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Journal Articles

Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models

Lilley Leong, Derek Sim, Chandra Patel, Katherine Tran, Perry Liu, Elena Ho, Thomas Thompson, Peter J. Kretschmer, Hironao Wakabayashi, Philip J. Fay, John E. Murphy

Blood (2015) 125 (2): 392–398.

https://doi.org/10.1182/blood-2014-02-555656

Published: 2015

Includes: Supplemental data

Journal Articles

Stabilizing Factor VIIIa By Combining Mutations That Modulate Inter-Subunit Interactions and Proteolytic Inactivation

Hironao Wakabayashi, MD, PhD, Jennifer Wintermute, Philip J. Fay, PhD

Blood (2013) 122 (21): 3572.

https://doi.org/10.1182/blood.V122.21.3572.3572

Published: 2013

Journal Articles

A Coagulation Mechanism for the Mild Bleeding Tendency in a Patient with Severe Hemophilia A Possessing an Arg1781His Mutation.

Koji Yada, MD, Keiji Nogami, MD, PhD, Kenichi Ogiwara, MD, PhD, Hironao Wakabayashi, MD, PhD, Philip J. Fay, PhD, Midori Shima, MD, PhD

Blood (2012) 120 (21): 2213.

https://doi.org/10.1182/blood.V120.21.2213.2213

Published: 2012

Journal Articles

Increasing Hydrophobicity and Disulfide Bridging Between A1 and C2 Subunits Improves Factor VIII Stability.

Hironao Wakabayashi, MD, PhD, Amy E Griffiths, MS, Philip Fay, PhD

Blood (2009) 114 (22): 3176.

https://doi.org/10.1182/blood.V114.22.3176.3176

Published: 2009

Journal Articles

Enhancement of Factor VIII Stability by Replacing Multiple Charged Residues at the A2 Domain Interface

Hironao Wakabayashi, MD, PhD, Amy E Griffiths, MS, Philip Fay, PhD

Blood (2008) 112 (11): 1016.

https://doi.org/10.1182/blood.V112.11.1016.1016

Published: 2008

Journal Articles

Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface

Hironao Wakabayashi, Fatbardha Varfaj, Jennifer DeAngelis, Philip J. Fay

Blood (2008) 112 (7): 2761–2769.

https://doi.org/10.1182/blood-2008-02-142158

Published: 2008

Journal Articles

Localization of Factor VIII Residues Contributing to Factor VIII and/or VIIIa Structural Stability as Detected by Rates of Activity Decay.

Hironao Wakabayashi, MD, PhD, Philip J. Fay, PhD

Blood (2007) 110 (11): 1763.

https://doi.org/10.1182/blood.V110.11.1763.1763

Published: 2007

Journal Articles

P2 and P2′ Residues Are Important for the Efficient Proteolysis of Factor VIIIa at Arg336 Catalyzed by Activated Protein C.

Fatbardha Varfaj, Ph.D., Jennifer DeAngelis, BS, Hironao Wakabayashi, Ph.D., Philip J. Fay, Ph.D.

Blood (2007) 110 (11): 2689.

https://doi.org/10.1182/blood.V110.11.2689.2689

Published: 2007

Journal Articles

The Mutation Leu335Pro in Factor VIII Results in Its Rapid Inactivation by Thrombin-Catalyzed Proteolysis at Arg336.

Fatbardha Varfaj, Ph.D., Hironao Wakabayashi, Ph.D., Philip J. Fay, PhD

Blood (2007) 110 (11): 2690.

https://doi.org/10.1182/blood.V110.11.2690.2690

Published: 2007

Journal Articles

A3 Domain Residue Glu1829 Contributes to A2 Subunit Retention in Factor VIIIa.

Hironao Wakabayashi, PhD, Qian Zhou, M. S., Fatbardha Varfaj, M. S., Philip J. Fay, Ph.D.

Blood (2006) 108 (11): 1690.

https://doi.org/10.1182/blood.V108.11.1690.1690

Published: 2006

Journal Articles

Contribution of P4-P3′ Residues Surrounding P1 Residues Arg336 and Arg562 in the Activated Protein C-Catalyzed Inactivation of Factor VIIIa.

Fatbardha Varfaj, MS, Hironao Wakabayashi, Ph.D., Philip J. Fay, Ph.D.

Blood (2006) 108 (11): 1693.

https://doi.org/10.1182/blood.V108.11.1693.1693

Published: 2006

Journal Articles

pH-Dependent Association of Factor VIII Chains: Enhancement of Affinity at Physiological pH by Cu 2+ .

Hironao Wakabayashi, MD, PhD, Qian Zhou, MS, Keiji Nogami, MD, Charles Ansong, MS, Fatbardha Varfaj, MS, Stephen Miles, PhD, Philip J. Fay, PhD

Blood (2005) 106 (11): 1015.

https://doi.org/10.1182/blood.V106.11.1015.1015

Published: 2005

Journal Articles

Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P 1 site

Keiji Nogami, Qian Zhou, Hironao Wakabayashi, Philip J. Fay

Blood (2005) 105 (11): 4362–4368.

https://doi.org/10.1182/blood-2004-10-3939

Published: 2005

Journal Articles

Exosite Interactions Contribute to the Activated Protein C-Catalyzed Inactivation of Factor VIIIa.

Fatbardha Varfaj, Julie Neuberg, Hironao Wakabayashi, Ph.D., Philip J. Fay, Ph. D.

Blood (2004) 104 (11): 1739.

https://doi.org/10.1182/blood.V104.11.1739.1739

Published: 2004

Journal Articles

Effects of Single Point Mutations within Proposed Copper Binding Sites on Specific Activity and Inter-Chain Affinity of Factor VIII.

Hironao Wakabayashi, Ph.D., Qian Zhou, M.S., Keiji Nogami, M.D./Ph. D., Philip J. Fay, Ph. D.

Blood (2004) 104 (11): 1730.

https://doi.org/10.1182/blood.V104.11.1730.1730

Published: 2004

Journal Articles

Mechanism of Interaction between the Heavy Chain of Factor VIII and Thrombin.

Keiji Nogami, M.D./Ph. D., Qian Zhou, Hironao Wakabayashi, Ph.D., Timothy Myles, Ph.D., Lawrence L. Leung, M. D., Philip J. Fay, Ph. D.

Blood (2004) 104 (11): 1711.

https://doi.org/10.1182/blood.V104.11.1711.1711

Published: 2004

Journal Articles

Factor VIII:E113A Represents a High Specific Activity Factor VIII Arising from a Single Point Mutation within a Ca 2+ Binding Site.

Hironao Wakabayashi, Ph.D., Philip J. Fay, Ph. D.

Blood (2004) 104 (11): 1725.

https://doi.org/10.1182/blood.V104.11.1725.1725

Published: 2004

NARROW

Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models

Stabilizing Factor VIIIa By Combining Mutations That Modulate Inter-Subunit Interactions and Proteolytic Inactivation

A Coagulation Mechanism for the Mild Bleeding Tendency in a Patient with Severe Hemophilia A Possessing an Arg1781His Mutation.

Increasing Hydrophobicity and Disulfide Bridging Between A1 and C2 Subunits Improves Factor VIII Stability.

Enhancement of Factor VIII Stability by Replacing Multiple Charged Residues at the A2 Domain Interface

Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface

Localization of Factor VIII Residues Contributing to Factor VIII and/or VIIIa Structural Stability as Detected by Rates of Activity Decay.

P2 and P2′ Residues Are Important for the Efficient Proteolysis of Factor VIIIa at Arg336 Catalyzed by Activated Protein C.

The Mutation Leu335Pro in Factor VIII Results in Its Rapid Inactivation by Thrombin-Catalyzed Proteolysis at Arg336.

A3 Domain Residue Glu1829 Contributes to A2 Subunit Retention in Factor VIIIa.

Contribution of P4-P3′ Residues Surrounding P1 Residues Arg336 and Arg562 in the Activated Protein C-Catalyzed Inactivation of Factor VIIIa.

pH-Dependent Association of Factor VIII Chains: Enhancement of Affinity at Physiological pH by Cu 2+ .

Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P 1 site

Exosite Interactions Contribute to the Activated Protein C-Catalyzed Inactivation of Factor VIIIa.

Effects of Single Point Mutations within Proposed Copper Binding Sites on Specific Activity and Inter-Chain Affinity of Factor VIII.

Mechanism of Interaction between the Heavy Chain of Factor VIII and Thrombin.

Factor VIII:E113A Represents a High Specific Activity Factor VIII Arising from a Single Point Mutation within a Ca 2+ Binding Site.

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American Society of Hematology

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