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Journal Articles

BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice

Blood (2020) 135 (17): 1484–1496.

https://doi.org/10.1182/blood.2019001292

Published: 2020

Includes: Supplemental data

Journal Articles

Liver-Directed Gene Therapy for Hemophilia B with Immune Stealth Lentiviral Vectors

Alessio Cantore, Michela Milani, Andrea Annoni, Tongyao Liu, Sara Bartolaccini, Mauro Biffi, Fabio Russo, Robert Peters, PhD, Angelo Lombardo, Timothy C. Nichols, MD, Eduard Ayuso, Luigi Naldini

Blood (2017) 130 (Supplement 1): 605.

https://doi.org/10.1182/blood.V130.Suppl_1.605.605

Published: 2017

Journal Articles

Evaluation of Enhanced in Vitro Plasma Stability of a Novel Long Acting Recombinant FVIIIFc-VWF-XTEN Fusion Protein

Ekta Seth Chhabra, PhD, Nancy Moore, Chris Furcht, Amy M Holthaus, BS, MS, Jiayun Liu, MS, Tongyao Liu, Volker Schellenberger, PhD, John Kulman, PhD, Joe Salas, PhD, Robert Peters, PhD

Blood (2015) 126 (23): 2279.

https://doi.org/10.1182/blood.V126.23.2279.2279

Published: 2015

Journal Articles

Recombinant FVIIIFc-VWF-XTEN Demonstrates Significant Bioavailability Following Subcutaneous Administration in Hemophilia A Mice

Douglas Drager, Sue Patarroyo-White, Hoson Chao, Ayman Ismail, PhD, Jiayun Liu, Amy M Holthaus, BS, MS, Ekta Chhabra, John Kulman, PhD, Volker Schellenberger, PhD, Tongyao Liu, Robert Peters, PhD

Blood (2015) 126 (23): 3492.

https://doi.org/10.1182/blood.V126.23.3492.3492

Published: 2015

Journal Articles

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Jennifer A. Dumont, Tongyao Liu, Susan C. Low, Xin Zhang, George Kamphaus, Paul Sakorafas, Cara Fraley, Douglas Drager, Thomas Reidy, Justin McCue, Helen W. G. Franck, Elizabeth P. Merricks, Timothy C. Nichols, Alan J. Bitonti, Glenn F. Pierce, Haiyan Jiang

Blood (2012) 119 (13): 3024–3030.

https://doi.org/10.1182/blood-2011-08-367813

Published: 2012

Includes: Supplemental data

Journal Articles

A Novel Single Chain Recombinant Factor VIII Fc Fusion Protein Is Active In Vitro and Fully Efficacious in An In Vivo Hema Mouse Bleeding Model

Yang Buyue, PhD, Tongyao Liu, Thomas Reidy, Susannah Patarroyo-White, George D Kamphaus, PhD, Mark Slein, BS, Glenn F Pierce, M.D., PhD, Jurg M Sommer, PhD, Robert Peters, PhD

Blood (2011) 118 (21): 1192.

https://doi.org/10.1182/blood.V118.21.1192.1192

Published: 2011

Journal Articles

A Standardized Rotation Thromboelastometry (ROTEM) Method for Evaluation of FVIII and FIX Products in a Multi-National Clinical Trial

Frank Driessler, PhD, Xiaolei Li, PhD, Tongyao Liu, Xin Zhang, M.D., Haiyan Jiang, PhD, Alvin Luk, PhD, Glenn F Pierce, M.D., PhD, Jurg M Sommer, PhD

Blood (2011) 118 (21): 1199.

https://doi.org/10.1182/blood.V118.21.1199.1199

Published: 2011

Journal Articles

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment

Baisong Mei, Clark Pan, Haiyan Jiang, Hendri Tjandra, Jonathan Strauss, Yaoqi Chen, Tongyao Liu, Xin Zhang, Joanne Severs, Jim Newgren, Jianmin Chen, Jian-Ming Gu, Babu Subramanyam, Michael A. Fournel, Glenn F. Pierce, John E. Murphy

Blood (2010) 116 (2): 270–279.

https://doi.org/10.1182/blood-2009-11-254755

Published: 2010

Journal Articles

Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice

Junliang Pan, Tongyao Liu, Ji-Yun Kim, Daguang Zhu, Chandra Patel, Zhi-Hua Cui, Xin Zhang, James O. Newgren, Aaron Reames, Dodie Canivel, Gary Jesmok, Glenn F. Pierce, Jurg M. Sommer, Haiyan Jiang

Blood (2009) 114 (13): 2802–2811.

https://doi.org/10.1182/blood-2009-03-212423

Published: 2009

Journal Articles

Site-Specific PEGylation of Factor VIII (PEG-FVIII) Preserves Full Clotting Activity and Extends Therapeutic Efficacy in HemophiliaA Dogs

Tongyao Liu, David Lillicrap, Xin Zhang, Andrea Labelle, Sandra Powell, Baisong Mei, John E. Murphy, Glenn F. Pierce, Haiyan Jiang

Blood (2008) 112 (11): 511.

https://doi.org/10.1182/blood.V112.11.511.511

Published: 2008

Journal Articles

Enhanced Efficacy of Recombinant Factor VIII in Non-Covalent Complex with PEGylated Liposome in Hemophilia A Mice.

Junliang Pan, PhD, Tongyao Liu, Ji-Yun Kim, PhD, Chandra Patel, PhD, Jim Newgren, MS, Jurg Sommer, PhD, Glenn Pierce, MD, PhD, Haiyan Jiang, PhD

Blood (2007) 110 (11): 3149.

https://doi.org/10.1182/blood.V110.11.3149.3149

Published: 2007

Journal Articles

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

Haiyan Jiang, Linda B. Couto, Susannah Patarroyo-White, Tongyao Liu, Dea Nagy, Joseph A. Vargas, Shangzhen Zhou, Ciaran D. Scallan, Jurg Sommer, Sharmila Vijay, Federico Mingozzi, Katherine A. High, Glenn F. Pierce

Blood (2006) 108 (10): 3321–3328.

https://doi.org/10.1182/blood-2006-04-017913

Published: 2006

Journal Articles

Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs

Haiyan Jiang, David Lillicrap, Susannah Patarroyo-White, Tongyao Liu, Xiaobing Qian, Ciaran D. Scallan, Sandra Powell, Tracey Keller, Morag McMurray, Andrea Labelle, Dea Nagy, Joseph A. Vargas, Shangzhen Zhou, Linda B. Couto, Glenn F. Pierce

Blood (2006) 108 (1): 107–115.

https://doi.org/10.1182/blood-2005-12-5115

Published: 2006

Journal Articles

Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice

Ciaran D. Scallan, Haiyan Jiang, Tongyao Liu, Susannah Patarroyo-White, Jurg M. Sommer, Shangzhen Zhou, Linda B. Couto, Glenn F. Pierce

Blood (2006) 107 (5): 1810–1817.

https://doi.org/10.1182/blood-2005-08-3229

Published: 2006

Journal Articles

AAV8-Factor IX Hepatic Gene Transfer with Transient Immunosuppression Is Safe but Is Abrogated by Low Titers of Neutralizing Antibody in Rhesus Macaques.

Haiyan Jiang, PhD, Susannah Patarroyo-White, BS, Tongyao Liu, BS, Bin Yang, Ph.D, Dea Nagy, M.D, Lin He, M.D, Ciaran D. Scallan, Ph.D, Jurg Sommer, Ph.D, Shangzhen Zhou, M.D, Linda B. Couto, Ph.D, Katherine A. High, M.D, Glenn F. Pierce, M.D/Ph.D

Blood (2005) 106 (11): 5532.

https://doi.org/10.1182/blood.V106.11.5532.5532

Published: 2005

Journal Articles

Improved Coagulation in Bleeding Disorders by NASP Treatment.

Kirk W. Johnson, PhD, George J. Broze, MD, Tongyao Liu, BS

Blood (2005) 106 (11): 4081.

https://doi.org/10.1182/blood.V106.11.4081.4081

Published: 2005

Journal Articles

Phenotypic correction of a mouse model of hemophilia A using AAV2 vectors encoding the heavy and light chains of FVIII

Ciaran D. Scallan, Tongyao Liu, Amy E. Parker, Susannah L. Patarroyo-White, Haifeng Chen, Haiyan Jiang, Joseph Vargas, Dea Nagy, Sharon K. Powell, J. Fraser Wright, Rita Sarkar, Haig H. Kazazian, Alan McClelland, Linda B. Couto

Blood (2003) 102 (12): 3919–3926.

https://doi.org/10.1182/blood-2003-01-0222

Published: 2003

Journal Articles

Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector

Ciaran D. Scallan, David Lillicrap, Haiyan Jiang, Xiaobing Qian, Susannah L. Patarroyo-White, Amy E. Parker, Tongyao Liu, Joseph Vargas, Dea Nagy, Sharon K. Powell, J. Fraser Wright, Patricia V. Turner, Shawn J. Tinlin, Sandra E. Webster, Alan McClelland, Linda B. Couto

Blood (2003) 102 (6): 2031–2037.

https://doi.org/10.1182/blood-2003-01-0292

Published: 2003

NARROW

BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice

Liver-Directed Gene Therapy for Hemophilia B with Immune Stealth Lentiviral Vectors

Evaluation of Enhanced in Vitro Plasma Stability of a Novel Long Acting Recombinant FVIIIFc-VWF-XTEN Fusion Protein

Recombinant FVIIIFc-VWF-XTEN Demonstrates Significant Bioavailability Following Subcutaneous Administration in Hemophilia A Mice

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

A Novel Single Chain Recombinant Factor VIII Fc Fusion Protein Is Active In Vitro and Fully Efficacious in An In Vivo Hema Mouse Bleeding Model

A Standardized Rotation Thromboelastometry (ROTEM) Method for Evaluation of FVIII and FIX Products in a Multi-National Clinical Trial

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment

Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice

Site-Specific PEGylation of Factor VIII (PEG-FVIII) Preserves Full Clotting Activity and Extends Therapeutic Efficacy in HemophiliaA Dogs

Enhanced Efficacy of Recombinant Factor VIII in Non-Covalent Complex with PEGylated Liposome in Hemophilia A Mice.

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs

Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice

AAV8-Factor IX Hepatic Gene Transfer with Transient Immunosuppression Is Safe but Is Abrogated by Low Titers of Neutralizing Antibody in Rhesus Macaques.

Improved Coagulation in Bleeding Disorders by NASP Treatment.

Phenotypic correction of a mouse model of hemophilia A using AAV2 vectors encoding the heavy and light chains of FVIII

Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector

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American Society of Hematology

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American Society of Hematology

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