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Journal Articles

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3 + T regulatory cells

Hideto Matsui, Masaru Shibata, Brian Brown, Andrea Labelle, Carol Hegadorn, Chandler Andrews, Marinee Chuah, Thierry VandenDriessche, Carol H. Miao, Christine Hough, David Lillicrap

Blood (2009) 114 (3): 677–685.

https://doi.org/10.1182/blood-2009-03-202267

Published: 2009

Journal Articles

Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4 + CD25 + -dependent mechanism and by shifting cytokine production to favor a Th1 response

Braden Waters, Mohammad Qadura, Erin Burnett, Rouzbeh Chegeni, Andrea Labelle, Patrick Thompson, Christine Hough, David Lillicrap

Blood (2009) 113 (1): 193–203.

https://doi.org/10.1182/blood-2008-04-151597

Published: 2009

Includes: Supplemental data

Journal Articles

Recombinant Protein Infusion and Hydrodynamic Plasmid Delivery Strategies Provide Distinct and Complementary Approaches to the Characterization of Variant Forms of Von Willeband Factor (VWF) in VWF Knockout Mice.

Cynthia M. Pruss, BSc, Carol A. Hegadorn, Andrea Labelle, Erin Burnett, Mia Golder, David Lillicrap, MD

Blood (2008) 112 (11): 2020.

https://doi.org/10.1182/blood.V112.11.2020.2020

Published: 2008

Journal Articles

Site-Specific PEGylation of Factor VIII (PEG-FVIII) Preserves Full Clotting Activity and Extends Therapeutic Efficacy in HemophiliaA Dogs

Tongyao Liu, David Lillicrap, Xin Zhang, Andrea Labelle, Sandra Powell, Baisong Mei, John E. Murphy, Glenn F. Pierce, Haiyan Jiang

Blood (2008) 112 (11): 511.

https://doi.org/10.1182/blood.V112.11.511.511

Published: 2008

Journal Articles

Anti-CD3 Therapy Expands the CD4 + CD25 + Compartment in Hemophilia a Mice Inducing Tregs That Potently Prevent Factor VIII Inhibitor Formation

Braden Waters, B.Sc. H, Mohammad Qadura, B.Sc.H, Erin Burnett, Rouzbeh Chegeni, PhD, Andrea Labelle, Patrick Thompson, David Lillicrap, MD

Blood (2008) 112 (11): 241.

https://doi.org/10.1182/blood.V112.11.241.241

Published: 2008

Journal Articles

Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A

Srinivasa Prasad, David Lillicrap, Andrea Labelle, Sabine Knappe, Tracy Keller, Erin Burnett, Sandra Powell, Kirk W. Johnson

Blood (2008) 111 (2): 672–679.

https://doi.org/10.1182/blood-2007-07-098913

Published: 2008

Journal Articles

Long-Term Phenotypic Correction of Hemophilia A Mice Following Intravenous Injection of miRNA-Regulated Lentiviral Vectors.

Hideto Matsui, MD, PhD, Margareth Ozelo, MD/PhD, Carol Hegadorn, Andrea Labelle, Erin Burnett, Angie Tuttle, Brian Brown, PhD, Luigi Naldini, MD/PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2007) 110 (11): 2587.

https://doi.org/10.1182/blood.V110.11.2587.2587

Published: 2007

Journal Articles

Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance

Maha Othman, Andrea Labelle, Ian Mazzetti, Hisham S. Elbatarny, David Lillicrap

Blood (2006) 109 (7): 2832–2839.

https://doi.org/10.1182/blood-2006-06-032524

Published: 2006

Journal Articles

Ex Vivo Gene Trasfer for Hemophilia A That Enhances Safety and Results in Sustained In Vivo Factor VIII Expression from Lentivirally-Engineered Endothelial Progenitors.

Hideto Matsui, MD, PhD, Masaru Shibata, MD/PhD, Brian Brown, PhD, Andrea Labelle, Carol Hegadorn, Chandler Andrews, Robert P. Hebbel, MD, Jacques Galipeau, MD, Christine Hough, PhD, David Lillicrap, MD

Blood (2006) 108 (11): 3251.

https://doi.org/10.1182/blood.V108.11.3251.3251

Published: 2006

Journal Articles

Reduction in Factor VIII Inhibitors Mediated through Tolerogenic Antigen Presentation by immature Dendritic Cells.

Mohammad Qadura, BSc, Andrea Labelle, Kirsten Walker, Kathleen Pratt, PhD, Maha Othman, MD, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2006) 108 (11): 762.

https://doi.org/10.1182/blood.V108.11.762.762

Published: 2006

Journal Articles

The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

Paula D. James, Colleen Notley, Carol Hegadorn, Jayne Leggo, Angie Tuttle, Shawn Tinlin, Christine Brown, Chandler Andrews, Andrea Labelle, Yvette Chirinian, Lee O'Brien, Maha Othman, Georges Rivard, Dilys Rapson, Christine Hough, David Lillicrap, for the Association of Hemophilia Clinic Directors of Canada

Blood (2006) 109 (1): 145–154.

https://doi.org/10.1182/blood-2006-05-021105

Published: 2006

Journal Articles

Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs

Haiyan Jiang, David Lillicrap, Susannah Patarroyo-White, Tongyao Liu, Xiaobing Qian, Ciaran D. Scallan, Sandra Powell, Tracey Keller, Morag McMurray, Andrea Labelle, Dea Nagy, Joseph A. Vargas, Shangzhen Zhou, Linda B. Couto, Glenn F. Pierce

Blood (2006) 108 (1): 107–115.

https://doi.org/10.1182/blood-2005-12-5115

Published: 2006

Journal Articles

Dexamethasone Promotes Transgene Expression and Supresses the Early Immune /Inflammatory Response in Adenovirus- Mediated Gene Delivery to Hemophilic Mice.

Maha Othman, MD, PhD, Ian Mazzetti, Andrea Labelle, David Lillicrap, MD FRCPC

Blood (2005) 106 (11): 5534.

https://doi.org/10.1182/blood.V106.11.5534.5534

Published: 2005

Journal Articles

Adenovirus Induced Thrombocytopenia: The Role of P-Selectin and von Willebrand Factor in Virus- Mediated Platelet Clearance.

Maha Othman, MD, PhD, Andrea Labelle, Ian Mazzetti, David Lillicrap, MD FRCP

Blood (2005) 106 (11): 222.

https://doi.org/10.1182/blood.V106.11.222.222

Published: 2005

Journal Articles

Prevention of Anti-FVIII Inhibitor Formation Post Protein Infusion in Hemophilic Mice by Prior Feeding of the FVIII-C2 Domain.

Fiona Rawle, BSc, Andrea Labelle, RVT, Earl Davie, PhD, Kathleen Pratt, PhD, David Lillicrap, MD

Blood (2004) 104 (11): 39.

https://doi.org/10.1182/blood.V104.11.39.39

Published: 2004

NARROW

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3 + T regulatory cells

Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4 + CD25 + -dependent mechanism and by shifting cytokine production to favor a Th1 response

Recombinant Protein Infusion and Hydrodynamic Plasmid Delivery Strategies Provide Distinct and Complementary Approaches to the Characterization of Variant Forms of Von Willeband Factor (VWF) in VWF Knockout Mice.

Site-Specific PEGylation of Factor VIII (PEG-FVIII) Preserves Full Clotting Activity and Extends Therapeutic Efficacy in HemophiliaA Dogs

Anti-CD3 Therapy Expands the CD4 + CD25 + Compartment in Hemophilia a Mice Inducing Tregs That Potently Prevent Factor VIII Inhibitor Formation

Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A

Long-Term Phenotypic Correction of Hemophilia A Mice Following Intravenous Injection of miRNA-Regulated Lentiviral Vectors.

Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance

Ex Vivo Gene Trasfer for Hemophilia A That Enhances Safety and Results in Sustained In Vivo Factor VIII Expression from Lentivirally-Engineered Endothelial Progenitors.

Reduction in Factor VIII Inhibitors Mediated through Tolerogenic Antigen Presentation by immature Dendritic Cells.

The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs

Dexamethasone Promotes Transgene Expression and Supresses the Early Immune /Inflammatory Response in Adenovirus- Mediated Gene Delivery to Hemophilic Mice.

Adenovirus Induced Thrombocytopenia: The Role of P-Selectin and von Willebrand Factor in Virus- Mediated Platelet Clearance.

Prevention of Anti-FVIII Inhibitor Formation Post Protein Infusion in Hemophilic Mice by Prior Feeding of the FVIII-C2 Domain.

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American Society of Hematology

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American Society of Hematology

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