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Journal Articles

Predicting Clinical Response and Safety of JCAR017 in B-NHL Patients: Potential Importance of Tumor Microenvironment Biomarkers and CAR T-Cell Tumor Infiltration

Christina Swanson, PhD, Trevor Do, Samantha Merrigan, Shaparak Lonning, Kim Merriam, Joshua Prentiss, Janani Sridar, Claire L Sutherland, PhD, Benhuai Xie, PhD, Minh Pham, Daniel Li, PhD, Tina Albertson, MD, Howard M Stern, MDPhD, Sharon Moulis, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 194.
https://doi.org/10.1182/blood.V130.Suppl_1.194.194
Published: 2017
Journal Articles

Duvelisib (IPI-145) Inhibits Malignant B-Cell Proliferation and Disrupts Signaling from the Tumor Microenvironment through Mechanisms That Are Dependent on PI3K-δ and PI3K-γ

Marisa Peluso, MS, Kerrie Faia, MS, David Winkler, PhD, Nidhi Patel, MS, Erin Brophy, BS, Kerry White, BA, Mark Douglas, MS, Howard M. Stern, MD PhD, Vito Palombella, PhD, Karen McGovern, PhD, Jeffery L. Kutok, MD PhD
Journal: Blood
Blood (2014) 124 (21): 328.
https://doi.org/10.1182/blood.V124.21.328.328
Published: 2014
Journal Articles

Duvelisib (IPI-145), a PI3K-δ,γ Inhibitor, Is Clinically Active in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

Susan O'Brien, Manish Patel, Brad S. Kahl, MD, Steven M. Horwitz, MD, Francine M. Foss, MD, Pierluigi Porcu, MD, Jennifer Sweeney, Kerstin Allen, MA, Kerrie Faia, MS, Howard M. Stern, MD PhD, Patrick Kelly, MD, Ian Flinn
Journal: Blood
Blood (2014) 124 (21): 3334.
https://doi.org/10.1182/blood.V124.21.3334.3334
Published: 2014
Journal Articles

Clinical Activity of Duvelisib (IPI-145), a Phosphoinositide-3-Kinase-δ,γ Inhibitor, in Patients Previously Treated with Ibrutinib

Pierluigi Porcu, MD, Ian Flinn, Brad S. Kahl, MD, Steven M. Horwitz, MD, Yasuhiro Oki, John C. Byrd, MD, Jennifer Sweeney, Kerstin Allen, MA, Kerrie Faia, MS, Min Ni, PhD, Howard M. Stern, MD PhD, Patrick Kelly, MD, Susan O'Brien
Journal: Blood
Blood (2014) 124 (21): 3335.
https://doi.org/10.1182/blood.V124.21.3335.3335
Published: 2014
Journal Articles

a Phase 1 Evaluation of Duvelisib (IPI-145), a PI3K-δ,γ Inhibitor, in Patients with Relapsed/Refractory iNHL

Ian Flinn, Yasuhiro Oki, MD, Manish Patel, Steven M. Horwitz, MD, Francine M. Foss, MD, Jennifer Sweeney, Kerstin Allen, MA, Mark Douglas, MS, Lori Steelman, Joi Dunbar, PharmD, Howard M. Stern, MD PhD, Patrick Kelly, MD, Brad Kahl, MD
Journal: Blood
Blood (2014) 124 (21): 802.
https://doi.org/10.1182/blood.V124.21.802.802
Published: 2014
Journal Articles

Duvelisib (IPI-145), a Phosphoinositide-3-Kinase-δ,γ Inhibitor, Shows Activity in Patients with Relapsed/Refractory T-Cell Lymphoma

Steven M. Horwitz, MD, Pierluigi Porcu, MD, Ian Flinn, Brad S. Kahl, MD, Jennifer Sweeney, Howard M. Stern, MD PhD, Mark Douglas, MS, Kerstin Allen, MA, Patrick Kelly, MD, Francine M. Foss, MD
Journal: Blood
Blood (2014) 124 (21): 803.
https://doi.org/10.1182/blood.V124.21.803.803
Published: 2014
Journal Articles

The Potent PI3K-δ,γ Inhibitor IPI-145 Exhibits Differential Activity In Diffuse Large B-Cell Lymphoma (DLBCL) Cell Lines

Veronica Campbell, BS, Ryan Thompson, PhD, Vivian Villegas, MS, Jennifer Proctor, B.S., Karen McGovern, PhD, Jeffery L. Kutok, MD, PhD, Howard M. Stern, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1832.
https://doi.org/10.1182/blood.V122.21.1832.1832
Published: 2013
Journal Articles

Treatment With The Potent PI3K-δ,γ Inhibitor IPI-145 Is Associated With Rapid Decreases In Specific Cytokines, Chemokines and Matrix Metalloproteinases In The Serum Of Patients With Chronic Lymphocytic Leukemia and Indolent Non-Hodgkin Lymphoma

Mark Douglas, M.S., Ken Allison, M.S., Synder Ted, B.A., Kerstin Allen, MA, Brad S. Kahl, MD, Steven M. Horwitz, MD, Ian W. Flinn, MD, PhD, Patrick Kelly, MD, Howard M. Stern, M.D., Ph.D
Journal: Blood
Blood (2013) 122 (21): 1633.
https://doi.org/10.1182/blood.V122.21.1633.1633
Published: 2013
Journal Articles

Preliminary Safety and Efficacy Of IPI-145, a Potent Inhibitor Of Phosphoinositide-3-Kinase-δ,γ, In Patients With Chronic Lymphocytic Leukemia

Ian Flinn, MD, PhD, Manish Patel, MD, Brad S. Kahl, MD, Steven M. Horwitz, MD, Francine M. Foss, MD, Yasuhiro Oki, MD, Pierluigi Porcu, MD, Jennifer Sweeney, BS, Kerstin Allen, MA, Kerrie Faia, MS, Patricia Harris, MPH, Joi Dunbar, PharmD, Howard M. Stern, M.D., Ph.D., Patrick Kelly, MD, Susan O'Brien, MD
Journal: Blood
Blood (2013) 122 (21): 677.
https://doi.org/10.1182/blood.V122.21.677.677
Published: 2013
Journal Articles

Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma

Shrikanta Chattopadhyay, MBBS, Alison L. Stewart, PhD, Siddhartha Mukherjee, MD, PhD, Cherrie Huang, Kimberly A. Hartwell, PhD, Peter G. Miller, PhD, Leigh Carmody, PhD, Rushdia Z. Yusuf, MBBS, MPH, David B. Sykes, MD, PhD, Sonia Vallet, Loredana Santo, Diana D. Cirstea, MD, Teru Hideshima, MD, PhD, Vladimir Dancik, PhD, Jaime Cheah, PhD, Edmund Price, Abigail Bracha, PhD, Max Majireck, PhD, Mahmud Hussain, PhD, Shambhavi Singh, Nicola Tolliday, PhD, Malcolm A.S. Moore, D.Phil, Andrew M. Stern, PhD, Alykhan F Shamji, PhD, Benjamin L. Ebert, MD, PhD, Todd R. Golub, MD, Noopur Raje, MD, David T. Scadden, MD, Stuart L. Schreiber, PhD
Journal: Blood
Blood (2012) 120 (21): 571.
https://doi.org/10.1182/blood.V120.21.571.571
Published: 2012
Journal Articles

Niche-Based Screening Reveals Leukemia Stem Cell Specific Therapeutics

Kimberly A. Hartwell, PhD, Peter G. Miller, PhD, Alison L. Stewart, PhD, Alissa R. Kahn, MD, David J. Logan, PhD, Joseph Negri, Mildred Duvet, Shrikanta Chattopadhyay, MD, Sebastian Shterental, Lisa P Chu, Jae Hung Shieh, PhD, Marcus Jaeraas, MD, Vladimir Dancik, PhD, Rajiv Narayan, PhD, Christina Huang, J Erika Haydu, Siddhartha Mukherjee, MD, PhD, Alykhan F Shamji, PhD, Nicola J Tolliday, PhD, Anne E. Carpenter, PhD, Stuart L. Schreiber, PhD, Andrew M. Stern, PhD, Malcolm AS Moore, D Phil, David T. Scadden, MD, Benjamin L. Ebert, MD, D.Phil, Todd R. Golub, MD
Journal: Blood
Blood (2011) 118 (21): 760.
https://doi.org/10.1182/blood.V118.21.760.760
Published: 2011
Journal Articles

An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens

Clinical Trials & Observations
Wendy M. Leisenring, Paul J. Martin, Effie W. Petersdorf, Anne E. Regan, Nada Aboulhosn, Jean M. Stern, Saundra N. Aker, Raymond C. Salazar, George B. McDonald
Journal: Blood
Blood (2006) 108 (2): 749–755.
https://doi.org/10.1182/blood-2006-01-0254
Published: 2006
Journal Articles

Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation

David Traver, Alissa Winzeler, Howard M. Stern, Elizabeth A. Mayhall, David M. Langenau, Jeffrey L. Kutok, A. Thomas Look, Leonard I. Zon
Journal: Blood
Blood (2004) 104 (5): 1298–1305.
https://doi.org/10.1182/blood-2004-01-0100
Published: 2004
Includes: Multimedia, Supplemental data
Journal Articles

Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia

Clinical Trials & Observations
Dietmar Seiffert, Andrew M. Stern, William Ebling, Richard J. Rossi, Yu Chen Barrett, Richard Wynn, Gregory F. Hollis, Bokang He, Cathy J. Kieras, Donna L. Pedicord, Debra A. Cromley, Tsushung A. Hua, Robert B. Stein, Robert N. Daly, Anthony Sferruzza, Henry J. Pieniaszek, Jeffrey T. Billheimer
Journal: Blood
Blood (2003) 101 (1): 58–63.
https://doi.org/10.1182/blood-2002-02-0471
Published: 2003
Journal Articles

Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated

Clinical Trials & Observations
Jeffrey T. Billheimer, Ira B. Dicker, Richard Wynn, Jodi D. Bradley, Debra A. Cromley, Helen E. Godonis, Lisa C. Grimminger, Bokang He, Cathy J. Kieras, Donna L. Pedicord, Susan M. Spitz, Beth E. Thomas, Nina I. Zolotarjova, Mary A. Gorko, Gregory F. Hollis, Robert N. Daly, Andrew M. Stern, Dietmar Seiffert
Journal: Blood
Blood (2002) 99 (10): 3540–3546.
https://doi.org/10.1182/blood.V99.10.3540
Published: 2002
Journal Articles

Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders

Douglas B. Cines, Eleanor S. Pollak, Clayton A. Buck, Joseph Loscalzo, Guy A. Zimmerman, Rodger P. McEver, Jordan S. Pober, Timothy M. Wick, Barbara A. Konkle, Bradford S. Schwartz, Elliot S. Barnathan, Keith R. McCrae, Bruce A. Hug, Ann-Marie Schmidt, David M. Stern
Journal: Blood
Blood (1998) 91 (10): 3527–3561.
https://doi.org/10.1182/blood.V91.10.3527
Published: 1998
Journal Articles

Two populations of granulocytes in paroxysmal nocturnal hemoglobinuria

M Stern, WF Rosse
Journal: Blood
Blood (1979) 53 (5): 928–934.
https://doi.org/10.1182/blood.V53.5.928.928
Published: 1979