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Journal Articles

Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies

Teresa Sadras, PhD, Mickaël Martin, MD PhD, Lauren Kim-Sing, Jevon Cutler, PhD, Gal Lenz, PhD, Anne Marie Knapp, Dana Ghergus, MD PhD, Fabien Delmotte, Cédric Schleiss, Anne-Sophie Korganow, MD PhD, Pauline Soulas-Sprauel, PharmD, PhD, Zhengshan Chen, MD PhD, Akhilesh Pandey, MD PhD, David M. Weinstock, MD, Hassan Jumaa, PhD, Eric Meffre, PhD, Thierry Martin, MD PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 295.

https://doi.org/10.1182/blood-2019-128999

Published: 2019

Journal Articles

The VLA-4 Integrin Is Constitutively Activated in a Fraction of CD49d-Expressing Chronic Lymphocytic Leukemia Via Autonomous BCR-Mediated Signaling

Blood (2019) 134 (Supplement_1): 849.

https://doi.org/10.1182/blood-2019-124313

Published: 2019

Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 748.

https://doi.org/10.1182/blood-2019-127263

Published: 2019

Journal Articles

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Franziska Auer, PhD, Jaewoong Lee, PhD, Anthony Abarientos, BSc, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 547.

https://doi.org/10.1182/blood-2018-99-116956

Published: 2018

Journal Articles

Chronic Lymphocytic Leukemia B Cells Display IgM and IgD Isotype-Restricted Features That Affect Association with Co-Receptors, BCR Signaling, and Leukemic B-Cell Growth In Vivo

Andrea Nicola Mazzarello, PhD, Marcus Dühren-von Minden, PhD, Eva Gentner, BSc, MSc, PhD, Palash Chandra Maity, PhD, Gerardo Ferrer, PhD, Tatyana Tarasenko, Stefano Vergani, PhD, Jacqueline C Barrientos, MD MS, Kanti R Rai, MD, Peter McGuire, Hassan Jumaa, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 3124.

https://doi.org/10.1182/blood-2018-99-119989

Published: 2018

Journal Articles

Lgr5 Functions As Negative Regulator of Wnt Signaling in B Cells and Is Critical for Self-Renewal of Normal and Transformed B Cells

Kadriye Nehir Nehir Cosgun, PhD, Anna Hecht, MD, Xin Yang, MD, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Lars Klemm, Msc, Chao Hong, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Hans Clevers, MD PhD, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 3989.

https://doi.org/10.1182/blood.V130.Suppl_1.3989.3989

Published: 2017

Journal Articles

Targeting of the Interleukin-7 Receptor Alpha-Chain (IL-7Rα) Blocks B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Development and Reduces Leukemic Infiltration to the Central Nervous System (CNS)

Ameera Alsadeq, PhD, Anila George Vadakumchery, Ali Almasri, Hend Abdelrasoul, Markus Werner, PhD, Lennart Lenk, Felix Seyfried, Klaus-Michael Debatin, MD, Lueder-Hinrich Myer, MD, Gunnar Cario, MD, Martin Schrappe, MD PhD, Denis Martin Schewe, MD, Hassan Jumaa, PhD

Blood (2017) 130 (Supplement 1): 479.

https://doi.org/10.1182/blood.V130.Suppl_1.479.479

Published: 2017

Journal Articles

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

Andrea Nicola Mazzarello, PhD, Marcus Dühren-von Minden, PhD, Palash Chandra Maity, PhD, Gentner Eva, PhD, Stefano Vergani, PhD, Gerardo Ferrer, PhD, Davide Bagnara, PhD, Shih-Shih Chen, PhD, Sophia Yancopoulos, Xiao J. Yan, MDPhD, Jacqueline C. Barrientos, MD, Kanti Rai, MD, Hassan Jumaa, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 1716.

https://doi.org/10.1182/blood.V130.Suppl_1.1716.1716

Published: 2017

Journal Articles

Primary Mediastinal Large B-Cell Lymphoma Exhibits Autonomous BCR Signaling and Responds to the Second Generation BTK Inhibitor Acalabrutinib

Marvyn T. Koning, BSc, Rudolf Übelhart, PhD, Sander A.J. van der Zeeuw, BSc, Philip Kluin, MD PhD, Marieke Griffioen, PhD, Hans G. Drexler, MD PhD, Szymon M. Kielbasa, PhD, Marcelo A. Navarrete, MD PhD, Hassan Jumaa, PhD, Hendrik Veelken, MD PhD

Blood (2016) 128 (22): 4171.

https://doi.org/10.1182/blood.V128.22.4171.4171

Published: 2016

Journal Articles

Antigen-Independent, Autonomous B-Cell Receptor Signaling As a Dominant Candidate Oncogenic Mechanism in ABC DLBCL

Marvyn T. Koning, BSc, Rudolf Übelhart, PhD, Arjen H.G. Cleven, PhD, Willem H. Zoutman, BSc, Sander A.J. van der Zeeuw, BSc, Philip Kluin, MD PhD, Marieke Griffioen, PhD, Cornelis P. Tensen, PhD, Maarten H. Vermeer, MD PhD, Rein Willemze, MD PhD, Szymon M. Kielbasa, PhD, Marcelo A. Navarrete, MD PhD, Hassan Jumaa, PhD, Hendrik Veelken, MD PhD

Blood (2016) 128 (22): 778.

https://doi.org/10.1182/blood.V128.22.778.778

Published: 2016

Journal Articles

Immunoglobulin Heavy Chain (IgH) Knockout Inhibits Proliferation of Pre-BCR + B-Cell Acute Lymphoblastic Leukemia (B-ALL) Via a FOXO1 and MYC Dependent Mechanism

Stefan Koehrer, MD, Ondrej Havranek, MDPhD, R Eric Davis, MD, Felix Seyfried, MD, Greg Coffey, PhD, Ekaterina Kim, MS, Nathalie Y. Rosin, PhD, Elisa ten Hacken, PhD, Ulrich Jäger, MD, Katrina Vanura, PhD, Susan O'Brien, MD, Deborah A. Thomas, MD, Hagop M. Kantarjian, MD, Dipanjan Ghosh, PhD, Zhiqiang Wang, Lüder Hinrich Meyer, MD, Hassan Jumaa, PhD, Jan A. Burger, MDPhD

Blood (2014) 124 (21): 287.

https://doi.org/10.1182/blood.V124.21.287.287

Published: 2014

Journal Articles

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Zhengshan Chen, MD PhD, Seyedmehdi Shojaee, PhD, Huimin Geng, PhD, Jae-Woong Lee, PhD, Maike Buchner, PhD, Lars Klemm, Clifford A. Lowell, MD PhD, Elisabeth Paietta, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Ari Melnick, MD, Jae U. Jung, PhD, Hassan Jumaa, PhD, John E. Coligan, PhD, Silvia Bolland, PhD, Tak W. Mak, OC, PhD DSc, FRSC, FRS, Markus Muschen, MDPhD

Blood (2014) 124 (21): 792.

https://doi.org/10.1182/blood.V124.21.792.792

Published: 2014

Journal Articles

B Cell Receptors Of Chlamydophila Psittaci negative MALT Lymphomas Of The Ocular Adnexa Recognize Common Self-Antigens

Daxing Zhu, MD, Xiaoqing Lu, M.D, Marcus Dühren-von Minden, M.Sc., Shruti Bhatt, MS, Chen Lossos, Jennifer R. Chapman-Fredricks, MD, Hendrik Veelken, MD PhD, Hassan Jumaa, PhD, Izidore S Lossos, MD

Blood (2013) 122 (21): 4266.

https://doi.org/10.1182/blood.V122.21.4266.4266

Published: 2013

Journal Articles

Pre-BCR Signaling Activity Predicts Sensitivity To Syk Kinase Inhibition In B Cell Acute Lymphoblastic Leukemia (B-ALL)

Stefan Koehrer, MD, Richard E. Davis, M.D., Greg Coffey, PhD, Ekaterina Kim, MS, Nathalie Y. Rosin, PhD, Elisa ten Hacken, Susan O'Brien, MD, William G. Wierda, MD, PhD, Zeev Estrov, MD, Deborah A. Thomas, MD, Hagop M. Kantarjian, MD, Zhiqiang Wang, Ph.D., Hassan Jumaa, PhD, Jan A. Burger, MD, PhD

Blood (2013) 122 (21): 614.

https://doi.org/10.1182/blood.V122.21.614.614

Published: 2013

Journal Articles

Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia

Zhengshan Chen, MD, PhD, Seyedmehdi Shojaee, PhD, Huimin Geng, PhD, Jaewoong Lee, PhD, Maike Buchner, PhD, Lars Klemm, Clifford A. Lowell, MD, PhD, Elisabeth Paietta, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Ari M. Melnick, MD, Jae U. Jung, PhD, Hassan Jumaa, PhD, John E. Coligan, PhD, Silvia Bolland, PhD, Tak W. Mak, Markus Muschen, MD, PhD

Blood (2013) 122 (21): 229.

https://doi.org/10.1182/blood.V122.21.229.229

Published: 2013

Journal Articles

The Functional Role of Acquired N-Linked Glycosylation Sites On Follicular Lymphoma B Cell Antigen Receptors.

Dunja Schneider, MS, Hendrik Veelken, MD PhD, Hassan Jumaa, PhD

Blood (2012) 120 (21): 2704.

https://doi.org/10.1182/blood.V120.21.2704.2704

Published: 2012

Journal Articles

The Role of the BCR Class Expressed by Eμ- TCL1 tg Mice and Human CLL

Marcus Dühren-von Minden, MSc, Thomas Wossning, PhD, Hassan Jumaa, PhD, Hendrik Veelken, MD PhD

Blood (2012) 120 (21): 182.

https://doi.org/10.1182/blood.V120.21.182.182

Published: 2012

Journal Articles

Comparison of the Transforming Effect of Different SYK Oncogenes in Vivo Reveals TEL-SYK As Inducer of an MDS/MPS Overlap Syndrome in Mice

Clara Sprissler, Helga Maurer, Hassan Jumaa, PhD, Hendrik Veelken, MD PhD, Christine Dierks

Blood (2012) 120 (21): 1310.

https://doi.org/10.1182/blood.V120.21.1310.1310

Published: 2012

Journal Articles

SOX4 enables Oncogenic Survival Signals in Acute Lymphoblastic Leukemia

Parham Ramezani-Rad, Huimin Geng, PhD, Lai N Chan, PhD, Christian Hurtz, Hassan Jumaa, PhD, Ari Melnick, MD, Elisabeth Paietta, PhD, William L. Carroll, MD, Cheryl L Willman, MD, Véronique Lefebvre, PhD, Markus Muschen, MD, PhD

Blood (2012) 120 (21): 863.

https://doi.org/10.1182/blood.V120.21.863.863

Published: 2012

Journal Articles

SYK Inhibition Targets CD38−Mediated Survival and Proliferation Signals in Chronic Lymphocytic Leukemia Cells

Maike Buchner, PhD, Natalie Stickel, MS, Arlette Dörffel, BS, Ariane Ott, BS, Marcus Duehren von Minden, MS, Christine Dierks, MD, Hassan Jumaa, PhD, Hendrik J. Veelken, MD, PhD, Katja Zirlik, MD

Blood (2011) 118 (21): 800.

https://doi.org/10.1182/blood.V118.21.800.800

Published: 2011

NARROW

Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies

The VLA-4 Integrin Is Constitutively Activated in a Fraction of CD49d-Expressing Chronic Lymphocytic Leukemia Via Autonomous BCR-Mediated Signaling

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Chronic Lymphocytic Leukemia B Cells Display IgM and IgD Isotype-Restricted Features That Affect Association with Co-Receptors, BCR Signaling, and Leukemic B-Cell Growth In Vivo

Lgr5 Functions As Negative Regulator of Wnt Signaling in B Cells and Is Critical for Self-Renewal of Normal and Transformed B Cells

Targeting of the Interleukin-7 Receptor Alpha-Chain (IL-7Rα) Blocks B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Development and Reduces Leukemic Infiltration to the Central Nervous System (CNS)

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

Primary Mediastinal Large B-Cell Lymphoma Exhibits Autonomous BCR Signaling and Responds to the Second Generation BTK Inhibitor Acalabrutinib

Antigen-Independent, Autonomous B-Cell Receptor Signaling As a Dominant Candidate Oncogenic Mechanism in ABC DLBCL

Immunoglobulin Heavy Chain (IgH) Knockout Inhibits Proliferation of Pre-BCR + B-Cell Acute Lymphoblastic Leukemia (B-ALL) Via a FOXO1 and MYC Dependent Mechanism

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

B Cell Receptors Of Chlamydophila Psittaci negative MALT Lymphomas Of The Ocular Adnexa Recognize Common Self-Antigens

Pre-BCR Signaling Activity Predicts Sensitivity To Syk Kinase Inhibition In B Cell Acute Lymphoblastic Leukemia (B-ALL)

Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia

The Functional Role of Acquired N-Linked Glycosylation Sites On Follicular Lymphoma B Cell Antigen Receptors.

The Role of the BCR Class Expressed by Eμ- TCL1 tg Mice and Human CLL

Comparison of the Transforming Effect of Different SYK Oncogenes in Vivo Reveals TEL-SYK As Inducer of an MDS/MPS Overlap Syndrome in Mice

SOX4 enables Oncogenic Survival Signals in Acute Lymphoblastic Leukemia

SYK Inhibition Targets CD38−Mediated Survival and Proliferation Signals in Chronic Lymphocytic Leukemia Cells

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American Society of Hematology

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American Society of Hematology

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