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Helen Wheadon
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Journal Articles

Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche

Martha M. Zarou, Amy Dawson, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Giovanny Rodriguez Blanco, Mary Scott, Karen Dunn, Vaidehi Krishnan, Mhairi Copland, David Vetrie, Ravi Bhatia, Seth Coffelt, S.Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G. Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 2704.
https://doi.org/10.1182/blood-2023-181630
Published: 2023
Journal Articles

Synergistic Leukaemia Cell Death Induced with PARP and TiP60 Inhibitors Is a Prospective Therapeutic Strategy for AML

Tae Ju Park, Laura Monaghan, Mhairi Copland, Xu Huang, Helen Wheadon, Heather G Jørgensen
Journal: Blood
Blood (2022) 140 (Supplement 1): 13001–13002.
https://doi.org/10.1182/blood-2022-166103
Published: 2022
Journal Articles

NFATC2 regulates Targets of MYC Signaling in MLL-AF9 AML

Shaun David Patterson, Matthew E Massett, Helen Wheadon, Xu Huang, Heather G Jørgensen, Alison M Michie
Journal: Blood
Blood (2021) 138 (Supplement 1): 3301.
https://doi.org/10.1182/blood-2021-151388
Published: 2021
Journal Articles

The Role of the BMP Pathway in Sustaining CML Stem Cells in the Bone Marrow Niche

Caroline Busch, BSc, MSc, Chloe Gulliver, BSc, MSc, Theresa Mulholland, BSc, Michele Zagnoni, BSc, MSc, PhD, Catherine C. Berry, BSc,PhD, Helen Wheadon, BSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3732.
https://doi.org/10.1182/blood-2019-123967
Published: 2019
Journal Articles

Gene Expression Profiling of CD93-Selected CP-CML Stem Cells Confirms Their Quiescent Character and Biomarker Potential

Gillian A. Horne, BSc hons, MBChB, MRCP, MRes, Chinmay Rajiv Munje, PhD BSc, Ross Kinstrie, PhD BSc, Eduardo Gómez-Castañeda, BSc, MRes, Helen Wheadon, PhD, Mhairi Copland, BSc (Hons) MB ChB PhD FRCP FRCPath
Journal: Blood
Blood (2016) 128 (22): 4231.
https://doi.org/10.1182/blood.V128.22.4231.4231
Published: 2016
Journal Articles

Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML)

Gillian A. Horne, BSc hons, MBChB, MRCP, MRes, Heather Morrison, BSc hons, Victoria Campbell, BSc hons, MBBS, MRCP, FRCPath, Ross Kinstrie, PhD BSc, Jennifer Cassels, BSc hons, Alan Hair, BSc, PhD, David Vetrie, BSc, PhD, Helen Wheadon, PhD, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Mhairi Copland, BSc (Hons) MB ChB PhDFRCP FRCPath
Journal: Blood
Blood (2016) 128 (22): 3057.
https://doi.org/10.1182/blood.V128.22.3057.3057
Published: 2016
Journal Articles

The Bone Marrow Niche Distinguishes Young and Old Leukemia

Shahzya S Chaudhury, MBBChir, MA (cantab), Helen Wheadon, PhD, Brenda Gibson, MD PhD, Karen Keeshan, PhD
Journal: Blood
Blood (2016) 128 (22): 1548.
https://doi.org/10.1182/blood.V128.22.1548.1548
Published: 2016
Journal Articles

Unravelling the Complexities of Hedgehog Mediated Signal Transduction in Acute Myeloid Leukaemia and Normal Haematopoiesis

Victoria Campbell, BSc hons, MBBS, MRCP, FRCPath, Anuradha Tarafdar, PhD, Edwina Dobbin, PhD, Gillian A. Horne, BSc hons, MBChB, MRCP, MRes, Laura Park, PhD, Colin Nixon, John R. Goodlad, MD FRCPath, Helen Wheadon, PhD, Mhairi Copland, PhD BSc, MB, ChB, MRCP, FRCPath
Journal: Blood
Blood (2016) 128 (22): 2881.
https://doi.org/10.1182/blood.V128.22.2881.2881
Published: 2016
Journal Articles

Characterizing the Inflammasome in Polycythemia Vera

Susan C Rhodes, MBChB, Rafaella Gavriilidou, Mark W. Drummond, PhDMD, Mhairi Copland, BSc (Hons) MB ChB PhDFRCP FRCPath, Helen Wheadon
Journal: Blood
Blood (2015) 126 (23): 2827.
https://doi.org/10.1182/blood.V126.23.2827.2827
Published: 2015
Journal Articles

Investigating the Efficacy of Ofatumumab and Rituximab in Abrogating the Survival of NOTCH1 Mutated Chronic Lymphocytic Leukaemic (CLL) Cells

Odette Middleton, Alison McCaig, Mike Leach, Alison Michie, Helen Wheadon
Journal: Blood
Blood (2014) 124 (21): 3289.
https://doi.org/10.1182/blood.V124.21.3289.3289
Published: 2014
Journal Articles

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34 + cells in vitro and in vivo

Paolo Gallipoli, Amy Cook, Susan Rhodes, Lisa Hopcroft, Helen Wheadon, Anthony D. Whetton, Heather G. Jørgensen, Ravi Bhatia, Tessa L. Holyoake
Journal: Blood
Blood (2014) 124 (9): 1492–1501.
https://doi.org/10.1182/blood-2013-12-545640
Published: 2014
Includes: Supplemental data
Journal Articles

The coupling of TEL/PDGFβR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases

Helen Wheadon, Melanie J. Welham
Journal: Blood
Blood (2003) 102 (4): 1480–1489.
https://doi.org/10.1182/blood-2002-09-2974
Published: 2003