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Journal Articles

Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

João Arezes, Niall Foy, Kirsty McHugh, Doris Quinkert, Susan Benard, Anagha Sawant, Joe N. Frost, Andrew E. Armitage, Sant-Rayn Pasricha, Pei Jin Lim, May S. Tam, Edward Lavallie, Debra D. Pittman, Orla Cunningham, Matthew Lambert, John E. Murphy, Simon J. Draper, Reema Jasuja, Hal Drakesmith

Blood (2020) 135 (8): 547–557.

https://doi.org/10.1182/blood.2019003140

Published: 2020

Includes: Supplemental data

Journal Articles

Antibodies Against the Erythroferrone N-Terminal Domain Prevent Hepcidin Suppression and Ameliorate Murine Thalassemia

Blood (2019) 134 (Supplement_1): 964.

https://doi.org/10.1182/blood-2019-130246

Published: 2019

Journal Articles

Adeno-Associated Virus Mediated Delivery of a TFPI Antibody Restores Hemostasis in Mouse Model of Hemophilia

Swapnil Rakhe, MS, Reema Jasuja, PhD, Rajani Shelke, Anagha Sawant, Suryanarayan Somanathan, PhD, John E. Murphy, PhD, Debra D Pittman, MS

Blood (2019) 134 (Supplement_1): 3357.

https://doi.org/10.1182/blood-2019-130054

Published: 2019

Journal Articles

Efficacy and Safety in 15 Hemophilia B Patients Treated with the AAV Gene Therapy Vector Fidanacogene Elaparvovec and Followed for at Least 1 Year

Lindsey A. George, MD, Spencer K. Sullivan, MD, John E.J. Rasko, MBBS, PhD, Adam Giermasz, MD PhD, Benjamin J. Samelson-Jones, MD PhD, Jonathan M. Ducore, MD MPH, Jerome M. Teitel, MD FRCPC, Catherine E. McGuinn, MD, Alexa R. Runowski, MS, Fraser Wright, PhD, Xavier M. Anguela, PhD, Katherine A. High, MD, Denis Rybin, PhD, John E. Murphy, PhD, Jeremy Rupon, MD

Blood (2019) 134 (Supplement_1): 3347.

https://doi.org/10.1182/blood-2019-124091

Published: 2019

Journal Articles

Efficacy of Anti-TFPI Antibody PF-06741086 Alone and in Combination with Activated Prothrombin Complex Concentrates in Mouse Hemophilia a Bleeding Model

Amey Barakat, Reema Jasuja, PhD, John E. Murphy, PhD, Debra D Pittman, MS

Blood (2018) 132 (Supplement 1): 2460.

https://doi.org/10.1182/blood-2018-99-118431

Published: 2018

Journal Articles

The Tissue Factor Pathway Inhibitor Antibody, PF-06741086, Increases Thrombin Generation in Rare Bleeding Disorder and Von Willebrand Factor Deficient Plasmas

Swapnil Rakhe, MS, Sunita R. Patel-Hett, PhD, Sheryl Bowley, PhD, John E. Murphy, PhD, Debra D Pittman, MS

Blood (2018) 132 (Supplement 1): 2462.

https://doi.org/10.1182/blood-2018-99-119674

Published: 2018

Journal Articles

A Neutralizing Monoclonal Antibody (PF-06741086) Against Tissue Factor Pathway Inhibitor in Combination with Activated Prothrombin Complex Concentrate Increases Hemostasis in Inhibitor Hemophilia Plasmas without Excessive Thrombin Generation

Swapnil Rakhe, MS, Sheryl Bowley, PhD, John E. Murphy, PhD, Debra D Pittman, MS

Blood (2018) 132 (Supplement 1): 3779.

https://doi.org/10.1182/blood-2018-99-119831

Published: 2018

Journal Articles

Rivipansel: A Small Pan-Selectin Antagonist Improves Cerebral Perfusion and Inhibits Leukocyte Adhesion and in Murine Sickle Cell Disease Model

Reema Jasuja, Georgette Suidan, Sunita Patel Hett, Kunal Desai, Kevin X Le, Elizabeth Parks, Robert Bell, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 270.

https://doi.org/10.1182/blood.V128.22.270.270

Published: 2016

Journal Articles

Chronic Administration of the PDE9 Inhibitor PF-04447943 Reduces Leukocyte-Platelet Aggregates and Markers of Endothelial Activation in a Mouse Model of Sickle Cell Disease

Reema Jasuja, Elizabeth Parks, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 1293.

https://doi.org/10.1182/blood.V128.22.1293.1293

Published: 2016

Journal Articles

An Antibody to Tissue Factor Pathway Inhibitor (PF-06741086) in Combination with Recombinant Factor VIIa Increases Hemostasis in Hemophilia Plasma without Excessive Thrombin Generation

Swapnil Rakhe, Sunita Patel Hett, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 2566.

https://doi.org/10.1182/blood.V128.22.2566.2566

Published: 2016

Journal Articles

An Antibody to Tissue Factor Pathway Inhibitor (TFPI) Restores Hemostasis after the Onset of Bleeding in Hemophilic a Mouse Injury Models

Reema Jasuja, Amey Barakat, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 3761.

https://doi.org/10.1182/blood.V128.22.3761.3761

Published: 2016

Journal Articles

Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models

Lilley Leong, Derek Sim, Chandra Patel, Katherine Tran, Perry Liu, Elena Ho, Thomas Thompson, Peter J. Kretschmer, Hironao Wakabayashi, Philip J. Fay, John E. Murphy

Blood (2015) 125 (2): 392–398.

https://doi.org/10.1182/blood-2014-02-555656

Published: 2015

Includes: Supplemental data

Journal Articles

Glycopegylated Factor IX Enables Prolonged Efficacy After Subcutaneous Injection But Requires a Higher Than Expected Plasma Activity To Prevent Bleeding In Hemophilia B Mice

Derek S Sim, Alan Brooks, Cornell Mallari, Yifan Xu, Rick I Feldman, Doug Schneider, Chandra Patel, Eric Blasko, Elena Ho, Yan Su, Bing Liu, Volker Laux, John E Murphy

Blood (2013) 122 (21): 1104.

https://doi.org/10.1182/blood.V122.21.1104.1104

Published: 2013

Journal Articles

Waveform Analysis Extends the Capabilities of aPTT and PT Clotting Assays for Detecting Factor Deficiency and Monitoring Procoagulant Drug Therapy

Lilley Leong, PhD, MS, Xiaoqiao Jiang, BS, Jill Cifrese, MS, John E. Murphy, PhD, Jesper Haaning, PhD, Timothy Myles, PhD

Blood (2011) 118 (21): 1205.

https://doi.org/10.1182/blood.V118.21.1205.1205

Published: 2011

Journal Articles

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment

Baisong Mei, Clark Pan, Haiyan Jiang, Hendri Tjandra, Jonathan Strauss, Yaoqi Chen, Tongyao Liu, Xin Zhang, Joanne Severs, Jim Newgren, Jianmin Chen, Jian-Ming Gu, Babu Subramanyam, Michael A. Fournel, Glenn F. Pierce, John E. Murphy

Blood (2010) 116 (2): 270–279.

https://doi.org/10.1182/blood-2009-11-254755

Published: 2010

Journal Articles

Site-Specific PEGylation of Factor VIII (PEG-FVIII) Preserves Full Clotting Activity and Extends Therapeutic Efficacy in HemophiliaA Dogs

Tongyao Liu, David Lillicrap, Xin Zhang, Andrea Labelle, Sandra Powell, Baisong Mei, John E. Murphy, Glenn F. Pierce, Haiyan Jiang

Blood (2008) 112 (11): 511.

https://doi.org/10.1182/blood.V112.11.511.511

Published: 2008

Journal Articles

Towards a New Therapy for Hemophilia A: Evaluation of Multiple Approaches To Prolong the In Vivo Efficacy of Recombinant Factor VIII.

John E. Murphy, Clark Pan, Baisong Mei, Jonathan Strauss, Hendri Tjandra, Liang Tang, Pamela Esmon, James Newgren, Gary Jesmok, Kyle Landskroner, Mohan Parmathi, Klaus-Peter Radtke, Joanne Severs, John Teare, Haiyan Jiang, Michael Fournel

Blood (2006) 108 (11): 1606.

https://doi.org/10.1182/blood.V108.11.1606.1606

Published: 2006

Journal Articles

PEGylation of Factor VIII Reduces the Inhibitory Effects of Human Antibody Inhibitors on the Factor VIII Molecule.

Liang Tang, Clark Pan, Harpartap Atwal, Jennifer Nixon, Thomas Barnett, John E. Murphy, Baisong Mei, Michael Fournel

Blood (2006) 108 (11): 4017.

https://doi.org/10.1182/blood.V108.11.4017.4017

Published: 2006

NARROW

Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

Antibodies Against the Erythroferrone N-Terminal Domain Prevent Hepcidin Suppression and Ameliorate Murine Thalassemia

Adeno-Associated Virus Mediated Delivery of a TFPI Antibody Restores Hemostasis in Mouse Model of Hemophilia

Efficacy and Safety in 15 Hemophilia B Patients Treated with the AAV Gene Therapy Vector Fidanacogene Elaparvovec and Followed for at Least 1 Year

Efficacy of Anti-TFPI Antibody PF-06741086 Alone and in Combination with Activated Prothrombin Complex Concentrates in Mouse Hemophilia a Bleeding Model

The Tissue Factor Pathway Inhibitor Antibody, PF-06741086, Increases Thrombin Generation in Rare Bleeding Disorder and Von Willebrand Factor Deficient Plasmas

A Neutralizing Monoclonal Antibody (PF-06741086) Against Tissue Factor Pathway Inhibitor in Combination with Activated Prothrombin Complex Concentrate Increases Hemostasis in Inhibitor Hemophilia Plasmas without Excessive Thrombin Generation

Rivipansel: A Small Pan-Selectin Antagonist Improves Cerebral Perfusion and Inhibits Leukocyte Adhesion and in Murine Sickle Cell Disease Model

Chronic Administration of the PDE9 Inhibitor PF-04447943 Reduces Leukocyte-Platelet Aggregates and Markers of Endothelial Activation in a Mouse Model of Sickle Cell Disease

An Antibody to Tissue Factor Pathway Inhibitor (PF-06741086) in Combination with Recombinant Factor VIIa Increases Hemostasis in Hemophilia Plasma without Excessive Thrombin Generation

An Antibody to Tissue Factor Pathway Inhibitor (TFPI) Restores Hemostasis after the Onset of Bleeding in Hemophilic a Mouse Injury Models

Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models

Glycopegylated Factor IX Enables Prolonged Efficacy After Subcutaneous Injection But Requires a Higher Than Expected Plasma Activity To Prevent Bleeding In Hemophilia B Mice

Waveform Analysis Extends the Capabilities of aPTT and PT Clotting Assays for Detecting Factor Deficiency and Monitoring Procoagulant Drug Therapy

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment

Site-Specific PEGylation of Factor VIII (PEG-FVIII) Preserves Full Clotting Activity and Extends Therapeutic Efficacy in HemophiliaA Dogs

Towards a New Therapy for Hemophilia A: Evaluation of Multiple Approaches To Prolong the In Vivo Efficacy of Recombinant Factor VIII.

PEGylation of Factor VIII Reduces the Inhibitory Effects of Human Antibody Inhibitors on the Factor VIII Molecule.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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