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Journal Articles

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3

Scott M. Steward-Tharp, Arian Laurence, Yuka Kanno, Alex Kotlyar, Alejandro V. Villarino, Giuseppe Sciume, Stefan Kuchen, Wolfgang Resch, Elizabeth A. Wohlfert, Kan Jiang, Kiyoshi Hirahara, Golnaz Vahedi, Hong-wei Sun, Lionel Feigenbaum, Joshua D. Milner, Steven M. Holland, Rafael Casellas, Fiona Powrie, John J. O'Shea
Journal: Blood
Blood (2014) 123 (19): 2978–2987.
https://doi.org/10.1182/blood-2013-09-523167
Published: 2014
Includes: Supplemental data
Journal Articles

Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function

M. Pilar Gil, Mickaël J. Y. Ploquin, Wendy T. Watford, Seung-Hwan Lee, Kwangsin Kim, Xin Wang, Yuka Kanno, John J. O'Shea, Christine A. Biron
Journal: Blood
Blood (2012) 120 (18): 3718–3728.
https://doi.org/10.1182/blood-2012-05-428672
Published: 2012
Includes: Supplemental data
Journal Articles

The transcription factors STAT5A/B regulate GM-CSF–mediated granulopoiesis

Akiko Kimura, Michael A. Rieger, James M. Simone, Weiping Chen, Mark C. Wickre, Bing-Mei Zhu, Philipp S. Hoppe, John J. O'Shea, Timm Schroeder, Lothar Hennighausen
Journal: Blood
Blood (2009) 114 (21): 4721–4728.
https://doi.org/10.1182/blood-2009-04-216390
Published: 2009
Includes: Multimedia, Supplemental data
Journal Articles

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

Kevin M. Elias, Arian Laurence, Todd S. Davidson, Geoffrey Stephens, Yuka Kanno, Ethan M. Shevach, John J. O'Shea
Journal: Blood
Blood (2008) 111 (3): 1013–1020.
https://doi.org/10.1182/blood-2007-06-096438
Published: 2008
Includes: Supplemental data
Journal Articles

Nonredundant roles for Stat5a/b in directly regulating Foxp3

Zhengju Yao, Yuka Kanno, Marc Kerenyi, Geoffrey Stephens, Lydia Durant, Wendy T. Watford, Arian Laurence, Gertraud W. Robinson, Ethan M. Shevach, Richard Moriggl, Lothar Hennighausen, Changyou Wu, John J. O'Shea
Journal: Blood
Blood (2007) 109 (10): 4368–4375.
https://doi.org/10.1182/blood-2006-11-055756
Published: 2007
Includes: Supplemental data
Journal Articles

Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma

Brief Report
Marko Pesu, Linda Muul, Yuka Kanno, John J. O'Shea
Journal: Blood
Blood (2006) 108 (3): 983–985.
https://doi.org/10.1182/blood-2005-09-3824
Published: 2006
Includes: Supplemental data
Journal Articles

Jak3 negatively regulates dendritic-cell cytokine production and survival

Kunihiro Yamaoka, Booki Min, Yong-Jie Zhou, William E. Paul, John J. O'Shea
Journal: Blood
Blood (2005) 106 (9): 3227–3233.
https://doi.org/10.1182/blood-2005-02-0769
Published: 2005
Includes: Supplemental data
Journal Articles

Structure of a Janus kinase: molecular insights and prospects for optimizing a new class of immunosuppressants

John J. O'Shea, Massimo Gadina, Xiaomin Chen
Journal: Blood
Blood (2005) 106 (3): 765–766.
https://doi.org/10.1182/blood-2005-05-1947
Published: 2005
Journal Articles

Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation

Clinical Trials & Observations
Joseph L. Roberts, Andrea Lengi, Stephanie M. Brown, Min Chen, Yong-Jie Zhou, John J. O'Shea, Rebecca H. Buckley
Journal: Blood
Blood (2004) 103 (6): 2009–2018.
https://doi.org/10.1182/blood-2003-06-2104
Published: 2004
Journal Articles

Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

Roberta Visconti, Massimo Gadina, Mario Chiariello, Elbert H. Chen, Louis F. Stancato, J. Silvio Gutkind, John J. O'Shea
Journal: Blood
Blood (2000) 96 (5): 1844–1852.
https://doi.org/10.1182/blood.V96.5.1844
Published: 2000
Journal Articles

The gene for familial Mediterranean fever, MEFV , is expressed in early leukocyte development and is regulated in response to inflammatory mediators

Michael Centola, Geryl Wood, David M. Frucht, Jerome Galon, Martin Aringer, Christopher Farrell, Douglas W. Kingma, Mitchell E. Horwitz, Elizabeth Mansfield, Steven M. Holland, John J. O'Shea, Helene F. Rosenberg, Harry L. Malech, Daniel L. Kastner
Journal: Blood
Blood (2000) 95 (10): 3223–3231.
https://doi.org/10.1182/blood.V95.10.3223
Published: 2000
Journal Articles

Structural and Functional Basis for JAK3-Deficient Severe Combined Immunodeficiency

Fabio Candotti, Scott A. Oakes, James A. Johnston, Silvia Giliani, Richard F. Schumacher, Patrizia Mella, Maurilia Fiorini, Alberto G. Ugazio, Raffaele Badolato, Luigi D. Notarangelo, Fabio Bozzi, Paolo Macchi, Dario Strina, Paolo Vezzoni, R. Michael Blaese, John J. O'Shea, Anna Villa
Journal: Blood
Blood (1997) 90 (10): 3996–4003.
https://doi.org/10.1182/blood.V90.10.3996
Published: 1997
Journal Articles

Differentiation stimuli induce receptors for plasma fibronectin on the human myelomonocytic cell line HL-60

CG Pommier, J O'Shea, T Chused, T Takahashi, M Ochoa, TB Nutman, C Bianco, EJ Brown
Journal: Blood
Blood (1984) 64 (4): 858–866.
https://doi.org/10.1182/blood.V64.4.858.858
Published: 1984