1-20 of 31
Tom E. Howard
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

Paul S. de Vries, Paula Reventun, Michael R. Brown, Adam S. Heath, Jennifer E. Huffman, Ngoc-Quynh Le, Allison Bebo, Jennifer A. Brody, Gerard Temprano-Sagrera, Laura M. Raffield, Ayse Bilge Ozel, Florian Thibord, Deepti Jain, Joshua P. Lewis, Benjamin A. T. Rodriguez, Nathan Pankratz, Kent D. Taylor, Ozren Polasek, Ming-Huei Chen, Lisa R. Yanek, German D. Carrasquilla, Riccardo E. Marioni, Marcus E. Kleber, David-Alexandre Trégouët, Jie Yao, Ruifang Li-Gao, Peter K. Joshi, Stella Trompet, Angel Martinez-Perez, Mohsen Ghanbari, Tom E. Howard, Alex P. Reiner, Marios Arvanitis, Kathleen A. Ryan, Traci M. Bartz, Igor Rudan, Nauder Faraday, Allan Linneberg, Lynette Ekunwe, Gail Davies, Graciela E. Delgado, Pierre Suchon, Xiuqing Guo, Frits R. Rosendaal, Lucija Klaric, Raymond Noordam, Frank van Rooij, Joanne E. Curran, Marsha M. Wheeler, William O. Osburn, Jeffrey R. O'Connell, Eric Boerwinkle, Andrew Beswick, Bruce M. Psaty, Ivana Kolcic, Juan Carlos Souto, Lewis C. Becker, Torben Hansen, Margaret F. Doyle, Sarah E. Harris, Angela P. Moissl, Jean-François Deleuze, Stephen S. Rich, Astrid van Hylckama Vlieg, Harry Campbell, David J. Stott, Jose Manuel Soria, Moniek P. M. de Maat, Laura Almasy, Lawrence C. Brody, Paul L. Auer, Braxton D. Mitchell, Yoav Ben-Shlomo, Myriam Fornage, Caroline Hayward, Rasika A. Mathias, Tuomas O. Kilpeläinen, Leslie A. Lange, Simon R. Cox, Winfried März, Pierre-Emmanuel Morange, Jerome I. Rotter, Dennis O. Mook-Kanamori, James F. Wilson, Pim van der Harst, J. Wouter Jukema, M. Arfan Ikram, John Blangero, Charles Kooperberg, Karl C. Desch, Andrew D. Johnson, Maria Sabater-Lleal, Charles J. Lowenstein, Nicholas L. Smith, Alanna C. Morrison
Journal: Blood
Blood (2024) 143 (18): 1845–1855.
https://doi.org/10.1182/blood.2023021452
Published: 2024
Includes: Supplemental data
Journal Articles

Results from an Association-Scan of the Extended MHC-Class-II Region Using Novel Association-Based Statistical Methods Establish That DQ Allotypes and Race Independently Influence the Risk of Factor VIII Inhibitor Development in Hemophilia-A Patients

Paola Ibarra, Marcio A. Almeida, Vincent P. Diego, Bernadette W. Luu, Kevin R. Viel, Raja Rajalingam, Afshin Ameri, Meera Chitlur, Benjamin Kim, Grecia Castillo, Jerry S. Powell, Juan M. Peralta, Miguel A. Escobar, Sarah Williams-Blangero, John Blangero, Carol K. Kasper, Laura Almasy, Tom E. Howard
Journal: Blood
Blood (2023) 142 (Supplement 1): 1247.
https://doi.org/10.1182/blood-2023-191140
Published: 2023
Journal Articles

Gene-Centric Association Scans of Pleiotropic Immune-Mediated Disease Genes in the PATH Study Identify Novel Determinants of Factor VIII Inhibitor Risk in Hemophilia-A Patients and Confirm Race as an Independent Predictor

Ruayda Bouls, Marcio A. Almeida, Vincent P. Diego, Bernadette W. Luu, Raja Rajalingam, Afshin Ameri, Kevin R. Viel, Meera Chitlur, Benjamin Kim, Miguel A. Escobar, Sarah Williams-Blangero, Carol K. Kasper, Laura Almasy, John Blangero, Tom E. Howard
Journal: Blood
Blood (2023) 142 (Supplement 1): 1246.
https://doi.org/10.1182/blood-2023-190094
Published: 2023
Journal Articles

The Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) 353 R>q in the Coagulation Factor VII (FVII) Gene, F7 , is Associated with Decreased Plasma FVII Levels and a Decreased Risk of Coronary Heart Disease (CHD) in Mexican Americans of South Texas

Kanisha Patel, Vincent P. Diego, Alberto D. Lopez, Marcio A. Almeida, Joanne E. Curran, Miguel Escobar, Jerry S. Powell, Donna M. Lehman, Ralph A DeFronzo, Sarah Williams-Blangero, Ravi Duggirala, Laura Almasy, John Blangero, Tom E. Howard
Journal: Blood
Blood (2022) 140 (Supplement 1): 2799–2800.
https://doi.org/10.1182/blood-2022-168478
Published: 2022
Journal Articles

A Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) in TFPI , the Gene Encoding Tissue Factor Pathway Inhibitor (TFPI), is Pleiotropically Associated with Increased Plasma TFPI Levels and a Decreased Risk of Type 2 Diabetes (T2D) in Mexican Americans of South Texas

Alberto D. Lopez, Vincent P. Diego, Kanisha Patel, Marcio A. Almeida, Joanne E. Curran, Miguel Escobar, Jerry S. Powell, Donna M. Lehman, Ralph A DeFronzo, Sarah Williams-Blangero, Ravi Duggirala, Laura Almasy, John Blangero, Tom E. Howard
Journal: Blood
Blood (2022) 140 (Supplement 1): 8536–8537.
https://doi.org/10.1182/blood-2022-171201
Published: 2022
Journal Articles

The Factor II (FII) Expression Quantitative Trait Locus (eQTL) Prothrombin G20210A Is Pleiotropically Associated with Plasma Fibrinogen Levels and Has a Profound Effect on Obesity in Mexican Americans of South Texas

Hoang Anh Thi Nguyen, Vincent P. Diego, Shuchita Jhaveri, Marcio A. Almeida, Satish Kumar, Juan M Peralta, Joanne E. Curran, Bernadette W. Luu, Donna M. Lehman, Ralph A DeFronzo, Miguel A. Escobar, Sarah Williams-Blangero, Ravi Duggirala, Jerry S. Powell, Laura Almasy, John Blangero, Tom E. Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 1059.
https://doi.org/10.1182/blood-2021-154338
Published: 2021
Journal Articles

On the Role of Hemostasis Variables in Cardiometabolic Outcomes

Alberto D. Lopez, Kanisha Patel, Vincent P. Diego, Marcio A. Almeida, John Blangero, Jerry S. Powell, Tom E. Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 4266.
https://doi.org/10.1182/blood-2021-154441
Published: 2021
Journal Articles

The G505A Nonsynonymous Single-Nucleotide Polymorphism (SNP) in TAFI , the Gene Encoding Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Is Pleiotropically Associated with TAFI Antigen Levels and Coronary Heart Disease (CHD) in Mexican Americans of South Texas

Shuchita Jhaveri, Vincent P. Diego, Hoang Anh Thi Nguyen, Satish Kumar, Marcio A. Almeida, Juan M Peralta, Joanne E. Curran, Bernadette W. Luu, Donna M. Lehman, Ralph A DeFronzo, Miguel A. Escobar, Sarah Williams-Blangero, Ravi Duggirala, Jerry S. Powell, Laura Almasy, John Blangero, Tom E. Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 3217.
https://doi.org/10.1182/blood-2021-151968
Published: 2021
Journal Articles

N-Linked Glycans on Therapeutic Factor VIII (FVIII) Proteins Attenuate Immunogenicity Potential: Evidence from Independent HLA-Class-II/FVIII (HLAcII/FVIII) Peptidomes

Vincent P. Diego, PhD, Bernadette W. Luu, B.S., M.T. (CLS), Hari Movva, B.S., Marco Hofmann, M.S., Marcio A. Almeida, PhD, Long V. Dinh, PhD, Jerry S. Powell, MD, Raja Rajalingam, PhD, Juan M Peralta, M.S., Henry Mead, M.B.A., M.P.H., Satish Kumar, PhD, Joanne E. Curran, PhD, Miguel A. Escobar, MD, Sarah Williams-Blangero, PhD, Eugene Maraskovsky, PhD, John Blangero, PhD, Tom E. Howard, MD, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-142493
Published: 2020
Journal Articles

Specific Correction of the Intron-22 Inverted Factor VIII Gene in Autologous Blood Outgrowth Endothelial Cells from Patients with Severe Hemophilia A

Long V. Dinh, PhD, Eli Fine, PhD, Afshin Ameri, MD, Bernadette W. Luu, B.S., M.T. (CLS), Satish Kumar, PhD, Vincent P. Diego, PhD, Joanne E. Curran, PhD, Juan M Peralta, M.S., Henry Mead, M.B.A., M.P.H., Miguel A. Escobar, MD, Sarah Williams-Blangero, PhD, John Blangero, PhD, Jerry S. Powell, MD, Timothy C. Nichols, MD, Robert P. Hebbel, MD, Tom E. Howard, MD, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-142679
Published: 2020
Journal Articles

Disentangling the Effects of HLA DRB1*15:01 and DQB1*06:02 to Establish the True HLA Risk Allele for Inhibitor Development in the Treatment of Hemophilia A

Vincent P. Diego, PhD, Bernadette W. Luu, B.S., M.T. (CLS), Alexis Garza, B.S., Marco Hofmann, M.S., Marcio A. Almeida, PhD, Jerry S. Powell, MD, Long V. Dinh, PhD, Raja Rajalingam, PhD, Juan M Peralta, M.S., Satish Kumar, PhD, Eli Fine, PhD, Joanne E. Curran, PhD, Miguel A. Escobar, MD, Sarah Williams-Blangero, PhD, Eugene Maraskovsky, PhD, John Blangero, PhD, Tom E. Howard, MD, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-142716
Published: 2020
Journal Articles

The Dendritic Cell HLA-Class-II/Therapeutic Factor VIII (FVIII) Peptidome Is Influenced in Unanticipated Ways By the B-Domain of FVIII and the FVIII Chaperon Protein, Von Willebrand Factor: The Outrigger and Glycosylation-Umbrella (GUMB) Hypotheses

Tom E. Howard, MD, PhD, Bernadette W. Luu, B.S., M.T. (CLS), Marco Hofmann, M.S., Marcio A. Almeida, PhD, Satish Kumar, PhD, Long V. Dinh, PhD, Henry Mead, M.B.A., M.P.H., Jerry S. Powell, MD, Miguel A. Escobar, MD, Raja Rajalingam, PhD, Sarah Williams-Blangero, PhD, John Blangero, PhD, Maraskovsky Eugene, PhD, Vincent P. Diego, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 161.
https://doi.org/10.1182/blood-2019-131727
Published: 2019
Journal Articles

On the Role of F8 Sequence Mismatch and Class-II Human Leukocyte Antigen Binding in the Development of Neutralizing Antibodies ("Inhibitors") Directed Against Therapeutic Factor VIII Proteins (tFVIIIs): Evidence from the PATH Study

Vincent P. Diego, PhD, Bernadette W. Luu, B.S., M.T. (CLS), Afshin Ameri, MD, Meera B. Chitlur, MD, Marcio A. Almeida, PhD, Karin Haack, PhD, Satish Kumar, PhD, Long V. Dinh, PhD, Henry Mead, M.B.A., M.P.H., Jerry S. Powell, MD, Miguel A. Escobar, MD, Raja Rajalingam, PhD, Sarah Williams-Blangero, PhD, Carol K. Kasper, MD, Laura Almasy, PhD, Shelley Cole, PhD, John Blangero, PhD, Tom E. Howard, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2393.
https://doi.org/10.1182/blood-2019-132218
Published: 2019
Journal Articles

Genetics of Factor VIII Inhibitor Development in Hemophilia Patients: Novel Statistical Approaches in the PATH Study

Vincent P. Diego, PhD, Marcio A. Almeida, PhD, Bernadette W. Luu, BS, MT/CLS, Karin Haack, PhD, Meera B. Chitlur, MD, Afshin Ameri, MD, Long V. Dinh, PhD, Raja Rajalingam, PhD, Jerry S. Powell, MD, John Blangero, PhD, Laura Almasy, PhD, Shelley Cole, PhD, Tom E. Howard
Journal: Blood
Blood (2018) 132 (Supplement 1): 1199.
https://doi.org/10.1182/blood-2018-99-120021
Published: 2018
Journal Articles

The Role of Class II Human Leukocyte Antigens (cII-HLAs) in Determining the Immunogenic Potential of Therapeutic Factor VIII Proteins in Hemophilia Patients: The "Gate Keeper" Hypothesis

Vincent P. Diego, PhD, Bernadette W. Luu, BS, MT/CLS, Marco Hofmann, MS, Marcio A. Almeida, PhD, Jose Antonio G. Hernandez, PhD, Juan Peralta, MS, Joanne Curran, PhD, Jerry S. Powell, MD, Raja Rajalingam, PhD, Long V. Dinh, PhD, Sarah Williams-Blangero, PhD, Miguel A Escobar, MD, Eugene Maraskovsky, PhD, John Blangero, PhD, Tom E. Howard
Journal: Blood
Blood (2018) 132 (Supplement 1): 5022.
https://doi.org/10.1182/blood-2018-99-115537
Published: 2018
Journal Articles

A Novel Biomarker for Inhibitor Risk Prediction-the HLA-II Bound and Unbound Components of FVIII Derived Peptides-Reveals a Protective Influence for N-Linked Glycosylation

Kevin R. Viel, PhD, Marco Hofmann, MD PhD, Sabine Zollner, Bernadette W. Luu, Rajalingam Raja, PhD, Jerry Sherman Powell, MD, Eugene Maraskovsky, MD, PhD, Tom E. Howard, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2292.
https://doi.org/10.1182/blood.V126.23.2292.2292
Published: 2015
Journal Articles

The intron-22–inverted F8 locus permits factor VIII synthesis: explanation for low inhibitor risk and a role for pharmacogenomics

Zuben E. Sauna, Jay N. Lozier, Carol K. Kasper, Chen Yanover, Timothy Nichols, Tom E. Howard
Journal: Blood
Blood (2015) 125 (2): 223–228.
https://doi.org/10.1182/blood-2013-12-530113
Published: 2015
Journal Articles

The Spectrum of Amino Acid Substitutions Resulting from Single Nucleotide Substitutions in the Coagulation Biosystem: Impact on Identification By Mass Spectrometry

Kevin R. Viel, PhD, Benjamin Kim, MD MPhil, Maria Elizabeth Tejero, PhD, Shelley S. Cole, PhD, Tom E. Howard, MD PhD, Amparo Santamaría Ortiz, MD, PhD
Journal: Blood
Blood (2014) 124 (21): 4221.
https://doi.org/10.1182/blood.V124.21.4221.4221
Published: 2014
Journal Articles

Single-Nucleotide Variations Defining Previously Unreported ADAMTS13 Haplotypes Are Associated With Differential Expression and Activity Of The VWF-Cleaving Protease In a Salvadoran Congenital Thrombotic Thrombocytopenic Purpura Family

Benjamin Kim, M.D., M.Phil., Zachary A. Hing, Andrew Wu, Tal Schiller, Evi B. Struble, Ph.D., David Liuwantara, Ph.D., Pamela H. Kempert, M.D., Eric J. Broxham, M.D., Nathan C. Edwards, Victor J. Marder, M.D., Vijaya L. Simhadri, Ph.D., Zuben E. Sauna, Ph.D., Tom E. Howard, M.D., Ph.D., Chava Kimchi-Sarfaty, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 2319.
https://doi.org/10.1182/blood.V122.21.2319.2319
Published: 2013
Journal Articles

F8 and HLA -II Haplotypes in the Hispanic Population: Implications for Inhibitor Risk Development in Hispanic Hemophilia A Patients

Benjamin Kim, M.D., M.Phil., Zuben E. Sauna, Ph.D., Melanie A. Carless, Ph.D., Joanne E. Curran, Ph.D., Kevin R. Viel, Ph.D., Shelley S. Cole, Ph.D., Rajalingam Raja, Ph.D., John Blangero, Ph.D., Tom E. Howard, M.D., Ph.D.
Journal: Blood
Blood (2012) 120 (21): 3365.
https://doi.org/10.1182/blood.V120.21.3365.3365
Published: 2012