hans-Georg Kopp, MD, Stefan Wirths, MD, Martin R Müller, MD, PhD

Blood (2012) 120 (21): 3909.

https://doi.org/10.1182/blood.V120.21.3909.3909

Published: 2012

Journal Articles

Genetic Loss of NFAT2 Induces Profound Acceleration of CLL in the TCL1 Mouse Model

Melanie Märklin, M. Sc., Stefanie Bugl, M. Sc., Jonas S. Heitmann, B. Sc., Alexandra Poljak, B. Sc., Bettina S, Hackl, B. Sc., Hans-Georg Kopp, MD, Lothar Kanz, MD, Anjana Rao, PhD, Stefan Wirths, MD, Martin R Müller, MD, PhD

Blood (2012) 120 (21): 862.

https://doi.org/10.1182/blood.V120.21.862.862

Published: 2012

Journal Articles

Ca 2+ /NFAT Signaling Regulates the Expression CD38 and ZAP70 in Murine B Cells and Controls B1a Cell Homeostasis

Melanie Märklin, M. Sc., Stefanie Bugl, M. Sc., Marina Bechtel, M.Sc., Alexandra Poljak, B. Sc., Hans-Georg Kopp, MD, Lothar Kanz, MD, Anjana Rao, PhD, Stefan Wirths, MD, Martin R Müller, MD, PhD

Blood (2011) 118 (21): 183.

https://doi.org/10.1182/blood.V118.21.183.183

Published: 2011

Journal Articles

Targeting RANKL for Immunotherapy of Multiple Myeloma

Benjamin J Schmiedel, Ludger Grosse-Hovest, Stefanie Bugl, M. Sc., Hans-Georg Kopp, MD, Stefan Wirths, MD, Bernd J Pichler, Miyuki Azuma, Pascal Schneider, Lothar Kanz, MD, Gundram Jung, Helmut R. Salih, MD

Blood (2011) 118 (21): 2905.

https://doi.org/10.1182/blood.V118.21.2905.2905

Published: 2011

Journal Articles

Inhibition of Calcineurin/NFAT Signalling Breaks Resistance of Ph+ ALL to Imatinib

Melanie Märklin, M. Sc., Stefanie Bugl, M. Sc., Jana Pasternak, B. Sc., Alexandra Poljak, B. Sc., Hans-Georg Kopp, MD, Lothar Kanz, MD, Stefan Wirths, MD, Martin R Müller, MD, PhD

Blood (2011) 118 (21): 2486.

https://doi.org/10.1182/blood.V118.21.2486.2486

Published: 2011

NARROW

Lck Is a Crucial Anergy Regulator in CLL

Platelet Programmed Cell Death Ligand 1 (pPDL-1) Is a Prognostic Marker in Advanced Lung Cancer

Unique Alterations in the Immunopeptidome of Colorectal Cancer Reflect Specific Transformations in Cancer-Associated Signaling Pathways and Reveal Tumor-Specific HLA-Ligand Modulations

Knock-Down of the NFAT2 Long and Intermediate Isoforms Leads to CLL Acceleration

Interplay Between the Immune System and Colorectal Carcinoma - Towards Tumor-Specific Peptide-Based Vaccination for Any HLA-Type

Defects in Primary Hemostasis and Acquired Von Willebrand Disease As Cause of Bleeding in Patients with Multiple Myeloma

C-Cbl Regulates c-Mpl Receptor Trafficking and Its Internalization

Genetic Loss of NFAT2 Leads to CLL Transformation

Platelet-Derived Proteases ADAM10 and ADAM17 Impair NK Cell Immunosurveillance of Metastasizing Tumor Cells By Diminishing NKG2D Ligand Surface Expression

NFAT2 Regulates Anergy Induction in CLL through Lck

C-CBL Is a Critical Negative Regulator of Megakaryopoesis

Bone Marrow Derived Mesenchymal Cells Secrete Granulopoietic Cytokines upon Danger Signaling

Platelets Impair NK Cell Immunosurveillance Of Metastasizing Tumor Cells By Altering Surface Expression and Shedding Of Ligands For The Activating Immunoreceptor NKG2D

Transcriptional Mistargeting Of NFAT2 In CLL

NFAT2 Is a Critical Regulator Of Anergy Induction In CLL

Overexpression and Aberrant Nuclear Translocation of NFAT2 in CLL

Genetic Loss of NFAT2 Induces Profound Acceleration of CLL in the TCL1 Mouse Model

Ca 2+ /NFAT Signaling Regulates the Expression CD38 and ZAP70 in Murine B Cells and Controls B1a Cell Homeostasis

Targeting RANKL for Immunotherapy of Multiple Myeloma

Inhibition of Calcineurin/NFAT Signalling Breaks Resistance of Ph+ ALL to Imatinib

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American Society of Hematology

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