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Journal Articles

CD16-IL15-CLEC12A Trispecific Killer Engager (TriKE) Drives NK Cell Expansion, Activation, and Antigen Specific Killing of Cancer Stem Cells in Acute Myeloid Leukemia

Upasana Sunil Arvindam, MSc, BSc, Paulien van Hauten, MSc-MD, Caroline Hallstrom, BS, Daniel A. Vallera, PhD, Harry Dolstra, PhD, Jeffrey S. Miller, MD, Martin Felices, PhD

Blood (2018) 132 (Supplement 1): 1454.

https://doi.org/10.1182/blood-2018-99-117150

Published: 2018

Journal Articles

Decitabine enhances targeting of AML cells by CD34 + progenitor-derived NK cells in NOD/SCID/IL2Rg null mice

Jeannette Cany, Mieke W. H. Roeven, Janneke S. Hoogstad-van Evert, Willemijn Hobo, Frans Maas, Rosalia Franco Fernandez, Nicole M. A. Blijlevens, Walter J. van der Velden, Gerwin Huls, Joop H. Jansen, Nicolaas P. M. Schaap, Harry Dolstra

Blood (2018) 131 (2): 202–214.

https://doi.org/10.1182/blood-2017-06-790204

Published: 2018

Includes: Supplemental data

Journal Articles

A Phase I/II Study on the Anti-CD3/CD7 Immunotoxin Combination (T-GuardTM) for the Treatment of Steroid-Refractory Acute Gvhd

Christoph Groth, MD, Lenneke F J Groningen, Manita E J Bremmers, Frank W M B Preijers, Harry Dolstra, Tiago R Matos, Christian Reicherts, Eric G van Hooren, Ypke V J M van Oosterhout, John E Levine, MD, James L Ferrara, Nicole M A Blijlevens, Matthias Stelljes, MD, Walter J F M van der Velden

Blood (2017) 130 (Supplement 1): 513.

https://doi.org/10.1182/blood.V130.Suppl_1.513.513

Published: 2017

Journal Articles

A Phase I Study of Allogeneic Natural Killer Cell Therapy Generated from Cord Blood Hematopoietic Stem and Progenitor Cells in Elderly Acute Myeloid Leukemia Patients

Blood (2015) 126 (23): 1357.

https://doi.org/10.1182/blood.V126.23.1357.1357

Published: 2015

Journal Articles

Preclinical Evaluation of MCLA117, a CLEC12AxCD3 Bispecific Antibody Efficiently Targeting a Novel Leukemic Stem Cell Associated Antigen in AML

Pieter Fokko Van Loo, PhD, Robert Doornbos, PhD, Harry Dolstra, PhD, Setareh Shamsili, MD PhD, Lex Bakker, PhD

Blood (2015) 126 (23): 325.

https://doi.org/10.1182/blood.V126.23.325.325

Published: 2015

Journal Articles

The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1 Stimulates Expression of NK Cell Related Transcription Factors, Thereby It Facilitates Generation of Highly Functional NK Cells in Vitro

Mieke WH Roeven, MD, Jeanette Cany, PhD, Frans Maas, Arwa Kohela, Jansen Joop, PhD, Nicole MA Blijlevens, MD PhD, Nicolaas PM Schaap, MD PhD, Harry Dolstra, PhD

Blood (2014) 124 (21): 3833.

https://doi.org/10.1182/blood.V124.21.3833.3833

Published: 2014

Journal Articles

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

Anniek B. van der Waart, Noortje M. P. van de Weem, Frans Maas, Cynthia S. M. Kramer, Michel G. D. Kester, J. H. Frederik Falkenburg, Nicolaas Schaap, Joop H. Jansen, Robbert van der Voort, Luca Gattinoni, Willemijn Hobo, Harry Dolstra

Blood (2014) 124 (23): 3490–3500.

https://doi.org/10.1182/blood-2014-05-578583

Published: 2014

Includes: Supplemental data

Journal Articles

Influence Of DNA Methyltransferese Inhibitors On The Anti-Leukemic Effect Of Umbilical Cord Blood Derived NK Cells Against Acute Myeloid Leukemia

Harry Dolstra, PhD, Jeannette Cany, PhD, Anniek B. van der Waart, MSc, Marleen Tordoir, BSc, Basav Nagaraj Hangalapura, PhD, Jan Spanholtz, PhD, Robbert van der Voort, PhD, Nicolaas PM Schaap, MD, PhD

Blood (2013) 122 (21): 4496.

https://doi.org/10.1182/blood.V122.21.4496.4496

Published: 2013

Journal Articles

LB-ARHGDIB-1R As Novel Minor Histocompatibility Antigen For Therapeutic Application

Margot J Pont, Willemijn Hobo, PhD, M. Willy Honders, Simone A.P. van Luxemburg-Heijs, Michel G.D. Kester, Cornelis A.M. van Bergen, Harry Dolstra, PhD, J.H. Frederik Falkenburg, MD, PhD, Marieke Griffioen, PhD

Blood (2013) 122 (21): 4465.

https://doi.org/10.1182/blood.V122.21.4465.4465

Published: 2013

Journal Articles

Akt Signalling Inhibition Promotes The Ex Vivo generation Of Minor Histocompatibility Antigen-Specific CD8+ Memory Stem T Cells

Anniek B. van der Waart, MSc, Noortje van der Weem, Luca Gattinoni, MD, Nicolaas PM Schaap, MD, PhD, Robbert van der Voort, PhD, Willemijn Hobo, PhD, Harry Dolstra, PhD

Blood (2013) 122 (21): 3269.

https://doi.org/10.1182/blood.V122.21.3269.3269

Published: 2013

Journal Articles

Ex Vivo Generation Of Functional Plasmacytoid and Myeloid Dendritic Cells Is Strongly Promoted By The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1

Soley Thordardottir, MSc, Hangalapura Basav N., PhD, Tim Hutten, MSc, Marta Cossu, MSc, Jan Spanholtz, PhD, Nicolaas PM Schaap, MD, PhD, Timothy Radstake, MD, PhD, Robbert van der Voort, PhD, Harry Dolstra, PhD

Blood (2013) 122 (21): 2025.

https://doi.org/10.1182/blood.V122.21.2025.2025

Published: 2013

Journal Articles

Gender influences the birth order effect in HLA-identical stem cell transplantation

Miranda P. Dierselhuis, Eric Spierings, Ronald Brand, Matthijs Hendriks, Angelica Canossi, Harry Dolstra, Jean-François Eliaou, Jürgen Enczmann, Thibaut Gervais, Brigitte Kircher, David Laurin, Pascale Loiseau, Ruhena Sergeant, Els Goulmy

Blood (2013) 121 (23): 4809–4811.

https://doi.org/10.1182/blood-2013-02-485722

Published: 2013

Journal Articles

Coinhibitory molecules in hematologic malignancies: targets for therapeutic intervention

Wieger J. Norde, Willemijn Hobo, Robbert van der Voort, Harry Dolstra

Blood (2012) 120 (4): 728–736.

https://doi.org/10.1182/blood-2012-02-412510

Published: 2012

Journal Articles

CXCR3 Is Required for the Efficient Recruitment of Bone Marrow-Resident Memory T Cells to Inflamed Tissues,

Robbert van der Voort, PhD, Claudia Brandao, MSc, Thomas J. Volman, PhD, Viviènne Verweij, Klaas van Gisbergen, PhD, Bao Lu, MD, Craig Gerard, MD, PhD, Martijn A. Nolte, PhD, Harry Dolstra, PhD

Blood (2011) 118 (21): 3242.

https://doi.org/10.1182/blood.V118.21.3242.3242

Published: 2011

Journal Articles

Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-Versus-Host-Disease Upon Allogeneic Stem Cell Transplantation,

Willemijn Hobo, Kelly Broen, Walter J.F.M. van der Velden, MD, PhD, Annelies Greupink-Draaisma, Niken Adisty, Yannick Wouters, Michel G.D. Kester, Hanny Fredrix, Joop H. Jansen, PhD, Bert A. van der Reijden, PhD, J.H. Frederik Falkenburg, Theo de Witte, MD, PhD, Frank W.M.B. Preijers, PhD, Anton Schattenberg, MD, PhD, Ton Feuth, Nicole N.A. Blijlevens, MD, PhD, Nicolaas Schaap, MD, PhD, Harry Dolstra, PhD

Blood (2011) 118 (21): 4136.

https://doi.org/10.1182/blood.V118.21.4136.4136

Published: 2011

Journal Articles

Anti-CTLA-4 Antibody Is Not Able to Trigger Apoptosis in CTLA-4 Expressing Myeloid Tumor Cells

Sandra van Bijnen, MD, Maria Rogkoti, Marian Withaar, Theo de Witte, MD, PhD, Petra Muus, MD, PhD, Harry Dolstra, PhD

Blood (2011) 118 (21): 5054.

https://doi.org/10.1182/blood.V118.21.5054.5054

Published: 2011

Journal Articles

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen–specific CD8 + T cells

Willemijn Hobo, Frans Maas, Niken Adisty, Theo de Witte, Nicolaas Schaap, Robbert van der Voort, Harry Dolstra

Blood (2010) 116 (22): 4501–4511.

https://doi.org/10.1182/blood-2010-04-278739

Published: 2010

Journal Articles

T Cells Expressing the Activating NK Cell Receptors KIR2DS4, NKG2C and NKG2D Are Elevated In Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Cytotoxic towards Hematopoietic Progenitor Cell Lines

Sandra van Bijnen, MD, Marian Withaar, Frank Preijers, PhD, Arnold van der Meer, PhD, Theo de Witte, MD, PhD, Petra Muus, MD, PhD, Harry Dolstra, PhD

Blood (2010) 116 (21): 2235.

https://doi.org/10.1182/blood.V116.21.2235.2235

Published: 2010

Journal Articles

Clinical Scale Generation of Functional Human Natural Killer Cells From Umbilical Cord Blood CD34-Positive Cells for Immunotherapy.

Jan Spanholtz, Marleen Tordoir, Carel Trilsbeek, Jos Paardekooper, Diana Eissens, Arnold van der Meer, Irma Joosten, Frank Preijers, T. M. de Witte, Nicolaas Schaap, MD, PhD, Harry Dolstra

Blood (2009) 114 (22): 2666.

https://doi.org/10.1182/blood.V114.22.2666.2666

Published: 2009

Journal Articles

Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1–reactive cytotoxic T cells

Wieger J. Norde, Ingrid M. Overes, Frans Maas, Hanny Fredrix, Johanna C. M. Vos, Michel G. D. Kester, Robbert van der Voort, Inge Jedema, J. H. Frederik Falkenburg, Anton V. Schattenberg, Theo M. de Witte, Harry Dolstra

Blood (2009) 113 (10): 2312–2323.

https://doi.org/10.1182/blood-2008-04-153825

Published: 2009

Includes: Supplemental data

NARROW

CD16-IL15-CLEC12A Trispecific Killer Engager (TriKE) Drives NK Cell Expansion, Activation, and Antigen Specific Killing of Cancer Stem Cells in Acute Myeloid Leukemia

Decitabine enhances targeting of AML cells by CD34 + progenitor-derived NK cells in NOD/SCID/IL2Rg null mice

A Phase I/II Study on the Anti-CD3/CD7 Immunotoxin Combination (T-GuardTM) for the Treatment of Steroid-Refractory Acute Gvhd

A Phase I Study of Allogeneic Natural Killer Cell Therapy Generated from Cord Blood Hematopoietic Stem and Progenitor Cells in Elderly Acute Myeloid Leukemia Patients

Preclinical Evaluation of MCLA117, a CLEC12AxCD3 Bispecific Antibody Efficiently Targeting a Novel Leukemic Stem Cell Associated Antigen in AML

The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1 Stimulates Expression of NK Cell Related Transcription Factors, Thereby It Facilitates Generation of Highly Functional NK Cells in Vitro

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

Influence Of DNA Methyltransferese Inhibitors On The Anti-Leukemic Effect Of Umbilical Cord Blood Derived NK Cells Against Acute Myeloid Leukemia

LB-ARHGDIB-1R As Novel Minor Histocompatibility Antigen For Therapeutic Application

Akt Signalling Inhibition Promotes The Ex Vivo generation Of Minor Histocompatibility Antigen-Specific CD8+ Memory Stem T Cells

Ex Vivo Generation Of Functional Plasmacytoid and Myeloid Dendritic Cells Is Strongly Promoted By The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1

Gender influences the birth order effect in HLA-identical stem cell transplantation

Coinhibitory molecules in hematologic malignancies: targets for therapeutic intervention

CXCR3 Is Required for the Efficient Recruitment of Bone Marrow-Resident Memory T Cells to Inflamed Tissues,

Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-Versus-Host-Disease Upon Allogeneic Stem Cell Transplantation,

Anti-CTLA-4 Antibody Is Not Able to Trigger Apoptosis in CTLA-4 Expressing Myeloid Tumor Cells

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen–specific CD8 + T cells

T Cells Expressing the Activating NK Cell Receptors KIR2DS4, NKG2C and NKG2D Are Elevated In Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Cytotoxic towards Hematopoietic Progenitor Cell Lines

Clinical Scale Generation of Functional Human Natural Killer Cells From Umbilical Cord Blood CD34-Positive Cells for Immunotherapy.

Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1–reactive cytotoxic T cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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