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Journal Articles

Vector integration and fate in the hemophilia dog liver multiple years after AAV-FVIII gene transfer

Paul Batty, Sylvia Fong, Matteo Franco, Choong-Ryoul Sihn, Laura L. Swystun, Saira Afzal, Lorianne Harpell, David Hurlbut, Abbey Pender, Cheng Su, Hauke Thomsen, Christopher Wilson, Loubna Youssar, Andrew Winterborn, Irene Gil-Farina, David Lillicrap

Blood (2024) 143 (23): 2373–2385.

https://doi.org/10.1182/blood.2023022589

Published: 2024

Includes: Supplemental data

Journal Articles

Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients

Laura L. Swystun, Kenichi Ogiwara, Orla Rawley, Christine Brown, Ilinca Georgescu, Wilma Hopman, Veerle Labarque, Christoph Male, Katharina Thom, Victor S. Blanchette, Manuel D. Carcao, David Lillicrap

Blood (2019) 134 (11): 880–891.

https://doi.org/10.1182/blood.2019000190

Published: 2019

Includes: Supplemental data

Journal Articles

Exome Sequencing Studies Identify Mutations in STAB2 As a Genetic Risk for Venous Thromboembolic Disease

Karl Desch, MD, Ayse Bilge Ozel, PhD, Matthew Halvorsen, PhD, Alison L. Michels, Laura L Swystun, BSc, PhD, Lauren Mokry, PhD, Brent Richards, Marine Germain, David A. Tregouet, PhD, Pieter H. Reitsma, PhD, Clive Kearon, MB, Jun Z Li, PhD, David B. Goldstein, PhD, David Lillicrap, MD FRCPC, David Ginsburg, MD

Blood (2017) 130 (Supplement 1): 457.

https://doi.org/10.1182/blood.V130.Suppl_1.457.457

Published: 2017

Journal Articles

VWF-FVIII Interactions Influence Hemostatic Thrombus Stability in Murine Models of Hemophilia Α and Type 2N VWD

Laura L Swystun, PhD, Courtney Dwyer, Kate Nesbitt, Kassandra Hebert, David Lillicrap, MD

Blood (2016) 128 (22): 1403.

https://doi.org/10.1182/blood.V128.22.1403.1403

Published: 2016

Journal Articles

Differential Glycosylation Between Recombinant Factor VIII Produced in Baby Hamster Kidney and Chinese Hamster Ovary Cells Confers Differences in Immunogenicity in a Humanized Hemophilia Α Mouse Model

Jesse Lai, BSc, Laura L Swystun, PhD, Dominique Cartier, Cunjie Zhang, MSc, Kate Nesbitt, James Dennis, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2016) 128 (22): 326.

https://doi.org/10.1182/blood.V128.22.326.326

Published: 2016

Journal Articles

The role of leukocytes in thrombosis

Laura L. Swystun, Patricia C. Liaw

Blood (2016) 128 (6): 753–762.

https://doi.org/10.1182/blood-2016-05-718114

Published: 2016

Journal Articles

Histones Induce Endothelial Von Willebrand Factor Release and Subsequent Platelet Capture in In Vitro and In Vivo Models

Alison Michels, BSc, Laura L Swystun, PhD, Silvia Albánez, MSc, Jeffrey Mewburn, Kate Sponagle, David Lillicrap, MD

Blood (2014) 124 (21): 2768.

https://doi.org/10.1182/blood.V124.21.2768.2768

Published: 2014

Journal Articles

Characterization of Type 2N Von Willebrand Disease Mutations Using Ιn Vitro and Ιn Vivo Mouse Models

Laura L Swystun, PhD, Ilinca Georgescu, Meghan Deforest, Mia Golder, PhD, Kate Sponagle, Christine Brown, Colleen Notley, David Lillicrap, MD

Blood (2014) 124 (21): 471.

https://doi.org/10.1182/blood.V124.21.471.471

Published: 2014

Journal Articles

Clearance and Genetic Variability of Von Willebrand Factor Are Major Determinants of the Pharmacokinetic Behavior of Factor VIII Concentrates in the Treatment of Pediatric Hemophilia A

Kenichi Ogiwara, MD PhD, Laura L Swystun, PhD, Ilinca Georgescu, Christine Brown, Angie Tuttle, Shawn Tinlin, Jayne Leggo, Silvia Albánez, MSc, Manuel Carcao, MD MSc, Victor S. Blanchette, MD FRCPC, Christoph Male, MD MSC, Katharina Thom, David Lillicrap, MD

Blood (2014) 124 (21): 473.

https://doi.org/10.1182/blood.V124.21.473.473

Published: 2014

Journal Articles

FVIII stabilization: VWF D′D3 will do

Laura L. Swystun, David Lillicrap

Blood (2014) 124 (3): 313–315.

https://doi.org/10.1182/blood-2014-06-578955

Published: 2014

Journal Articles

Regulation Of Factor VIII Clearance By Mannose-Binding Lectins

Laura L. Swystun, PhD, Colleen Notley, Kate Sponagle, Paula D. James, MD, David Lillicrap

Blood (2013) 122 (21): 2340.

https://doi.org/10.1182/blood.V122.21.2340.2340

Published: 2013

Journal Articles

Platelet-Mediated Mechanical Tensile Force Influences ADAMTS13 Localization and Regulation Of Thrombus Development At The Site Of Platelet Accumulation

Yasuaki Shida, MD, PhD, Laura L. Swystun, PhD, Christine Brown, Jeff Mewburn, Kate Sponagle, Ozge Danisment, Jacob Riches, Christine Hough, PhD, David Lillicrap

Blood (2013) 122 (21): 454.

https://doi.org/10.1182/blood.V122.21.454.454

Published: 2013

Journal Articles

The Endothelial Lectin Receptor CLEC4M Internalizes Factor VIII and Von Willebrand Factor Via a Clathrin-Coated Pit-Dependent Mechanism

Laura L. Swystun, PhD, Colleen Notley, Ilinca Georgescu, Paula D. James, MD, David Lillicrap, MD

Blood (2013) 122 (21): 1091.

https://doi.org/10.1182/blood.V122.21.1091.1091

Published: 2013

Journal Articles

The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels

Natalia Rydz, Laura L. Swystun, Colleen Notley, Andrew D. Paterson, J. Jacob Riches, Kate Sponagle, Boonchai Boonyawat, Robert R. Montgomery, Paula D. James, David Lillicrap

Blood (2013) 121 (26): 5228–5237.

https://doi.org/10.1182/blood-2012-10-457507

Published: 2013

Includes: Supplemental data

Journal Articles

Genetic Variability of the CLEC4M Endothelial Lectin Receptor Modulates Binding and Internalization of Von Willebrand Factor and Contributes to Variance in Plasma VWF Levels

Laura L. Swystun, PhD, Natalia Rydz, MD, Colleen Notley, Jonathan J. Riches, Andrew D Paterson, MD, Robert R. Montgomery, MD, Paula D. James, MD, David Lillicrap, MD

Blood (2012) 120 (21): 16.

https://doi.org/10.1182/blood.V120.21.16.16

Published: 2012

NARROW

Vector integration and fate in the hemophilia dog liver multiple years after AAV-FVIII gene transfer

Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients

Exome Sequencing Studies Identify Mutations in STAB2 As a Genetic Risk for Venous Thromboembolic Disease

VWF-FVIII Interactions Influence Hemostatic Thrombus Stability in Murine Models of Hemophilia Α and Type 2N VWD

Differential Glycosylation Between Recombinant Factor VIII Produced in Baby Hamster Kidney and Chinese Hamster Ovary Cells Confers Differences in Immunogenicity in a Humanized Hemophilia Α Mouse Model

The role of leukocytes in thrombosis

Histones Induce Endothelial Von Willebrand Factor Release and Subsequent Platelet Capture in In Vitro and In Vivo Models

Characterization of Type 2N Von Willebrand Disease Mutations Using Ιn Vitro and Ιn Vivo Mouse Models

Clearance and Genetic Variability of Von Willebrand Factor Are Major Determinants of the Pharmacokinetic Behavior of Factor VIII Concentrates in the Treatment of Pediatric Hemophilia A

FVIII stabilization: VWF D′D3 will do

Regulation Of Factor VIII Clearance By Mannose-Binding Lectins

Platelet-Mediated Mechanical Tensile Force Influences ADAMTS13 Localization and Regulation Of Thrombus Development At The Site Of Platelet Accumulation

The Endothelial Lectin Receptor CLEC4M Internalizes Factor VIII and Von Willebrand Factor Via a Clathrin-Coated Pit-Dependent Mechanism

The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels

Genetic Variability of the CLEC4M Endothelial Lectin Receptor Modulates Binding and Internalization of Von Willebrand Factor and Contributes to Variance in Plasma VWF Levels

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American Society of Hematology

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ASH Publications

American Society of Hematology

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