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Journal Articles

Expansion of T Helper Cell Subsets in Chronic Lymphocytic Leukemia Cell Co-Cultures with Nurselike Cells

Alicia Vaca, PhD, Mariela Sivina, Karen Clise-Dwyer, PhD, Ekaterina Kim, MS, Michael J Keating, MBBS, Alessandra Ferrajoli, MD, William G. Wierda, MD PhD, Dan Li, PhD, Qing Ma, PhD, Jan A. Burger, MD PhD

Blood (2019) 134 (Supplement_1): 1746.

https://doi.org/10.1182/blood-2019-125827

Published: 2019

Journal Articles

Single-Cell RNA Sequencing Reveals Distinct Hematopoietic Stem Cell Hierarchies in MDS

Irene Ganan-Gomez, PhD, Hui Yang, PhDMD, Feiyang Ma, Bs, Matteo Pellegrini, PhD, Karen Clise-Dwyer, PhD, Guillermo Garcia-Manero, MD, Simona Colla, PhD

Blood (2019) 134 (Supplement_1): 771.

https://doi.org/10.1182/blood-2019-128798

Published: 2019

Journal Articles

Induced PD-1 Expression on Bone Marrow CD34+ Cells from MDS Patients Treated with 5-Azacitadine in Combination with Nivolumab and/or Ipilimumab

Hui Yang, PhDMD, Zhihong Fang, Karen Clise-Dwyer, PhD, Kathryn Ruisaard, Simona Colla, PhD, Irene Ganan-Gomez, PhD, Guillermo Montalban-Bravo, MD, Kelly Soltysiak, Naval G. Daver, MD, Elias J. Jabbour, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD

Blood (2018) 132 (Supplement 1): 1807.

https://doi.org/10.1182/blood-2018-99-119278

Published: 2018

Journal Articles

Pembrolizumab Enhances the Anti-Leukemia Activity of Antigen Specific Cytotoxic T Lymphocytes

Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Anne V. Philips, PhD, Na Qiao, PhD, Celine Kerros, PhD, Lisa St. John, PhD, Alexander A. Perakis, BS, Karen Clise-Dwyer, PhD, Elizabeth Mittendorf, MD PhD, Naval G. Daver, MD, Jeffrey J. Molldrem, MD, Qing Ma, PhD, Gheath Alatrash, DO, PhD

Blood (2018) 132 (Supplement 1): 4542.

https://doi.org/10.1182/blood-2018-99-114864

Published: 2018

Journal Articles

Telomere Damage Maintains Hematopoietic Stem Cells (HSCs) in an Activated Metabolic State, Which Compromises Their Self-Renewal Capability

Andrea Santoni, PhD, Elena Fiorini, MS, Fides D Lay, PhD BSc, Matteo Marchesini, PhD, Yamini Ogoti, Christopher Jackson, Ashley Rose, Karen Clise-Dwyer, PhD, Irene Ganan-Gomez, PhD, Guillermo Garcia-Manero, MD, Simona Colla, PhD

Blood (2018) 132 (Supplement 1): 174.

https://doi.org/10.1182/blood-2018-174

Published: 2018

Journal Articles

Cell-Type Specific Mechanisms of Hematopoietic Stem Cell (HSC) Expansion Underpin Progressive Disease in Myelodysplastic Syndromes (MDS) and Provide a Rationale for Targeted Therapies

Blood (2018) 132 (Supplement 1): 1798.

https://doi.org/10.1182/blood-2018-99-116881

Published: 2018

Journal Articles

Humanized Anti-PR1/HLA-A2 T Cell Receptor-like Monoclonal Antibody, h8F4, Has Multiple Effector Mechanisms

Anna Sergeeva, PhD, Hong He, MD, Kathryn Cox, Lisa St John, PhD, Mei Sang, Celine Kerros, PhD, Qiaochuan Li, PhD MD, Amanda Herrmann, Karen Clise-Dwyer, PhD, Qing Ma, PhD, Gregory Lizee, PhD, Gheath Alatrash, DO, PhD, Jeffrey J. Molldrem, MD

Blood (2016) 128 (22): 4061.

https://doi.org/10.1182/blood.V128.22.4061.4061

Published: 2016

Journal Articles

Hematopoietic Architecture of MDS before and after Progression Reveals Two Biologically Distinct Disease Subtypes

Irene Gañán-Gómez, PhD, Ana Alfonso, MD, Yamini Ogoti, MS, Hui Yang, MD PhD, Guillermo Montalban-Bravo, MD, Abraham C Yu, BS, Matteo Marchesini, PhD, Carlos E Bueso-Ramos, MD PhD, Koichi Takahashi, MD, Karen Clise-Dwyer, PhD, Guillermo Garcia-Manero, MD, Simona Colla, PhD

Blood (2016) 128 (22): 4310.

https://doi.org/10.1182/blood.V128.22.4310.4310

Published: 2016

Journal Articles

ILF2-YB1 Protein Interaction Modulates RNA Splicing to Induce Resistance to Chemotherapy in High Risk Multiple Myeloma

Matteo Marchesini, PhD, Yamini Ogoti, MS, Elena Fiorini, MS, Marianna D'anca, PhD, Paola Storti, PhD, Luigi Nezi, PhD, Mehmet K. Samur, PhD, Irene Gañán-Gómez, PhD, Mariateresa Fulciniti, PhD, Zachary S. Bohannan, MA, Karen Clise-Dwyer, PhD, Nicola Giuliani, MD PhD, Nikhil C Munshi, MD, Robert Z. Orlowski, PhD, MD, Guillermo Garcia-Manero, MD, Ronald A. DePinho, Simona Colla, PhD

Blood (2016) 128 (22): 359.

https://doi.org/10.1182/blood.V128.22.359.359

Published: 2016

Journal Articles

Inhibition of T Cell Proliferation By Granulocyte Membrane-Associated Proteinase 3 Is Reversed By Blocking the Interaction of Calreticulin with LRP on T Cells

Tian-Hui Yang, PhD, Lisa S. St. John, PhD, Karen Clise-Dwyer, PhD, Kathryn Ruisaard, MS, Gheath Alatrash, DO, PhD, Jeffrey J. Molldrem, MD

Blood (2014) 124 (21): 4110.

https://doi.org/10.1182/blood.V124.21.4110.4110

Published: 2014

Journal Articles

Cathepsin G Is Broadly Expressed By AML and Is an Effective Immunotherapeutic Target Against AML in Vivo

Gheath Alatrash, DO, PhD, Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Yihua Qiu, MD, Amjad H. Talukder, PhD, Vladimir Senyukov, PhD, Lisa S. St. John, PhD, Hong He, MD, Anna Sergeeva, PhD, Jason Roszik, PhD, Karen Clise-Dwyer, PhD, Sijie Lu, PhD, Qing Ma, PhD, Elizabeth A. Mittendorf, MD PhD, Dean A. Lee, MD PhD, David H Hawke, PhD, Lizee Gregory, PhD, Jeffrey J. Molldrem, Steven M. Kornblau, MD

Blood (2014) 124 (21): 3761.

https://doi.org/10.1182/blood.V124.21.3761.3761

Published: 2014

Journal Articles

A Mouse Model of Telomere Dysfunction Recapitulates Hallmark Features of Human Myelodysplastic Syndrome

Blood (2014) 124 (21): 523.

https://doi.org/10.1182/blood.V124.21.523.523

Published: 2014

Journal Articles

RNA-Seq Expression Profiling of AML Stem Cells Reveals Differential Expression of Lineage Differentiation Markers and Novel Splice Variants.

Benjamin G Vincent, MD, Darshan Singh, MS, Michael Wu, PhD, Sally A. Hunsucker, PhD, Gheath Alatrash, DO, PhD, Kathryn Ruisaard, MS, Pariya Sukhumalchandra, BS, Karen Clise-Dwyer, PhD, Jonathan S Serody, MD, Jan F Prins, PhD, Jeffrey J. Molldrem, M.D., Paul M. Armistead, MD, PhD

Blood (2012) 120 (21): 2502.

https://doi.org/10.1182/blood.V120.21.2502.2502

Published: 2012

Journal Articles

Membrane-Associated Proteinase 3 On Granulocytes and Myeloid Leukemia Mediates Reversible Inhibition of T Cell Proliferation Associated with Altered ZAP70 and ERK Signaling

Tian-Hui Yang, MD, PhD, Karen Clise-Dwyer, PhD, S Lisa, St. John, PhD, Gheath Alatrash, DO, PhD, Kathryn Ruisaard, MS, Sijie Lu, PhD, Jeffrey J. Molldrem, MD

Blood (2012) 120 (21): 1031.

https://doi.org/10.1182/blood.V120.21.1031.1031

Published: 2012

Journal Articles

Multiple Myeloma Cross-Presents Neutrophil Elastase and Proteinase 3 and Becomes Susceptible to PR1-Targeting Immunotherapy

Gheath Alatrash, DO, PhD, Pariya Sukhumalchandra, BS, Mao Zhang, MPH, Anna Sergeeva, PhD, Haroon Jakher, BS, Jinsheng Weng, Ph.D, Lisa S St. John, PhD, Kathryn Ruisaard, BS, Karen Clise-Dwyer, PhD, Sijie Lu, PhD, Jeffrey J. Molldrem, MD

Blood (2012) 120 (21): 4973.

https://doi.org/10.1182/blood.V120.21.4973.4973

Published: 2012

Journal Articles

Membrane-Associated Proteinase 3 on Granulocytes and Myeloid Leukemia Mediates Reversible Inhibition of T Cell Proliferation

Tian-Hui Yang, MD, PhD, Karen Clise-Dwyer, PhD, Gheath Alatrash, DO, PhD, Kathryn Ruisaard, MS, Shoudan Liang, PhD, Jeffrey J. Molldrem, MD

Blood (2011) 118 (21): 1916.

https://doi.org/10.1182/blood.V118.21.1916.1916

Published: 2011

Journal Articles

Treatment with 8F4, An Anti-PR1/HLA-A2 T Cell Receptor-Like Antibody, Reduces Established Acute Myeloid Leukemia and Eliminates Leukemia Stem Cells in Mice

Anna Sergeeva, PhD, Hong He, MD, PhD, Kathryn Ruisaard, MS, Karen Clise-Dwyer, PhD, Lisa S St. John, PhD, Rebecca Patenia, Pariya Sukhumalchandra, BS, Gheath Alatrash, DO, PhD, William K Decker, PhD, Elizabeth J Shpall, MD, M. James You, MD, PhD, Qing Ma, PhD, Jeffrey J. Molldrem, MD

Blood (2011) 118 (21): 766.

https://doi.org/10.1182/blood.V118.21.766.766

Published: 2011

Journal Articles

A Novel HLA-A2 Restricted Peptide Derived From Cathepsin G Is An Effective Immunotherapeutic Target for Myeloid Leukemia

Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Atim A. Enyenihi, PhD, Lisa S St. John, PhD, Sally A. Hunsucker, PhD, Kathryn Ruisaard, MS, Zein Al Atrache, Patricia A Ropp, PhD, Tania Rodriguez-Cruz, BS, Elizabeth Mittendorf, MD, Gregory Lizee, PhD, Karen Clise-Dwyer, PhD, Sijie Lu, PhD, Gary L. Glish, PhD, Jeffrey J. Molldrem, MD, Paul M Armistead, MD, PhD, Gheath Alatrash, D.O., Ph.D.

Blood (2011) 118 (21): 2986.

https://doi.org/10.1182/blood.V118.21.2986.2986

Published: 2011

Journal Articles

Soluble Inflammatory Mediators Proteinase-3 and Neutrophil Elastase Are Targeted by PR1-Specific Immunotherapy After Cellular Uptake and Cross Presentation of PR1 Peptide by Breast Cancer Cells

Gheath Alatrash, DO, PhD, Elizabeth Mittendorf, MD, Anna Sergeeva, PhD, Pariya Sukhumalchandra, BS, Na Qiao, PhD, Kathryn Quintanilla, MS, Mao Zhang, MPH, Lu Sijie, PhD, Karen Clise-Dwyer, PhD, Jeffrey J. Molldrem, MD

Blood (2010) 116 (21): 2089.

https://doi.org/10.1182/blood.V116.21.2089.2089

Published: 2010

Journal Articles

Cellular Uptake of Soluble Neutrophil Elastase Increases Cyclin E (CCNE) Isoform Expression and Significantly Augments Susceptibility of Breast Cancer Cells to Cytolysis by CCNE-Specific Cytotoxic T Lymphocytes

Elizabeth Mittendorf, M.D., Gheath Alatrash, Na Qiao, Pariya Sukhumalchandra, Sijie Lu, Kathryn Quintanilla, Karen Clise-Dwyer, PhD, Jeffrey J. Molldrem, MD

Blood (2010) 116 (21): 2090.

https://doi.org/10.1182/blood.V116.21.2090.2090

Published: 2010

NARROW

Expansion of T Helper Cell Subsets in Chronic Lymphocytic Leukemia Cell Co-Cultures with Nurselike Cells

Single-Cell RNA Sequencing Reveals Distinct Hematopoietic Stem Cell Hierarchies in MDS

Induced PD-1 Expression on Bone Marrow CD34+ Cells from MDS Patients Treated with 5-Azacitadine in Combination with Nivolumab and/or Ipilimumab

Pembrolizumab Enhances the Anti-Leukemia Activity of Antigen Specific Cytotoxic T Lymphocytes

Telomere Damage Maintains Hematopoietic Stem Cells (HSCs) in an Activated Metabolic State, Which Compromises Their Self-Renewal Capability

Cell-Type Specific Mechanisms of Hematopoietic Stem Cell (HSC) Expansion Underpin Progressive Disease in Myelodysplastic Syndromes (MDS) and Provide a Rationale for Targeted Therapies

Humanized Anti-PR1/HLA-A2 T Cell Receptor-like Monoclonal Antibody, h8F4, Has Multiple Effector Mechanisms

Hematopoietic Architecture of MDS before and after Progression Reveals Two Biologically Distinct Disease Subtypes

ILF2-YB1 Protein Interaction Modulates RNA Splicing to Induce Resistance to Chemotherapy in High Risk Multiple Myeloma

Inhibition of T Cell Proliferation By Granulocyte Membrane-Associated Proteinase 3 Is Reversed By Blocking the Interaction of Calreticulin with LRP on T Cells

Cathepsin G Is Broadly Expressed By AML and Is an Effective Immunotherapeutic Target Against AML in Vivo

A Mouse Model of Telomere Dysfunction Recapitulates Hallmark Features of Human Myelodysplastic Syndrome

RNA-Seq Expression Profiling of AML Stem Cells Reveals Differential Expression of Lineage Differentiation Markers and Novel Splice Variants.

Membrane-Associated Proteinase 3 On Granulocytes and Myeloid Leukemia Mediates Reversible Inhibition of T Cell Proliferation Associated with Altered ZAP70 and ERK Signaling

Multiple Myeloma Cross-Presents Neutrophil Elastase and Proteinase 3 and Becomes Susceptible to PR1-Targeting Immunotherapy

Membrane-Associated Proteinase 3 on Granulocytes and Myeloid Leukemia Mediates Reversible Inhibition of T Cell Proliferation

Treatment with 8F4, An Anti-PR1/HLA-A2 T Cell Receptor-Like Antibody, Reduces Established Acute Myeloid Leukemia and Eliminates Leukemia Stem Cells in Mice

A Novel HLA-A2 Restricted Peptide Derived From Cathepsin G Is An Effective Immunotherapeutic Target for Myeloid Leukemia

Soluble Inflammatory Mediators Proteinase-3 and Neutrophil Elastase Are Targeted by PR1-Specific Immunotherapy After Cellular Uptake and Cross Presentation of PR1 Peptide by Breast Cancer Cells

Cellular Uptake of Soluble Neutrophil Elastase Increases Cyclin E (CCNE) Isoform Expression and Significantly Augments Susceptibility of Breast Cancer Cells to Cytolysis by CCNE-Specific Cytotoxic T Lymphocytes

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American Society of Hematology

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ASH Publications

American Society of Hematology

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