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Ivo P. Touw, PhD
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Journal Articles

RUNX1 TAD and RHD Mutations Found in SCN/AML Differentially Affect HSPC Expansion in Conjunction with Truncated CSF3 Receptors

Free
Julia C. Obenauer, M.Sc., Paulina M. H. van Strien, B.Sc., Remco M. Hoogenboezem, M.Sc., Marry M. van den Heuvel-Eibrink, MD PhD, Ivo P. Touw, PhD
Journal: Blood
Blood (2015) 126 (23): 3606.
https://doi.org/10.1182/blood.V126.23.3606.3606
Published: 2015
Journal Articles

Deletion of Sbds from Hematopoietic Progenitors Causes Neutropenia in a Mouse Model of Shwachman-Diamond Syndrome By Specifically Blocking Myeloid Lineage Progression at Late Differentiation Stages

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Noemi A. Zambetti, Paulina M.H. Van Strien, Marijke G. Valkhof, Maria N. Adisty, Eric M. J. Bindels, PhD, Remco M. Hoogenboezem, Mathijs A. Sanders, MSc, Johanna M. Rommens, PhD, Ivo P. Touw, PhD, Marc H.G.P. Raaijmakers, MD PhD
Journal: Blood
Blood (2014) 124 (21): 355.
https://doi.org/10.1182/blood.V124.21.355.355
Published: 2014
Journal Articles

Cooperativity Of RUNX1 and CSF3R Mutations In The Development Of Leukemia In Severe Congenital Neutropenia: A Unique Pathway In Myeloid Leukemogenesis

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Julia Skokowa, Doris Steinemann, Jenny Katsman-Kuipers, Cornelia Zeidler, MD, Olga Klimenkova, Maksim Klimiankou, Murat Uenalan, MD PhD, Siarhei Kandabarau, Vahagn Makaryan, MD, Renee Beekman, MD, Carol Stocking, PhD, J Obenauer, Susanne Schnittger, PhD, Alexander Kohlmann, PhD, M Valkhof, R Hoogenboezem, Gudrun Göhring, MD, Dirk Reinhardt, Brigitte Schlegelberger, MD, PhD, Martin Stanulla, MD, MSc, Peter Vandenberghe, MD, PhD, Jean Donadieu, Michel Zwaan, Ivo P. Touw, PhD, Marry M. van den Heuvel-Eibrink, David C. Dale, MD, Karl Welte
Journal: Blood
Blood (2013) 122 (21): 444.
https://doi.org/10.1182/blood.V122.21.444.444
Published: 2013
Journal Articles

Malignant Transformation in Congenital Neutropenia

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Ivo P. Touw, PhD
Journal: Blood
Blood (2013) 122 (21): SCI-44.
https://doi.org/10.1182/blood.V122.21.SCI-44.SCI-44
Published: 2013
Journal Articles

The Impact of Novel Molecular Markers on Risk Stratification in Acute Myeloid Leukemia

Free
Bob Löwenberg, MD, PhD, Peter Valk, PhD, Ivo P. Touw, PhD, Ruud Delwel, PhD
Journal: Blood
Blood (2012) 120 (21): SCI-33.
https://doi.org/10.1182/blood.V120.21.SCI-33.SCI-33
Published: 2012
Journal Articles

Methylated Retroviral Integration Mutagenesis (MRIM) in Mice and Comparative Analysis in Human AML Identify Reduced PTP4A3 Expression As a Prognostic Indicator

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Renee Beekman, MD, Marijke G. Valkhof, Stefan J. Erkeland, PhD, Erdogan Taskesen, Veronika Rockova, Justine K. Peeters, PhD, Peter Valk, Bob Lowenberg, MD, PhD, Ivo P. Touw, PhD
Journal: Blood
Blood (2011) 118 (21): 746.
https://doi.org/10.1182/blood.V118.21.746.746
Published: 2011
Journal Articles

Ablation of Dicer1 in Myeloid Progenitors Leads to Neutrophil Dysplasia and Depletion of Monocytes, Macrophages, and Myeloid Dendritic Cells

Free
Mir Farshid Alemdehy, Nicole G.J.A. van Boxtel, Hans de Looper, Iris J. van den Berge, Mathijs A. Sanders, Tom Cupedo, PhD, Ivo P. Touw, PhD, Stefan J. Erkeland, PhD
Journal: Blood
Blood (2011) 118 (21): 43.
https://doi.org/10.1182/blood.V118.21.43.43
Published: 2011
Journal Articles

Interferon-Gamma Induces Monopoiesis and Inhibits Neutrophil Development During Inflammation

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Alexander M. de Bruin, Marijke G. Valkhof, Louis Boon, PhD, Ivo P. Touw, PhD, Martijn A. Nolte, PhD
Journal: Blood
Blood (2011) 118 (21): 1320.
https://doi.org/10.1182/blood.V118.21.1320.1320
Published: 2011
Journal Articles

Characterization of a Juxtamembrane Lysine as a Determinant in Lysosomal Routing and Signal Downregulation of the Activated G-CSF Receptor (G-CSFR).

Free
Mahban Irandoust, MSc, Albert Wolfler, MD, Judith Gits, Onno Roovers, Ivo P. Touw, PhD
Journal: Blood
Blood (2007) 110 (11): 2190.
https://doi.org/10.1182/blood.V110.11.2190.2190
Published: 2007
Journal Articles

Expression of G-CSF Receptor during Embryonic Development in a Csf3r -Cre Knock-In Mouse Model.

Free
Ivo P. Touw, PhD, Marijke Valkhof, Stefan J. Erkeland, PhD, Karel Meijers, PhD, Astrid Danen-van Oorschot, PhD
Journal: Blood
Blood (2007) 110 (11): 2233.
https://doi.org/10.1182/blood.V110.11.2233.2233
Published: 2007
Journal Articles

G-CSF Receptor Lysine Residues Are Involved in Lysosomal Degradation and Attenuation of G-CSF Signaling Via Distinct Effector Mechanisms.

Free
Lambertus H. Aarts, PhD, Mahban Irandoust, MSc, Onno Roovers, BSc, Marijke Valkhof, BSc, Stefan J. Erkeland, PhD, Ivo P. Touw, PhD
Journal: Blood
Blood (2005) 106 (11): 3155.
https://doi.org/10.1182/blood.V106.11.3155.3155
Published: 2005
Journal Articles

A Novel Subgroup of Poor Prognostic AML with Low CEBPA Expression, CEBPA Promoter Hypermethylation and DNMT3b Overexpression.

Free
Hendrik Rudolpf Delwel, PhD, Claudia Erpelinck, Roel Verhaak, MSc, Ivo P. Touw, PhD, Bob Lowenberg, MD, PhD, Peter J.M. Valk, PhD
Journal: Blood
Blood (2004) 104 (11): 418.
https://doi.org/10.1182/blood.V104.11.418.418
Published: 2004
Journal Articles

Role of the Vitamin D Upregulated Protein 1 (VDUP1)-Controlled Stress Pathway in Acute Myeloid Leukemia.

Free
Stefan J. Erkeland, MSc, Marijke Valkhof, Astrid Danen-van Oorschot, PhD, Ivo P. Touw, PhD
Journal: Blood
Blood (2004) 104 (11): 3386.
https://doi.org/10.1182/blood.V104.11.3386.3386
Published: 2004