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Liqin Liu
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Journal Articles

Novel CD123xCD3 Bispecific Igm Antibody, Igm-2537, Potently Induces T-Cell Mediated Cytotoxicity of Acute Myeloid Leukemia Cells In Vivo and in Vitro with Minimal Cytokine Release

Gene Li, Zhongde Ye, Poonam Yakkundi, Marigold Manlusoc, Kathryn Logronio, Leyla Tahrani, Rodnie Rosete, David Bernados, Paul Hinton, Deepal Pandya, Nardeen Hanna, Jey Anantam, Maya F Kotturi, Liz Bogaert, Jiyoung Hong, Christina Tsai, Thomas Manley, Bruce A Keyt, Angus M. Sinclair, Liqin Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 4177.
https://doi.org/10.1182/blood-2023-182891
Published: 2023
Journal Articles

CD123 Directed IgM Antibody-based T-cell Engager, IGM-2537, Demonstrates Potent in vitro and in vivo Activity with Minimal Cytokine Release

Liqin Liu, Gene Li, Ling Wang, Poonam Yakkundi, Paul R. Hinton, Deepal Pandya, Manal Amoury, Keerthana Sekar, Chian Liu, Rodnie Rosete, Nardeen Hanna, Maya F. Kotturi, Liz Bogaert, Jiyoung Hong, Christina Tsai, Bruce A. Keyt, Angus M. Sinclair
Journal: Blood
Blood (2022) 140 (Supplement 1): 5918–5919.
https://doi.org/10.1182/blood-2022-165817
Published: 2022
Journal Articles

Igm-2644, a Novel CD38xCD3 Bispecific IgM T Cell Engager Demonstrates Potent Efficacy on Myeloma Cells with an Improved Preclinical Safety Profile

Keyu Li, Rui Yun, Min Chai, Poonam Yakkundi, Rodnie Rosete, Gene Li, Liqin Liu, Dean Ng, Paul R. Hinton, Maya F. Kotturi, Angus M. Sinclair, Stephen F. Carroll, Umesh Muchhal, Bruce A. Keyt
Journal: Blood
Blood (2022) 140 (Supplement 1): 6010–6011.
https://doi.org/10.1182/blood-2022-159205
Published: 2022
Journal Articles

A Next-Generation Fc-Bearing CD3-Engaging Bispecific DART ® Platform with Extended Pharmacokinetic and Expanded Pharmacologic Window: Characterization As CD123 x CD3 and CD19 x CD3 DART Molecules

Ezio Bonvini, MD, Ross La Motte-Mohs, PhD, Ling Huang, Chia-Ying Kao Lam, PhD, Thomas Kaufman, Liqin Liu, PhD, Ralph F. Alderson, PhD, Kurt Stahl, Jennifer G. Brown, PhD, Hua Li, Sharad Sharma, PhD, James Tamura, PhD, Syd Johnson, PhD, Paul Moore, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5230.
https://doi.org/10.1182/blood-2018-99-116264
Published: 2018
Journal Articles

MGD011, Humanized CD19 x CD3 DART ® Protein with Enhanced Pharmacokinetic Properties, Demonstrates Potent T-Cell Mediated Anti-Tumor Activity in Preclinical Models and Durable B-Cell Depletion in Cynomolgus Monkeys Following Once-a-Week Dosing

Liqin Liu, PhD, Annie Lam, PhD, Ralph Alderson, PhD, Yinhua Yang, MD, Hua Li, M.S., Vatana Long, M.S., Sergey Gorlatov, PhD, Steve Burke, B.S., Valentina Ciccarone, PhD, Jeffrey Nordstrom, PhD, Syd Johnson, PhD, Paul Moore, PhD, Ezio Bonvini, MD
Journal: Blood
Blood (2014) 124 (21): 1775.
https://doi.org/10.1182/blood.V124.21.1775.1775
Published: 2014
Journal Articles

Phosphatidylinositol-3 Kinase Delta (PI3Kδ) Inhibitor AMG 319 Is a Potent, Selective and Orally Bioavailable Small Molecule Inhibitor That Suppresses PI3K-Mediated Signaling and Viability in Neoplastic B Cells

Angus Sinclair, Daniela Metz, Tim Cushing, Liqin Liu, Rachael Brake, Charlie Starnes, Gary Means, Kirk Henne, Ivonne Archibeque, Bethany Mattson, Allison Drew, Leigh Busse, Ling Wang, Ali-Samer Al-Assaad, Graham Molineux
Journal: Blood
Blood (2011) 118 (21): 4964.
https://doi.org/10.1182/blood.V118.21.4964.4964
Published: 2011
Journal Articles

New Insights on Assessing Intra-Family Selectivity for Jak2 Inhibitors

Liqin Liu, Violeta Yu, Jeanne Pistillo, Josie Lee, Laurie B Schenkel, Stephanie Geuns-Meyer, Ivonne Archibeque, Angus Sinclair, Renee Emkey, Graham Molineux
Journal: Blood
Blood (2011) 118 (21): 5150.
https://doi.org/10.1182/blood.V118.21.5150.5150
Published: 2011
Journal Articles

Potency and Selectivity Assessment of Small Molecules Against Janus Kinase (JAK) 2: Widely Used AG490 Inhibitor Is Neither Potent Nor Selective for JAK2

Angus Sinclair, Ivonne Archibeque, Jinghui Zhan, Liqin Liu, Renee Emkey, Elizabeth Doherty, C. Glenn Begley, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4780.
https://doi.org/10.1182/blood.V118.21.4780.4780
Published: 2011
Journal Articles

Phosphatidylinsoitol-3 Kinase Delta (PI3Kδ) Inhibitor AMG 319 Combined with Vincristine Enhances G2/M Arrest and Apoptotic Death in Neoplastic B Cells

Liqin Liu, Bee-Chun Sun, Jeanne Pistillo, Marc Payton, Ling Wang, Ivonne Archibeque, Graham Molineux, Angus Sinclair
Journal: Blood
Blood (2011) 118 (21): 4963.
https://doi.org/10.1182/blood.V118.21.4963.4963
Published: 2011
Journal Articles

Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells

Angus M. Sinclair, Angela Coxon, Ian McCaffery, Stephen Kaufman, Katherine Paweletz, Liqin Liu, Leigh Busse, Susan Swift, Steven Elliott, C. Glenn Begley
Journal: Blood
Blood (2010) 115 (21): 4264–4272.
https://doi.org/10.1182/blood-2009-10-248666
Published: 2010
Includes: Supplemental data
Journal Articles

Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders

Sigal Gery, Saskia Gueller, Katya Chumakova, Norihiko Kawamata, Liqin Liu, H. Phillip Koeffler
Journal: Blood
Blood (2007) 110 (9): 3360–3364.
https://doi.org/10.1182/blood-2007-05-089326
Published: 2007
Includes: Supplemental data