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James Lorens
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Journal Articles

Final Analysis of the Dose Escalation, Expansion and Biomarker Correlations in the Ph I/II Trial BGBC003 with the Selective Oral AXL Inhibitor Bemcentinib (BGB324) in Relapsed/Refractory AML and MDS

Sonja Loges, MD, PhD, Michael Heuser, MD, Joerg Chromik, Carlos E Vigil, MD, Peter Paschka, MD, Isabel Ben-Batalla, PhD, Nuray Akyüz, David Micklem, Robert Holt, Anthony Brown, James Lorens, Murray Yule, Maxim Kebenko, MD, Melanie Janning, Mascha Binder, MD, Walter Fiedler, MD, Jorge E. Cortes, MD, Bjorn Gjertsen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2672.
https://doi.org/10.1182/blood-2018-99-120380
Published: 2018
Journal Articles

The Orally Available Selective Axl Inhibitor BGB324 Induces Diversification of the Immune Repertoire and Specific Changes in Plasma Biomarker Profiles

Sonja Loges, MD PhD, Bjørn Tore Gjertsen, Michael Heuser, MD, Joerg Chromik, Isabel Ben-Batalla, Nuray Akyüz, David Micklem, Anthony Brown, James Lorens, Murray Yule, Maxim Kebenko, MD, Melanie Janning, Mascha Binder, MD, Walter Fiedler, MD, Jorge E. Cortes, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1375.
https://doi.org/10.1182/blood.V130.Suppl_1.1375.1375
Published: 2017
Journal Articles

BGB324 Represents an Axl and BCR-ABL1 Inhibitor with Activity in the T315I Mutant

Robert Erdmann, PhDMSc, Heather Jorgensen, PhD, Isabel Ben-Batalla, PhD, Nils Kruse, PhD, David Micklem, PhD, Gunhild von Amsberg, MD, Philippe Schafhausen, MD, Alexander Schultze, MD MSc, Mark Wroblewski, MSc, Mascha Binder, Miguel Cubas-Cordova, MSc, Tobias Hadlich, MD, Melanie Janning, MD MSc, Stefanie Sawall, Victoria Gensch, Elaine K Allan, Leena Mukherjee, PhD, Heather Morrison, BSc, Jennifer Cassells, Nicolaus Kroeger, MD, James Lorens, MD, Richard E. Clark, MD, Steffen Koschmieder, MD, Peter Vandenberghe, MD PhD, Tim H. Brümmendorf, MD, Andreas Hochhaus, MD, Peter Carmeliet, MD PhD, Tessa L. Holyoake, MD PhD, Klaus Pantel, MD PhD, Carsten Bokemeyer, MD, Sonja Loges, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4512.
https://doi.org/10.1182/blood.V124.21.4512.4512
Published: 2014
Journal Articles

Axl Represents a Therapeutic Target In T315I-Mutated and WT Chronic Myeloid Leukemia

Robert Erdmann, PhD MSc, Heather Jorgensen, PhD, Alexander Schultze, MD, MSc, Gunhild von Amsberg, MD, Isabel Ben-Battala, PhD, MSc, Mark Wroblewski, MSc, Miguel Cubas Cordova, MSc, Stefanie Sawall, Victoria Witzke, Elaine K Allan, Leena Mukherjee, PhD, Heather Morrison, Jennifer Cassels, Philippe Schafhausen, MD, Nicolaus Kroeger, MD, James Lorens, MD, Richard E. Clark, MBBS, MD, FRCP, FRCPath, Peter Vandenberghe, MD, PhD, Tim H. Brümmendorf, MD, Andreas Hochhaus, MD, Peter Carmeliet, MD, PhD, Klaus Pantel, MD, PhD, Carsten Bokemeyer, MD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Sonja Loges, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1469.
https://doi.org/10.1182/blood.V122.21.1469.1469
Published: 2013
Journal Articles

Anti-Tumor Activity of Immunoproteasome Selective Inhibitors.

Francesco Parlati, Monette Aujay, Siv Lise Bedringaas, Susan Demo, Bjorn Gjertsen, Eileen Goldstein, Jing Jiang, Christopher Kirk, Guy Laidig, James Lorens, Yan Lu, David Micklem, Paulina Ruurs, Kevin Shenk, Catherine Sylvain, Congcong Sun, Tina Woo, Han-Jie Zhou, Mark Bennett
Journal: Blood
Blood (2007) 110 (11): 1599.
https://doi.org/10.1182/blood.V110.11.1599.1599
Published: 2007