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Mark B Meads, PhD
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Journal Articles

Characterization of Synergistic Selinexor Combinations of Dexamethasone, Pomalidomide, Elotuzumab and Daratumumab in Primary MM Samples Ex Vivo

Kenneth H. Shain, MD PhD, Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan Reddy Alugubelli, Amit Kulkarni, PhD, Qi Zhang, PhD, Oliver Hampton, Constantine Logothetis, MD, Christian Argueta, PhD, Yosef Landesman, PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-140485
Published: 2020
Journal Articles

Dynamic Epigenetic Landscapes Define Multiple Myeloma Progression and Drug Resistance

Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Maria Silva, Praneeth Reddy Sudalagunta, PhD, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan R Alugubelli, MS, Amit Kulkarni, PhD, Qi Zhang, PhD, Oliver Hampton, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-142872
Published: 2020
Journal Articles

Ex Vivo Drug Sensitivity and Functional Genomics Platform Identifies Novel Combinations Targeting Intrinsic and Extrinsic Apoptotic Signaling Pathways in Multiple Myeloma

Ariosto Siqueira Silva, PhD, Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Maria D Coelho Siqueira Silva, MSc, Praneeth Reddy Sudalagunta, PhD, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan Reddy Alugubelli, Amit Kulkarni, PhD, Melissa Mitchell, Hongyue Dai, Qi Zhang, PhD, Oliver Hampton, Xin Lu, Dimple A. Modi, PhD, Monica Motwani, PhD, Jason Harb, PhD, Jeremy A. Ross, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 49–50.
https://doi.org/10.1182/blood-2020-134924
Published: 2020
Journal Articles

Composition of Immune Subpopulations Influence Multiple Myeloma Disease Progression

Rupal Ramakrishnan, Alexandra Achille, Tuan Nyugen, Ian Taylor, BS, Gabriel De Avila, BS, Raghunandanreddy Alugubelli, MS, Mark B. Meads, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD, Jason B. Brayer, PhDMD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4392.
https://doi.org/10.1182/blood-2019-131966
Published: 2019
Journal Articles

Re-Constructing and Exploiting Transcriptional Regulatory Networks in Multiple Myeloma Drug Resistance

Rafael Renatino-Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Alexandre Tungesvik, MD, Gabriel De Avila, Alugubelli Raghunandan Reddy, Minerva Nong, Jamie Teer, PhD, Eric A. Welsh, PhD, Tint Lwin, MD PhD, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5544.
https://doi.org/10.1182/blood-2019-128442
Published: 2019
Journal Articles

Integrated Multi-Level Omics to Characterize Bortezomib Resistance in Multiple Myeloma

David C. Koomen, BS, Mark B. Meads, PhD, Dario M. Magaletti, Joy D. Guingab, PhD, Paula S. Oliveira, Bin Fang, PhD, Victoria Izumi, MS, Rafael Renatino-Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria Silva, Raghunandanreddy Alugubelli, MS, Gabe De Avilla, Alex Tungeskiv, Eric A. Welsh, PhD, Laurel E. Meke, Wei Zhang, PhD, Steven A. Eschrich, PhD, Timothy J. Garrett, PhD, Ariosto Siqueira Silva, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5534.
https://doi.org/10.1182/blood-2019-132001
Published: 2019
Journal Articles

A CK1δ/CK1ε Regulated Metabolic Circuit Is a Therapeutic Vulnerability for Multiple Myeloma

Karen L Burger, PhD, Mark B. Meads, PhD, Anders Berglund, Paula S. Oliveira, Allison Distler, Praneeth Reddy Sudalagunta, PhD, Timothy Jacobson, Jamie Teer, PhD, Eric A. Welsh, PhD, Hongyue Dai, PhD, John M. Koomen, PhD, Alugubelli Raghunandan Reddy, Gabriel De Avila, Alexandre Tungesvik, MD, William Roush, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD, John Cleveland, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5537.
https://doi.org/10.1182/blood-2019-130830
Published: 2019
Journal Articles

A Systems Biology Approach to Identify Mechanisms of Therapy Resistance in Multiple Myeloma

Rafael Renatino Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Priscilla Granados, Anders Berglund, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Ion Petre, PhD, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3266.
https://doi.org/10.1182/blood-2018-99-118784
Published: 2018
Journal Articles

Proteometabolomics of Melphalan Resistance in Multiple Myeloma

David C. Koomen, BS, Joy D. Guingab, PhD, Paula S. Oliveira, Bin Fang, PhD, Min Liu, PhD, Eric A. Welsh, PhD, Mark B. Meads, PhD, Tuan Nguyen, Laurel E. Meke, Steven A. Eschrich, PhD, Timothy J. Garrett, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5619.
https://doi.org/10.1182/blood-2018-99-117747
Published: 2018
Journal Articles

Pharmacodynamical Modeling of Two-Way Synergistic Effect for High-Throughput Drug Combination Screening in an Ex Vivo Reconstruction of Bone Marrow Using Primary Multiple Myeloma Cells

Praneeth Reddy Sudalagunta, PhD, Rafael Renatino Canevarolo, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Alex Tungesvik, MD, Gabriel De Avila, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1919.
https://doi.org/10.1182/blood-2018-99-118978
Published: 2018
Journal Articles

Systems Biology Analysis Identifies Targetable Vulnerability Networks to Proteasome Inhibitors in Multiple Myeloma

Mark B. Meads, PhD, Rafael Renatino Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Paula S. Oliveira, Dario M. Magaletti, Bin Fang, PhD, Maria D Coelho Siqueira Silva, MSc, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Ion Petre, PhD, John M. Koomen, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 950.
https://doi.org/10.1182/blood-2018-99-120269
Published: 2018
Journal Articles

Functional Analysis of HDAC11 in Plasma Cell Development and Multiple Myeloma Survival

AGM Mostofa, PhD, Allison Distler, Mark B. Meads, PhD, Eva Sahakian, PhD, John J. Powers, BS, Tuan Nguyen, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Javier Pinilla Ibarz, MD, Eduardo Sotomayor, MD, Kenneth H. Shain, MD PhD, Jason B. Brayer, PhD MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2018-99-119119
Published: 2018
Journal Articles

Identification of Target Pathways of Acquired IMiD and Proteasome Inhibitor Resistance in Multiple Myeloma

Mark B. Meads, PhD, Paula Oliveira, Bin Fang, Praneeth Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Tuan Nguyen, Allison Distler, Salah-Eddin Komrokji, Aunshka Collins, Hongyue Dai, PhD, John M. Koomen, Ariosto Siqueira Silva, PhD, Kenneth H Shain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4411.
https://doi.org/10.1182/blood.V130.Suppl_1.4411.4411
Published: 2017
Journal Articles

HDAC11 Is a Candidate Therapeutic Target in Multiple Myeloma

Jason B. Brayer, PhDMD, Allison Distler, Mark B. Meads, PhD, Eva Sahakian, PhD, John J. Powers, BS, Tuan Nguyen, Melissa Alsina, MD, Taiga Nishihori, MD, Rachid Baz, MD, Javier Pinilla-Ibarz, MD PhD, Eduardo Martin Sotomayor, MD, Ken H Shain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1800.
https://doi.org/10.1182/blood.V130.Suppl_1.1800.1800
Published: 2017
Journal Articles

A CK1δ/CK1ε-to-β-Catenin Circuit Is a Therapeutic Vulnerability for Primary and Drug Resistant Multiple Myeloma

Karen L Burger, PhD, Mark B. Meads, PhD, Ariosto Siqueira Silva, PhD, Paula Oliveira, Tuan Nguyen, Allison Distler, Maria Coelho Siqueira Silva, Timothy Jacobson, Jamie Teer, PhD, Hongyue Dai, PhD, William Roush, PhD, John Cleveland, PhD, Kenneth H Shain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 591.
https://doi.org/10.1182/blood.V130.Suppl_1.591.591
Published: 2017
Journal Articles

Identification of Target Pathways Induced By the Multiple Myeloma Tumor Microenvironment Using Activity-Based Protein Profiling and Ex Vivo Protein Kinase Inhibitor Screening

Mark B Meads, PhD, Paula Oliveira, BS, Allison Distler, B.S., Maria Silva, M.Sc, Karen Burger, PhD, Bin Fang, PhD, Aunshka Collins, BS, John L. Cleveland, PhD, John M. Koomen, PhD, Ariosto Silva, PhD, Dmitri Rebatchouk, PhD, Kenneth H. Shain, MD PhD, William R. Roush, PhD
Journal: Blood
Blood (2016) 128 (22): 3288.
https://doi.org/10.1182/blood.V128.22.3288.3288
Published: 2016
Journal Articles

a Combination of Ex Vivo and Computational Models Predicts Clinical Response in MM Treatment Combinations of Proteasome Inhibitors, Imids, Nuclear Export Inhibitors and Alkylating Agents

Ariosto Silva, PhD, Maria Silva, M.Sc, Timothy Jacobson, B.S., Mark B Meads, PhD, Allison Distler, B.S., Aunshka Collins, BS, Chris Cubitt, PhD, Lia E Perez, MD, Rachid Baz, MD, Dmitri Rebatchouk, PhD, Robert Gatenby, MD, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3291.
https://doi.org/10.1182/blood.V128.22.3291.3291
Published: 2016
Journal Articles

Combination Therapy with Bortezomib or Carfilzomib and Selinexor Induces Nuclear Localization of Ikbα and Overcomes Acquired Proteasome Inhibitor Resistance in Human Multiple Myeloma

Joel G Turner, PhD, Trinayan Kashyap, MS, Jana L Dawson, BS, Juan A Gomez, BS, Alexis Bauer, BS, Steven Grant, MD, Yun Dai, PhD, Kenneth H. Shain, MD PhD, Mark B Meads, PhD, Yosef Landesman, PhD, Daniel M Sullivan, MD
Journal: Blood
Blood (2016) 128 (22): 3299.
https://doi.org/10.1182/blood.V128.22.3299.3299
Published: 2016
Journal Articles

The Synergistic Effect of Melphalan and XPO1 Inhibition in Pre-Clinical Models of Multiple Myeloma

Yan Cui, MD, Joel G Turner, PhD, Jana L Dawson, BS, Juan A Gomez, BS, Kenneth H. Shain, MD PhD, Mark B Meads, PhD, Erkan Baloglu, PhD, William S. Dalton, PhD MD, Taiga Nishihori, MD, Daniel M Sullivan, MD
Journal: Blood
Blood (2016) 128 (22): 5662.
https://doi.org/10.1182/blood.V128.22.5662.5662
Published: 2016
Journal Articles

A CK1δ/CK1ε-to-Wnt/β-Catenin Circuit Is a Therapeutic Vulnerability in Primary and Drug Resistant Multiple Myeloma

Karen L. Burger, PhD, Mark B Meads, PhD, Ariosto Silva, PhD, Allison Distler, B.S., Maria Coelho Siqueira Silva, Timothy Jacobson, B.S., Jamie K Teer, PhD, William R. Roush, PhD, Kenneth H. Shain, MD PhD, John L. Cleveland, PhD
Journal: Blood
Blood (2016) 128 (22): 2094.
https://doi.org/10.1182/blood.V128.22.2094.2094
Published: 2016