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Journal Articles

Safety of dabigatran etexilate for the secondary prevention of venous thromboembolism in children

Leonardo R. Brandão, Manuela Albisetti, Jacqueline Halton, Lisa Bomgaars, Elizabeth Chalmers, Lesley G. Mitchell, Ildar Nurmeev, Pavel Svirin, Tomas Kuhn, Ondrej Zapletal, Igor Tartakovsky, Monika Simetzberger, Fenglei Huang, Zhichao Sun, Jörg Kreuzer, Savion Gropper, Martina Brueckmann, Matteo Luciani

Blood (2020) 135 (7): 491–504.

https://doi.org/10.1182/blood.2019000998

Published: 2020

Includes: Supplemental data

Journal Articles

Pharmacokinetics (PK) and Pharmacodynamics (PD), Safety and Tolerability of a Single-Dose Oral Solution of Dabigatran Etexilate Given after Standard Anticoagulant Therapy in Children from Birth to Less Than One Year Old, with Venous Thromboembolism

Jacqueline ML Halton, MD, Anne-Caroline Picard, Ruth Harper, Fenglei Huang, Martina Brueckmann, MD, Savion Gropper, MD, Hugo Maas, Igor Tartakovsky, MD, Ildar Nurmeev, Lesley G Mitchell, Leonardo R. Brandão, MD MSc, Manuela Albisetti, MD

Blood (2016) 128 (22): 1441.

https://doi.org/10.1182/blood.V128.22.1441.1441

Published: 2016

Journal Articles

Rationale and Design of a Phase IIb/III Open-Label, Multicenter Study of Dabigatran Etexilate for Venous Thromboembolism in Children: The Diversity Study

Manuela Albisetti, MD, Ivan Manastirski, Martina Brueckmann, MD, Savion Gropper, MD, Bushi Wang, Igor Tartakovsky, MD, Branislav Biss, Fenglei Huang, Lesley G Mitchell, MSc, Leonardo R. Brandão, MD MSc, Jacqueline ML Halton, MD

Blood (2016) 128 (22): 5025.

https://doi.org/10.1182/blood.V128.22.5025.5025

Published: 2016

Journal Articles

Rationale and Design of a Phase III Single-Arm Multicenter Study of Dabigatran Etexilate for the Secondary Prevention of Venous Thromboembolism in Children

Matteo Luciani, Manuela Albisetti, MD, Ivan Manastirski, Martina Brueckmann, MD, Savion Gropper, MD, Igor Tartakovsky, MD, Bushi Wang, Branislav Biss, Lesley G Mitchell, Fenglei Huang, Jacqueline ML Halton, MD, Leonardo R. Brandão, MD MSc

Blood (2016) 128 (22): 5028.

https://doi.org/10.1182/blood.V128.22.5028.5028

Published: 2016

Journal Articles

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of a Single-Dose Oral Solution of Dabigatran Given after Standard Anticoagulant Therapy in Children (Two Age Groups: 1-<2 and 2-<12 Years Old), with Venous Thromboembolism

Jacqueline ML Halton, MD, Manuela Albisetti, MD, Matteo Luciani, Fenglei Huang, Branislav Biss, Martina Brueckmann, MD, Savion Gropper, MD, Hugo Maas, Igor Tartakovsky, MD, Lesley G Mitchell

Blood (2016) 128 (22): 87.

https://doi.org/10.1182/blood.V128.22.87.87

Published: 2016

Journal Articles

Comparison Of Ultrasound Versus Magnetic Resonance Venography For Diagnosis Of Catheter-Related Thrombosis In Children: A Multicenter Multinational Study

Christoph Male, Donald L Yee, MD, Christian Loewe, Rajesh Krishnamurthy, Elizabeth Chalmers, Jane Newburger, Luz-Margarita Ramirez, Ronald Portman, Lesley G Mitchell

Blood (2013) 122 (21): 2377.

https://doi.org/10.1182/blood.V122.21.2377.2377

Published: 2013

Journal Articles

Central Venous Catheters and Venous Thrombotic Events in Pediatric Oncology Patients: A Multicenter Case Control Study

Ketan P Kulkarni, MD, Jacqueline Halton, MD, Maria Spavor, MD FRCPC, Evan Shereck, MD, Sara J. Israels, MD, Kevin Dietrich, Sharon Abish, MD, Lesley G Mitchell

Blood (2012) 120 (21): 3400.

https://doi.org/10.1182/blood.V120.21.3400.3400

Published: 2012

Journal Articles

Can Heparin-Based Therapy in Children Be Monitored on Samples Drawn Through Ports? An Analysis From Clinical Trials Data,

Marilyn J. Manco-Johnson, MD, Neil Goldenberg, Lesley G Mitchell, Linda J. Jacobson, BS

Blood (2011) 118 (21): 3365.

https://doi.org/10.1182/blood.V118.21.3365.3365

Published: 2011

Journal Articles

The VKORC1 and CYP2C9 Genotypes Significantly Affect Vitamin K Antagonist Dosing Only in Patients Aged 20 Years or Older

Ulrike Nowak-Gottl, MD, Kevin Dietrich, Andre Franke, Noha Sharaf El-Din, Yutaka Yasui, Lesley G Mitchell

Blood (2011) 118 (21): 1243.

https://doi.org/10.1182/blood.V118.21.1243.1243

Published: 2011

Journal Articles

In pediatric patients, age has more impact on dosing of vitamin K antagonists than VKORC1 or CYP2C9 genotypes

Ulrike Nowak-Göttl, Kevin Dietrich, Daria Schaffranek, Noha Sharaf Eldin, Yutaka Yasui, Christof Geisen, Lesley G. Mitchell

Blood (2010) 116 (26): 6101–6105.

https://doi.org/10.1182/blood-2010-05-283861

Published: 2010

Includes: Supplemental data

Journal Articles

Incidence of Post-Thrombotic Syndrome Following Asymptomatic Thrombosis in Survivors of Childhood Acute Lymphoblastic Leukemia.

Stefan Kuhle, MD, Maria Spavour, Jacqueline Halton, MD, Patricia Massicotte, Irene Cherrick, David Dix, Donald Mahoney, Sunil Desai, Lesley G. Mitchell

Blood (2007) 110 (11): 1631.

https://doi.org/10.1182/blood.V110.11.1631.1631

Published: 2007

Journal Articles

Pharmacokinetics and Dose-Finding of Fragmin in Pediatric Patients at Risk for Thromboembolic Events.

Lesley G. Mitchell, Patricia Massicotte, Patricia Vegh, Peter Cox, Dimple Patel, Castillo Maria, Etches Wai, Stang Linda, Barrett Jeff

Blood (2007) 110 (11): 1861.

https://doi.org/10.1182/blood.V110.11.1861.1861

Published: 2007

Journal Articles

Twenty-Seven Percent of Children with Congenital Heart Disease Have a Thrombotic Event Detected in the Post Operative Period: A Prospective Cohort Study.

Lesley G. Mitchell, Patricia Massicotte, Shehla Qayyum, Ivan Rebeyka, David Ross, Ravi Bhargava, Mary Bauman, Karina Black

Blood (2007) 110 (11): 1636.

https://doi.org/10.1182/blood.V110.11.1636.1636

Published: 2007

Journal Articles

Newborns Are Hyperfibrinolytic at Physiologic tPA Concentrations and the Increased Fibrinolysis Is Related to Decreased Apparent TAFIa.

Lesley G. Mitchell, Laszlo Bajzar, Amal Rahal

Blood (2007) 110 (11): 1756.

https://doi.org/10.1182/blood.V110.11.1756.1756

Published: 2007

Journal Articles

Incorporation of a Comprehensive Pediatric Thrombosis Program into the Multidisciplinary Care Team for Children with Congenital Heart Disease: A Prospective Cohort Study.

Mary Patricia Massicotte, MSc MD, Ivan M. Rebeyka, MD, Mary Bauman, RN BA, Lesley G. Mitchell, ART MSc, Alf Conradi, MD

Blood (2004) 104 (11): 4062.

https://doi.org/10.1182/blood.V104.11.4062.4062

Published: 2004

Journal Articles

Comparison of the Anticoagulant Effect of Melagatran and Lmwh in an Acquired Antithrombin Deficiency in Children with All Treated with L-Asparaginase.

Lesley G. Mitchell, MSc, Stefan Kuhle, MD, Patrica Vegh, Alice Lau, BSc

Blood (2004) 104 (11): 1860.

https://doi.org/10.1182/blood.V104.11.1860.1860

Published: 2004

Journal Articles

Increased Incidence of Major Bleeding in Children Receiving Unfractionated Heparin for Clinical Management: A Prospective Cohort Study.

Lesley G. Mitchell, MSc, Stefan Kuhle, MD, Patricia M. Massicotte, MD, Patricia Vegh

Blood (2004) 104 (11): 1772.

https://doi.org/10.1182/blood.V104.11.1772.1772

Published: 2004

NARROW

Safety of dabigatran etexilate for the secondary prevention of venous thromboembolism in children

Pharmacokinetics (PK) and Pharmacodynamics (PD), Safety and Tolerability of a Single-Dose Oral Solution of Dabigatran Etexilate Given after Standard Anticoagulant Therapy in Children from Birth to Less Than One Year Old, with Venous Thromboembolism

Rationale and Design of a Phase IIb/III Open-Label, Multicenter Study of Dabigatran Etexilate for Venous Thromboembolism in Children: The Diversity Study

Rationale and Design of a Phase III Single-Arm Multicenter Study of Dabigatran Etexilate for the Secondary Prevention of Venous Thromboembolism in Children

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of a Single-Dose Oral Solution of Dabigatran Given after Standard Anticoagulant Therapy in Children (Two Age Groups: 1-<2 and 2-<12 Years Old), with Venous Thromboembolism

Comparison Of Ultrasound Versus Magnetic Resonance Venography For Diagnosis Of Catheter-Related Thrombosis In Children: A Multicenter Multinational Study

Central Venous Catheters and Venous Thrombotic Events in Pediatric Oncology Patients: A Multicenter Case Control Study

Can Heparin-Based Therapy in Children Be Monitored on Samples Drawn Through Ports? An Analysis From Clinical Trials Data,

The VKORC1 and CYP2C9 Genotypes Significantly Affect Vitamin K Antagonist Dosing Only in Patients Aged 20 Years or Older

In pediatric patients, age has more impact on dosing of vitamin K antagonists than VKORC1 or CYP2C9 genotypes

Incidence of Post-Thrombotic Syndrome Following Asymptomatic Thrombosis in Survivors of Childhood Acute Lymphoblastic Leukemia.

Pharmacokinetics and Dose-Finding of Fragmin in Pediatric Patients at Risk for Thromboembolic Events.

Twenty-Seven Percent of Children with Congenital Heart Disease Have a Thrombotic Event Detected in the Post Operative Period: A Prospective Cohort Study.

Newborns Are Hyperfibrinolytic at Physiologic tPA Concentrations and the Increased Fibrinolysis Is Related to Decreased Apparent TAFIa.

Incorporation of a Comprehensive Pediatric Thrombosis Program into the Multidisciplinary Care Team for Children with Congenital Heart Disease: A Prospective Cohort Study.

Comparison of the Anticoagulant Effect of Melagatran and Lmwh in an Acquired Antithrombin Deficiency in Children with All Treated with L-Asparaginase.

Increased Incidence of Major Bleeding in Children Receiving Unfractionated Heparin for Clinical Management: A Prospective Cohort Study.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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