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Tony Muchamuel
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Journal Articles

Blocking Protein Secretion with Novel Small Molecule Inhibitors of Sec61 Represents a Potential Treatment Strategy Against Hematologic Malignancies

Eric Lowe, BS, Andrea R Fan, PhD, Jing Jiang, Henry W. B. Johnson, PhD, Christopher J. Kirk, PhD, Dustin McMinn, PhD, Tony Muchamuel, MS, Yu Qian, PhD, Brian B. Tuch, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 408.
https://doi.org/10.1182/blood-2019-123782
Published: 2019
Journal Articles

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

Yu Qian, PhD, Henry W.B. Johnson, PhD, Christopher J. Kirk, PhD, Eric Lowe, BS, Dustin McMinn, PhD, Beatriz Millare, BS, Tony Muchamuel, MS, Jinhai Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2076.
https://doi.org/10.1182/blood-2019-125988
Published: 2019
Journal Articles

Dose Intensive Administration of PR-047, a Novel Orally Bioavailable Inhibitor of the 20S Proteasome, Is Well Tolerated in Experimental Animals.

Tony Muchamuel, Shirin Kapur, PhD, Christopher J Kirk, Ph.D, Jing Jiang, M.D., Susan Lee, Mark K Bennett, PhD, Evan Lewis, Jinfu Yang, Mouhannad Jumaa, Eileen Ring, Pasit Phiasivongsa, Han-Jie Zhou, PhD, Zhengping Wang
Journal: Blood
Blood (2009) 114 (22): 4910.
https://doi.org/10.1182/blood.V114.22.4910.4910
Published: 2009
Journal Articles

Pharmacokinetics, Metabolism, Distribution and Excretion of Carfilzomib in Rats.

Jinfu Yang, Rachel Fang, Zhengping Wang, Jing Jiang, Tony Muchamuel, Susan Lee, Christopher J Kirk, Francisco Zhao, Mark K Bennett, Christopher J. Molineaux
Journal: Blood
Blood (2009) 114 (22): 2754.
https://doi.org/10.1182/blood.V114.22.2754.2754
Published: 2009
Journal Articles

The Selective Proteasome Inhibitor Carfilzomib Is Well Tolerated in Experimental Animals with Dose Intensive Administration

Christopher J Kirk, Jing Jiang, Tony Muchamuel, Maya Dajee, Deborah Swinarski, Monette Aujay, Mark K Bennett, PhD, Jinfu Yang, Evan Lewis, Guy Laidig, Christopher J. Molineaux, PhD
Journal: Blood
Blood (2008) 112 (11): 2765.
https://doi.org/10.1182/blood.V112.11.2765.2765
Published: 2008
Journal Articles

Preclinical Pharmacology and in Vitro Characterization of PR-047, An Oral Inhibitor of the 20S Proteasome

Tony Muchamuel, Monette Aujay, Mark K Bennett, PhD, Maya Dajee, Susan Demo, PhD, Christopher J Kirk, Ph.D, Ying Fang, Jing Jiang, M.D., Evan Lewis, Yan Lu, Guy Laidig, Francesco Parlati, PhD, Jamie Shields, Congcong m Sun, Jinfu Yang, Han-Jie Zhou, PhD
Journal: Blood
Blood (2008) 112 (11): 3671.
https://doi.org/10.1182/blood.V112.11.3671.3671
Published: 2008
Journal Articles

Immunoproteasome-Selective Keto-Epoxide Inhibitors: Potential Therapeutic Agents for the Treatment of Hematological Disorders.

Francesco Parlati, PhD, Monette A. Aujay, B.S., Susan D. Demo, Ph.D., Eileen D. Goldstein, B.S., Jing Jiang, B.S., Christopher J. Kirk, Ph.D., Guy J. Laidig, Ph.D., Yan Lu, M.S., Tony Muchamuel, M.S., Kevin D. Shenk, M.S., Catherine Sylvain, Ph.D., Congcong M. Sun, M.S., Tina M. Woo, B.S., Han-Jie Zhou, Ph.D., Mark K. Bennett, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 4392.
https://doi.org/10.1182/blood.V108.11.4392.4392
Published: 2006
Journal Articles

Pharmacologic Evaluation of Orally Bioavailable Inhibitors of the 20S Proteasome.

Christopher J. Kirk, PhD, Monette A. Aujay, B.S., Mark Ho, B.S., Jing Jiang, B.S., Guy J. Laidig, Ph.D., Evan R. Lewis, Ph.D., Yan Lu, M.S., Tony Muchamuel, M.S., Tina M. Woo, B.S., Congcong M. Sun, M.S., Catherine Sylvain, Ph.D., Jinfu Yang, Ph.D., Han-jie Zhou, Ph.D., Mark K. Bennett, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 3581.
https://doi.org/10.1182/blood.V108.11.3581.3581
Published: 2006
Journal Articles

Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses

Debra A. Cockayne, Tony Muchamuel, J. Christopher Grimaldi, Hélène Muller-Steffner, Troy D. Randall, Frances E. Lund, Richard Murray, Francis Schuber, Maureen C. Howard
Journal: Blood
Blood (1998) 92 (4): 1324–1333.
https://doi.org/10.1182/blood.V92.4.1324
Published: 1998