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John F. Lyons, PhD
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Journal Articles

Anti-Tumor Activity of ASTX029, a Dual Mechanism Inhibitor of ERK1/2, in Preclinical AML Models

Christopher J. Hindley, PhD, Lynsey Fazal, BSc, Joanne M. Munck, PhD, Vanessa Martins, BSc, Alpesh D. Shah, MSci, Nicola E. Wilsher, PhD, Nicola G. Wallis, PhD, Harold N. Keer, MDPhD, John F. Lyons, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-139175
Published: 2020
Journal Articles

A Phase II Study of AT9283, an Aurora Kinase Inhibitor, in Patients with Relapased or Refractory Multiple Myloma; NCIC Clinical Trials Group IND.191

Annette E Hay, MB ChB, Alli Murugesan, PhD, Ashley M. DiPasquale, BSc, Tom Kouroukis, MD MSc, FRCPC, Irwindeep Sandhu, MD FRCPC, Vishal Kukreti, MD, Nizar J Bahlis, MD, Johan Lategan, MD, Donna E. Reece, MD, John F. Lyons, PhD, Joana Sederias, MSc, Jean Powers, MSc, Hao Xu, MSc, Lesley K. Seymour, MD PhD FRCP (C), Anthony Reiman, MD
Journal: Blood
Blood (2014) 124 (21): 5734.
https://doi.org/10.1182/blood.V124.21.5734.5734
Published: 2014
Journal Articles

Identification of Novel Methylation Biomarkers to Predict Clinical Response to SGI-110, a Second Generation Hypomethylating Agent (HMA), in Patients with Acute Myeloid Leukaemia (AML)

Simone Jueliger, PhD, John F Lyons, PhD, Joern Lewin, PhD, Mohammad Azab, MD, Pietro Taverna, PhD
Journal: Blood
Blood (2014) 124 (21): 1050.
https://doi.org/10.1182/blood.V124.21.1050.1050
Published: 2014
Journal Articles

A Phase II Study of AT7519M, a CDK Inhibitor, in Patients with Chronic Lymphocytic Leukemia: NCIC CTG Trial IND.193

Matthew D. Seftel, MDMPH FRCPC, John Kuruvilla, MD, Versha Banerji, MD, Graeme Fraser, MDFRCPC, Hao Xu, MSc, Jean Powers, MSc, Susan Crocker, PhD, Marcia Toguchi, PhD, John F Lyons, PhD, Lesley Seymour, MDPhD, Annette E Hay, MB ChB
Journal: Blood
Blood (2014) 124 (21): 5670.
https://doi.org/10.1182/blood.V124.21.5670.5670
Published: 2014
Journal Articles

Determinants Of Demethylation and Clinical Response In AML Patients Treated With SGI-110, a Novel Subcutaneous (SQ) Hypomethylating Agent (HMA) In a Phase 1 Study

Woonbok Chung, PhD, Pietro Taverna, PhD, John F Lyons, PhD, Yong Hao, PhD, Mohammad Azab, MD, Hagop M. Kantarjian, MD, Patricia Kropf, MD, Jean-Pierre Issa, MD
Journal: Blood
Blood (2013) 122 (21): 1442.
https://doi.org/10.1182/blood.V122.21.1442.1442
Published: 2013
Journal Articles

A Phase I/II Open-Label Multicenter Study Of The Cyclin Kinase Inhibitor AT7519M Alone and In Combination With Bortezomib In Patients With Previously Treated Multiple Myeloma

Noopur Raje, MD, Parameswaran N. Hari, MD, MRCP, MS, Heather Landau, MD, Paul G. Richardson, MD, Jacalyn Rosenblatt, MD, Nicole Couture, RN, John F. Lyons, PhD, Gillian Langford, PhD, Murray Yule, MD
Journal: Blood
Blood (2013) 122 (21): 1976.
https://doi.org/10.1182/blood.V122.21.1976.1976
Published: 2013
Journal Articles

The Activity of AT9283 in Acute Myeloid Leukemia in Vitro and in the Clinic Is Karyotype Dependent.

John F Lyons, PhD, Matthew S Squires, John Goodall, Murray Yule, Farhad Ravandi, MD, James Foran, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2009) 114 (22): 4159.
https://doi.org/10.1182/blood.V114.22.4159.4159
Published: 2009
Journal Articles

Activity of the Multi-Targeted Kinase Inhibitor, AT9283 on Imatinib-Resistant CML Models.

Ruriko Tanaka, MMSc, Matthew S Squires, PhD, Shinya Kimura, MD, PhD, Asumi Yokota, MMSc, Kirsty Mallett, PhD, Tomoko Smyth, PhD, Neil T Thompson, PhD, Rina Nagao, Takahiro Yamauchi, MD, Takashi Ushiki, MD, John F Lyons, PhD, Taira Maekawa, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1104.
https://doi.org/10.1182/blood.V112.11.1104.1104
Published: 2008
Journal Articles

AT7519, a Potent CDK Inhibitor, Is Active in Leukemia Models and Primary CLL Patient Samples.

Matthew S. Squires, PhD, Ruth E. Feltell, BSc, Victoria Lock, Donna M. Smith, PhD, Jon E. Lewis, Jacqueline Higgins, Murray Yule, MD, Neil T. Thompson, PhD, Laurence Cooke, Kimiko D. Croce, Wenqing Qi, John F. Lyons, PhD, Daruka Mahadevan
Journal: Blood
Blood (2007) 110 (11): 3127.
https://doi.org/10.1182/blood.V110.11.3127.3127
Published: 2007