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Krystle Nomie, PhD
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Journal Articles

Integration and Iteration: Using Advanced, High-Content Imaging and Single-Cell Gene Expression Analysis to Uncover Unique Aspects of Follicular Lymphoma Biology

Andrea J. Radtke, PhD, Arthur L. Shaffer, III, PhD, Stefania Pittaluga, MD PhD, Alexander Bagaev, MS, Nishant Thakur, PhD, Theresa Davies-Hill, BS, Olga Plotnikova, MS, Ilia Galkin, MS, Ekaterina Postovalova, PhD, Viktor Svekolkin, MS, Sergei Isaev, MS, Yaroslav Lozinsky, MS, Mark Meerson, MS, Arina Varlamova, MS, Pavel Ovcharov, MS, Margarita Polyakova, MD, Krystle Nomie, PhD, Ekaterina Nuzhdina, MS, Nikita Kotlov, MS, Maria Tsiper, PhD, Felix Frenkel, PhD, Ravshan Attaulakhanov, PhD, Nathan H Fowler, MD, Ziv Yaniv, PhD, Bradley C Lowekamp, PhD, Michael Kelly, PhD, Ezzat Dadkhah, PhD, Da Wei Huang, MD, Jagan R. Muppidi, MD PhD, Elaine S. Jaffe, MD, Wyndham H. Wilson, MD PhD, Louis M. Staudt, MD PhD, Ronald N. Germain, MD PhD, Mark Roschewski, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-142633
Published: 2020
Journal Articles

Single Cell Transcriptomic Evolution and Resistance Mechanisms of BTK and BCL-2 Inhibition in Mantle Cell Lymphoma

Vivian Changying Jiang, PhD, Shaojun Zhang, PhD, Junwei Lian, PhD, Yuanxin Wang, Rongjia Zhang, Yang Liu, PhD, Joseph McIntosh, BS, Guangchun Han, Ruiping Wang, PhD, David Santos, Maria Badillo, MSN, RN, OCN, CCRP, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Hun Lee, MD, Raphael Eric Steiner, MD, Jorge Enrique Romaguera, MD, Preetesh Jain, MBBS,MDDM,PhD, Krystle Nomie, PhD, Andy Futreal, Linghua Wang, MDPhDMS, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-140882
Published: 2020
Journal Articles

Genetically Defined Metabolic Targets Overcome Ibrutinib Resistance in Mantle Cell Lymphoma

Liang Zhang, MD PhD, Hui Guo, PhD, Hui Zhang, Yixin Yao, PhD, Yang Liu, MD, Shaojun Zhang, PhD, Lixin Rui, PhD, Linghua Wang, PhD, Krystle Nomie, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 395.
https://doi.org/10.1182/blood-2019-125934
Published: 2019
Journal Articles

Transcriptomic Heterogeneity and Clonal Evolution Associated with Therapeutic Resistance in Mantle Cell Lymphoma Revealed By Single Cell RNA-Seq

Changying Jiang, PhD, Shaojun Zhang, PhD, Yuanxin Wang, Rongjia Zhang, Yang Liu, MD, Joseph Mitchell McIntosh, Guangchun Han, PhD, Ruiping Wang, PhD, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Hun Ju Lee, Raphael E Steiner, MD, Jorge Enrique Romaguera, MD, Preetesh Jain, MBBS, MDDM, PhD, Krystle Nomie, PhD, Andy Futreal, PhD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5217.
https://doi.org/10.1182/blood-2019-129134
Published: 2019
Journal Articles

Pdox Models Empower Preclinical Drug Evaluation and Mechanistic Studies Via Faithful Recapitulation of the Pathology, Complex Heterogeneity, Genetic-Transcriptomic Landscape, and Therapeutic Response of Mantle Cell Lymphoma

Changying Jiang, PhD, Shaojun Zhang, PhD, Shengjian Huang, PhD, Yang Liu, MD, Rongjia Zhang, Angela Leeming, Joseph Mitchell McIntosh, William Lee, Krystle Nomie, PhD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3974.
https://doi.org/10.1182/blood-2019-128810
Published: 2019
Journal Articles

Targeting PI3K and PLK1 to Overcome Ibrutinib-Venetoclax Resistance in Mantle Cell Lymphoma

Changying Jiang, PhD, Rongjia Zhang, Shaojun Zhang, PhD, William Lee, Shengjian Huang, PhD, Yang Liu, MD, Angela Leeming, Joseph Mitchell McIntosh, Preetesh Jain, MBBS,MDDM,PhD, Krystle Nomie, PhD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4062.
https://doi.org/10.1182/blood-2019-128299
Published: 2019
Journal Articles

Non-Bcl2 Mutations Are Predominant in Patients (pts) with Venetoclax Resistant Mantle Cell Lymphoma (MCL) - Response and Clinical Outcomes in Ultra-Refractory MCL

Preetesh Jain, MBBS,MDDM,PhD, Shuangtao Zhao, PhD, Rashmi Kanagal-Shamanna, MD, Lucy Navsaria, MB BCh BAO, Holly Hill, Ankita Misra, Krystle Nomie, PhD, Changying Jiang, PhD, Yixin Yao, PhD, Liang Zhang, MD PhD, Loretta J. Nastoupil, MD MSc, F. B. Hagemeister, MD, Jason R. Westin, MD, Ranjit Nair, MD, Raphael Eric Steiner, MD, Onyeka Oriabure, Wendy Chen, Guilin Tang, MD, C. Cameron Yin, MD PhD, Keyur Patel, MD PhD, Jorge Enrique Romaguera, MD, Nathan H. Fowler, MD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2815.
https://doi.org/10.1182/blood-2019-126175
Published: 2019
Journal Articles

BI-1206, a Monoclonal Antibody Against Fcγriib, Showed Superior Anti-Tumor Activity in an Ibrutinib-Venetoclax Dual Resistant PDX Model in Mantle Cell Lymphoma

Changying Jiang, PhD, Yang Liu, MD, Joseph Mitchell McIntosh, Angela Leeming, Rongjia Zhang, William Lee, Krystle Nomie, PhD, Ingrid Karlsson, PhD, Linda Mårtensson, PhD, Mathilda Kovacek, Ingrid Teige, PhD, Björn Frendéus, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2863.
https://doi.org/10.1182/blood-2019-126957
Published: 2019
Journal Articles

Frontline Treatment with Ibrutinib Plus Rituximab (IR) Followed By Short Course R-Hypercvad/MTX Is Extremely Potent and Safe in Patients (age ≤ 65 years) with Mantle Cell Lymphoma (MCL) - Results of Phase-II Window-1 Clinical Trial

Michael L. Wang, MD, Preetesh Jain, MBBS,MDDM,PhD, Hun Ju Lee, MD, F. B. Hagemeister, MD, Felipe Samaniego, MD, Jason R. Westin, MD, Loretta J. Nastoupil, MD MSc, Wendy Chen, Krystle Nomie, PhD, Shaojun Zhang, PhD, Omar Moghrabi, Shuangtao Zhao, PhD, Rashmi Kanagal-Shamanna, MD, Chi Young Ok, MD, Onyeka Oriabure, Graciela M. Nogueras González, MPH, Dayoung Jung, Lucy Navsaria, MB BCh BAO, Ann Uy, Archie Pedersen, Liang Zhang, MD PhD, Changying Jiang, PhD, Feng Lei, MS, Yixin Yao, PhD, Guofang Xu, MD, Nicolaus Wagner-Bartak, MD, Selvi Thirumurthi, David Santos, Guilin Tang, MD, Keyur Patel, MD PhD, C. Cameron Yin, MD PhD, Michelle Avellaneda, Maria Badillo, Luis Fayad, MD, Sattva S Neelapu, MD, Nathan H. Fowler, MD, Jorge Enrique Romaguera, MD, Linghua Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3987.
https://doi.org/10.1182/blood-2019-126044
Published: 2019
Journal Articles

Frontline Treatment with Ibrutinib with Rituximab (IR) Combination Is Highly Effective in Elderly (≥65 years) Patients with Mantle Cell Lymphoma (MCL) - Results from a Phase II Trial

Preetesh Jain, MBBS,MDDM,PhD, Hun Ju Lee, MD, Raphael Eric Steiner, MD, F. B. Hagemeister, MD, Felipe Samaniego, MD, Jason R. Westin, MD, Loretta J. Nastoupil, MD MSc, Sairah Ahmed, MD, Swaminathan P. Iyer, MD, Jorge Enrique Romaguera, MD, Shuangtao Zhao, PhD, Krystle Nomie, PhD, Chi Young Ok, MD, Rashmi Kanagal-Shamanna, MD, Onyeka Oriabure, Guofang Xu, MD, Liang Zhang, MD PhD, Changying Jiang, PhD, Dayoung Jung, Lucy Navsaria, MB BCh BAO, Wendy Chen, Omar Moghrabi, Tayyaba Nizam, Chloe Marie McClain, Maria Badillo, Selvi Thirumurthi, David Santos, Guilin Tang, MD, Keyur Patel, MD PhD, Sattva S Neelapu, MD, Linghua Wang, PhD, Nathan H. Fowler, MD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3988.
https://doi.org/10.1182/blood-2019-125800
Published: 2019
Journal Articles

Tumor Microenvironment Molecular Signatures That Define Therapeutic Resistance in Mantle Cell Lymphoma

Krystle Nomie, PhD, Nikita Kotlov, PhD, Viktor Svekolkin, PhD, Alexander Bagaev, PhD, Qingsong Cai, PhD, Jasmine Falahat, Omar Moghrabi, Felix Frenkel, PhD, Ravshan Attaulakhanov, PhD, Angela Leeming, Dayoung Jung, Holly Hill, Kelley Paige Murfin, MSPH, Zhihong Chen, Kimberly Hartig, Maria Badillo, Preetesh Jain, MBBS,MDDM,PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2762.
https://doi.org/10.1182/blood-2019-130512
Published: 2019
Journal Articles

Analysis of Factors Predictive of Risk of Transformation and Time to Transformation in Patients (pts) with Mantle Cell Lymphoma - Cohort Study of 369 Patients

Preetesh Jain, MBBS,MDDM,PhD, Rashmi Kanagal-Shamanna, MD, Chi Young Ok, MD, Gonzalez-Pagan Omarya, Lucy Navsaria, MB BCh BAO, Graciela M. Nogueras González, MPH, Shaojun Zhang, PhD, Guangchun Han, Ahmad Ghorab, Prajwal Boddu, MD, F. B. Hagemeister, MD, Hun Ju Lee, MD, Krystle Nomie, PhD, Changying Jiang, PhD, Luis Fayad, MD, Jason R. Westin, MD, Loretta J. Nastoupil, MD MSc, Sairah Ahmed, MD, Swaminathan P. Iyer, MD, Richard E. Champlin, MD, Sattva S Neelapu, MD, Jorge Enrique Romaguera, MD, Nathan H. Fowler, MD, Guilin Tang, MD, Shaoying Li, MD, Keyur Patel, MD PhD, Selvi Thirumurthi, Pan Tinsu, Guofang Xu, MD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1526.
https://doi.org/10.1182/blood-2019-125936
Published: 2019
Journal Articles

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Yixin Yao, PhD, Yang Liu, MD, Hui Zhang, Angela Leeming, Joseph Mitchell McIntosh, Preetesh Jain, MBBS,MDDM,PhD, Liang Zhang, MD PhD, Krystle Nomie, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1506.
https://doi.org/10.1182/blood-2019-126738
Published: 2019
Journal Articles

The Development of a Precision Medicine Platform to Overcome Ibrutinib Resistance in Mantle Cell Lymphoma

Yang Liu, MD, Shuangtao Zhao, PhD, Changying Jiang, PhD, Yixin Yao, PhD, Kelley Paige Murfin, MSPH, Hadley Grundman, Liang Zhang, MD PhD, Krystle Nomie, PhD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1487.
https://doi.org/10.1182/blood-2019-131079
Published: 2019
Journal Articles

FoxM1-Mediated Signaling Promotes the Progression of Mantle Cell Lymphoma

Hui Guo, PhD, Yixin Yao, PhD, Hui Zhang, Elizabeth Lorence, Makhdum Ahmed, MD PhD MPH, Lingyan Ping, MD PhD, Krystle Nomie, PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4176.
https://doi.org/10.1182/blood-2018-99-119349
Published: 2018
Journal Articles

Outcomes, Causes of Discontinuation and Mutation Profile of Patients with Mantle Cell Lymphoma Who Progressed on Acalabrutinib

Preetesh Jain, MBBS, MDDM, PhD, Rashmi Kanagal-Shamanna, MD, Shaojun Zhang, PhD, Chi Young Ok, MD, Makhdum Ahmed, MD PhD MPH, Diana Nava, Maria Badillo, Krystle Nomie, PhD, Keyur Patel, MD PhD, Hun Ju Lee, MD, F. B. Hagemeister, MD, Luis Fayad, MD, Loretta J. Nastoupil, MD, L. Jeffrey Medeiros, MD, Sattva S. Neelapu, MD, Jorge Enrique Romaguera, Nathan H. Fowler, MD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4151.
https://doi.org/10.1182/blood-2018-99-115179
Published: 2018
Journal Articles

A Novel Patient-Derived Xenograft Model of Secondary CD20 - CNS Lymphoma for Mechanistic and Therapeutic Exploration

Liang Zhang, MD PhD, Hui Zhang, Hui Guo, PhD, Yuting Sun, PhD, Ningping Feng, PhD, Joseph R Marszalek, PhD, Makhdum Ahmed, MDPhDMPH, Krystle Nomie, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1669.
https://doi.org/10.1182/blood-2018-99-112205
Published: 2018
Journal Articles

Clinical and Genomic Characteristics in De Novo Blastoid/Pleomorphic ( dn MCL) and Transformed Blastoid/Pleomorphic (t-MCL) Mantle Cell Lymphoma (MCL) in the Ibrutinib Era: Comprehensive Analysis of 168 Patients

Preetesh Jain, MBBS,MDDM,PhD, Rashmi Kanagal-Shamanna, MD, Shaojun Zhang, PhD, Chi Young Ok, MD, Graciela M. Nogueras González, MPH, Makhdum Ahmed, MDPhDMPH, Gonzalez-Pagan Omarya, Ahmad Ghorab, MDMSc, Prajwal C Boddu, MD, Wendy Chen, Hun Ju Lee, MD, Maria Badillo, Krystle Nomie, PhD, Luis Fayad, MD, Loretta J. Nastoupil, MD, Richard E Champlin, MD, Sattva S. Neelapu, MD, Keyur Patel, MD PhD, L. Jeffrey Medeiros, MD, Jorge Enrique Romaguera, Nathan H. Fowler, MD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1599.
https://doi.org/10.1182/blood-2018-99-115360
Published: 2018
Journal Articles

Ibrutinib-Resistant Mantle Cell Lymphoma Undergoes Metabolic Reprogramming Towards Oxphos

Krystle Nomie, PhD, Liang Zhang, MD PhD, Yixin Yao, PhD, Yang Liu, PhD, Shaojun Zhang, PhD, Hui Zhang, Hui Guo, PhD, Makhdum Ahmed, MDPhDMPH, Maria Badillo, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 41.
https://doi.org/10.1182/blood-2018-99-117279
Published: 2018
Journal Articles

Unravelling the Heterogeneity of Mantle Cell Lymphoma Ecosystem By Single Cell RNA Sequencing

Makhdum Ahmed, MD PhD MPH, Hui Guo, PhD, Shaojun Zhang, PhD, Lalit Sehgal, PhD MPhil, Preetesh Jain, MBBS, MDDM, PhD, Rashmi Kanagal-Shamanna, MD, Chi Young Ok, MD, Angela Leeming, Yixin Yao, PhD, Liang Zhang, MD PhD, Krystle Nomie, PhD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4118.
https://doi.org/10.1182/blood-2018-99-110540
Published: 2018