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Journal Articles

Results from an Association-Scan of the Extended MHC-Class-II Region Using Novel Association-Based Statistical Methods Establish That DQ Allotypes and Race Independently Influence the Risk of Factor VIII Inhibitor Development in Hemophilia-A Patients

Paola Ibarra, Marcio A. Almeida, Vincent P. Diego, Bernadette W. Luu, Kevin R. Viel, Raja Rajalingam, Afshin Ameri, Meera Chitlur, Benjamin Kim, Grecia Castillo, Jerry S. Powell, Juan M. Peralta, Miguel A. Escobar, Sarah Williams-Blangero, John Blangero, Carol K. Kasper, Laura Almasy, Tom E. Howard

Blood (2023) 142 (Supplement 1): 1247.

https://doi.org/10.1182/blood-2023-191140

Published: 2023

Journal Articles

Gene-Centric Association Scans of Pleiotropic Immune-Mediated Disease Genes in the PATH Study Identify Novel Determinants of Factor VIII Inhibitor Risk in Hemophilia-A Patients and Confirm Race as an Independent Predictor

Ruayda Bouls, Marcio A. Almeida, Vincent P. Diego, Bernadette W. Luu, Raja Rajalingam, Afshin Ameri, Kevin R. Viel, Meera Chitlur, Benjamin Kim, Miguel A. Escobar, Sarah Williams-Blangero, Carol K. Kasper, Laura Almasy, John Blangero, Tom E. Howard

Blood (2023) 142 (Supplement 1): 1246.

https://doi.org/10.1182/blood-2023-190094

Published: 2023

Journal Articles

A Novel Biomarker for Inhibitor Risk Prediction-the HLA-II Bound and Unbound Components of FVIII Derived Peptides-Reveals a Protective Influence for N-Linked Glycosylation

Kevin R. Viel, PhD, Marco Hofmann, MD PhD, Sabine Zollner, Bernadette W. Luu, Rajalingam Raja, PhD, Jerry Sherman Powell, MD, Eugene Maraskovsky, MD, PhD, Tom E. Howard, MD PhD

Blood (2015) 126 (23): 2292.

https://doi.org/10.1182/blood.V126.23.2292.2292

Published: 2015

Journal Articles

The Spectrum of Amino Acid Substitutions Resulting from Single Nucleotide Substitutions in the Coagulation Biosystem: Impact on Identification By Mass Spectrometry

Kevin R. Viel, PhD, Benjamin Kim, MD MPhil, Maria Elizabeth Tejero, PhD, Shelley S. Cole, PhD, Tom E. Howard, MD PhD, Amparo Santamaría Ortiz, MD, PhD

Blood (2014) 124 (21): 4221.

https://doi.org/10.1182/blood.V124.21.4221.4221

Published: 2014

Journal Articles

F8 and HLA -II Haplotypes in the Hispanic Population: Implications for Inhibitor Risk Development in Hispanic Hemophilia A Patients

Benjamin Kim, M.D., M.Phil., Zuben E. Sauna, Ph.D., Melanie A. Carless, Ph.D., Joanne E. Curran, Ph.D., Kevin R. Viel, Ph.D., Shelley S. Cole, Ph.D., Rajalingam Raja, Ph.D., John Blangero, Ph.D., Tom E. Howard, M.D., Ph.D.

Blood (2012) 120 (21): 3365.

https://doi.org/10.1182/blood.V120.21.3365.3365

Published: 2012

Journal Articles

Common SNPs within or near Three Immune Response Genes Implicated in the Risk of FVIII Immunogenicity in Hemophilia A Do Not Influence Steady-State Levels of Their Encoded mRNAs

Tom E. Howard, M.D., Ph.D., Eugene Drigalenko, Ph.D., Matthew P. Johnson, Ph.D., Shelley S. Cole, Ph.D., Benjamin Kim, M.D., M.Phil., Kevin R. Viel, Ph.D., Zuben E. Sauna, Ph.D., Joanne E. Curran, Ph.D., John Blangero, Ph.D., Laura A. Almasy, Ph.D., Harald H. Göring, Ph.D.

Blood (2012) 120 (21): 3366.

https://doi.org/10.1182/blood.V120.21.3366.3366

Published: 2012

Journal Articles

No Evidence of Cis -Acting SNPs In Immune Response Genes Previously Associated with Factor VIII Inhibitors: The San Antonio Family Heart Study

Tom E. Howard, M.D., Ph.D., Kevin R. Viel, Ph.D., Eugene Drigalenko, Ph.D., Shelley Cole, Ph.D., Melinda Epstein, Ph.D., Melanie Carless, Ph.D., Richard Hughes, Ph.D., Benjamin Kim, MD, Tom Dyer, M.S., Kathleen P. Pratt, PhD, Jean W. MacCluer, Ph.D., Joanne E. Curran, Ph.D., Matthew P. Johnson, Ph.D., Eric K. Moses, Ph.D., John Blangero, Ph.D., Laura Almasy, Ph.D., Harald Göring, Ph.D.

Blood (2010) 116 (21): 4422.

https://doi.org/10.1182/blood.V116.21.4422.4422

Published: 2010

Journal Articles

Heritability of Commonly Measured Blood Cell Phenotypes in the San Antonio Family Heart Study.

Kevin R. Viel, PhD, Tom Howard, PhD, MD, Joanne E. Curran, PhD, Laura Almasy, PhD, Eric K. Moses, PhD, David C. Glahn, PhD, Afshin Ameri, MD, Blangero John, PhD

Blood (2007) 110 (11): 3687.

https://doi.org/10.1182/blood.V110.11.3687.3687

Published: 2007

Journal Articles

A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels

Kevin R. Viel, Deepa K. Machiah, Diane M. Warren, Manana Khachidze, Alfonso Buil, Karl Fernstrom, Juan C. Souto, Juan M. Peralta, Todd Smith, John Blangero, Sandra Porter, Stephen T. Warren, Jordi Fontcuberta, Jose M. Soria, W. Dana Flanders, Laura Almasy, Tom E. Howard

Blood (2007) 109 (9): 3713–3724.

https://doi.org/10.1182/blood-2006-06-026104

Published: 2007

Includes: Supplemental data

Journal Articles

Allelically Mismatched Replacement Therapy Due to Common African−Restricted Haplotypes of the Factor (F)VIII Protein May Underlie the Increased Incidence of FVIII Inhibitors Observed in Hemophilia−A Patients of African−Descent.

Tom E. Howard, MD, PhD, Kevin R. Viel, BS, Karl M. Fernstrom, BS, Seema Deshpande, PhD, Afshin Ameri, MD, M. Showkat Ali, PhD, Cynthia Channell, BS, Rathi V. Iyer, MD, Raymond G. Watts, MD, Charles Lutcher, MD, Shelley Nakaya, BS, Carol K. Kasper, MD, Arthur R. Thompson, MD, PhD, Thomas C. Abshire, MD, Laura Almasy, PhD

Blood (2006) 108 (11): 765.

https://doi.org/10.1182/blood.V108.11.765.765

Published: 2006

Journal Articles

Potential Spectrum of Missense and Nonsense Factor (F)VIII Gene (F8) Alleles Based on Single Nucleotide Substitutions - How Many Remain To Be Identified?.

Kevin R. Viel, BS, Manana Khachidze, MD, PhD, MPH, Laura Almasy, PhD, Arthur R. Thompson, MD, PhD, Tom E. Howard, MD, PhD

Blood (2006) 108 (11): 4039.

https://doi.org/10.1182/blood.V108.11.4039.4039

Published: 2006

Journal Articles

The Pharmacogenetics and Inhibitor Risk (PIR) Study: Establishing the Spectrum of Factor (F)VIII Gene (F8) Mutations in African-American Hemophilia A Patients.

Tom E. Howard, MD, PhD, Deepa K. Machiah, BS, Kevin R. Viel, PhD, Cynthia Channel, BS, Afshin Ameri, MD, Rathi V. Iyer, MD, Ray G. Watts, MD, Charles Lutcher, MD, Joanna Davis, MD, Thomas C. Abshire, MD, Laura Almasy, PhD

Blood (2005) 106 (11): 3207.

https://doi.org/10.1182/blood.V106.11.3207.3207

Published: 2005

Journal Articles

A Quantitative Trait Locus for Cholesterol/Low Density Lipoprotein within the Promoter of the Factor IX Gene.

Kevin R. Viel, BS, Manana Khachidze, MD, PhD, MPH, Alfonso Buil, BS, José Manuel Soria, PhD, Juan Carlos Souto, MD, PhD, Jordi Fontcuberta, MD, PhD, Francisco Blanco-Vaca, MD, PhD, Jordi Ordoñez-Llanos, MD, PhD, Laura Almasy, PhD, Howard Tom, MD, PhD

Blood (2004) 104 (11): 4000.

https://doi.org/10.1182/blood.V104.11.4000.4000

Published: 2004

Journal Articles

African-Americans Express Multiple Haplotypic Forms of the Wildtype Factor VIII (FVIII) Protein: A Possible Role for Pharmacogenetics in FVIII Inhibitor Development?.

Tom Howard, M.D., Ph.D., Deepa M. Machiah, Ph.D., Thuy T. Tran, Kevin R. Viel, B.S., Cynthia Channell, B.S., Jose Manuel Soria, Ph.D., Afshin Ameri, M.D., Rathi V. Iyer, M.D., Cara Brown, B.S., R.N., Christopher Doering, Ph.D., Laura Almasy, Ph.D., Ray Watts, M.D., Joanna Davis, M.D., Thomas C. Abshire, M.D.

Blood (2004) 104 (11): 384.

https://doi.org/10.1182/blood.V104.11.384.384

Published: 2004

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Results from an Association-Scan of the Extended MHC-Class-II Region Using Novel Association-Based Statistical Methods Establish That DQ Allotypes and Race Independently Influence the Risk of Factor VIII Inhibitor Development in Hemophilia-A Patients

Gene-Centric Association Scans of Pleiotropic Immune-Mediated Disease Genes in the PATH Study Identify Novel Determinants of Factor VIII Inhibitor Risk in Hemophilia-A Patients and Confirm Race as an Independent Predictor

A Novel Biomarker for Inhibitor Risk Prediction-the HLA-II Bound and Unbound Components of FVIII Derived Peptides-Reveals a Protective Influence for N-Linked Glycosylation

The Spectrum of Amino Acid Substitutions Resulting from Single Nucleotide Substitutions in the Coagulation Biosystem: Impact on Identification By Mass Spectrometry

F8 and HLA -II Haplotypes in the Hispanic Population: Implications for Inhibitor Risk Development in Hispanic Hemophilia A Patients

Common SNPs within or near Three Immune Response Genes Implicated in the Risk of FVIII Immunogenicity in Hemophilia A Do Not Influence Steady-State Levels of Their Encoded mRNAs

No Evidence of Cis -Acting SNPs In Immune Response Genes Previously Associated with Factor VIII Inhibitors: The San Antonio Family Heart Study

Heritability of Commonly Measured Blood Cell Phenotypes in the San Antonio Family Heart Study.

A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels

Allelically Mismatched Replacement Therapy Due to Common African−Restricted Haplotypes of the Factor (F)VIII Protein May Underlie the Increased Incidence of FVIII Inhibitors Observed in Hemophilia−A Patients of African−Descent.

Potential Spectrum of Missense and Nonsense Factor (F)VIII Gene (F8) Alleles Based on Single Nucleotide Substitutions - How Many Remain To Be Identified?.

The Pharmacogenetics and Inhibitor Risk (PIR) Study: Establishing the Spectrum of Factor (F)VIII Gene (F8) Mutations in African-American Hemophilia A Patients.

A Quantitative Trait Locus for Cholesterol/Low Density Lipoprotein within the Promoter of the Factor IX Gene.

African-Americans Express Multiple Haplotypic Forms of the Wildtype Factor VIII (FVIII) Protein: A Possible Role for Pharmacogenetics in FVIII Inhibitor Development?.

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