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Journal Articles

A cell-based functional assay that accurately links genotype to phenotype in familial HLH

Tahereh Noori, Jesse A. Rudd-Schmidt, Alisa Kane, Katie Frith, Paul E. Gray, Hannah Hu, Danny Hsu, Clara W. T. Chung, Adrian W. Hodel, Joseph A. Trapani, Ilia Voskoboinik

Blood (2023) 141 (19): 2330–2342.

https://doi.org/10.1182/blood.2022018398

Published: 2023

Includes: Supplemental data

Journal Articles

Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1

Daniela Castiblanco, Jesse A. Rudd-Schmidt, Tahereh Noori, Vivien R. Sutton, Ya Hui Hung, Thijs W. H. Flinsenberg, Adrian W. Hodel, Neil D. Young, Nicholas Smith, Drago Bratkovic, Heidi Peters, Mark Walterfang, Joseph A. Trapani, Amelia J. Brennan, Ilia Voskoboinik

Blood (2022) 139 (12): 1833–1849.

https://doi.org/10.1182/blood.2021013477

Published: 2022

Includes: Multimedia, Supplemental data

Journal Articles

Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

Ilia Voskoboinik, Paul Lacaze, Helena Sung-In Jang, Thijs Flinsenberg, Suran L. Fernando, Ian Kerridge, Moeen Riaz, Robert Sebra, Kevin Thia, Taherah Noori, Eric E. Schadt, John J. McNeil, Joseph A. Trapani

Blood (2020) 135 (8): 582–584.

https://doi.org/10.1182/blood.2019003487

Published: 2020

Includes: Supplemental data

Journal Articles

Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome

Stephen Opat, Anna C. Hearps, Kevin Thia, Agnes Yuen, Ben Rogers, Mkunde Chachage, Gregory Moore, Jake Shortt, Georgina Ryland, Piers Blombery, Anthony P. Schwarer, Tahereh Noori, Joseph A. Trapani, Anthony Jaworowski, Ilia Voskoboinik

Blood (2018) 131 (6): 699–702.

https://doi.org/10.1182/blood-2017-08-803668

Published: 2018

Includes: Supplemental data

Journal Articles

Bigger, Stronger, Faster: Chimeric Antigen Receptor T Cells Are Olympic Killers

Paul J Neeson, BSc, PhD, Alexander James Davenport, BSC, MSc, Joseph A Trapani, Michael Kershaw, PhD, Ryan Cross, H. Miles Prince, MD PhD, Ricky W Johnstone, PhD, David Ritchie, MD PhD, Phil Darcy, Misty R Jenkins

Blood (2016) 128 (22): 814.

https://doi.org/10.1182/blood.V128.22.814.814

Published: 2016

Journal Articles

A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation and Onset of Gvhd

Joanne E Davis, PhD, Michael Harvey, BSc(Hons), Nicholas A Gherardin, BSc(Hons), Rachel Koldej, PhD, Nicholas Huntington, PhD, Paul Neeson, PhD, Joseph A Trapani, PhD MBBS, FRACP, David Ritchie, MBBS, PhD FRACP, FRCPA

Blood (2014) 124 (21): 3805.

https://doi.org/10.1182/blood.V124.21.3805.3805

Published: 2014

Journal Articles

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Jamie A. Lopez, Olivia Susanto, Misty R. Jenkins, Natalya Lukoyanova, Vivien R. Sutton, Ruby H. P. Law, Angus Johnston, Catherina H. Bird, Phillip I. Bird, James C. Whisstock, Joseph A. Trapani, Helen R. Saibil, Ilia Voskoboinik

Blood (2013) 121 (14): 2659–2668.

https://doi.org/10.1182/blood-2012-07-446146

Published: 2013

Includes: Multimedia, Supplemental data

Journal Articles

Surprisingly variable “dangers, toils, and snares” faced by humans and mice

Joseph A. Trapani, Ilia Voskoboinik

Blood (2013) 121 (4): 568–570.

https://doi.org/10.1182/blood-2012-11-468652

Published: 2013

Journal Articles

Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin

Jenny Chia, Kevin Thia, Amelia J. Brennan, Margaret Little, Bronwyn Williams, Jamie A. Lopez, Joseph A. Trapani, Ilia Voskoboinik

Blood (2012) 119 (7): 1713–1716.

https://doi.org/10.1182/blood-2011-08-374355

Published: 2012

Includes: Supplemental data

Journal Articles

Response: dexamethasone dose alters expression of NK activating receptors in vivo

Andy Hsu, Hang Quach, Tsin Tai, H. Miles Prince, Simon J. Harrison, Joseph A. Trapani, Mark J. Smyth, Paul J. Neeson, David S. Ritchie

Blood (2011) 118 (24): 6466–6468.

https://doi.org/10.1182/blood-2011-10-382291

Published: 2011

Journal Articles

The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy

Andy K. Hsu, Hang Quach, Tsin Tai, H. Miles Prince, Simon J. Harrison, Joseph A. Trapani, Mark J. Smyth, Paul Neeson, David S. Ritchie

Blood (2011) 117 (5): 1605–1613.

https://doi.org/10.1182/blood-2010-04-278432

Published: 2011

Includes: Supplemental data

Journal Articles

Targeting Lewis Y-Positive Multiple Myeloma and Acute Myeloid Leukemia with Gene-Modified T Cells Demonstrating Memory Phenotype

Stefan Peinert, David S. Ritchie, Dirk Hoenemann, Simon J. Harrison, Preethi Guru, Michael H. Kershaw, Amanda Shin, Mark J. Smyth, Joseph A. Trapani, Andrew M Scott, Glenn A Cartwright, Fiona E Smyth, Barbara E Power, Phillip K. Darcy, Peter Gambell, David Westerman, Paul Neeson, H. Miles Prince

Blood (2008) 112 (11): 3900.

https://doi.org/10.1182/blood.V112.11.3900.3900

Published: 2008

Journal Articles

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

Ilia Voskoboinik, Vivien R. Sutton, Annette Ciccone, Colin M. House, Jenny Chia, Phillip K. Darcy, Hideo Yagita, Joseph A. Trapani

Blood (2007) 110 (4): 1184–1190.

https://doi.org/10.1182/blood-2007-02-072850

Published: 2007

Journal Articles

Adoptive transfer of gene-engineered CD4 + helper T cells induces potent primary and secondary tumor rejection

Maria Moeller, Nicole M. Haynes, Michael H. Kershaw, Jacob T. Jackson, Michele W. L. Teng, Shayna E. Street, Loretta Cerutti, Stephen M. Jane, Joseph A. Trapani, Mark J. Smyth, Phillip K. Darcy

Blood (2005) 106 (9): 2995–3003.

https://doi.org/10.1182/blood-2004-12-4906

Published: 2005

Journal Articles

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis

Ilia Voskoboinik, Marie-Claude Thia, Joseph A. Trapani

Blood (2005) 105 (12): 4700–4706.

https://doi.org/10.1182/blood-2004-12-4935

Published: 2005

Journal Articles

Immune surveillance of lymphoma in humans?

Mark J. Smyth, Ilia Voskoboinik, Joseph A. Trapani

Blood (2005) 105 (11): 4159–4160.

https://doi.org/10.1182/blood-2005-03-1019

Published: 2005

Journal Articles

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

Nicole M. Haynes, Joseph A. Trapani, Michèle W. L. Teng, Jacob T. Jackson, Loretta Cerruti, Stephen M. Jane, Michael H. Kershaw, Mark J. Smyth, Phillip K. Darcy

Blood (2002) 100 (9): 3155–3163.

https://doi.org/10.1182/blood-2002-04-1041

Published: 2002

NARROW

A cell-based functional assay that accurately links genotype to phenotype in familial HLH

Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1

Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome

Bigger, Stronger, Faster: Chimeric Antigen Receptor T Cells Are Olympic Killers

A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation and Onset of Gvhd

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Surprisingly variable “dangers, toils, and snares” faced by humans and mice

Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin

Response: dexamethasone dose alters expression of NK activating receptors in vivo

The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy

Targeting Lewis Y-Positive Multiple Myeloma and Acute Myeloid Leukemia with Gene-Modified T Cells Demonstrating Memory Phenotype

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

Adoptive transfer of gene-engineered CD4 + helper T cells induces potent primary and secondary tumor rejection

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis

Immune surveillance of lymphoma in humans?

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

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American Society of Hematology

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ASH Publications

American Society of Hematology

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