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Jeffrey Rubnitz, MD PhD
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Journal Articles

Integrative Analysis of Pediatric Acute Leukemia Identifies Immature Subtypes That Span a T Lineage and Myeloid Continuum with Distinct Prognoses

Tanja A. Gruber, MD PhD, Jing Ma, PhD, Sanne Noort, MD MSc, Yu Liu, PhD, Michael P Walsh, PhD, Stephanie Nance, PhD, Yanling Liu, PhD, Yuanyuan Wang, PhD, Guangchun Song, PhD, Tamara Lamprecht, BS, John Easton, PhD, Martina Pigazzi, PhD, Marie Jarosova, PhD, Kelaidi Charikleia, MD, Jeffrey Rubnitz, MD PhD, Dirk Reinhardt, MD, Marry M. van den Heuvel-Eibrink, Prof, MD PhD, Franco Locatelli, MD PhD, Henrik Hasle, Jeffery M. Klco, MD PhD, James R. Downing, MD, Stanley Pounds, PhD, Jinghui Zhang, PhD, Christian Michel Zwaan, MD PhD, Maarten Fornerod, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 918.
https://doi.org/10.1182/blood-2019-127411
Published: 2019
Journal Articles

Safety and Efficacy of Venetoclax in Combination with Navitoclax in Adult and Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Norman J. Lacayo, MD, Vinod A. Pullarkat, MD, Wendy Stock, MD, Elias Jabbour, MD, Ashish Bajel, MBBS, FRACP, FRCPA, Jeffrey Rubnitz, MD PhD, Jessica Leonard, MD, Charles G. Mullighan, MBBS, MD, Seong Lin Khaw, MD, Susan I. Vear, MD MSCI, Joseph T. Opferman, PhD, Ahmed Hamed Salem, PhD FCP, Michelle Schmidt, Bo Tong, PhD, Lang Zhou, PhD, Jeremy A. Ross, PhD, Lindsey Bensman, Amanda Jacobson, PhD, Robin Norris, MD MS, MPH, Thomas Alexander, MDMPH
Journal: Blood
Blood (2019) 134 (Supplement_1): 285.
https://doi.org/10.1182/blood-2019-126977
Published: 2019
Journal Articles

Home or Away from Home: A Multi-Institution Study Comparing Medical Outcomes, Patient Perspectives, and Health-Related Quality of Life for Outpatient Versus Inpatient Management after Chemotherapy for Pediatric Acute Myeloid Leukemia

Kelly D Getz, Yimei Li, PhD, Julia E Szymczak, PhD, Catherine Aftandilian, MD, Staci D. Arnold, MD MBA, MPH, Kira O Bona, MDMPH, Emi Caywood, MD, Anderson B. Collier, MD, Maria Monica Monica Gramatges, MD PhD, Meret Henry, MD, Craig Lotterman, MD, Kelly Maloney, MD, Amir Mian, Rajen Mody, MD MS, Elizabeth A. Raetz, MD, Jeffrey Rubnitz, MD PhD, Anupam Verma, MD, Naomi Winick, MD, Jennifer J. Wilkes, MDMSCE, Jennifer C. Yu, MD, Brian T. Fisher, DO, MSCE, Richard Aplenc, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 379.
https://doi.org/10.1182/blood-2019-131761
Published: 2019
Journal Articles

Venetoclax in Combination with High-Dose Chemotherapy Is Active and Well-Tolerated in Children with Relapsed or Refractory Acute Myeloid Leukemia

Seth E Karol, MD, Thomas Alexander, MDMPH, Amit Budraja, PhD, Stanley Pounds, PhD, Kristin E Canavera, PhD, Lei Wang, MS, Joshua Wolf, MBBS, PhD, Jeffery M. Klco, MD PhD, Ahmed Hamed Salem, PhD FCP, Tammy Palenski, PhD, Norman J. Lacayo, MD, Ching-Hon Pui, MD, Joseph T. Opferman, PhD, Jeffrey Rubnitz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 178.
https://doi.org/10.1182/blood-2019-127716
Published: 2019
Journal Articles

A 5-Gene Ara-C, Daunorubicin and Etoposide (ADE) Drug Response Score As a Prognostic Tool to Predict AML Treatment Outcome

Abdelrahman H. Elsayed, MSc, Huiyun Wu, PhD, Xueyuan Cao, PhD, Susana C. Raimondi, PhD, James R. Downing, MD, Raul Ribeiro, MD, Tanja A. Gruber, MD PhD, Rhonda E. Ries, MA, Soheil Meshinchi, MD PhD, Jeffrey Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder K Lamba, M.Sc., PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1429.
https://doi.org/10.1182/blood-2019-128787
Published: 2019
Journal Articles

Pediatric LSC3 (pLSC3) Score Derived from DNMT3B-CD34-GPR56 As a Prognostic Tool to Predict AML Patient Outcome: Results from Two Independent Pediatric AML Cohorts

Abdelrahman H Elsayed, MSc, Huiyun Wu, PhD, Xueyuan Cao, PhD, Susana C. Raimondi, PhD, James R. Downing, MD, Raul Ribeiro, MD, Tanja A. Gruber, MD PhD, Jeffrey Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder K Lamba, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 290.
https://doi.org/10.1182/blood-2018-99-116462
Published: 2018
Journal Articles

Metabolomics Profiling Reveals Markers for Chemosensitivity and Clinical Outcomes in Pediatric AML Patients

Bradley Stockard, PharmD, Huiyun Wu, PhD, Joy D. Guingab, PhD, Timothy J. Garrett, PhD, Jeffrey Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder K Lamba, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1536.
https://doi.org/10.1182/blood-2018-99-116665
Published: 2018
Journal Articles

Venetoclax and Navitoclax in Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Thomas Alexander, MD MPH, Norman J. Lacayo, MD, Vinod A. Pullarkat, MD, Elias J. Jabbour, MD, Seong Lin Khaw, MD, Charles G. Mullighan, MBBS, MD, Ashish Bajel, MBBS, FRACP, FRCPA, Jessica Leonard, MD, Robin Norris, MD, Jeffrey Rubnitz, MD PhD, Susan I. Vear, MD MSCI, Michelle Schmidt, Bo Tong, PhD, Ying Zhou, PhD, Jeremy A. Ross, PhD, Lindsey Rosenwinkel, Amanda Jacobson, PhD, Su Young Kim, MD PhD, Wendy Stock, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3966.
https://doi.org/10.1182/blood-2018-99-113464
Published: 2018
Journal Articles

Integrated Genome Wide Association Study (GWAS) Identifies SNPs Associated with Outcome in Pediatric AML

Abdelrahman H Elsayed, MSc, Huiyun Wu, PhD, Xueyuan Cao, PhD, Soheil Meshinchi, MD PhD, Raul Ribeiro, MD, Jeffrey Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder K Lamba, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2758.
https://doi.org/10.1182/blood-2018-99-120367
Published: 2018
Journal Articles

Outcome of Infants Younger Than 1 Year with Acute Lymphoblastic Leukemia Treated with the Interfant-06 Protocol; Results from an International Randomised Study

Rob Pieters, MDPhDMSc, Paola De Lorenzo, PhD, Philip Ancliffe, Luis Alberto Aversa, MD, Benoit Brethon, Andrea Biondi, MD, Myriam Campbell, Gabriele Escherich, Alina Ferster, MD, Rebecca Gardner, MD, Rishi Sury Kotecha, MBBChir, MRCP, FRACP, PhD, Birgitte Lausen, MD, Chi Kong Li, MD, Franco Locatelli, Andishe Attarbaschi, Christina Peters, MD, Jeffrey Rubnitz, MD PhD, Lewis B. Silverman, MD, Jan Stary, MD PhD, Tomasz Szczepanski, MD PhD, Ajay Vora, MD, Martin Schrappe, MD PhD, Maria Grazia Valsecchi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 655.
https://doi.org/10.1182/blood-2018-99-112854
Published: 2018
Journal Articles

Cytarabine-Induced Gene Expression Signatures in AML Patients and Its Association with Clinical Outcome.

Jatinder K. Lamba, PhD, Stanley Pounds, PhD, Xueyuan Cao, PhD, Kristine Crews, PharmD, Dario Campana, MD., PhD, James R. Downing, MD, Raul Ribeiro, MD, Jeffrey Rubnitz, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2470.
https://doi.org/10.1182/blood.V120.21.2470.2470
Published: 2012
Journal Articles

Pediatric Acute Myeloid Leukemia with t(8;16)(p11;p13): A Distinct Clinical and Biological Entity. Results of a Collaborative Study by the International Berlin-Frankfurt-Münster AML Study Group.

Eva A Coenen, MD, C. Michel Zwaan, Christine J Harrison, PhD, FRCPath, Oskar A. Haas, Valerie de Haas, MD, PhD, V Mihal, Barbara De Moerloose, M.D., M Jeison, Jeffrey Rubnitz, MD, PhD, Daisuke Tomizawa, MD, Donna Johnston, MD, FRCPC, Todd A. Alonzo, PhD, Henrik Hasle, Dirk Reinhardt, MD, PhD, Anne Auvrignon, Michael Dworzak, Andrea Pession, Vincent H.J. van der Velden, John Swansbury, Kit Fai Wong, MD, Kiminori Terui, MD, PhD, Sureyya Savasan, MD, M Winstanley, G Vaitkeviciene, Martin Zimmermann, Rob Pieters, MD, PhD, Marry M. van den Heuvel-Eibrink
Journal: Blood
Blood (2012) 120 (21): 2516.
https://doi.org/10.1182/blood.V120.21.2516.2516
Published: 2012
Journal Articles

Clinical Impact of Additional Cytogenetic Aberrations and Treatment in Pediatric t(8;21)-Positive AML: Results from an International Retrospective I-BFM-SG Study

Ardine Reedijk, MSc, Gertjan Kaspers, MD, PhD, Marta Fiocco, PhD, Andrea Pession, Prof, MD, Dirk Reinhardt, MD, PhD, Martin Zimmermann, PhD, Michael Dworzak, Todd A. Alonzo, PhD, Donna Johnston, MD, FRCPC, Michal Zapotocky, Barbara De Moerloose, Fynn Finita, Vincent Lee, MD, PhD, Takashi Taga, MD, Akio Tawa, MD, PhD, Anne Auvrignon, Bernward Zeller, Carmen Salgado, MD, PhD, Walentyna Balwierz, MD, PhD, Alexander Popa, Jeffrey Rubnitz, MD, PhD, H.B. Berna Beverloo, PhD, Christine J Harrison, PhD, FRCPath, Brenda Gibson
Journal: Blood
Blood (2012) 120 (21): 884.
https://doi.org/10.1182/blood.V120.21.884.884
Published: 2012
Journal Articles

Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases: A Report From the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project

Tanja A Gruber, MD, PhD, Amanda Larson Gedman, PhD, Huy Q. Ta, PhD, Jinghui Zhang, PhD, Cary Koss, BS, Shann-Ching Chen, PhD, Xiaoping Su, PhD, Vedant Gupta, BS, Stacey Ogden, PhD, Anna K. Andersson, PhD, John Easton, PhD, Jianmin Wang, PhD, Michael Rusch, BA, Li Ding, PhD, Giovanni Cazzaniga, Andrea Biondi, MD, Steven M. Kornblau, MD, Farhad Ravandi, MD, Hagop M. Kantarjian, Stephen D. Nimer, MD, Konstanze Doehner, Prof., Hartmut Doehner, MD, Timothy J Ley, MD, Sheila Shurtleff, PhD, Jeffrey Rubnitz, MD, PhD, Ching-Hon Pui, MD, Elaine R. Mardis, PhD, Richard K. Wilson, PhD, James R. Downing, MD
Journal: Blood
Blood (2011) 118 (21): 757.
https://doi.org/10.1182/blood.V118.21.757.757
Published: 2011
Journal Articles

Clinical Impact of Additional Cytogenetic Aberrations and Complex Karyotype In Pediatric 11q23/ MLL -Rearranged AML: Results from an International Retrospective Study

Eva A Coenen, MD, Susana C. Raimondi, PhD, Jochen Harbott, Zimmermann Martin, Brian V Balgobind, Todd A. Alonzo, PhD, Anne Auvrignon, Berna Beverloo, Myron Chang, Ursula Creutzig, MD, Michael Dworzak, Erik Forestier, Brenda Gibson, Henrik Hasle, MD, PhD, Christine J Harrison, PhD, FRCPath, Nyla A. Heerema, Ph.D., Gertjan J. Kaspers, MD, PhD, Anna Leszl, Nathalia Litvinko, Luca lo Nigro, Akira Morimoto, Christine Perot, Dirk Reinhardt, MD, PhD, Jeffrey Rubnitz, MD, PhD, Franklin O. Smith, MD, Jan Stary, Irina Stasevich, Sabine Strehl, Takashi Taga, MD, PhD, Daisuke Tomizawa, MD, David Webb, Zuzana Zemanova, PhD, Rob Pieters, MD, PhD, C. Michel Zwaan, Marry van den Heuvel-Eibrink
Journal: Blood
Blood (2010) 116 (21): 762.
https://doi.org/10.1182/blood.V116.21.762.762
Published: 2010
Journal Articles

Myeloid Leukemia of Down Syndrome: The Results of An International Retrospective Study

Marjolein Blink, Marry M. Van den Heuvel-Eibrink, Válerie de Haas, MD, PhD, Henrik Hasle, MD, PhD, Maureen O'Brien, MD, MS, Batia Stark, Julie Tandonnet, MD, Andrea Pession, Katerina Tousovska, Daniel K.L. Cheuk, Kazuko Kudo, MD, Takashi Taga, MD, PhD, Jeffrey Rubnitz, MD, PhD, Irén Haltrich, Walentyna Balwierz, Bertil Johansson, MD, PhD, Martin Zimmermann, Dirk Reinhardt, MD, PhD, Rob Pieters, MD, PhD, Erik Forestier, Christian M. Zwaan, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2718.
https://doi.org/10.1182/blood.V116.21.2718.2718
Published: 2010
Journal Articles

Pathway Based Pharmacogenomics of Cytarabine In Pediatric Acute Myeloid Leukemia

Jatinder Lamba, PhD, Amit Mitra, Kristine Crews, Pounds Stanley, PhD, Xueyuan Cao, PhD, Varsha Gandhi, PhD, William Plunkett, PhD, Jeffrey Rubnitz, MD, PhD, Raul Ribeiro
Journal: Blood
Blood (2010) 116 (21): 294.
https://doi.org/10.1182/blood.V116.21.294.294
Published: 2010
Journal Articles

Minimal Residual Disease–Directed Therapy for Childhood Acute Myeloid Leukemia: Results of the AML02 Multicenter Trial.

Jeffrey Rubnitz, MD, PhD, Hiroto Inaba, MD, PhD, Gary Dahl, MD, W. Paul Bowman, Jeffrey Taub, MD, Ching-Hon Pui, MD, Stanley Pounds, Norman J. Lacayo, MD, Xueyuan Cao, Raul C. Ribeiro, MD, Soheil Meshinchi, MD, PhD, Barbara Degar, MD, Gladstone Airewele, Mihaela Onciu, MD, Elaine Coustan-Smith, MS, Dario Campana, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 16.
https://doi.org/10.1182/blood.V114.22.16.16
Published: 2009
Journal Articles

Synergistic Antileukemic Interactions Between Valproic Acid and Cytarabine: A Potential Means to Improve the Treatment of Pediatric Acute Myeloid Leukemia.

Chengzhi Xie, Holly Edwards, Lisa Polin, Hui Zhou, Xuanlin Wang, Song Yang, Salvatore B LoGrasso, Steven Buck, Mark Stout, Jeffrey Rubnitz, MD, PhD, Larry Matherly, PhD, Jeffrey Taub, MD, Qun Yu, Yubin Ge, PhD
Journal: Blood
Blood (2009) 114 (22): 2084.
https://doi.org/10.1182/blood.V114.22.2084.2084
Published: 2009
Journal Articles

Acute Megakaryoblastic Leukemia (AMKL) in Children without Down Syndrome.

Maureen O'Brien, MD, Gary Dahl, MD, Stanley Pounds, Norman J. Lacayo, MD, Jeffrey Taub, MD, Myron Chang, Howard J. Weinstein, MD, Yaddanapudi Ravindranath, MBBS, Dario Campana, MD, PhD, Ching-Hon Pui, MD, Jeffrey Rubnitz, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 482.
https://doi.org/10.1182/blood.V114.22.482.482
Published: 2009