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Journal Articles

Blocking Protein Secretion with Novel Small Molecule Inhibitors of Sec61 Represents a Potential Treatment Strategy Against Hematologic Malignancies

Eric Lowe, BS, Andrea R Fan, PhD, Jing Jiang, Henry W. B. Johnson, PhD, Christopher J. Kirk, PhD, Dustin McMinn, PhD, Tony Muchamuel, MS, Yu Qian, PhD, Brian B. Tuch, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 408.
https://doi.org/10.1182/blood-2019-123782
Published: 2019
Journal Articles

Lnk/Sh2b3 Deficiency Restores Hematopoietic Stem Cell Function and Genome Integrity in Fanconi Anemia

Wei Tong, PhD, Joanna Balcerek, PhD, Jing Jiang, PhD, Nicholas Holdreith, MS, Qinqin Jiang, Krasimira A. Rozenova, PhD, Weihua Li, Roger A Greenberg
Journal: Blood
Blood (2017) 130 (Supplement 1): 1134.
https://doi.org/10.1182/blood.V130.Suppl_1.1134.1134
Published: 2017
Journal Articles

LNK (SH2B3) Deficiency Ameliorates Hematopoietic Stem Cell Defects in Fanconi Anemi

Joanna Balcerek, Jing Jiang, PhD, Qinqin Jiang, Kaosheng Lyu, PhD, Roger Greenberg, MD PhD, Wei Tong, PhD
Journal: Blood
Blood (2016) 128 (22): 2670.
https://doi.org/10.1182/blood.V128.22.2670.2670
Published: 2016
Journal Articles

Control of JAK2 Ubiquitination and Stability By CBL Family E3 Ubiquitin Ligases in Hematopoietic Stem/Progenitor Cells and Myeloid Malignancies

Kaosheng Lyu, PhD, Jing Jiang, PhD, Wei An, PhD, Wallace Y Langdon, PhD, Hamid Band, MD PhD, Wei Tong, PhD
Journal: Blood
Blood (2016) 128 (22): 723.
https://doi.org/10.1182/blood.V128.22.723.723
Published: 2016
Journal Articles

MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling

Krasimira Rozenova, Jing Jiang, Ryan Donaghy, Bernadette Aressy, Roger A. Greenberg, Wei Tong
Journal: Blood
Blood (2015) 125 (11): 1730–1738.
https://doi.org/10.1182/blood-2014-07-588145
Published: 2015
Includes: Supplemental data
Journal Articles

Dual Role Of MERIT40 In Hematopoietic Stem and Progenitor Cells

Krasimira Rozenova, PhD, Jing Jiang, PhD, Chao Wu, Junmin Wu, Bernadette Aressy, PhD, Roger Greenberg, MD, PhD, Wei Tong, PhD
Journal: Blood
Blood (2013) 122 (21): 797.
https://doi.org/10.1182/blood.V122.21.797.797
Published: 2013
Journal Articles

A Novel Mutation in MPL (Y252H) Results in Increased Thrombopoietin Sensitivity and Moderate Thrombocytosis in a Pediatric Patient with Essential Thrombocytosis

Michele Lambert, MD, Jing Jiang, Wei Tong
Journal: Blood
Blood (2011) 118 (21): 2817.
https://doi.org/10.1182/blood.V118.21.2817.2817
Published: 2011
Journal Articles

14-3-3 Regulates the Lnk/JAK2 Pathway In Hematopoietic Stem and Progenitor Cells

Joanna Balcerek, Jing Jiang, Alexey Bersenev, Yiwen Song, Chao Wu, Wei Tong
Journal: Blood
Blood (2010) 116 (21): 86.
https://doi.org/10.1182/blood.V116.21.86.86
Published: 2010
Journal Articles

Dose Intensive Administration of PR-047, a Novel Orally Bioavailable Inhibitor of the 20S Proteasome, Is Well Tolerated in Experimental Animals.

Tony Muchamuel, Shirin Kapur, PhD, Christopher J Kirk, Ph.D, Jing Jiang, M.D., Susan Lee, Mark K Bennett, PhD, Evan Lewis, Jinfu Yang, Mouhannad Jumaa, Eileen Ring, Pasit Phiasivongsa, Han-Jie Zhou, PhD, Zhengping Wang
Journal: Blood
Blood (2009) 114 (22): 4910.
https://doi.org/10.1182/blood.V114.22.4910.4910
Published: 2009
Journal Articles

Pharmacokinetics, Metabolism, Distribution and Excretion of Carfilzomib in Rats.

Jinfu Yang, Rachel Fang, Zhengping Wang, Jing Jiang, Tony Muchamuel, Susan Lee, Christopher J Kirk, Francisco Zhao, Mark K Bennett, Christopher J. Molineaux
Journal: Blood
Blood (2009) 114 (22): 2754.
https://doi.org/10.1182/blood.V114.22.2754.2754
Published: 2009
Journal Articles

The Selective Proteasome Inhibitor Carfilzomib Is Well Tolerated in Experimental Animals with Dose Intensive Administration

Christopher J Kirk, Jing Jiang, Tony Muchamuel, Maya Dajee, Deborah Swinarski, Monette Aujay, Mark K Bennett, PhD, Jinfu Yang, Evan Lewis, Guy Laidig, Christopher J. Molineaux, PhD
Journal: Blood
Blood (2008) 112 (11): 2765.
https://doi.org/10.1182/blood.V112.11.2765.2765
Published: 2008
Journal Articles

Preclinical Pharmacology and in Vitro Characterization of PR-047, An Oral Inhibitor of the 20S Proteasome

Tony Muchamuel, Monette Aujay, Mark K Bennett, PhD, Maya Dajee, Susan Demo, PhD, Christopher J Kirk, Ph.D, Ying Fang, Jing Jiang, M.D., Evan Lewis, Yan Lu, Guy Laidig, Francesco Parlati, PhD, Jamie Shields, Congcong m Sun, Jinfu Yang, Han-Jie Zhou, PhD
Journal: Blood
Blood (2008) 112 (11): 3671.
https://doi.org/10.1182/blood.V112.11.3671.3671
Published: 2008
Journal Articles

Anti-Tumor Activity of Immunoproteasome Selective Inhibitors.

Francesco Parlati, Monette Aujay, Siv Lise Bedringaas, Susan Demo, Bjorn Gjertsen, Eileen Goldstein, Jing Jiang, Christopher Kirk, Guy Laidig, James Lorens, Yan Lu, David Micklem, Paulina Ruurs, Kevin Shenk, Catherine Sylvain, Congcong Sun, Tina Woo, Han-Jie Zhou, Mark Bennett
Journal: Blood
Blood (2007) 110 (11): 1599.
https://doi.org/10.1182/blood.V110.11.1599.1599
Published: 2007
Journal Articles

Immunoproteasome-Selective Keto-Epoxide Inhibitors: Potential Therapeutic Agents for the Treatment of Hematological Disorders.

Francesco Parlati, PhD, Monette A. Aujay, B.S., Susan D. Demo, Ph.D., Eileen D. Goldstein, B.S., Jing Jiang, B.S., Christopher J. Kirk, Ph.D., Guy J. Laidig, Ph.D., Yan Lu, M.S., Tony Muchamuel, M.S., Kevin D. Shenk, M.S., Catherine Sylvain, Ph.D., Congcong M. Sun, M.S., Tina M. Woo, B.S., Han-Jie Zhou, Ph.D., Mark K. Bennett, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 4392.
https://doi.org/10.1182/blood.V108.11.4392.4392
Published: 2006
Journal Articles

Pharmacologic Evaluation of Orally Bioavailable Inhibitors of the 20S Proteasome.

Christopher J. Kirk, PhD, Monette A. Aujay, B.S., Mark Ho, B.S., Jing Jiang, B.S., Guy J. Laidig, Ph.D., Evan R. Lewis, Ph.D., Yan Lu, M.S., Tony Muchamuel, M.S., Tina M. Woo, B.S., Congcong M. Sun, M.S., Catherine Sylvain, Ph.D., Jinfu Yang, Ph.D., Han-jie Zhou, Ph.D., Mark K. Bennett, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 3581.
https://doi.org/10.1182/blood.V108.11.3581.3581
Published: 2006
Journal Articles

Pharmacokinetics, Pharmacodynamics and Anti-Tumor Efficacy of PR-171, a Novel Inhibitor of the 20S Proteasome.

Christopher J. Kirk, PhD, Mark K. Bennett, PhD, Tonia J. Buchholz, MS, Susan D. Demo, PhD, Mark N. Ho, BS, Jing Jiang, BS, Guy J. Laidig, PhD, Evan R. Lewis, PhD, Kevin D. Shenk, BS, Mark S. Smyth, PhD, Congcong M. Sun, MS, Marcy K. Vallone, BS, Tina M. Woo, BS, Christopher J. Molineaux, PhD
Journal: Blood
Blood (2005) 106 (11): 609.
https://doi.org/10.1182/blood.V106.11.609.609
Published: 2005