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Journal Articles

Targeting the CXCR4 Pathway: Safety, Tolerability and Clinical Activity of Ulocuplumab (BMS-936564), an Anti-CXCR4 Antibody, in Relapsed/Refractory Acute Myeloid Leukemia

Pamela S. Becker, MD PhD, James M. Foran, MD, Jessica K. Altman, MD, Abdulraheem Yacoub, MD MB, Januario E. Castro, MD, Peter Sabbatini, PhD, Clifford Dilea, Mark Wade, Guan Xing, PhD, Andres Gutierrez, MD PhD, Lewis Cohen, MD MS, B. Douglas Smith, MD
Journal: Blood
Blood (2014) 124 (21): 386.
https://doi.org/10.1182/blood.V124.21.386.386
Published: 2014
Journal Articles

Novel CXCR4-Targeted Therapy to Inhibit Multiple Myeloma Bone Dissemination

Aldo M Roccaro, MD PhD, Antonio Sacco, BS, Michele Moschetta, MD, Yuji Mishima, PhD, Patricia Maiso, PhD, Daisy Huynh, MPS, Marco Chiarini, MSc, Pina M. Cardarelli, PhD, Lewis Cohen, MD MS, Michelle Kuhne, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2014) 124 (21): 4709.
https://doi.org/10.1182/blood.V124.21.4709.4709
Published: 2014
Journal Articles

Phase Ib Study of the Novel Anti-CXCR4 Antibody Ulocuplumab (BMS-936564) in Combination with Lenalidomide Plus Low-Dose Dexamethasone, or with Bortezomib plus Dexamethasone in Subjects with Relapsed or Refractory Multiple Myeloma

Irene M. Ghobrial, MD, Raymond Perez, MD, Rachid Baz, MD, Paul G. Richardson, Kenneth C. Anderson, MD, Peter Sabbatini, PhD, Clifford Dilea, Pina M. Cardarelli, PhD, Mark Wade, Guan Xing, PhD, Andres Gutierrez, MD PhD, Lewis Cohen, MD MS, Pamela S. Becker, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3483.
https://doi.org/10.1182/blood.V124.21.3483.3483
Published: 2014
Journal Articles

C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma

Aldo M. Roccaro, Antonio Sacco, Cristina Jimenez, Patricia Maiso, Michele Moschetta, Yuji Mishima, Yosra Aljawai, Ilyas Sahin, Michelle Kuhne, Pina Cardarelli, Lewis Cohen, Jesus F. San Miguel, Ramon Garcia-Sanz, Irene M. Ghobrial
Journal: Blood
Blood (2014) 123 (26): 4120–4131.
https://doi.org/10.1182/blood-2014-03-564583
Published: 2014
Includes: Supplemental data
Journal Articles

BMS-936564 (Anti-CXCR4 Antibody) Induces Specific Leukemia Cell Mobilization and Objective Clinical Responses In CLL Patients Treated Under a Phase I Clinical Trial

Manoj Kumar Kashyap, PhD, Carlos I. Amaya-Chanaga, MD, Harrison Jones, BS, Eiman A. AlMahasnah, MBBS, Michael Y. Choi, MD, Michelle R. Kuhne, PhD, Lewis Cohen, MD, MS, Peter Sabbatini, PhD, Thomas J. Kipps, MD, PhD, Pina M. Cardarelli, Ph.D., Januario E. Castro, M.D.
Journal: Blood
Blood (2013) 122 (21): 4190.
https://doi.org/10.1182/blood.V122.21.4190.4190
Published: 2013
Journal Articles

Mobilization Of Blasts and Leukemia Stem Cells by Anti-CXCR4 Antibody BMS-936564 (MDX 1338) in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Sylvia Chien, Lauren E. Beyerle, Brent L. Wood, MD, PhD, Elihu H. Estey, MD, Frederick R. Appelbaum, MD, Pina M. Cardarelli, Ph.D., Peter Sabbatini, PhD, Suresh Shelat, MD-PhD, Lewis Cohen, MD, MS, Pamela S. Becker, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3882.
https://doi.org/10.1182/blood.V122.21.3882.3882
Published: 2013
Journal Articles

BMS-936564 (MDX1338): A Fully Human Anti-CXCR4 Antibody Induces Apoptosis in an in Vitro Model of Stromal – Leukemia Cell Interaction for Chronic Lymphocytic Leukemia.

Manoj Kumar Kashyap, PhD, Deepak Kumar, PhD, Harrison Jones Jones, BS, Michael Y. Choi, MD, Johanna Melo-Cardenas, B.Sc, Michelle R. Kuhne, PhD, Peter Sabbatini, PhD, Lewis Cohen, MD, MS, Suresh Shelat, MD-PhD, Pina M Cardarelli, Ph.D., Thomas J. Kipps, MD, PhD, Januario E. Castro, M.D.
Journal: Blood
Blood (2012) 120 (21): 2887.
https://doi.org/10.1182/blood.V120.21.2887.2887
Published: 2012
Journal Articles

CXCR4 Monoclonal Antibody, BMS-936564 (MDX-1338), Modulates Epithelial to Mesenchymal Transition (EMT) in Multiple Myeloma Cells

Aldo M Roccaro, MD, PhD, Antonio Sacco, BS, Michelle R. Kuhne, PhD, Abdel Kareem Azab, PhD, BSPharm, Patricia Maiso, PhD, Feda Azab, BPharm, Salomon Manier, MD, Yosra Aljaway, BS, Michaela R Reagan, PhD, Lewis Cohen, MD, MS, Pina M Cardarelli, Ph.D., Irene M. Ghobrial, MD
Journal: Blood
Blood (2012) 120 (21): 4009.
https://doi.org/10.1182/blood.V120.21.4009.4009
Published: 2012
Journal Articles

BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Anti Tumor Activity In Vivo

Michelle R. Kuhne, PhD, Tanya Mulvey, Sharline Chen, Chin Pan, Ph.D., Colin Chong, Wafa Niekro, Tom Kempe, Ph.D., Karla A. Henning, Ph.D., Lewis Cohen, MD, MS, Alan Korman, Ph.D., Pina M Cardarelli, Ph.D.
Journal: Blood
Blood (2011) 118 (21): 1543.
https://doi.org/10.1182/blood.V118.21.1543.1543
Published: 2011