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Jae-Woong Lee
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Journal Articles

Autonomous Ca 2+ Oscillations Reflect Oncogenic BCR-Signaling in Multiple B-Cell Malignancies and Are Essential for Survival and Proliferation

Free
Kohei Kume, PhD, Liting Chen, PhD, Jae-Woong Lee, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1373.
https://doi.org/10.1182/blood-2018-99-117315
Published: 2018
Journal Articles

Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling

Free
Lai N Chan, Christian Hurtz, PhD, Huimin Geng, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Jae-Woong Lee, PhD, Kadriye Nehir Cosgun, PhD, B Hilda Ye, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1336.
https://doi.org/10.1182/blood-2018-99-115514
Published: 2018
Journal Articles

CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies

Free
Jae-Woong Lee, PhD, Kohei Kume, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, Chun-Wei Chen, PhD, Raju Pillai, MD, Wing C Chan, MD, Stephen J Forman, Larry W Kwak, MD PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, David M Weinstock, MD, Ari M Melnick, MD, Vu N Ngo, PhD, Huimin Geng, PhD, Selina Luger, MD, Mark R. Litzow, MD, Alexandre Belot, MDPhD, Gulbu Uzel, MD, Michael T McManus, PhD, Elisabeth M. Paietta, PhD, Eric Meffre, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 776.
https://doi.org/10.1182/blood-2018-99-117553
Published: 2018
Journal Articles

IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation

Free
Jae-Woong Lee, PhD, Huimin Geng, PhD, Derek S Dinson, Gang Xiao, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, Zhengshan Chen, MDPhD, Michael Farzan, MDPhD, Jae U Jung, PhD, Arun P Wiita, MDPhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 552.
https://doi.org/10.1182/blood-2018-99-117472
Published: 2018
Journal Articles

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

Free
Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Lars Klemm, BSc, MSc, Kadriye Nehir Cosgun, PhD, Gang Xiao, PhD, Behzad Masouleh, Christian Hurtz, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4088.
https://doi.org/10.1182/blood.V128.22.4088.4088
Published: 2016
Journal Articles

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

Free
Jae-Woong Lee, PhD, Huimin Geng, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, PhD, Zhengshan Chen, MD PhD, Eugene Park, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2738.
https://doi.org/10.1182/blood.V128.22.2738.2738
Published: 2016
Journal Articles

CD25 (IL2RA) Orchestrates Negative Feedback Control and Stabilizes Oncogenic Signaling Strength in Acute Lymphoblastic Leukemia

Free
Jae-Woong Lee, PhD, Zhengshan Chen, MDPhD, Huimin Geng, PhD, Gang Xiao, PhD, Eugene PARK, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Muschen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1434.
https://doi.org/10.1182/blood.V126.23.1434.1434
Published: 2015
Journal Articles

IFITM3 (CD225) Links the B Cell Antigen CD19 to PI3K-AKT Signaling in Human ALL Cells

Free
Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Eugene PARK, PhD, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Muschen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1325.
https://doi.org/10.1182/blood.V126.23.1325.1325
Published: 2015
Journal Articles

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Free
Zhengshan Chen, MD PhD, Seyedmehdi Shojaee, PhD, Huimin Geng, PhD, Jae-Woong Lee, PhD, Maike Buchner, PhD, Lars Klemm, Clifford A. Lowell, MD PhD, Elisabeth Paietta, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Ari Melnick, MD, Jae U. Jung, PhD, Hassan Jumaa, PhD, John E. Coligan, PhD, Silvia Bolland, PhD, Tak W. Mak, OC, PhD DSc, FRSC, FRS, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 792.
https://doi.org/10.1182/blood.V124.21.792.792
Published: 2014
Journal Articles

Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia

Free
Huimin Geng, PhD, Christian Hurtz, PhD, Dirk Baumjohann, PhD, Zhengshan Chen, MD PhD, Wei-Yi Chen, PhD, Erica Ballabio, PhD, Gang Xiao, PhD, Jae-Woong Lee, PhD, Anne Deucher, MDPhD, Zhongxia Qi, PhD, Chuanxin Huang, PhD, Rahul Nahar, PhD, Soo-mi Kweon, PhD, Seyedmehdi Shojaee, PhD, Lai N Chan, PhD, Jingwei Yu, PhD, Jeffrey W. Tyner, PhD, Bill H Chang, MD PhD, Steven M. Kornblau, MD, Janetta Jacoba Bijl, PhD, B. Hilda Ye, PhD, Elisabeth Paietta, PhD, Ari Melnick, MD, Robert Roeder, PhD, Stephen Hunger, MD, Mignon Loh, MD, Thomas Milne, PhD, Markus Muschen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 284.
https://doi.org/10.1182/blood.V124.21.284.284
Published: 2014
Journal Articles

IL2RA (CD25) Recruits Inhibitory Phosphatases to the Cell Membrane and Mediates Negative Feedback Control of STAT5 Signaling in Acute Lymphoblastic Leukemia

Free
Huimin Geng, PhD, Jae-Woong Lee, PhD, Zhengshan Chen, MD PhD, Behzad Kharabi Masouleh, MD, Christian Hurtz, PhD, Eugene Park, Gang Xiao, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Elisabeth Paietta, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 788.
https://doi.org/10.1182/blood.V124.21.788.788
Published: 2014
Journal Articles

IFITM3 (CD225) Regulates CD19 Surface Expression and CD19-Mediated Activation of PI3K Signaling in Pre-B Acute Lymphoblastic Leukemia Cells

Free
Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Eugene Park, Angela Park, Lars Klemm, Charles Bailey, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 1070.
https://doi.org/10.1182/blood.V124.21.1070.1070
Published: 2014
Journal Articles

The Linker Protein GAS7 Negatively Regulates Pre-B Cell Differentiation and Amplifies Proliferation and Survival Signals in Acute Lymphoblastic Leukemia

Free
Jae-Woong Lee, PhD, Maike Buchner, PhD, Huimin Geng, PhD, Srividya Swaminathan, PhD, Eugene Park, Angela Park, Sue Lin-Chao, Chi Wai So, Markus Muschen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3777.
https://doi.org/10.1182/blood.V124.21.3777.3777
Published: 2014