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J. Keith Joung
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Journal Articles

Combined +58 and +55 BCL11A enhancer Editing Yields Exceptional Efficiency, Specificity and HbF Induction in Human and NHP Preclinical Models

Jing Zeng, Selami Demirci, My Anh Nguyen, Linda Yingqi Lin, Stacy A. Maitland, Esther Mintzer, Yuxuan Wu, Danilo Pellin, Amornrat Tangprasittipap, Chokdee Vong, Shaina N. Porter, Kevin Luk, Pengpeng Liu, Varun Katta, Marioara-Felicia Ciuculescu, Daniela Abriss, Jonathan Hsu, Naoya Uchida, Khaled Essawi, Robert Donahue, Karl Petri, Vikram Pattanayak, Luca Pinello, Christian Brendel, David A Williams, John P Manis, Shengdar Q. Tsai, Shondra M. Pruett-Miller, J. Keith Joung, Duantida Songdej, Suradej Hongeng, Myriam Armant, Scot A. Wolfe, John F. Tisdale, Daniel E. Bauer
Journal: Blood
Blood (2021) 138 (Supplement 1): 1852.
https://doi.org/10.1182/blood-2021-152634
Published: 2021
Journal Articles

Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway

Zhilian Hu, Yang Liu, Michael C. Huarng, Marzia Menegatti, Deepak Reyon, Megan S. Rost, Zachary G. Norris, Catherine E. Richter, Alexandra N. Stapleton, Neil C. Chi, Flora Peyvandi, J. Keith Joung, Jordan A. Shavit
Journal: Blood
Blood (2017) 130 (5): 666–676.
https://doi.org/10.1182/blood-2017-02-765206
Published: 2017
Includes: Supplemental data
Journal Articles

Factor X Mutant Zebrafish Tolerate a Severe Hemostatic Defect in Early Development Yet Develop Lethal Hemorrhage in Adulthood

Zhilian Hu, PhD, Yang Liu, PhD, Michael Huarng, BS, Deepak Reyon, PhD, Catherine Richter, BS, MS, Alexandra Stapleton, J. Keith Joung, MD PhD, Jordan A. Shavit, MD PhD
Journal: Blood
Blood (2015) 126 (23): 426.
https://doi.org/10.1182/blood.V126.23.426.426
Published: 2015
Journal Articles

Genome and Epigenome Editing: A Revolution in Science and Medicine

J. Keith Joung, MD PhD
Journal: Blood
Blood (2014) 124 (21): SCI-10.
https://doi.org/10.1182/blood.V124.21.SCI-10.SCI-10
Published: 2014
Journal Articles

Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function

Yang Liu, Colin A. Kretz, Morgan L. Maeder, Catherine E. Richter, Philip Tsao, Andy H. Vo, Michael C. Huarng, Thomas Rode, Zhilian Hu, Rohit Mehra, Steven T. Olson, J. Keith Joung, Jordan A. Shavit
Journal: Blood
Blood (2014) 124 (1): 142–150.
https://doi.org/10.1182/blood-2014-03-561027
Published: 2014
Includes: Multimedia, Supplemental data
Journal Articles

A Zebrafish Model Of Antithrombin III Deficiency Displays Bleeding and Thrombosis Secondary To Disseminated Intravascular Coagulation

Yang Liu, Ph.D., Colin A. Kretz, PhD, Morgan L. Maeder, Ph.D., Michael C. Huarng, Catherine E. Richter, Andy H. Vo, Philip Tsao, Alok Swaroop, J. Keith Joung, MD, PhD, Jordan A. Shavit, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 200.
https://doi.org/10.1182/blood.V122.21.200.200
Published: 2013