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Kieran O'Donovan
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Journal Articles

NVG-222: A First-in-Class Autoregulating Half-Life Extended ROR1xCD3 T Cell Engager Heralding a New Class of Safer Drugs

David Granger, Vincent Muczynski, Patricia Henne, Annalisa Baccaro, Dinusha Fernando, Mittal Shah, John Devlin, Kieran O'Donovan, Amit C. Nathwani
Journal: Blood
Blood (2023) 142 (Supplement 1): 2820.
https://doi.org/10.1182/blood-2023-189058
Published: 2023
Journal Articles

Time Limited Exposure to a ROR1 Targeting Bispecific T Cell Engager (NVG-111) Leads to Durable Responses in Subjects with Relapsed Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)

William Townsend, Sarah Leong, Mittal Shah, Toby Batten, David Tucker, Bryson Pottinger, Shankaranarayana Paneesha, Dima El-Sharkawi, Toby A. Eyre, Ho Pui Jeff Lam, Jiexin Zheng, Sarah Cook, David Granger, David Ahern, Kieran O'Donovan, Amit C. Nathwani, Parag Jasani
Journal: Blood
Blood (2023) 142 (Supplement 1): 329.
https://doi.org/10.1182/blood-2023-188607
Published: 2023
Journal Articles

First-in-Human Phase I Trial of a ROR1 Targeting Bispecific T Cell Engager (NVG-111) in Combination with Ibrutinib or As Monotherapy in Subjects with Relapsed Refractory Chronic Lymphocytic Leukaemia (CLL) and Mantle Cell Lymphoma (MCL)

William Townsend, Sarah Leong, David Tucker, Bryson Pottinger, Shankara Paneesha, Dima El-Sharkawi, Toby A. Eyre, Toby Batten, Mittal Shah, Sarah Cook, David Granger, Kieran O'Donovan, Amit C. Nathwani, Parag Jasani
Journal: Blood
Blood (2022) 140 (Supplement 1): 4162–4163.
https://doi.org/10.1182/blood-2022-169658
Published: 2022
Journal Articles

Pre-Clinical Development of a First in Class Half-Life Extended T Cell Engager Targeting ROR-1

David Granger, Patricia Henne, Annalisa Baccaro, Dinusha Fernando, Jasmine Gore, Ephraim Gbajumo, Vincent Muczynski, Mittal Shah, Kieran O'Donovan, Kerry Chester, Amit C. Nathwani
Journal: Blood
Blood (2022) 140 (Supplement 1): 7810–7811.
https://doi.org/10.1182/blood-2022-168961
Published: 2022