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Journal Articles

Synergistic Leukaemia Cell Death Induced with PARP and TiP60 Inhibitors Is a Prospective Therapeutic Strategy for AML

Tae Ju Park, Laura Monaghan, Mhairi Copland, Xu Huang, Helen Wheadon, Heather G Jørgensen
Journal: Blood
Blood (2022) 140 (Supplement 1): 13001–13002.
https://doi.org/10.1182/blood-2022-166103
Published: 2022
Journal Articles

NFATC2 regulates Targets of MYC Signaling in MLL-AF9 AML

Shaun David Patterson, Matthew E Massett, Helen Wheadon, Xu Huang, Heather G Jørgensen, Alison M Michie
Journal: Blood
Blood (2021) 138 (Supplement 1): 3301.
https://doi.org/10.1182/blood-2021-151388
Published: 2021
Journal Articles

A Synthetic Lethal Approach to Eradicate AML Via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors

Sha Li, Anne-Louise Latif, Ashley Newcombe, Kathryn Gilrory, Neil Robertson, Xue Lei, Darren Finlay, PhD, Karina Barbosa, BSc, Helen Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi Delori, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-Ichi Sakamaki, Jennifer Morton, Kevin Ryan, Stephen Tait, Sheela Abraham, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Brian Higgins, Xu Huang, BSc, PhD, Karen Blyth, Mhairi Copland, PhD MBBChir, FRCP, FRCPath, Timothy Chevassut, Aniruddha J. Deshpande, PhD, Karen Keeshan, Peter Adams, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-143079
Published: 2020
Journal Articles

Efficient Elimination of Acute Myeloid Leukemia Cells through Inhibition of KDM4A in Combination with PARP Inhibition

Laura Monaghan, BSc, Matthew Edward Massett, MSc, BSc, Roderick P Bunschoten, BSc, Petrisor Alin Pirvan, MSc, BSc, Alex Hoose, Bsc, PhD, Taeju Park, BSc, Joana Bittencourt-Silvestre, BSc, MSc, Robert M J Liskamp, BSc, PhD, Heather G Jørgensen, Xu Huang, BSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3756.
https://doi.org/10.1182/blood-2019-125355
Published: 2019
Journal Articles

The Histone Demethylase KDM4A Is Required to Sustain H3K9me3/H3K27me3 Epigenetic States and Oncogenesis in MLL-AF9 Acute Myeloid Leukemia

Matthew E Massett, BSc, Niamh Mannion, BSc,PhD, Laura Monaghan, BSc, Joana Bittencourt-Silvestre, BSc, MSc, Sandra Marmiroli, BSc,PhD, Robert M J Liskamp, BSc, PhD, Alison M Michie, BSc, PhD, David Vetrie, BSc, PhD, Xu Huang, BSc, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3879.
https://doi.org/10.1182/blood-2018-99-111256
Published: 2018
Journal Articles

BET Inhibitors Potentiate Activation of p53 and Killing of AML By MDM2 Inhibitors — a Candidate Combination Therapy

Peter D Adams, Anne Louise Latif, Ashley Newcombe, Neil Robertson, Maria Terradas, Helen Stewart, Claire Reid, Loveena Rishi Delori, Timothy Chevassut, Xu Huang, BSc, PhD, Karen Keeshan, Karen Blyth, Mhairi Copland
Journal: Blood
Blood (2018) 132 (Supplement 1): 3912.
https://doi.org/10.1182/blood-2018-99-115509
Published: 2018
Journal Articles

Pharmacological Inhibitors of LSD1 Promote Differentiation of Myeloid Leukemia Cells through a Mechanism Independent of Histone Demethylation

James T Lynch, PhD, Gary J Spencer, PhD, William J Harris, PhD, Alba Maiques-Díaz, PhD, Filippo Ciceri, PhD, Xu Huang, PhD, Tim C P Somervaille, PhD FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 267.
https://doi.org/10.1182/blood.V124.21.267.267
Published: 2014
Journal Articles

FOXC1 Is Derepressed to Functional Effect in Human Acute Myeloid Leukemia

Tim D D Somerville, BSc, Xu Huang, PhD, James T Lynch, PhD, Gary J Spencer, PhD, Tim C P Somervaille, PhD FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 889.
https://doi.org/10.1182/blood.V124.21.889.889
Published: 2014
Journal Articles

Clinical Implications Of Severe Isolated Hepatic Gvhd Post-DLI

Ting Yang, M.D., Ph.D., Xu Huang, M.D., Xiaofeng Luo, M.D., Xiaohong Yuan, M.D., Danhui Fu, Zhizhe Chen, Prof., Jianda Hu, MD
Journal: Blood
Blood (2013) 122 (21): 5481.
https://doi.org/10.1182/blood.V122.21.5481.5481
Published: 2013
Journal Articles

Enhancers of Polycomb EPC1 and EPC2 Prevent Accumulation of MYC to Sustain the Oncogenic Potential of MLL Leukemia Stem Cells

Xu Huang, PhD, Tim Somervaille, PhD MRCP FRCPath
Journal: Blood
Blood (2012) 120 (21): 400.
https://doi.org/10.1182/blood.V120.21.400.400
Published: 2012
Journal Articles

Pharmacological Inhibition or Genetic Knockdown of Kdm1a (Lsd1 or Aof2) Induces Differentiation of MLL Acute Myeloid Leukaemia Stem Cells

William J Harris, BSc, Xu Huang, PhD, James T Lynch, PhD, Tim Somervaille, PhD MRCP FRCPath
Journal: Blood
Blood (2011) 118 (21): 58.
https://doi.org/10.1182/blood.V118.21.58.58
Published: 2011