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Brian Higgins
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Journal Articles

Quantitative Analysis of Bone Marrow Features Highlights Heterogeneity in Myelofibrosis Patients Treated with Zinpentraxin Alfa in a Phase II Clinical Study

Hosuk Ryou, Korsuk Sirinukunwattana, Ruby Wood, Alan Aberdeen, Jens Rittscher, Olga Weinberg, Robert Hasserjian, Olga Pozdnyakova, Frank Peale, Brian Higgins, Pontus Lundberg, Kerstin Trunzer, Claire N Harrison, Daniel Royston
Journal: Blood
Blood (2023) 142 (Supplement 1): 4558.
https://doi.org/10.1182/blood-2023-181784
Published: 2023
Journal Articles

Clinico-Genomic Characterization of AML Patients Based on IL2RA (CD25) Expression Uncovers an Association with Stem Cell Signatures and FLT3-ITD Status and Informs Drug Combinations

Habib Hamidi, Diana Dunshee, Brian Higgins, Monique Dail, Michael Boyiadzis
Journal: Blood
Blood (2023) 142 (Supplement 1): 4329.
https://doi.org/10.1182/blood-2023-181236
Published: 2023
Journal Articles

Zinpentraxin Alfa Reduces Myelofibrosis in a JAK2 -V617F Mouse Model of Myeloproliferative Neoplasms

Shivam Rai, Hui Hao-Shen, Stefan Dirnhofer, Julien Roux, Rajbharan Yadav, Anamarija Pfeiffer, Jakob Vowinckel, Audrey Arjomandi, Brian Higgins, Lyrialle Han, Kerstin Trunzer, Pontus Lundberg, Radek C. Skoda
Journal: Blood
Blood (2023) 142 (Supplement 1): 1787.
https://doi.org/10.1182/blood-2023-186631
Published: 2023
Journal Articles

Uncoupling p53 from an Embryonic Regulome Exhausts Quiescent CML Stem Cells through Inhibition of a HIF1alpha Molecular Program

Mary T Scott, Wei Liu, Rebecca Mitchell, Cassie Clarke, Hassan Almasoudi, Felix Warren, Ross Kinstrie, Karen Dunn, John Pritchard, Mark E Drotar, Alison M Michie, Heather G Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie
Journal: Blood
Blood (2021) 138 (Supplement 1): 1541.
https://doi.org/10.1182/blood-2021-150372
Published: 2021
Journal Articles

Molecular Response Patterns in Hydroxyurea (HU)-Resistant or Intolerant Polycythemia Vera (PV) during Treatment with Idasanutlin: Results of an Open-Label, Single-Arm Phase 2 Study

Francesco Passamonti, Kate Burbury, MBBS, FRACP, FRCPA, DPhil, Tarec Christoffer El-Galaly, Aaron T. Gerds, MDMS, Vikas Gupta, MD FRCP, FRCPath, Brian Higgins, Ling-Yuh Huw, PhD, Margherita Maffioli, MD, Ruben Mesa, MD, Jeanne M. Palmer, MD, Alessandro Rambaldi, MD, David M Ross, MBBS, PhD FRACP, FRCPA, Alessandro M. Vannucchi, MD, Abdulraheem Yacoub, MD, John Mascarenhas, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–40.
https://doi.org/10.1182/blood-2020-136135
Published: 2020
Journal Articles

Safety and Efficacy of Idasanutlin in Patients (pts) with Hydroxyurea (HU)-Resistant/Intolerant Polycythemia Vera (PV): Results of an International Phase II Study

John Mascarenhas, MD, Brian Higgins, Doreen Anders, Kate Burbury, MD, Tarec Christoffer El-Galaly, Aaron T. Gerds, MDMS, Vikas Gupta, MD FRCP, FRCPath, Bruno Kovic, Margherita Maffioli, MD, Ruben Mesa, MD, Jeanne M. Palmer, MD, Francesco Passamonti, MD, Alessandro Rambaldi, MD, David M Ross, MBBS, PhD FRACP, FRCPA, Alessandro M. Vannucchi, MD, Abdulraheem Yacoub, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–31.
https://doi.org/10.1182/blood-2020-135868
Published: 2020
Journal Articles

A Synthetic Lethal Approach to Eradicate AML Via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors

Sha Li, Anne-Louise Latif, Ashley Newcombe, Kathryn Gilrory, Neil Robertson, Xue Lei, Darren Finlay, PhD, Karina Barbosa, BSc, Helen Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi Delori, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-Ichi Sakamaki, Jennifer Morton, Kevin Ryan, Stephen Tait, Sheela Abraham, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Brian Higgins, Xu Huang, BSc, PhD, Karen Blyth, Mhairi Copland, PhD MBBChir, FRCP, FRCPath, Timothy Chevassut, Aniruddha J. Deshpande, PhD, Karen Keeshan, Peter Adams, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-143079
Published: 2020
Journal Articles

Phase 1/1b Study of RG7388, a Potent MDM2 Antagonist, in Acute Myelogenous Leukemia (AML) Patients (Pts)

Karen Yee, MD, Giovanni Martinelli, MD, Norbert Vey, MDPhD, Michael J. Dickinson, MBBS, FRACP, FRCPA, Karen Seiter, MD, Sarit Assouline, MD MSc, Mark Drummond, MD PhD, Sung-Soo Yoon, MDPhD, Margaret Kasner, MD, Je-Hwan Lee, MD PhD, Kevin R. Kelly, MD PhD, Steven Blotner, PhD, Brian Higgins, Steven Middleton, PhD, Gwen Nichols, MD, Gong Chen, PhD, Hua Zhong, PhD, William E. Pierceall, PhD, Jianguo Zhi, PhD, Lin-Chi Chen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 116.
https://doi.org/10.1182/blood.V124.21.116.116
Published: 2014